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Sergio Marchetti 7a7132d781 changed VGSC con refractory

2026-04-19 13:38:07 +00:00

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soma.md

Qui comprendiamo:

SOMA: il soma
VGSC-SOMA-H: Na ion channels. Open only when VDB high
VGSC-SOMA-M: Na ion channels. Open only when VDB medium
VGSC-SOMA-L: Na ion channels. Open only when VDB low

SOMA: container

Simplified verifiable behaviors:

— ms:

Resting at -70 mV: Leak channels + pumps (keep at resting)
VDB Depolarization : ~1-2 ms: Na⁺ enters (some VGSCs open)
Opened VGSC and then remain closed for a refractory period
Spike if depolarized above threshold: to -50 mV
Ca2+ enter
Repolarization to -70 mV: ~1-2 ms: K⁺ exits (VG K⁺ channels open) ← NOT pumps!
After-hyperpolarization: ~5-20 ms: K⁺ channels still open

— secs:

Return to exact -70 mV: ~100-1000 ms: Na⁺/K⁺ pumps restore gradients
Ca2+ accumulation

— mins:

VGSC modulation

G expression:

— ms:

based on VDB, VGSC open and let Na+ in. VGSG then go into refractory
if Na fullness then ApCtx. Here the threshold is based only on the integration of Na+
increase SpikeTrainTraces (fast at spike)
increase Ca2+ traces
decrease Na: fast pump which decreases Na+, we do not model K+ -- there is a tug of war between Na entering and exiting. Na can reach fullness only if VDB increases fast (derivative)
there are 2 context: ApCtx and RefractorySoma imlemented with timers and tunable
decrease SpikeTraintraces slow, only if away from spiketrain this is empty
Tune: -- The threshold is tuned during the spiketrain. Low threshold at rest, to increase sensitivity, threshold increase during spike to increase discrimination

— secs:

SpikeTrainTraces

— mins:

Tune: -- refractory lenght

Tubs:

VDB: dendrites deliver current
Na: are a proxy for the Coulombs of charge building up on the somatic membrane. They are used to check threshold, but also to mimic Na+ and K+ pumping
Ca2+: Medium term traces to guide tuning and Night development. It is a local trace, ATP is a global (Astrocyte)
SpikeTrainTraces: sono le tracce che consentono al neurone di far partire il Tuning neuronale, quando e' lontano da uno spike-train, ovvero e' in riposo.
RefractorySoma: tracce di refractory

container: SOMA

  expansion: 
    - VGSC-SOMA-H ( fullness: 50x, active: 20x, emptiness: 10x ) 
      # modulated_by: VGSC-SOMA-H-TUN # possible/actual

    - VGSC-SOMA-M ( fullness: 50x, active: 20x, emptiness: 10x ) 
      # modulated_by: VGSC-SOMA-M-TUN # possible/actual

    - VGSC-SOMA-L ( fullness: 50x, active: 20x, emptiness: 10x ) 
      # modulated_by: VGSC-SOMA-L-TUN # possible/actual


  tub_local:
    - VDB
    - Na
    - Ca2+
    - RefractorySoma

  tub_intricated:  
    - SpikeTrainTraces ( contained_in: DAY-N )

ms: SOMA

VDB-Concentration: check_tpc

As dendrites deliver current (VDB), the soma acts like a capacitor. It "stores" this charge in the form of membrane potential. This contextualizes VGSC-SOMA to open ion channels that let Na+ ions in.

This only applies if not ApCtx, or in other words, SOMA is not in refractory period.

check_tpc: VDB-Concentration
  contained_by: SOMA

  tpc: any
  rf: ( active: 60x )

  condition: (VDB fullness ) AND NOT ApCtx
    out_tpc: VDBMaxCtx

  condition: ( VDB mediumness ) AND NOT ApCtx
    out_tpc: VDBMediumCtx 

  condition: ( VDB emptiness ) AND NOT ApCtx
    out_tpc: VDBLowCtx

SomaSpill: interacting

interacting: SomaSpill
  contained_by: SOMA

  context: any
  rf: ( active: 8x )

  hypothesis: NOT NA emptiness
    action: [ decrease NA ]
    trace:

SomaSpike: check_tpc

Qui siamo nella fase effettiva di spike, non refractory che viene dopo. Fa da contesto di durata fra un RF ed un altro.

