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# Tripartite Synapse — Biological Reference (companion to v13 pseudocode)
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> Companion to `tripartite_synapse_v13_pseudocode.md`. Explains the biology each variable and
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> behavior conflates. Variable meanings are unchanged; v13 refined the model logic:
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> per-spike calcium deposit (frequency emergent, not a parameter); BEHAVE now separates a FUEL
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> shortfall (deposits endurance need) from an OCCUPANCY/structure shortfall (short-term
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> depression — no endurance, since more fuel would not help); the endurance feedback term
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> (retrograde NO) appears only at the presynapse, where such a signal actually arrives, while
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> every other component's endurance proxy is own-state only; EVALUATE merged into TRACE
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> (judging a behavior is maintaining a trace); shipment is modelled as a transit-delayed flow
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> (axonal/dendritic transport takes a characteristic time, so distal targets receive later),
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> reflecting the general principle that every flow has a timescale.
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---
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## The three synaptic components and their support structures
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A SYNAPSE is composed of three first-class components:
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- **PRE** — presynaptic bouton (the axon's terminal at this synapse)
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- **POST** — postsynaptic spine (the dendrite's terminal at this synapse)
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- **ASTRO** — astrosynapse, the perisynaptic astrocytic process (the astrocyte's terminal)
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Each has an upstream support structure that supplies it:
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- **AXON** supplies PRE (transmission + transport from soma)
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- **DEND** supplies POST (integration + transport from soma)
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- the **astrocyte cell body** supplies ASTRO (energy + ECM material)
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- **SOMA** is the integrating center and the root of neuronal material
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The compartment analogy: AXON:PRE = DEND:POST = astrocyte-body:ASTRO = supply line : terminal.
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---
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## Resource variables
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### DAY budget (one per component)
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Aggregates fast energy AND fast consumables — everything needed to run moment-to-moment.
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- **pre_budget** — ATP for VGCC gating, vesicle fusion (SNARE), VATPase vesicle refill,
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plus fast consumables: vesicle membrane lipids, synaptotagmin recycling.
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- **post_budget** — ATP for the NaK pump (membrane reset after current), NMDA current
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handling, plus fast actin monomers for transient spine changes and receptor-recycling lipids.
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- **dend_budget** — ATP for bAP propagation (NaK reset along branch), local translation
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(ribosome running cost), SERCA Ca²⁺ resequestration, plus fast mRNA consumed by translation.
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- **soma_budget** — ATP for AP generation (Na⁺/K⁺ currents + NaK reset), CREB
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phosphorylation, nuclear Ca²⁺ handling, plus shipping running costs.
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- **axon_budget** — ATP for AP propagation at nodes of Ranvier, kinesin/dynein motor
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running cost, fast myelin maintenance.
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- **astro_central_budget** — ATP from glycolysis at the astrocyte cell body; funds EAAT
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clearance, serine→D-serine synthesis, lactate export, fast process motility.
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### astro_lactate[i]
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Lactate exported from the astrocyte cell body to synapse i. Biologically: glucose →
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(glycolysis) → lactate, released into extracellular space, absorbed by neuronal MCT2
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transporters, converted to pyruvate → TCA → ATP in the neuron's mitochondria. The astrocyte
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is the primary fast-energy supplier to pre, post, and dend.
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### NIGHT energy (one per component) — NOT recoverable
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ATP for structural assembly. Distinct from DAY budget because it is spent on building, and
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the work of assembly is thermodynamically gone once done (cannot be recovered by disassembly).
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- pre_energy: RIM/Munc13 incorporation, VGCC clustering.
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- post_energy: CaMKII anchoring, actin polymerization, PSD scaffold remodeling.
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- dend_energy: mitochondria incorporation, cytoskeletal reinforcement.
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- soma_energy: ribosome biogenesis, ion-channel incorporation.
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- axon_energy: myelination, microtubule stabilization.
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- astro_energy: process retraction, ECM secretion, racemase upregulation.
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### NIGHT material (one per component) — RECOVERABLE
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Slow structural proteins. Recoverable because disassembly (LTD) returns the proteins to a
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reusable pool (ubiquitin-proteasome → amino acids; internalized receptors → endosomal reserve).
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- **soma_material** (root) — all neuronal structural proteins from CREB-driven synthesis:
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AMPA subunits, PSD scaffold, AZ scaffold, mRNA transcripts (Arc, BDNF), organelles.
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- **dend_material** — from soma: Arc/plasticity mRNA, mitochondria, cytoskeletal proteins,
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AMPA subunits in transit to spines.
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- **post_material** — from dend: AMPA receptor subunits (GluA1/2), PSD scaffold (PSD-95,
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SHANK, Homer), structural actin, CaMKII.
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- **axon_material** — from soma: kinesin/dynein motors, microtubule components, myelin proteins.
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- **pre_material** — from axon: RIM, Munc13, VGCC subunits, structural vesicle proteins.
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- **astro_material** (root: astrocyte cell body) — EAAT proteins, serine racemase, ECM
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proteins (Glypicans, Thrombospondins), process cytoskeleton.
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**Why energy and material are separate in NIGHT but combined in DAY:** during DAY both are
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fast consumables replenished on the same timescale, so one `budget` variable suffices. During
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NIGHT they diverge — material is recoverable after LTD, energy is not — so they must be two
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variables. This asymmetry (material returns to the pool, energy is gone) is what makes one
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synapse's depression genuinely fund another's potentiation.
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---
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## Structural variables (strength ceilings — written in NIGHT)
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Each aggregates several correlated structural properties into one capacity.
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- **pre_structure** — active zone capacity:
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slot_ceiling (number of vesicle docking slots) + VGCC_coupling (Ca²⁺-channel proximity to
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slots, sets release efficiency) + refill_ceiling (max RRP replenishment rate).
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- **post_structure** — spine sensitivity capacity:
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slot_ceiling (number of PSD anchoring slots for AMPA) + spine_volume (local reserve and
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actin machinery) + reserve_ceiling (endosomal AMPA pool size).
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- **dend_structure** — branch capacity:
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bAP_fidelity(position) (mitochondrial density sets propagation strength, attenuates with
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distance) + translation_ceiling (local mRNA capacity) + transport_speed (cytoskeletal integrity).
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- **soma_structure** — somatic output capacity:
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baseline_threshold (inverse: ion-channel density at axon initial segment) + AP_reliability
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(Na⁺ channel density) + synthesis_ceiling (ribosome density + CREB machinery).
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- **axon_structure** — axonal capacity:
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propagation reliability (myelination density) + transport_ceiling (motor density + microtubule
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integrity) + mitochondrial density.
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- **astro_structure** — astrosynaptic environmental capacity:
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perisynaptic_distance⁻¹ (wall proximity — closer = more glutamate contained) + EAAT_density
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(clearance ceiling) + Dserine_tonic (baseline co-agonist) + ECM_integrity.
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**Self-reinforcing both directions:** tighter wrap + more tonic D-serine make future
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potentiation easier; looser wrap + zero tonic D-serine make future depression easier.
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---
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## Budget ceilings (endurance ceilings — written in NIGHT)
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- **{component}_budget_ceiling** — the maximum fuel the component can hold / the maximum
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duration of sustained behavior. Biologically: mitochondrial density and local fuel-storage
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capacity. Built by activity-driven mitochondrial biogenesis; lost by mitophagy when idle.
