soma description

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2026-04-08 18:28:34 +02:00
parent a538d6015e
commit f8127f2123
3 changed files with 87 additions and 23 deletions
+10 -14
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@@ -41,14 +41,14 @@ In this model we decide to simplify:
The simplifications imply that:
- Removing spine neck resistance means all spines contribute equally to V_dend regardless of their geometry or location. The physical basis of synaptic weighting by dendritic position is lost. All EPSPs are treated as equivalent inputs to the shared pool.
- Removing active conductances means the dendrite cannot generate dendritic spikes. Summation is strictly linear — two spines together produce exactly twice the V_dend of one spine alone. There is no threshold event within the dendrite itself, only at the soma.
- Removing active conductances means the dendrite cannot generate dendritic spikes. Integration is nearly linear — two spines together produce exactly twice the VDB of one spine alone. There is no threshold event within the dendrite itself, only at the soma.
- Removing bAP attenuation means all spines have equal access to the coincidence signal regardless of distance from the soma. Proximal and distal synapses have identical plasticity thresholds. The functional gradient that makes dendritic location matter is absent.
- Removing structural plasticity means the geometry of the dendrite is fixed. LTP and LTD change AMPA receptor density at each spine but do not change how well those spines couple electrically to the dendrite. The structural component of long-term potentiation — which in biology is arguably more important than the receptor component for sustained changes — is not captured.
The only behavior we model:
- Linear summation of spine EPSPs into V_dend each ms
- Uniform bAP distribution to all spines on soma firing. In this case the dendrites acts as a cable, relaying the bAp to Postsynapse. No modelling needed.
- Integrations of spine EPSPs into VDB
- Uniform bAP distribution to all spines on soma firing. In this case the dendrites acts as a cable, relaying the bAp to Postsynapse. bAp arrives here and directly to each spine, no distance from SOMA and attenuation.
---
@@ -56,14 +56,9 @@ The only behavior we model:
— ms:
- Each active spine contributes an EPSP to V_dend
V_dend += receptor_conductance_i * AMPA_weight
(summed across all spines; no neck attenuation)
- V_dend decays passively each ms
V_dend *= (1 - dt / tau_dend)
tau_dend is the membrane time constant of the branch
- V_dend passed to soma each ms (read externally)
- Each active spine contributes VPost (EPSP) to VDB
- VDB decays passively each ms
— secs:
- nothing in the simplified model
@@ -71,8 +66,7 @@ The only behavior we model:
— mins:
- nothing in the simplified model
(structural remodelling of spine neck geometry
under LTP/LTD would live here if added later)
(structural remodelling of spine neck geometry under LTP/LTD would live here if added later)
---
@@ -99,7 +93,7 @@ Container: BEH-BD
**Tubs:**
- **??**: ..
- **VPost**: e' l'integrazione degli EPSP della postsinapse
---
@@ -172,6 +166,8 @@ episode: VDBLow
Qui facciamo il clearance del VDB. Lo facciamo in questo modo perche' abbiamo semplificato quello che succede fra BD e SOMA.
Qui posso aggiungere il flush, clearance veloce quando c'e' il bAP.
```Gen
episode: VDBClearance
contained_by: BEH-BD