La fullness di Na rappresenta il threshold e puo' essere modificato. La fullness di RefractorySoma rappresenta la lunghezza del refractory.

check_tpc: SomaSpike
  contained_by: SOMA

  context: fixed
  rf: ( active: 60x )

  condition: ( Na fullness ) AND ( RefractorySoma emptiness )
    out_context: ApCtx
    out_context: bApCtx

ApBeh: interacting

Durante la fase effettiva di spike, eliminiamo Na accumulati, riempiamo RefractorySoma per fase di refractory e riempiamo Ca2+ per le tracce medio termine di potenziamento/depotenziamento.

interacting: ApBeh
  contained_by: SOMA

  context: ApCtx
  rf: ( active: 8x )

  hypothesis: NOT Na empty
    action: [ decrease Na ]
    trace: 

  hypothesis: NOT RefractorySoma full
    action: [ increase RefractorySoma ]
    trace: 

  hypothesis: NOT Ca2+ full
    action: [ increase Ca2+ ]
    trace:

RefractorySpill: interacting

Lo spill deve essere piu' lento dell'increase che avviene in APBeh

interacting: RefractorySpill
  contained_by: SOMA

  context: any
  rf: ( active: 16x )

  hypothesis: NOT RefractorySoma empty
    action: [ decrease RefractorySoma ]
    trace:

sec: SOMA

min: SOMA

VGSC-SOMA-TUN: Tuner

tuner: VGSC-SOMA-TUN

 contained_by: SOMA

 tunes: SOMA/expansion/VGSC-SOMA

 context_intricated:
  - TunPossible ( contained_by: DAY-N )

 tub_local:

 tub_intricated:

Check: check_tpc

context: check_tpc
  contained_by: VGSC-SOMA-TUN

  context: TunPossible
  rf: ( active: 60x )

  condition:  
  out_context: TunSomaVcgg

?: interacting

interacting: ?
  contained_by: TUN-PRE-VGCC

  context: TunSomaVcgg
  rf: ( active: x )

 hypothesis:  
  action: 
  trace:

VGSC-SOMA-H: container

Voltage Gated Sodium Channel: difficult to open (High)

container: VGSC-SOMA-H

  tub_local:
    Ready ( )

  tub_local:
    RefractoryH ( full: 60x, active: 30x, empty: 0x )

  tub_intricated:
    Na ( contained_in: SOMA)

sec: VGSC-SOMA-H

VGSC-H_TPC: check_tpc

Il check su refractory deve essere fatto ad un RF maggiore della eliminazione di Refractory. Questo perche' e' un era nella qualle avviene l'episodio.

check_tpc: VGSC-H_TPC
  contained_by: VGSC-SOMA-H

  tpc: VDBMaxCtx
  rf: ( active: 60x )

  condition: ( RefractoryH emptiness ) 
    out_context: NaEnterH_Ctx

NaEnterH: interacting

Se metto il controllo sulla (NOT Ready fullness) il VGSC puo' far entrare un numero di Na non superiore ad un massimo. Questo sopra è il commmento della versione precedente, ora la quantità di NA increase dipende dal rf di VGSC-H_TPC dato che li c'è la condition sulla presenza delle traccie di refractory

interacting: NaEnterH
  contained_by: VGSC-H-SOMA

  context: NaEnterH_Ctx
  rf: ( active: 1x )

  hypothesis: ( NOT Na full )
    action: [ Na increase]
    trace: None

  hypothesis: ( NOT RefractoryH full )
    action: [ RefractoryH increase ]
    trace: None

RefractoryHSpill: interacting

Lo Spill deve avere un rf maggiore dell'interacting che incrementa RefractoryH (interactor precedente)

interacting: RefractoryHSpill
  contained_by: VGSC-H-SOMA

  context: any
  rf: ( active: 1x )

  hypothesis: NOT ( RefractoryH empty )  
    action: [ RefractoryH decrease ]
    trace: None