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Parallel to structure: structure is strength capacity, budget_ceiling is endurance capacity.
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---
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## Trace variables
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### fast_trace (one per component) — DAY only, decays automatically
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The local record of recent activity that biases the next behavior.
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- **pre_fast_trace** — residual presynaptic Ca²⁺ after spikes (τ≈100ms). Biases NT release
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(facilitation) and provides tagging eligibility.
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- **post_fast_trace** — spine Ca²⁺ amplitude × rise-speed (τ≈tens ms). Encodes the LTP-vs-LTD
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instruction (fast rise → CaMKII → potentiation; slow rise → phosphatase → depression).
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- **dend_fast_trace** — branch Ca²⁺ from bAP + spine spillover (τ≈300ms). Integrates branch co-activity.
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- **soma_fast_trace** — nuclear Ca²⁺ from each AP (τ≈seconds). Drives toward CREB activation.
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- **axon_fast_trace** — propagation load (τ≈seconds). High load → Na⁺ inactivation at branch
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points → propagation failure (this is axonal short-term depression).
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- **astro_fast_trace** — perisynaptic Ca²⁺ from mGluR5 activation by glutamate spillover
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(τ≈seconds). Drives D-serine release.
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### soma timing traces (emergent refractory + adaptation + alignment)
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- **soma_Na_inactivation** (τ≈ms) — sodium-channel inactivation after an AP. Its recovery IS
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the refractory period (emergent, not a hardcoded timer). High → absolute refractory; decaying
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→ relative refractory; recovered → normal.
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- **soma_adaptation** (τ≈100s of ms) — slow K⁺ channel (SK/M-type) activation accumulating
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over a spike train, raising threshold. This is spike-frequency adaptation.
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- **soma_refractory_alignment** — deposited when a suprathreshold input arrives during
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refractoriness (a missed coincidence). Speeds future recovery so the soma aligns to its input
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rhythm. Bottom-up: no rhythm is represented; alignment emerges from accumulated local
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mismatches and decays when mismatches stop (self-limiting).
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### possible_tag (one per component) — intermediate, τ≈s–min
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Graded accumulation of tagging eligibility. For POST, this is the CANDIDATE tag lifetime.
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### endurance_need (one per component) — intermediate, τ≈s–min
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Deposited when budget depletion interrupts a behavior that was on a LOCALLY successful
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trajectory. Records that fuel — not structure, not significance — was the binding constraint
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on a forming success. Requires NO dopamine (homeostatic, not associative).
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**Local success proxy per component** (each uses only its own state + arrived signals):
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- PRE: own fast_trace high (was releasing strongly), optionally amplified by retrograde
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messenger (endocannabinoid / NO / BDNF) that has arrived.
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- POST: own Ca²⁺ climbing toward tagging threshold (naturally local).
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- DEND: own branch strongly active (high branch voltage/Ca²⁺) when propagation fell short.
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- SOMA: own nuclear Ca²⁺ climbing toward CREB.
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- AXON: own propagation load high (was carrying a strong train).
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- ASTRO: own local glutamate/Ca²⁺ high (was under heavy clearance/D-serine demand).
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### tag (one per component) — DAY→NIGHT bridge, τ≈hours
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The validated record of significance that survives to NIGHT and gates strength commits.
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Formed by coincidence of local eligibility + non-local validation (dopamine).
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**POST is special — two-phase, three coincidences:**
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- CANDIDATE: local Ca²⁺ above threshold + astrosynapse D-serine present (coincidence 1).
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- amplified when bAP confirms soma fired (coincidence 2).
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- STABLE: CANDIDATE + dopamine within stabilization window (coincidence 3).
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Biologically: early CaMKII creates a labile tag (early-LTP); PKA driven by dopamine via D1R
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stabilizes it (late-LTP). Without dopamine, the candidate degrades — early-LTP reverses.
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---
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## Behaviors — biological meaning
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### PRE | AP — neurotransmitter release
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`NT_flux = RRP × sat(pre_fast_trace, K_release)` models continuous NT release proportional to
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the readily-releasable pool and a saturating Ca²⁺ drive (synaptotagmin's cooperative Ca²⁺
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sensitivity, simplified to a saturating curve). RRP depletes as released (short-term depression
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as a consequence) and refills via VATPase (energy-throttled, so low budget deepens depression).
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The mGluR2/3 brake is presynaptic autoinhibition by spillover (Gi → reduced VGCC opening).
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### POST | NOT_bAP — three calcium sources, two plasticity cases
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- **Source 1 (AMPA):** glutamate opens AMPA → depolarizing current + small Ca²⁺; the
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depolarization begins ejecting the NMDA Mg²⁺ block.
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- **Source 2 (NMDA):** if depolarized enough (Mg²⁺ ejected) AND D-serine present (astrocyte
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co-agonist) AND glutamate bound → large Ca²⁺ influx. This is the coincidence detector.
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- **Source 3 (bAP, separate context):** back-propagating AP adds depolarization + Ca²⁺,
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amplifying an existing signal supralinearly.
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- **Case 1 (STP):** high Ca²⁺ drives AMPA receptors from the local reserve to the surface,
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bounded by the anchoring-slot ceiling. Fast, reversible, NO dopamine. When Ca²⁺ falls,
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receptors drift back — short-term depression as a passive consequence, never signaled.
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- **Case 2 (LTP tag):** high Ca²⁺ + (later) dopamine sets the tag that NIGHT uses to raise the
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slot ceiling. NIGHT builds slots; DAY fills them.
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### DEND | bAP — bidirectional signaling
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Propagates the bAP from soma toward spines (fidelity attenuates with distance — distal spines
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get weaker confirmation, are harder to potentiate) and integrates spine signals toward the soma.
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### SOMA | AP — integration, firing, emergent timing
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Fires when integrated branch input exceeds a threshold that is the baseline (from structure)
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raised by adaptation and modulated by neuromodulators, gated by the emergent refractory state.
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Each AP deposits three traces (inactivation → refractory, adaptation → threshold rise, nuclear
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Ca²⁺ → plasticity). The soma is the coincidence detector at the cellular scale (nuclear Ca²⁺ +
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dopamine → CREB), and the production bottleneck: its tag gates how much material all downstream
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components get in NIGHT.
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### AXON | AP — reliable propagation with frequency-dependent failure
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Propagation reliability is set by myelination and degraded by high-frequency load (Na⁺
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inactivation at branch points = axonal STD). The axon also transports material to boutons and
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sets the timescale of presynaptic structural commits.
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### ASTRO | CONTINUOUS — gatekeeper and energy hub
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Clears glutamate (EAAT), supplies D-serine (the NMDA co-agonist that gates postsynaptic LTP),
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and distributes lactate to the territory by demand-weighting (active synapses generating more
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clearance load pull more fuel; slow synapses get less). The same spillover that excites the
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astrocyte (mGluR5 → Ca²⁺ → D-serine) also brakes the presynapse (mGluR2/3 → Gi) — one signal,
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opposite effects via different receptors. The astrocyte is the energy root and the gain control
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of the whole synapse.
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---
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## NIGHT operations — biological meaning
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- **Step 1 (replenish/distribute):** overnight protein synthesis peaks (CREB-driven, gated by
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soma_tag — corresponds to slow-wave-sleep replay). Soma material flows to branches/axon then
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spines/boutons; astrocyte material flows to astrosynapses, tag-weighted.
