Update elements/neuron/postsynapse.md
This commit is contained in:
+170
-134
@@ -18,7 +18,7 @@ Qui comprendiamo:
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- bAP arrives → V_post receives additional depolarisation boost
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- NMDA gate checks coincidence: NT_cleft AND V_post both non-zero
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- Mg_block_removal = V_post / (V_post + V_NMDA_half) — sigmoid of V_post
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- Ca²⁺ enters spine via NMDA: Ca_post += k_NMDA × NT_cleft × Mg_block_removal
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- _Ca2 enters spine via NMDA: Ca_post += k_NMDA × NT_cleft × Mg_block_removal
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- Ca_post decays slowly each ms (single exponential, no pump detail)
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- Ca_post_history updated every ms (feeds seconds loop)
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- V_post_history updated every ms (retained for reference)
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@@ -43,13 +43,13 @@ Qui comprendiamo:
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```Gen
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bAP_ctx
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*bAP
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POSTSYNAPSE (ms)
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-- Ca Influx
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CaNDMAEnterMax: ( active: 2x ) accumulator
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CaNDMAEnterMed: ( active: 4x ) accumulator
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NOT bAP_ctx:
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NOT *bAP:
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POSTSYNAPSE (ms)
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-- Ca Influx
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CaNDMAEnterMedNotBap: ( active: 4x ) accumulator
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@@ -84,7 +84,7 @@ TunPossible_ctx
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- **Na**: Ioni entranti tramite AMPA receptors
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- **NT**:
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- **Ca2+**: Ioni entranti tramite NMDA
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- **_Ca2**: Ioni entranti tramite NMDA
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- **VPost**: il voltage che viene sentito in DB
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- **eCB**:
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- **Nox**:?
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@@ -97,37 +97,69 @@ TunPossible_ctx
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POSTSYNAPSE
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type: comprehension
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expand_comprehension:
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&POST-AMPA_ALL: POST-AMPA (full: 10x, active: 5x, empty: 2x)
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expansion:
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_@PostAmpaAll: TUB [ comprehension: POST-AMPA, full: 10x, active: 5x, empty: 2x ]
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intrication:
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# Scope
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!DAY: INTRICATION [ ref: &ORGANISM.!DAY ]
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!NIGHT: INTRICATION [ ref: &ORGANISM.!NIGHT ]
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# Context
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*bAP: INTRICATION [ ref: &SOMA.*bAP ]
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*TunPossible: INTRICATION [ ref: &?.*TunPossible ]
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# Tub
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_NT: INTRICATION [ ref: &ASTROSYNAPSE._NT ]
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_Vpost: INTRICATION [ ref: ??._VPost ]
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instantiation:
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# Context
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# Tub
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_Ca2: TUB [ full: 60x, active: 30x, empty: 0x ]
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_Na: TUB [ full: 60x, active: 30x, empty: 0x ]
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_Nox: TUB [ full: 100x, active: 20x, empty: 0x ] # Nitric Oxide (NO): A gas that diffuses freely.
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_eCB: TUB [ full: 100x, active: 20x, empty: 0x ] # Endocannabinoids (e.g., 2-AG)
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_posMod: TUB [ full: None, active: ??, empty: 0x) # riferimento a possible di BEH-PRE
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_actMod: TUB [ full: None, active: ??, empty: ??) # riferimento a active di BEH-PRE
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# Behaviour
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$: BEHAVIOUR [ behaviour: MAIN_POST ]
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$: BEHAVIOUR [ behaviour: TUN-POST-AMPA ]
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instantiate_container:
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POSTSYNAPSE-BEH []
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TUN-POST-AMPA [pass: &POST-AMPA_ALL]
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```
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### POSTSYNAPSE-BEH: Container
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### MAIN_POST: Behaviour
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```
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POSTSYNAPSE-BEH
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MAIN_POST
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type: behaviour
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type: container
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within_scope: !DAY
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activity_scope: !DAY
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snippet:
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*bAP
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@: ACCUMULATOR [ snippet: CaNDMAEnterMax, rf: active 2x ]
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@: ACCUMULATOR [ snippet: CaNDMAEnterMed, rf: active 4x ]
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tub_local:
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- Ca2+ ( full: 60x, active: 30x, empty: 0x )
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- Na ( full: 60x, active: 30x, empty: 0x )
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- Nox ( full: 100x, active: 20x, empty: 0x ) # Nitric Oxide (NO): A gas that diffuses freely.