VGSC-SOMA-M: container

Voltage Gated Sodium Channel: less difficult to open (Medium)

container: VGSC-SOMA-M

  tub_local:
    Ready ( )

  tub_local:
    RefractoryM ( full: 60x, active: 30x, empty: 0x )

  tub_intricated:
    Na ( contained_in: SOMA)

sec: VGSC-SOMA-M

VGSC-M_TPC: check_tpc

Il check su refractory deve essere fatto ad un RF maggiore della eliminazione di Refractory. Questo perche' e' un era nella qualle avviene l'episodio.

check_tpc: VGSC-M_TPC
  contained_by: VGSC-SOMA-M

  tpc: VDBMediumCtx OR VDBMaxCtx
  rf: ( active: 60x )

  condition: ( RefractoryH emptiness ) 
    out_context: NaEnterM_Ctx

NaEnterM: interacting

interacting: NaEnterM
  contained_by: VGSC-M-SOMA

  context: NaEnterM_Ctx
  rf: ( active: 1x )

  hypothesis: ( NOT Na full )
    action: [ Na increase]
    trace: None

  hypothesis: ( NOT RefractoryM full )
    action: [ RefractoryH increase ]
    trace: None

RefractoryMSpill: interacting

Lo Spill deve avere un rf maggiore dell'interacting che incrementa RefractoryH (interactor precedente)

interacting: RefractoryMSpill
  contained_by: VGSC-M-SOMA

  context: any
  rf: ( active: 1x )

  hypothesis: NOT ( RefractoryM empty )  
    action: [ RefractoryM decrease ]
    trace: None

VGSC-SOMA-L: container

Voltage Gated Sodium Channel: easy to open (Low)

container: VGSC-SOMA-L

  tub_local:
    Ready ( )

  tub_local:
    RefractoryL ( full: 60x, active: 30x, empty: 0x )

  tub_intricated:
    Na ( contained_in: SOMA)

sec: VGSC-SOMA-L

VGSC-L_TPC: check_tpc

Il check su refractory deve essere fatto ad un RF maggiore della eliminazione di Refractory. Questo perche' e' un era nella qualle avviene l'episodio.

check_tpc: VGSC-L_TPC
  contained_by: VGSC-SOMA-L

  tpc: VDBLowCtx OR VDBMediumCtx OR VDBMaxCtx
  rf: ( active: 60x )

  condition: ( RefractoryH emptiness ) 
    out_context: NaEnterL_Ctx

NaEnterL: interacting

interacting: NaEnterL
  contained_by: VGSC-L-SOMA

  context: NaEnterL_Ctx
  rf: ( active: 1x )

  hypothesis: ( NOT Na full )
    action: [ Na increase]
    trace: None

  hypothesis: ( NOT RefractoryL full )
    action: [ RefractoryL increase ]
    trace: None

RefractoryLSpill: interacting

Lo Spill deve avere un rf maggiore dell'interacting che incrementa RefractoryH (interactor precedente)

interacting: RefractoryLSpill
  contained_by: VGSC-L-SOMA

  context: any
  rf: ( active: 1x )

  hypothesis: NOT ( RefractoryL empty )  
    action: [ RefractoryL decrease ]
    trace: None

10 KiB Raw Blame History Unescape Escape

soma.md

SOMA: container

ms: SOMA

VDB-Concentration: check_tpc

SomaSpill: interacting

SomaSpike: check_tpc

ApBeh: interacting

RefractorySpill: interacting

sec: SOMA

min: SOMA

VGSC-SOMA-TUN: Tuner

Check: check_tpc

?: interacting

VGSC-SOMA-H: container

sec: VGSC-SOMA-H

VGSC-H_TPC: check_tpc

NaEnterH: interacting

RefractoryHSpill: interacting

VGSC-SOMA-M: container

sec: VGSC-SOMA-M

VGSC-M_TPC: check_tpc

NaEnterM: interacting

RefractoryMSpill: interacting

VGSC-SOMA-L: container

sec: VGSC-SOMA-L

VGSC-L_TPC: check_tpc

NaEnterL: interacting

RefractoryLSpill: interacting

10 KiB

Raw Blame History