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- **Step 2 (strength commits):** tagged components build structure — more slots, tighter
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coupling, tighter astrosynaptic wrap. Coherence bonus when pre+post+astro all tagged (the
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whole synapse agrees). astro_structure self-reinforces.
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- **Step 2b (endurance commits):** components with high endurance_need build budget_ceiling —
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mitochondrial biogenesis. Competes with step 2 for the same material/energy.
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- **Step 3 (passive decay):** both ceilings decay; maintenance from the remaining pool resists
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decay only where sufficient. Depotentiation and endurance-loss are both by neglect — no
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signal weakens anything; unmaintained capacity simply drifts down. Recovered material (not
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energy) returns to pools.
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- **Step 4 (homeostatic scaling):** if the soma fired too much overall, all synapses scale down
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proportionally (sleep-associated global downscaling), preserving relative differences.
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- **Step 5 (clear traces):** fast traces, possible tags, endurance needs, and soma timing traces
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reset; tags below expiry clear, above-expiry tags carry forward (multi-night consolidation);
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structure and budget_ceiling persist.
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### Shockwave lockdown
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Emergency global astrocytic Ca²⁺ wave → GABA + ATP release → mass AMPA internalization and
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hyperpolarization. Bypasses budget gates. A circuit breaker against runaway excitation.
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---
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## Pool-filling: private reserve vs contested supply
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The pseudocode uses two filling primitives, distinguished by where the resource comes from.
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**`fill` (private reserve).** The pool is replenished from a source the component owns
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outright, uncontested by siblings, bounded by the component's own ceiling and a rate cap.
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- RRP refill — vesicles mobilized from the bouton's own reserve pool toward the docking-slot
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ceiling, rate-limited by VATPase. The reserve is private to the bouton.
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- SOMA self-replenish — the soma fuels itself from its own mitochondria toward its budget
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ceiling. No other component draws on it.
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**`refill` (contested supply).** The pool is replenished from a supply that multiple
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components compete for, rationed by demand (gap to ceiling).
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- pre/post/dend/axon budgets — drawn from astrocytic lactate (shared across all synapses the
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astrocyte wraps) plus shipment from soma/axon/dendrite (shared across downstream targets).
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**Neither primitive (their own forms).** Some inflows are not fills toward a ceiling:
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- AMPA surface insertion — Ca²⁺-driven rate from the spine's private endosomal reserve, with
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an explicit passive drift-back (short-term depression) when Ca²⁺ is low. Not a steady fill.
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- D-serine release — demand-driven (saturating in astro Ca²⁺) and budget-limited, like NT
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release; a release process, not a pool top-up.
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- Root productions — `glycolysis(glucose)` at the astrocyte and `CREB_synth(soma_tag)` at the
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soma are the system's energy and material roots: raw inflows capped only by the external
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vascular supply, not fills toward an internal ceiling.
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The distinction matters biologically: a private reserve guarantees a component some autonomy
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(the bouton can refill its RRP from its own vesicles even when lactate is scarce), while a
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contested supply couples a component's fate to its neighbours' demands (operational budget
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fails first where many active synapses compete for the same lactate).
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---
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## PRE ↔ POST interaction: local computation, message-only coupling
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The presynapse and postsynapse never read each other's internal state. They interact only
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by writing to and reading from shared cleft channels. Each side computes entirely locally on
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what it has: its own variables plus whatever signals have arrived in the cleft. This is the
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message-passing realization of the locality principle.
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**Forward channel — glutamate (PRE → POST and ASTRO).** The presynapse writes glutamate via
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NT_flux. The postsynapse reads it (AMPA, NMDA) and the astrosynapse reads it (clearance,
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mGluR5). The astrosynapse clears it. PRE never knows whether POST responded — it only emits.
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||||||
|
**Gate channel — astro_Dserine (ASTRO → POST).** The astrosynapse writes D-serine; the
|
||||||
|
postsynapse reads it as the obligatory NMDA co-agonist. POST cannot open NMDA without this
|
||||||
|
arrived signal, but it does not read the astrocyte's state — only the delivered D-serine.
|
||||||
|
|
||||||
|
**Backward channel + — retro_NO (POST → PRE).** When the postsynapse's NMDA opens (Mg²⁺
|
||||||
|
ejected, D-serine present, glutamate bound), nNOS — physically tethered to the NMDA receptor
|
||||||
|
through PSD-95 — synthesises nitric oxide (and, on a slower timescale, BDNF is released).
|
||||||
|
These diffuse retrogradely to the presynapse. Biologically this is the classic retrograde
|
||||||
|
messenger of LTP: it tells the bouton that its release landed on a postsynapse that genuinely
|
||||||
|
responded. In the model, POST emits `retro_NO` proportional to its own NMDA-driven calcium —
|
||||||
|
computed purely from POST's local state — and PRE reads it as `retro_NO_local`.
|
||||||
|
|
||||||
|
`retro_NO_local` is exactly the grounding of the presynaptic endurance signal. The
|
||||||
|
presynapse's local success proxy is "I was releasing strongly" (`pre_fast_trace` high). On
|
||||||
|
its own that only says the bouton was working hard, not that the work mattered. `retro_NO`
|
||||||
|
adds the missing confirmation — that the postsynapse responded — without PRE ever reading
|
||||||
|
POST's calcium. So PRE deposits endurance need as `pre_fast_trace × (1 + retro_NO_local)`:
|
||||||
|
strong release that was confirmed effective makes the strongest claim that fuel, not
|
||||||
|
futility, was what interrupted a forming success. retro_NO is short-lived (NO degrades and
|
||||||
|
diffuses within seconds), so the channel decays fast — confirmation must be recent to count.
|
||||||
|
|
||||||
|
**Backward channel − — retro_eCB (POST → PRE).** When the postsynapse is strongly
|
||||||
|
depolarised, it synthesises endocannabinoids (2-AG, anandamide) that diffuse retrogradely and
|
||||||
|
bind presynaptic CB1 receptors, suppressing release. This is depolarisation-induced
|
||||||
|
suppression of excitation (DSE) — a homeostatic negative feedback: an over-driven postsynapse
|
||||||
|
tells the presynapse to release less. In the model, POST emits `retro_eCB` from its own
|
||||||
|
membrane potential, and PRE reads it as `retro_eCB_local`, which reduces the release drive
|
||||||
|
`sat(...) × (1 - retro_eCB_local)`. Again POST computes from its own state; PRE adjusts from
|
||||||
|
the arrived signal; neither reads the other's interior.
|
||||||
|
|
||||||
|
The two backward channels are opposite-signed messages the postsynapse sends about its own
|
||||||
|
condition: retro_NO says "your input was effective — worth sustaining," retro_eCB says "I am
|
||||||
|
saturated — ease off." Together with the forward glutamate and the D-serine gate, they make
|
||||||
|
the synapse a fully message-coupled system of locally-computing components.
|
||||||
|
|
||||||
|
**Why RRP refill is in NOT_AP only.** During an AP the bouton releases — RRP depletes. Refill
|
||||||
|
(VATPase reloading vesicles from the reserve pool) is a recovery process that proceeds between
|
||||||
|
spikes. Placing `fill(RRP, ...)` only in the NOT_AP context makes the AP context pure
|
||||||
|
depletion and the NOT_AP context pure recovery. A consequence falls out for free: during
|
||||||
|
sustained high-frequency firing there are many AP steps and few NOT_AP steps, so RRP depletes
|
||||||
|
faster than it recovers — short-term depression deepens with frequency, with no explicit
|
||||||
|
depression rule. The release itself is throttled further when budget is low (VATPase refill
|
||||||
|
is energy-limited), coupling metabolic state to the depth of depression.