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- eCB ( full: 100x, active: 20x, empty: 0x ) # Endocannabinoids (e.g., 2-AG)
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NOT *bAP
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@: ACCUMULATOR [ snippet: CaNDMAEnterLow, rf: active 12x ]
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@: ACCUMULATOR [ snippet: CaNDMAEnterMedNotBap, rf: active 4x ]
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@: ACCUMULATOR [ snippet: CaClearance, rf: active 24x ]
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@: ACCUMULATOR [ snippet: VPostMax, rf: active 4x ]
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@: ACCUMULATOR [ snippet: VPostMed, rf: active 8x ]
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@: ACCUMULATOR [ snippet: VPostMin, rf: active 16x ]
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@: ACCUMULATOR [ snippet: VPostClearance, rf: active 18x ]
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@: ACCUMULATOR [ snippet: NaClearanceHigh, rf: active 4x ]
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@: ACCUMULATOR [ snippet: NaClearanceLow, rf: active 16x ]
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tub_intricated:
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- NT ( contained_by: SYNAPSE )
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- VPost ( contained_by: BD )
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context_intricated:
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- bAp_ctx ( contained_by: SOMA )
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```
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#### bAp_ctx
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#### *bAP
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@@ -135,117 +167,117 @@ POSTSYNAPSE-BEH
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##### CaNDMAEnterMax: ( active: 2x ) accumulator
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```Gen
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CaNDMAEnterMax: ( active: 2x )
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type: accumulator
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contained_by: POSTSYNAPSE-BEH
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CaNDMAEnterMax
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type: accumulator
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in_context: bAp_ctx
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hypothesis: NOT (Ca2+ full) AND
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(Na fullness OR Na mediumness)
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action: [Ca2+ increase]
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in_context: *bAP
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hypothesis: NOT _Ca2 full AND
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( _Na fullness OR _Na mediumness )
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action: [ _Ca2 increase ]
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trace:
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```
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##### CaNDMAEnterMed: ( active: 4x ) accumulator
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```Gen
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CaNDMAEnterMed: ( active: 4x )
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type: accumulator
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contained_by: POSTSYNAPSE-BEH
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CaNDMAEnterMed
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type: accumulator
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in_context: bAp_ctx
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hypothesis: NOT (Ca2+ full) AND (Na emptiness)
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action: [Ca2+ increase]
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in_context: *bAP
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hypothesis: NOT _Ca2 full AND _Na emptiness
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action: [ _Ca2 increase ]
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trace:
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```
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#### NOT bAp_ctx
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#### NOT *bAP
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##### CaNDMAEnterLow: ( active: 12x ) accumulator
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```Gen
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CaNDMAEnterLow: ( active: 12x )
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type: accumulator
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contained_by: POSTSYNAPSE-BEH
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CaNDMAEnterLow
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type: accumulator
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in_context: NOT bAP_ctx
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hypothesis: NOT (Ca2+ full) AND (Na mediumness)
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action: [Ca2+ increase]
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in_context: NOT *bAP
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hypothesis: NOT _Ca2 full AND _Na mediumness
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action: [ _Ca2 increase ]
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trace:
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```
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##### CaNDMAEnterMedNotBap: ( active: 4x ) accumulator
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```Gen
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CaNDMAEnterMedNotBap: ( active: 4x )
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type: accumulator
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contained_by: POSTSYNAPSE-BEH
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CaNDMAEnterMedNotBap
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type: accumulator
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in_context: NOT bAP_ctx
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hypothesis: NOT (Ca2+ full) AND (Na fullness)
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action: [Ca2+ increase]
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in_context: NOT *bAP
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hypothesis: NOT _Ca2 full AND _Na fullness
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action: [ _Ca2 increase ]
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trace:
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```
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##### CaClearance: ( active: 24x ) accumulator
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```Gen
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CaClearance: ( active: 24x ) # Low
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type: accumulator
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contained_by: POSTSYNAPSE-BEH
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CaClearance # Low
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type: accumulator
