varie

2026-06-01 16:13:48 +02:00
parent 468a083e82
commit f88c08636e
2 changed files with 17 additions and 16 deletions
@@ -329,7 +329,7 @@ In this model we decide to simplify:
 - We do not model subthreshold oscillations — VSOMA is a simple leaky integrator
 - We do not model somatic ATP

-**Simplified verifiable behaviors**:
+#### Simplified verifiable behaviors

 — ms:

@@ -350,9 +350,17 @@ In this model we decide to simplify:

 - VGSC modulation

---
+The simplifications imply that:

-**G expression**:
+Removing the axon hillock as a separate compartment means the threshold comparison is applied directly to VSOMA rather than to a spatially distinct zone with its own channel density. In biology the hillock has a lower threshold than the soma body because of its higher Na⁺ channel density — this gradient is absent here. A single fixed threshold applied to VSOMA is a reasonable approximation for a single-compartment model, but it means the model cannot capture phenomena that depend on the hillock's spatial separation from the dendritic integration zone, such as the ability of strong distal dendritic inputs to bypass somatic inhibition.
+
+Removing neuromodulatory inputs means the threshold and gain of the soma are fixed across the entire simulation. In biology dopamine, serotonin, and acetylcholine continuously adjust VSOMA_threshold and the shape of the f-I curve in response to behavioural state. A neuron in an attentive animal fires more readily to the same input than the same neuron in a drowsy animal. This state-dependence is entirely absent — the soma responds identically to a given VDB at all times.
+
+Removing subthreshold oscillations means VSOMA behaves as a simple leaky integrator between APs. In some neuron types, voltage-gated channels produce rhythmic subthreshold fluctuations that bias the timing of AP generation toward specific phases of network oscillations. These are not modelled — VSOMA decays smoothly toward rest between threshold crossings.
+
+ATP is a simplification of convenience — at this stage we do not comprehend the total metabolic load.
+
+#### G expression

 — ms:

@@ -377,17 +385,6 @@ In this model we decide to simplify:
 - Tune:
 -- refractory lenght

-
-The simplifications imply that:
-
-Removing the axon hillock as a separate compartment means the threshold comparison is applied directly to VSOMA rather than to a spatially distinct zone with its own channel density. In biology the hillock has a lower threshold than the soma body because of its higher Na⁺ channel density — this gradient is absent here. A single fixed threshold applied to VSOMA is a reasonable approximation for a single-compartment model, but it means the model cannot capture phenomena that depend on the hillock's spatial separation from the dendritic integration zone, such as the ability of strong distal dendritic inputs to bypass somatic inhibition.
-
-Removing neuromodulatory inputs means the threshold and gain of the soma are fixed across the entire simulation. In biology dopamine, serotonin, and acetylcholine continuously adjust VSOMA_threshold and the shape of the f-I curve in response to behavioural state. A neuron in an attentive animal fires more readily to the same input than the same neuron in a drowsy animal. This state-dependence is entirely absent — the soma responds identically to a given VDB at all times.
-
-Removing subthreshold oscillations means VSOMA behaves as a simple leaky integrator between APs. In some neuron types, voltage-gated channels produce rhythmic subthreshold fluctuations that bias the timing of AP generation toward specific phases of network oscillations. These are not modelled — VSOMA decays smoothly toward rest between threshold crossings.
-
-ATP is a simplification of convenience — at this stage we do not comprehend the total metabolic load.
-
 ### Dendritic-branch

 #### Discursive description