|
||||||
@@ -0,0 +1,502 @@
|
|||||||
|
# Tripartite Synapse — Pseudocode v13
|
||||||
|
|
||||||
|
> Companion: `tripartite_synapse_v13_biology.md`.
|
||||||
|
> Changes from v12:
|
||||||
|
> (1) per-spike calcium deposit (frequency stays emergent, not a parameter)
|
||||||
|
> (2) BEHAVE splits FUEL shortfall (→ endurance) from OCCUPANCY shortfall (→ STD)
|
||||||
|
> (3) endurance feedback term only where a retrograde signal actually arrives
|
||||||
|
> (4) TRACE absorbs EVALUATE → seven-group grammar
|
||||||
|
> (5) parameter declarations completed (ship_cost, ACh_gain, NIGHT block)
|
||||||
|
> (6) shipment is a transit-delayed flow; every flow has a timescale
|
||||||
|
> (7) all group labels are standalone headers at one column
|
||||||
|
|
||||||
|
---
|
||||||
|
|
||||||
|
## Functional groups (seven-group grammar)
|
||||||
|
|
||||||
|
```
|
||||||
|
RECEIVE take in resources + signals that arrived from outside (boundary: in)
|
||||||
|
TRACE maintain the trace hierarchy — deposit fast trace; accumulate
|
||||||
|
possible_tag + endurance_need; stabilize tag on coincidence
|
||||||
|
ADJUST compute local operating parameters from structure + traces + modulators
|
||||||
|
BEHAVE the component's defining action, within both ceilings
|
||||||
|
EMIT send out — signals (messages) + resources (shipments) (boundary: out)
|
||||||
|
RECOVER refill own private pools consumed by behaving
|
||||||
|
DECAY let traces recede, closing their windows
|
||||||
|
```
|
||||||
|
|
||||||
|
EVALUATE merged into TRACE: judging a behavior is always maintaining a trace, whether or not
|
||||||
|
a trace is written. BEHAVE and EMIT stay separate — EMIT is the output half of the locality
|
||||||
|
interface (RECEIVE/EMIT are the only boundary crossings). TRACE spans all timescales: the
|
||||||
|
soma's inactivation, adaptation, and nuclear-Ca deposits are all TRACE. Order within a context
|
||||||
|
follows data dependencies; TRACE reads/writes whatever trace state is current.
|
||||||
|
|
||||||
|
EVERY FLOW HAS A TIMESCALE. Decay relaxes toward 0 over τ; creation/arrival relaxes toward a
|
||||||
|
target over τ — the same first-order operator. Within-step writes are the special case τ ≪ Δt.
|
||||||
|
Rate-limited inflows (fill/refill/flux·Δt) carry their τ implicitly; shipment carries an
|
||||||
|
explicit transit delay (see `transit`).
|
||||||
|
|
||||||
|
---
|
||||||
|
|
||||||
|
## Conventions
|
||||||
|
|
||||||
|
```
|
||||||
|
SCOPE = {DAY, NIGHT} CONTEXT = {AP, NOT_AP, bAP, NOT_bAP, CONTINUOUS}
|
||||||
|
|
||||||
|
DAY budget · fast_trace · possible_tag · endurance_need
|
||||||
|
BRIDGE tag (POST: CANDIDATE→STABLE)
|
||||||
|
NIGHT energy (not recoverable) · material (recoverable) · structure · budget_ceiling
|
||||||
|
|
||||||
|
LOCALITY only local state + arrived signals; no component reads another's internal state.
|
||||||
|
|
||||||
|
CLEFT MESSAGE CHANNELS SHIPMENT CHANNELS (transit-delayed)
|
||||||
|
glutamate PRE → POST, ASTRO soma_ship_dend SOMA→DEND
|
||||||
|
astro_Dserine ASTRO → POST soma_ship_axon SOMA→AXON
|
||||||
|
retro_NO POST → PRE (+) dend_ship_post DEND→POST
|
||||||
|
retro_eCB POST → PRE (−) axon_ship_pre AXON→PRE
|
||||||
|
```
|
||||||
|
|
||||||
|
---
|
||||||
|
|
||||||
|
## Primitives (return the increment; caller applies it)
|
||||||
|
|
||||||
|
```
|
||||||
|
sat(x, K) = x / (K + x)
|
||||||
|
|
||||||
|
fill(pool, ceiling, rate, cost, budget) -> amount: // PRIVATE reserve, rate-limited (implicit τ)
|
||||||
|
amount = min(rate, ceiling - pool)·Δt; budget -= amount·cost; return amount
|
||||||
|
|
||||||
|
refill(c from supply S) -> amount: // CONTESTED supply, gap-bounded
|
||||||
|
demand = c.budget_ceiling - c.budget
|
||||||
|
factor = min(1, S / (Σ demand over components on S + ε)); S -= demand·factor
|
||||||
|
return demand·factor
|
||||||
|
|
||||||
|
ship(from_budget, demand_sig, frac, cost) -> amount: // emit into transit (not to target directly)
|
||||||
|
amount = min(from_budget·frac, demand_sig); from_budget -= amount·(1+ship_cost); return amount
|
||||||
|
|
||||||
|
transit(channel, τ_transport) -> arrival: // delivers in-transit cargo over τ
|
||||||
|
arrival = channel·(Δt/τ_transport); channel -= arrival; return arrival
|
||||||
|
```
|
||||||
|
|
||||||
|
---
|
||||||
|
|
||||||
|
## SHARED parameters
|
||||||
|
|
||||||
|
```
|
||||||
|
dopamine NE ACh // organism broadcasts (external)
|
||||||
|
glucose geometry // physical (external)
|
||||||
|
elig dop_thr tag_thr tag_expiry // strength gates (universal)
|
||||||
|
traj_thr endur_thr // endurance gates (universal)
|
||||||
|
ship_cost // transport overhead (all shipments)
|
||||||
|
τ_transport_{dend,axon,spine,bouton} // shipment transit times (distance-dependent)
|
||||||
|
ε
|
||||||
|
```
|
||||||
|
|
||||||
|
## NIGHT parameters (consolidation only)
|
||||||
|
|
||||||
|
```
|
||||||
|
slot_cost cap_cost f_cap // commit sizes / endurance fraction
|
||||||
|
maint_frac cap_frac // maintenance allocation
|
||||||
|
decay_rate capacity_decay_rate recycle // passive decay + recovery
|
||||||
|
homeostatic_ceiling coherence_factor assembly_cost biogenesis_cost maint_cost
|
||||||
|
f_dend f_axon f_spine f_bouton // material distribution fractions
|
||||||
|
{dend,axon,pre,post}_ship_frac // DAY shipment fractions
|
||||||
|
{dend,axon,pre,post}_energy_frac // energy distribution fractions
|
||||||
|
```
|
||||||
|
|
||||||
|
---
|
||||||
|
---
|
||||||
|
# DAY
|
||||||
|
---
|
||||||
|
|
||||||
|
## PRE
|
||||||
|
|
||||||
|
```
|
||||||
|
// PARAMETERS K_release · release_cost · fusion_cost · vatpase_cost · spillover · brake
|
||||||
|
// INTERFACE
|
||||||
|
// EMIT glutamate → POST, ASTRO
|
||||||
|
// RECEIVE astro_lactate[syn] ← ASTRO ; axon_ship_pre ← AXON ; retro_NO, retro_eCB ← POST
|
||||||
|
// pre_material ← AXON(NIGHT) ; pre_energy ← SOMA(NIGHT)
|
||||||
|
// READ glutamate (own cleft, autobrake) ; dopamine (gates tag)
|
||||||
|
// OWN pre_structure{slot_ceiling, VGCC_coupling, refill_ceiling} ; pre_budget_ceiling
|
||||||
|
// EMERGENCY shockwave_lockdown ← ASTRO
|
||||||
|
|
||||||
|
DAY | AP:
|
||||||
|
// TRACE (Ca²⁺ bolus from THIS spike — also drives release; frequency is emergent)