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in_context: NOT bAP_ctx
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hypothesis: NOT (Ca2+ empty)
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action: [Ca2+ decrease]
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in_context: NOT *bAP
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hypothesis: NOT _Ca2 empty
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action: [ _Ca2 decrease ]
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trace: None
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```
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##### VPostMax: ( active: 4x ) accumulator
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```Gen
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VPostMax: ( active: 4x )
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type: accumulator
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contained_by: POSTSYNAPSE-BEH
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VPostMa
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type: accumulator
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in_context: NOT bAP_ctx
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hypothesis: ( NA fullness )
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action: [VPost increase]
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in_context: NOT *bAP
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hypothesis: _NA fullness
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action: [ _VPost increase ]
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trace: None
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```
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##### VPostMed: ( active: 8x ) accumulator
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```Gen
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VPostMed: ( active: 8x )
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type: accumulator
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contained_by: POSTSYNAPSE-BEH
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VPostMed
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type: accumulator
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in_context: NOT bAP_ctx
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hypothesis: ( NA mediumness )
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action: [VPost increase]
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in_context: NOT *bAP
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hypothesis: _NA mediumness
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action: [ _VPost increase ]
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trace: None
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```
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##### VPostMin: ( active: 16x ) accumulator
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```Gen
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VPostMin: ( active: 16x )
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type: accumulator
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contained_by: POSTSYNAPSE-BEH
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VPostMin
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type: accumulator
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in_context: NOT bAP_ctx
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hypothesis: ( NA emptiness )
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action: [VPost increase]
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in_context: NOT *bAP
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hypothesis: _NA emptiness
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action: [ _VPost increase ]
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trace: None
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```
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Il VPost clearance lo facciamo qui nel container dove creaiamo anche i VPost, perche' altrimenti, se lo facessimo in DB, perderemmo l'aspetto temporale della contribuzione dei singoli POST.
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##### VPostClearance: ( active: 18x ) accumulator
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```Gen
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VPostClearance: ( active: 18x )
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type: accumulator
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contained_by: POSTSYNAPSE-BEH
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VPostClearance
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type: accumulator
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in_context: NOT bAP_ctx
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hypothesis: NOT ( VPost empty )
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action: [VPost decrease]
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in_context: NOT *bAP
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hypothesis: NOT _VPost empty
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action: [ _VPost decrease ]
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trace: None
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```
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@@ -253,68 +285,68 @@ Il NA clearance lo mettiamo qui come sniplet, perche' gli AMPA creano, e questi
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##### NaClearanceHigh: ( active: 4x ) accumulator
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```Gen
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NaClearanceHigh: ( active: 4x )
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type: accumulator
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contained_by: POST-NA-CLEAR-BHE
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NaClearanceHigh
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type: accumulator
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in_context: NOT bAP_ctx ??any??
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hypothesis: ( Na mediumness ) OR ( Na fullness )
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action: [Na decrease]
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in_context: NOT *bAP
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hypothesis: _Na mediumness OR _Na fullness
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action: [ _Na decrease ]
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trace: None
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```
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##### NaClearanceLow: ( active: 16x ) accumulator
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```Gen
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NaClearanceLow: ( active: 16x )
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type: accumulator
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contained_by: POST-NA-CLEAR-BHE
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NaClearanceLow
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type: accumulator
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in_context: NOT bAP_ctx ??any??
