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ocrampal
2026-04-28 12:06:38 +02:00
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@@ -41,8 +41,14 @@ Qui comprendiamo:
**G expression**: **G expression**:
Qui riportiamo la struttura della espressione G e una descrizione di come leggerla (uno dei possibili modi):
- i possibili behavior della presynapsi sono espressi in due contesti. AP_ctx and NOT AP_ctx.
- i possibili behavior sono anche raggrupati in ms, sec e min, per facilitarne la verifica. Quello che conta sono gli RF specifici di ciascuno snipplet.
-
```Gen ```Gen
# indexG # G expression
PRESYNAPSE PRESYNAPSE
AP_ctx AP_ctx
@@ -476,11 +482,13 @@ container: VGCC-PRE
#### ms: AP_ctx: VGCC-PRE #### ms: AP_ctx: VGCC-PRE
##### Ca2+enterOpen: interacting
Here we comprehend the breaking activity on VGCC by: CDI, eCB and mGluR: Here we comprehend the breaking activity on VGCC by: CDI, eCB and mGluR:
![breaking-cases.png](.attachments/breaking-cases.png) ![breaking-cases.png](.attachments/breaking-cases.png)
Qui sostituiamo: Qui semplifichiamo:
- Approssimiamo CDI con concentrazione di Ca2+. - Approssimiamo CDI con concentrazione di Ca2+.
-- CDI is calcium-dependent inactivation of VGCCs. The inactivation happens because Ca²⁺ enters through the channel and binds to a calmodulin tethered to the channel's intracellular face, physically blocking it from reopening. This is a local, channel-specific event — it requires Ca²⁺ to be flowing through that channel right now, not residual Ca²⁺ drifting in the cytosol between spikes. -- CDI is calcium-dependent inactivation of VGCCs. The inactivation happens because Ca²⁺ enters through the channel and binds to a calmodulin tethered to the channel's intracellular face, physically blocking it from reopening. This is a local, channel-specific event — it requires Ca²⁺ to be flowing through that channel right now, not residual Ca²⁺ drifting in the cytosol between spikes.
@@ -494,8 +502,6 @@ Qui sostituiamo:
Devo controllare che le condizioni sotto siano esaustive. Devo controllare che le condizioni sotto siano esaustive.
##### Ca2+enterOpen: interacting
```Gen ```Gen
interacting: Ca2+enterLow interacting: Ca2+enterLow
contained_by: VGCC-PRE contained_by: VGCC-PRE