|
||||||
|
pre_fast_trace += spike_Ca(pre_structure.VGCC_coupling)
|
||||||
|
// ADJUST (release drive from residual Ca²⁺ + received DSE brake)
|
||||||
|
drive = sat(pre_fast_trace, K_release) × (1 - retro_eCB_local)
|
||||||
|
// BEHAVE (release; two distinct failure modes)
|
||||||
|
if pre_budget < release_cost:
|
||||||
|
// FUEL shortfall → endurance evidence (retro_NO-confirmed local success)
|
||||||
|
suppress(NT_flux)
|
||||||
|
if pre_fast_trace > traj_thr:
|
||||||
|
pre_endurance_need += pre_fast_trace × (1 + retro_NO_local)
|
||||||
|
exit
|
||||||
|
if RRP == 0:
|
||||||
|
// OCCUPANCY shortfall → short-term depression (NOT endurance; fuel was fine)
|
||||||
|
suppress(NT_flux)
|
||||||
|
exit
|
||||||
|
NT_flux = RRP × drive; RRP -= NT_flux·Δt; pre_budget -= NT_flux·fusion_cost
|
||||||
|
// EMIT (glutamate into cleft)
|
||||||
|
glutamate += NT_flux·Δt
|
||||||
|
if glutamate > spillover: drive *= brake // own-cleft autobrake
|
||||||
|
|
||||||
|
DAY | NOT_AP:
|
||||||
|
// RECEIVE (latch backward messages ; replenish budget from contested supply)
|
||||||
|
retro_NO_local = retro_NO; retro_eCB_local = retro_eCB
|
||||||
|
pre_budget += refill(pre from astro_lactate[syn] + transit(axon_ship_pre, τ_transport_bouton))
|
||||||
|
// TRACE (strength: eligibility → tag via dopamine)
|
||||||
|
if pre_fast_trace > elig: pre_possible_tag += pre_fast_trace
|
||||||
|
if dopamine > dop_thr and pre_possible_tag > tag_thr:
|
||||||
|
pre_tag += dopamine × pre_possible_tag
|
||||||
|
// RECOVER (RRP from private reserve toward its ceiling)
|
||||||
|
RRP += fill(RRP, pre_structure.slot_ceiling, pre_structure.refill_ceiling, vatpase_cost, pre_budget)
|
||||||
|
// DECAY
|
||||||
|
pre_fast_trace *= decay(100ms); pre_possible_tag *= decay(s)
|
||||||
|
pre_endurance_need *= decay(min); pre_tag *= decay(hr)
|
||||||
|
dopamine *= decay(ms); retro_NO *= decay(s); retro_eCB *= decay(s)
|
||||||
|
```
|
||||||
|
|
||||||
|
---
|
||||||
|
|
||||||
|
## POST
|
||||||
|
|
||||||
|
```
|
||||||
|
// PARAMETERS K_AMPA · AMPA_Ca · AMPA_cost · NMDA_cost · bAP_cost · pka_cost · traffic_cost
|
||||||
|
// req_cost · Mg_eject · Dserine_thr · Ca_STP · Ca_TAG · eCB_thr · drift · baseline
|
||||||
|
// NO_synth_cost · eCB_synth_cost
|
||||||
|
// INTERFACE
|
||||||
|
// EMIT retro_NO (+), retro_eCB (−) → PRE
|
||||||
|
// RECEIVE astro_lactate[syn] ← ASTRO ; dend_ship_post ← DEND ; post_material ← DEND(NIGHT) ; post_energy ← SOMA(NIGHT)
|
||||||
|
// READ glutamate ← PRE ; astro_Dserine ← ASTRO ; bAP (dend_structure.bAP_fidelity) ; dopamine
|
||||||
|
// OWN post_structure{slot_ceiling, spine_volume, reserve_ceiling} ; post_budget_ceiling
|
||||||
|
// EMERGENCY shockwave_lockdown ← ASTRO
|
||||||
|
// NOTE POST endurance is own-state only (own Ca climbing); no arrived feedback term.
|
||||||
|
|
||||||
|
DAY | NOT_bAP:
|
||||||
|
// RECEIVE
|
||||||
|
post_budget += refill(post from astro_lactate[syn] + transit(dend_ship_post, τ_transport_spine))
|
||||||
|
// ADJUST (AMPA drive from arrived glutamate)
|
||||||
|
a = sat(glutamate, K_AMPA)
|
||||||
|
// BEHAVE (SOURCE 1 AMPA: current + small Ca + begins Mg ejection)
|
||||||
|
AMPA_current = a × AMPA_surface; Vm += AMPA_current; post_budget -= AMPA_cost
|
||||||
|
// TRACE (Ca deposited by AMPA)
|
||||||
|
post_fast_trace += AMPA_Ca·AMPA_current
|
||||||
|
// BEHAVE (SOURCE 2 NMDA: large Ca on local coincidence)
|
||||||
|
if Vm > Mg_eject and astro_Dserine > Dserine_thr and glutamate > 0:
|
||||||
|
post_fast_trace += NMDA_Ca(glutamate)·rise_speed(); post_budget -= NMDA_cost
|
||||||
|
// EMIT (+ NO/BDNF: "release reached a responsive target")
|
||||||
|
retro_NO += NO_emit(post_fast_trace); post_budget -= NO_synth_cost
|
||||||
|
// EMIT (− endocannabinoid / DSE when over-driven)
|
||||||
|
if Vm > eCB_thr:
|
||||||
|
retro_eCB += eCB_emit(Vm); post_budget -= eCB_synth_cost
|
||||||
|
post_fast_trace *= decay(ms)
|
||||||
|
// BEHAVE (STP fill slots from private reserve ; else STD drift = consequence)
|
||||||
|
if post_fast_trace > Ca_STP:
|
||||||
|
if post_budget < traffic_cost:
|
||||||
|
// FUEL shortfall → endurance (own Ca was climbing toward a tag)
|
||||||
|
if post_fast_trace > traj_thr and post_fast_trace_rising:
|
||||||
|
post_endurance_need += post_fast_trace
|
||||||
|
else if AMPA_surface < post_structure.slot_ceiling:
|
||||||
|
AMPA_surface += Ca_insert(post_fast_trace); post_budget -= traffic_cost
|
||||||
|
// else: surface already at slot_ceiling → structure-limited (not endurance)
|
||||||
|
else:
|
||||||
|
AMPA_surface = max(AMPA_surface - drift·Δt, baseline) // STD = consequence
|
||||||
|
// TRACE (strength: CANDIDATE then STABLE via dopamine)
|
||||||
|
if post_fast_trace > Ca_TAG: post_possible_tag += post_fast_trace; post_budget -= pka_cost
|
||||||
|
if dopamine > dop_thr and post_possible_tag > tag_thr:
|
||||||
|
post_tag += dopamine × post_possible_tag
|
||||||
|
// DECAY
|
||||||
|
post_possible_tag *= decay(min); post_endurance_need *= decay(min)
|
||||||
|
post_tag *= decay(hr); dopamine *= decay(ms)
|
||||||
|
|
||||||
|
DAY | bAP:
|
||||||
|
// BEHAVE (SOURCE 3 bAP: depolarization + Ca, amplifies existing signal)
|
||||||
|
Vm += bAP_depol × dend_structure.bAP_fidelity; post_budget -= bAP_cost
|
||||||
|
// TRACE (supralinear boost only if a CANDIDATE is present)
|
||||||
|
if post_possible_tag > Ca_TAG: post_fast_trace += bAP_Ca_boost()
|
||||||
|
```
|
||||||
|
|
||||||
|
---
|
||||||
|
|
||||||
|
## DEND
|
||||||
|
|
||||||
|
```
|
||||||
|
// PARAMETERS prop_cost · branch_Ca_cost · integrate_cost · translate_cost · ACh_gain
|
||||||
|
// INTERFACE
|
||||||
|
// EMIT bAP_local → POST ; branch_Vm → SOMA ; dend_ship_post → POST
|
||||||
|
// RECEIVE astro_lactate[branch] ← ASTRO ; soma_ship_dend ← SOMA ; dend_material, dend_energy ← SOMA(NIGHT)
|
||||||
|
// READ SOMA.fired ; POST.Vm + spine spillover ; dopamine ; ACh
|
||||||
|
// OWN dend_structure{bAP_fidelity(pos), translation_ceiling, transport_speed} ; dend_budget_ceiling
|
||||||
|
// NOTE DEND endurance fires only on FUEL-limited propagation, not structural attenuation;
|
||||||
|
// own-state proxy (strong branch activity); no arrived feedback term.
