organism/neuron/soma.md

soma.md

Qui comprendiamo:

• BEH-SOMA: il soma

BEH-SOMA: Container

Simplified behaviors:

— ms:

• Resting at -70 mV: Leak channels + pumps (keep at resting)
• VDB Depolarization : ~1-2 ms: Na⁺ enters (some VGSCs open)
• Opened VGSC remain closed for a refractory period Spike if depolarized above threshold: to -50 mV
• Repolarization to -70 mV: ~1-2 ms: K⁺ exits (VG K⁺ channels open) ← NOT pumps!
• After-hyperpolarization: ~5-20 ms: K⁺ channels still open

— seconds:

• Return to exact -70 mV: ~100-1000 ms: Na⁺/K⁺ pumps restore gradients
• Ca2+ accumulation: SpikeTrainTraces

— mins:

• VGSC modulation

---

Tubs:

• VDB: dendrites deliver current

• VSOMA: are a proxy for the Coulombs of charge building up on the somatic membrane.

• AP:

• bAP:

• SpikeTrainTraces: sono le tracce che consentono al neurone di far partire il Tuning neuronale, quando e' lontano da uno spike-train, ovvero e' in riposo.

---

container: BEH-SOMA

  expansion: 
    - BEH-SOMA-VGSC ( fullness: 50x, active: 20x, emptiness: 10x ) 
      # modulated_by: TUN-SOMA-VCGG # possible/actual

  tub_local:

    - VDB

    - VSOMA

    - AP

    - bAP

  tub_intricated:
    - SpikeTrainTraces ( contained_by: TUN-N )

ms: behaviors SOMA

CheckVDB: Context

As dendrites deliver current (VDB​), the soma acts like a capacitor. It "stores" this charge in the form of membrane potential. VSOMA is proxy for the Coulombs of charge building up on the somatic membrane.

Contestualizziamo in maniera Fixed?

context: CheckVDB
  contained_by: BEH-SOMA

  in_context: Fixed
  rf: ( active: 60x )

  condition: (VDB fullness)
    out_context: VDBMax

  condition: (VDB mediumness)
    out_context: VDBMedium 

  condition: (VDB emptiness)
    out_context: VDBLow

AddVSOMAMax: Episode

episode: AddVSOMAMax
  contained_by: BEH-SOMA

  in_context: VDBMax
  rf: ( active: 2x )

 hypothesis: NOT (VSOMA full)
  action: [VSOMA increase]
  trace: 

AddVSOMAMed: Episode

episode: AddVSOMAMed
  contained_by: BEH-SOMA

  in_context: VDBMedium
  rf: ( active: 4x )

 hypothesis: NOT (VSOMA full)
  action: [VSOMA increase]
  trace: 

AddVSOMALow: Episode

episode: AddVSOMALow
  contained_by: BEH-SOMA

  in_context: VDBLow
  rf: ( active: 8x )

 hypothesis: NOT (VSOMA full)
  action: [VSOMA increase]
  trace: 

SomaSpike: Episode

episode: SomaSpike
  contained_by: BEH-SOMA

  in_context: 
  rf: ( active: 8x )

 hypothesis: 
  action: 
  trace: 

ClearVSOMA: Episode

episode: ClearVSOMA
  contained_by: BEH-SOMA

  in_context: 
  rf: ( active: 8x )

 hypothesis: 
  action: 
  trace: 

sec: behaviors SOMA

min: behaviors SOMA

TUN-SOMA-VCGG: Tuner

tuner: TUN-SOMA-VCGG

 contained_by: BEH-SOMA

 tunes: BEH-SOMA/expansion/BEH-SOMA-VCGG

  expansion: BEH-SOMA-VCGG
  tub_modulation: # in TUN agiamo su POS/ACT
   - posMod ( fullness: None, active: BEH-SOMA-VCGG/fullness, empty: 0x)  # riferimento a possible di BEH-PRE
   - actMod ( fullness: None, active: BEH-SOMA-VCGG/active, empty: BEH-SOMA-VCGG/emptiness)  # riferimento a active di BEH-PRE

 context_intricated:
  - TunPossible ( contained_by: DAY-N )

 tub_local:

 tub_intricated:

Context

context: Check
  contained_by: TUN-SOMA-VCGG

  in_context: TunPossible
  rf: ( active: 60x )

  condition:  
  out_context: TunSomaVcgg

Episode

episode: ?
  contained_by: TUN-PRE-VGCC

  in_context: TunSomaVcgg
  rf: ( active: x )

 hypothesis:  
  action: 
  trace: 

BEH-SOMA-VGSC: Container

Voltage Gated Sodium Channel

container: BEH-SOMA-VGSC

ms: behaviors SOMA-VGSC

Episode1

episode: ??
  contained_by: BEH-SOMA-VGSC

  in_context: xxx
  rf: ( active: 1x )

  hypothesis:  
  action: 
  trace: None