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hypothesis: NOT (Na empty)
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action: [Na decrease]
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in_context: NOT *bAP
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hypothesis: NOT _Na empty
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action: [ _Na decrease ]
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trace: None
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```
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### TUN-POST-AMPA: Container
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### TUN-POST-AMPA: Behaviour
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```Gen
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TUN-POST-AMPA
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type: container
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type: behaviour
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activity_scope: !DAY
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tub_modulation: # in TUN agiamo su POS/ACT
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- posMod ( fullness: None, active: BEH-POST-IC/fullness, empty: 0x) # riferimento a possible di BEH-PRE
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- actMod ( fullness: None, active: BEH-POST-IC/active, empty: BEH-POST-IC/emptiness) # riferimento a active di BEH-PRE
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snippet:
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# *TunPossible
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@: CONTEXTOR [ snippet: CheckTunPostAmpa, rf: active 60x ]
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context_intricated:
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- TunPossible ( contained_by: DAY-N )
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# *TryTunUpPostAmpa
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@: ACCUMULATOR [ snippet: PossibleUpPostAmpaTun, rf: active 10x ]
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tub_local:
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tub_intricated:
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# *TryTunDownPostAmpa
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@: ACCUMULATOR [ snippet: PossibleDownPostAmpaTun, rf: active 10x ]
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```
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#### TunPossible_ctx
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##### CheckTunPostAmpa: ( active: 60x ) contextor
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```Gen
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CheckTunPostAmpa: ( active: 60x )
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CheckTunPostAmpa
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type: contextor
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contained_by: TUN-POST-AMPA
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in_context: TunPossible_ctx
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in_context: *TunPossible
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condition: tbd1
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out_context: TryTunUpPostAmpa_ctx
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out_context: *TryTunUpPostAmpa
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condition: tbd2
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out_context: TryTunDownPostAmpa_ctx
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out_context: *TryTunDownPostAmpa
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```
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##### PossibleUpPostAmpaTun: ( active: 10x ) accumulator
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```Gen
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PossibleUpPostAmpaTun: ( active: 10x )
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type: accumulator
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contained_by: TUN-POST-AMPA
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in_context: TryTunUpPostAmpa_ctx
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in_context: TryTunUpPostAmpa
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hypothesis:
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action:
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trace:
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@@ -322,11 +354,10 @@ PossibleUpPostAmpaTun: ( active: 10x )
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##### PossibleDownPostAmpaTun: ( active: 10x ) accumulator
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```Gen
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PossibleDownPostAmpaTun: ( active: 10x )
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PossibleDownPostAmpaTun
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type: accumulator
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contained_by: TUN-POST-AMPA
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in_context: TryTunDownPostAmpa_ctx
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in_context: *TryTunDownPostAmpa
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hypothesis:
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action:
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trace:
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@@ -337,47 +368,52 @@ PossibleDownPostAmpaTun: ( active: 10x )
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POST-AMPA
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type: comprehension
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instantiate_container:
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POST-AMPA-BHE []
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expansion:
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intrication:
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# Tub
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_NT: INTRICATION [ ref: &ASTROSYNAPSE._NT ]
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_Na: INTRICATION [ ref: &POSTSYNAPSE._Na ]
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instantiation:
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$: BEHAVIOUR [ behaviour: POST-AMPA-BHE ]
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```
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### POST-AMPA: Container
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### POST-AMPA: Behaviour
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```Gen
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POST-AMPA-BHE
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type: container
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type: behavior
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activity_scope: !DAY
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within_scope: !DAY
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tub_intricated:
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- NT ( contained_by: ASTROCYTE/SYNAPSE )
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context_intricated:
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- Na ( contained_by: POSTSYNAPSE )
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snippet:
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# NOT *bAP
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@: ACCUMULATOR [ snippet: NaAMPAEnterMax, rf: active 2x ]
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@: ACCUMULATOR [ snippet: NaAMPAEnterMed, rf: active 4x ]
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```
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#### NOT bAP_ctx
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#### NOT *bAP
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##### NaAMPAEnterMax: ( active: 2x ) accumulator
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```Gen
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NaAMPAEnterMax: ( active: 2x )
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NaAMPAEnterMax
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type: accumulator
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contained_by: POST-AMPA-BHE
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in_context: NOT bAP_ctx
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hypothesis: (NT fullness)
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action: [Na increase]
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in_context: NOT *bAP
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hypothesis: _NT fullness
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action: [ _Na increase ]
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trace:
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```
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##### NaAMPAEnterMed: ( active: 4x ) accumulator
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```Gen
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NaAMPAEnterMed: ( active: 4x )
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NaAMPAEnterMed
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type: accumulator
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contained_by: POST-AMPA-BHE
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in_context: NOT bAP_ctx
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hypothesis: (NT mediumness)
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action: [Na increase]
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in_context: NOT *bAP
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hypothesis: _NT mediumness
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action: [ _Na increase ]
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trace:
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```
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Reference in New Issue
Block a user