|
||||||
|
|
||||||
|
DAY | bAP:
|
||||||
|
// ADJUST (propagation strength from structure — inside propagate())
|
||||||
|
// BEHAVE (propagate bAP; distinguish fuel-limited vs structure-limited shortfall)
|
||||||
|
if dend_budget < prop_cost:
|
||||||
|
// FUEL shortfall → endurance (branch was strongly active)
|
||||||
|
if dend_fast_trace > traj_thr:
|
||||||
|
dend_endurance_need += dend_fast_trace
|
||||||
|
bAP_local, reached = propagate_partial(dend_budget)
|
||||||
|
else:
|
||||||
|
bAP_local, reached = propagate(SOMA.fired, dend_structure.bAP_fidelity, geometry)
|
||||||
|
// reached < full here is structural attenuation (distance), NOT endurance
|
||||||
|
dend_budget -= prop_cost × reached
|
||||||
|
// TRACE
|
||||||
|
dend_fast_trace += bAP_Ca(bAP_local) + spine_spillover(); dend_budget -= branch_Ca_cost
|
||||||
|
// EMIT (integrated voltage to soma ; propagated bAP already reached spines)
|
||||||
|
branch_Vm = integrate(POST.Vm, spines); dend_budget -= integrate_cost
|
||||||
|
|
||||||
|
DAY | NOT_bAP:
|
||||||
|
// RECEIVE
|
||||||
|
dend_budget += refill(dend from astro_lactate[branch] + transit(soma_ship_dend, τ_transport_dend))
|
||||||
|
// TRACE (strength)
|
||||||
|
if dend_fast_trace > elig: dend_possible_tag += dend_fast_trace
|
||||||
|
if dopamine > dop_thr and dend_possible_tag > tag_thr:
|
||||||
|
dend_tag += dopamine × dend_possible_tag
|
||||||
|
// ADJUST (commit threshold lowered by attention)
|
||||||
|
commit_threshold *= 1/(1 + ACh·ACh_gain)
|
||||||
|
// EMIT (ship budget to spines; demand = post tag)
|
||||||
|
dend_ship_post = ship(dend_budget, post_demand, post_ship_frac, ship_cost)
|
||||||
|
// BEHAVE (local translation if tagged — fills dend capacity faster)
|
||||||
|
if dend_tag > tag_expiry and dend_budget > translate_cost: dend_budget -= translate_cost
|
||||||
|
// DECAY
|
||||||
|
dend_fast_trace *= decay(300ms); dend_possible_tag *= decay(s)
|
||||||
|
dend_endurance_need *= decay(min); dend_tag *= decay(hr)
|
||||||
|
```
|
||||||
|
|
||||||
|
---
|
||||||
|
|
||||||
|
## SOMA
|
||||||
|
|
||||||
|
```
|
||||||
|
// PARAMETERS ap_cost · nuclear_cost · creb_cost · mito_output · inactivation · ap_amp · ap_contrib
|
||||||
|
// base_recovery · τ_Na · τ_adapt · τ_nuclear · τ_align
|
||||||
|
// INTERFACE
|
||||||
|
// EMIT fired → AXON (propagate) + DEND (bAP) ; soma_ship_dend → DEND ; soma_ship_axon → AXON
|
||||||
|
// RECEIVE self (mitochondria, ROOT) ; branch_Vm ← DEND
|
||||||
|
// READ dopamine ; NE ; ACh
|
||||||
|
// OWN soma_structure{baseline_threshold, AP_reliability, synthesis_ceiling} ; soma_budget_ceiling
|
||||||
|
// NOTE SOMA endurance fires only on FUEL shortfall (budget < ap_cost);
|
||||||
|
// refractory / sub-threshold are timing limits, not endurance. Own-state proxy.
|
||||||
|
|
||||||
|
DAY | AP:
|
||||||
|
// ADJUST (threshold from structure + adaptation + neuromodulators ; refractory gate)
|
||||||
|
threshold = soma_structure.baseline_threshold × (1 + soma_adaptation) × neuromod(NE, ACh)
|
||||||
|
can_fire = soma_Na_inactivation < inactivation
|
||||||
|
// BEHAVE (fire if able)
|
||||||
|
if branch_Vm > threshold and can_fire:
|
||||||
|
if soma_budget < ap_cost:
|
||||||
|
// FUEL shortfall → endurance (firing was approaching CREB)
|
||||||
|
if soma_fast_trace > traj_thr and soma_fast_trace_rising:
|
||||||
|
soma_endurance_need += soma_fast_trace
|
||||||
|
exit
|
||||||
|
// EMIT (fired → AXON, DEND)
|
||||||
|
fired = True; soma_budget -= ap_cost
|
||||||
|
// TRACE (three traces from one AP — all timescales)
|
||||||
|
soma_Na_inactivation += ap_amp // → refractory (emergent)
|
||||||
|
soma_adaptation += ap_contrib // → threshold rise
|
||||||
|
soma_fast_trace += nuclear_Ca(); soma_budget -= nuclear_cost
|
||||||
|
// TRACE (strength)
|
||||||
|
if soma_fast_trace > elig: soma_possible_tag += soma_fast_trace
|
||||||
|
if dopamine > dop_thr and soma_possible_tag > tag_thr:
|
||||||
|
soma_tag += dopamine × soma_possible_tag
|
||||||
|
soma_budget -= creb_cost
|
||||||
|
|
||||||
|
DAY | NOT_AP:
|
||||||
|
// RECEIVE (self-replenish from private root ; integrate input)
|
||||||
|
soma_budget += fill(soma_budget, soma_budget_ceiling, mito_output, 0, soma_budget)
|
||||||
|
branch_Vm = integrate(DEND.branch_Vm, branches)
|
||||||
|
// TRACE (bottom-up refractory alignment: suprathreshold input during refractory)
|
||||||
|
if branch_Vm > threshold and soma_Na_inactivation > inactivation:
|
||||||
|
soma_refractory_alignment += (branch_Vm - threshold) × soma_Na_inactivation
|
||||||
|
// EMIT (ship downstream into transit; demand = propagated tags)
|
||||||
|
soma_ship_dend = ship(soma_budget, dend_demand, dend_ship_frac, ship_cost)
|
||||||
|
soma_ship_axon = ship(soma_budget, axon_demand, axon_ship_frac, ship_cost)
|
||||||
|
// RECOVER (inactivation recovery sped by alignment trace → emergent refractory)
|
||||||
|
recovery = base_recovery × (1 + soma_refractory_alignment)
|
||||||
|
soma_Na_inactivation *= decay(τ_Na / recovery)
|
||||||
|
// DECAY
|
||||||
|
soma_adaptation *= decay(τ_adapt); soma_fast_trace *= decay(τ_nuclear)
|
||||||
|
soma_refractory_alignment *= decay(τ_align) // self-limiting
|
||||||
|
soma_possible_tag *= decay(s); soma_endurance_need *= decay(min)
|
||||||
|
soma_tag *= decay(hr); dopamine *= decay(ms)
|
||||||
|
```
|
||||||
|
|
||||||
|
---
|
||||||
|
|
||||||
|
## AXON
|
||||||
|
|
||||||
|
```
|
||||||
|
// PARAMETERS prop_cost · budget_factor
|
||||||
|
// INTERFACE
|
||||||
|
// EMIT APs_delivered → PRE (propagation) ; axon_ship_pre → PRE
|
||||||
|
// RECEIVE soma_ship_axon ← SOMA ; astro_lactate[shaft] ← ASTRO ; axon_material, axon_energy ← SOMA(NIGHT)
|
||||||
|
// READ SOMA.fired ; dopamine
|
||||||
|
// OWN axon_structure{propagation, transport_ceiling, mito_density} ; axon_budget_ceiling
|
||||||
|
// NOTE AXON endurance fires only on FUEL shortfall; load-driven failure fail(fast_trace)
|
||||||
|
// is axonal STD (a consequence), not endurance. Own-state proxy.
|
||||||
|
|
||||||
|
DAY | AP:
|
||||||
|
// ADJUST (reliability from structure − load-driven failure)
|
||||||
|
reliability = axon_structure.propagation × (1 - fail(axon_fast_trace)) // fail() = STD, not endurance
|
||||||
|
// BEHAVE (propagate; FUEL shortfall degrades + flags endurance)
|
||||||
|
if axon_budget < prop_cost:
|
||||||
|
reliability *= budget_factor
|
||||||
|
if axon_fast_trace > traj_thr: // FUEL-limited → endurance
|
||||||
|
axon_endurance_need += axon_fast_trace
|
||||||
|
delivered = fired × reliability; axon_budget -= prop_cost × delivered
|
||||||
|
// EMIT (delivered APs reach boutons)
|
||||||
|
// TRACE
|
||||||
|
axon_fast_trace += delivered; axon_fast_trace *= decay(s)
|
||||||
|
|
||||||
|
DAY | NOT_AP:
|
||||||
|
// RECEIVE
|
||||||
|
axon_budget += refill(axon from soma_ship_axon + astro_lactate[shaft])
|
||||||
|
// TRACE (strength)
|
||||||
|
if axon_fast_trace > elig: axon_possible_tag += axon_fast_trace
|
||||||
|
if dopamine > dop_thr and axon_possible_tag > tag_thr:
|
||||||
|
axon_tag += dopamine × axon_possible_tag
|
||||||
|
// EMIT (ship to boutons; demand = pre tag)
|
||||||
|
axon_ship_pre = ship(axon_budget, pre_demand, pre_ship_frac, ship_cost)
|
||||||
|
// DECAY
|
||||||
|
axon_fast_trace *= decay(s); axon_possible_tag *= decay(s)
|
||||||
|
axon_endurance_need *= decay(min); axon_tag *= decay(hr)
|
||||||
|
```
|
||||||
|
|
||||||
|
---
|
||||||
|
|
||||||
|
## ASTRO
|
||||||
|
|
||||||
|
```
|
||||||
|
// PARAMETERS K_Dserine · Ds_max · Ds_frac · Ds_cost · EAAT_cost · lactate_cost · spillover · overload
|
||||||
|
// INTERFACE
|
||||||
|
// EMIT astro_lactate[i] → pre/post/dend budgets ; astro_Dserine[i] → POST (gate)
|
||||||
|
// RECEIVE glucose (ROOT) ; astro_material, astro_energy ← cell body (NIGHT)
|
||||||
|
// READ glutamate ← PRE (clearance + spillover) ; dopamine
|
||||||
|
// OWN astro_structure{perisynaptic_distance⁻¹, EAAT, Dserine_tonic, ECM} ; astro_budget_ceiling
|
||||||
|
// NOTE ASTRO endurance fires on BUDGET-limited synthesis (got<want via low budget);
|
||||||
|
// material/precursor-limited synthesis is a material limit, not endurance. Own-state proxy.
|
||||||
|
// EMERGENCY emits shockwave_lockdown on overload
|
||||||
|
|
||||||
|
DAY | CONTINUOUS: // per astrosynapse i
|
||||||
|
// RECEIVE (root production, capped by glucose)
|
||||||
|
astro_central_budget += glycolysis(glucose)·Δt
|
||||||
|
// ADJUST (demand weights across territory)
|
||||||
|
for each i: demand[i] = clearance_load[i] × astro_structure[i].delivery_eff
|
||||||
|
factor = min(1, astro_central_budget / (Σ demand·lactate_cost + ε))
|
||||||
|
// EMIT (demand-weighted lactate to all components)
|
||||||
|
for each i:
|
||||||
|
astro_lactate[i] = demand[i] × factor; astro_central_budget -= astro_lactate[i]·lactate_cost
|
||||||
|
// BEHAVE (clear glutamate ; supply tonic D-serine)
|
||||||
|
glutamate[i] -= astro_structure[i].EAAT × glutamate[i]·Δt; astro_central_budget -= clearance·EAAT_cost
|
||||||
|
astro_Dserine[i] += astro_structure[i].Dserine_tonic·Δt
|
||||||
|
if glutamate[i] > spillover:
|
||||||
|
// TRACE
|
||||||
|
astro_fast_trace[i] += mGluR_Ca(); astro_fast_trace[i] *= decay(s)
|
||||||
|
// ADJUST (D-serine demand from spillover)
|
||||||
|
want = sat(astro_fast_trace[i], K_Dserine) × Ds_max
|
||||||
|
got = min(want, astro_central_budget × Ds_frac)
|
||||||
|
// BEHAVE + EMIT (D-serine pulse to POST gate)
|
||||||
|
astro_Dserine[i] += got; astro_central_budget -= got·Ds_cost
|
||||||
|
// TRACE (endurance: BUDGET-limited synthesis under high own demand)
|
||||||
|
if got < want and astro_central_budget low and astro_fast_trace[i] > traj_thr:
|
||||||
|
astro_endurance_need[i] += (want - got)
|
||||||
|
// TRACE (strength)
|
||||||
|
if astro_fast_trace[i] > elig: astro_possible_tag[i] += astro_fast_trace[i]
|
||||||
|
if dopamine > dop_thr and astro_possible_tag[i] > tag_thr:
|
||||||
|
astro_tag[i] += dopamine × astro_possible_tag[i]
|
||||||
|
// DECAY
|
||||||
|
astro_possible_tag[i] *= decay(s); astro_endurance_need[i] *= decay(min); astro_tag[i] *= decay(hr)
|
||||||
|
// EMERGENCY
|
||||||
|
if astro_fast_trace[i] > overload: emit(shockwave_lockdown)
|
||||||
|
```
|
||||||
|
|
||||||
|
---
|
||||||
|
|
||||||
|
## Special — Shockwave Lockdown
|
||||||
|
|
||||||
|
```
|
||||||
|
DAY or NIGHT | OVERLOAD:
|
||||||
|
Vm = HYPERPOLARIZED; AMPA_surface = mass_internalize() → post reserve
|
||||||
|
axon_fast_trace += overdrive(); astro_central_budget -= emergency_cost
|
||||||
|
```
|
||||||
|
|
||||||
|
---
|
||||||
|
---
|
||||||
|
# NIGHT
|
||||||
|
Same grammar on ceilings, once per cycle.
|
||||||
|
|
||||||
|
```
|
||||||
|
NIGHT | 1 RECEIVE + ADJUST + EMIT (replenish, weight, distribute)
|
||||||
|
// RECEIVE overnight production at roots (capped by glucose; gated by soma_tag)
|
||||||
|
astro_central_{budget,energy,material} += overnight_*(glucose, …)·Δt
|
||||||
|
soma_{budget,energy} += overnight_*()·Δt ; soma_material += CREB_synth(soma_tag)·Δt
|
||||||
|
// ADJUST tag-weighted shares
|
||||||
|
for each i with astro_tag[i] > tag_expiry: w = astro_tag[i]/Σastro_tag
|
||||||
|
// EMIT distribute material + energy down the supply chains
|
||||||
|
astro_energy[i] += astro_central_energy·w; astro_material[i] += astro_central_material·w
|
||||||
|
dend_material += soma_material·f_dend ; axon_material += soma_material·f_axon ; soma_material -= …
|
||||||
|
post_material += dend_material·f_spine ; pre_material += axon_material·f_bouton
|
||||||
|
{pre,post,dend,axon}_energy += soma_energy·{·}_energy_frac
|
||||||
|
{pre,post,dend,axon}_budget += astro_lactate_reserve·{·}_frac·Δt
|
||||||
|
|
||||||
|
NIGHT | 2 TRACE + BEHAVE (strength commits → raise structure)
|
||||||
|
// ADJUST coherence bonus when pre, post, astro tags align
|
||||||
|
coherence = (pre_tag, post_tag, astro_tag all > tag_expiry) ? coherence_factor : 1
|
||||||
|
// TRACE+BEHAVE build structure for tagged components
|
||||||
|
for each c with c_tag > tag_expiry:
|
||||||
|
Δ = min(slot_cost, c_material, c_energy·f_cap)
|
||||||
|
c_structure += Δ × (coherence if c in {pre,post,astro} else 1)
|
||||||
|
c_material -= Δ; c_energy -= Δ·assembly_cost; if Δ < slot_cost: queue(→ next NIGHT)
|
||||||
|
|
||||||
|
NIGHT | 2b TRACE + BEHAVE (endurance commits → raise budget_ceiling ; no dopamine ; competes w/ 2)
|
||||||
|
for each c with c_endurance_need > endur_thr:
|
||||||
|
Δ = min(cap_cost, c_material·f_cap, c_energy·f_cap)
|
||||||
|
c_budget_ceiling += Δ; c_material -= Δ; c_energy -= Δ·biogenesis_cost; if Δ<cap_cost: queue
|
||||||
|
|
||||||
|
NIGHT | 3 DECAY + RECOVER (both ceilings decay by neglect ; material recovered)
|
||||||
|
maint = (total_material - consumed) × maint_frac / synapse_count
|
||||||
|
for each synapse: // DECAY
|
||||||
|
{pre,post,dend,astro}_structure -= decay_rate·Δt
|
||||||
|
{pre,post,dend,astro}_budget_ceiling -= capacity_decay_rate·Δt
|
||||||
|
if maint ≥ maint_cost: structure += full_maint ; budget_ceiling += full_cap_maint
|
||||||
|
else: structure += maint·frac ; budget_ceiling += maint·cap_frac
|
||||||
|
for each synapse with net_change < 0: // RECOVER
|
||||||
|
{pre,post,astro}_material += |net_change|·recycle·frac // material recovered, energy not
|
||||||
|
|
||||||
|
NIGHT | 4 BEHAVE (homeostatic scaling)
|
||||||
|
if soma_tag > homeostatic_ceiling:
|
||||||
|
s = homeostatic_ceiling / soma_tag
|
||||||
|
for each synapse: post_structure.slot_ceiling *= s ; pre_structure.slot_ceiling *= s
|
||||||
|
soma_material += Σ reduction·recycle
|
||||||
|
|
||||||
|
NIGHT | 5 DECAY (clear traces)
|
||||||
|
all fast_trace, possible_tag, endurance_need = 0
|
||||||
|
soma_Na_inactivation = soma_adaptation = soma_refractory_alignment = 0
|
||||||
|
for each tag: if tag < tag_expiry: tag = 0 // else carry forward
|
||||||
|
// structure and budget_ceiling PERSIST
|
||||||
|
```
|
||||||
|
|
||||||
|
---
|
||||||
|
|
||||||
|
## One-view summary
|
||||||
|
|
||||||
|
```
|
||||||
|
SEVEN-GROUP GRAMMAR, TWO TIMESCALES
|
||||||
|
RECEIVE · TRACE · ADJUST · BEHAVE · EMIT · RECOVER · DECAY
|
||||||
|
|
||||||
|
DAY grammar on OCCUPANCY within two ceilings (structure=strength, budget_ceiling=endurance)
|
||||||
|
TRACE yields two evidence streams from local state + arrived signals:
|
||||||
|
fast_trace + dopamine → tag (strength)
|
||||||
|
FUEL shortfall + interrupted LOCAL success → endurance_need (endurance)
|
||||||
|
OCCUPANCY/structure/timing shortfalls → short-term depression (NOT endurance)
|
||||||
|
NIGHT same grammar on the CEILINGS:
|
||||||
|
tag → structure ; endurance_need → budget_ceiling ; both draw one pool (compete)
|
||||||
|
unmaintained ceilings decay → recovered material funds the rest
|
||||||
|
FLOWS every flow has a timescale: decay relaxes toward 0 over τ, arrival toward a target
|
||||||
|
over τ; shipment is transit-delayed; rate-limited inflows carry τ implicitly.
|
||||||
|
LOCAL every group uses only own state + arrived signals; RECEIVE/EMIT are the only crossings.
|
||||||
|
```
|
||||||
Reference in New Issue
Block a user