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@@ -21,6 +21,8 @@ Container: BEH-BD
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## BEH-POST: Container
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## BEH-POST: Container
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**Discursive description**:
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The postsynapse is the receiving terminal of a neuron — a specialised patch of membrane on the surface of a dendrite, sitting directly across the synaptic cleft from the presynapse. Its job is to detect the neurotransmitters (NT) released by the presynapse, convert that chemical signal back into an electrical response, and decide — based on the history and pattern of that activity — whether to strengthen or weaken the connection for the future.
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The postsynapse is the receiving terminal of a neuron — a specialised patch of membrane on the surface of a dendrite, sitting directly across the synaptic cleft from the presynapse. Its job is to detect the neurotransmitters (NT) released by the presynapse, convert that chemical signal back into an electrical response, and decide — based on the history and pattern of that activity — whether to strengthen or weaken the connection for the future.
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To do this, the postsynapse maintains two types of receptor on its membrane surface. AMPA receptors are the fast responders: when NT binds them, they immediately open and allow sodium ions to rush in, raising the local membrane potential (V_post). NMDA receptors are the coincidence detectors: they can only open fully when two conditions are simultaneously true — NT must be present in the cleft, and the membrane must already be strongly depolarised. Under resting conditions a magnesium ion physically plugs the NMDA channel from the inside, blocking calcium entry. Only a sufficiently large depolarisation can eject this plug. This dual requirement makes NMDA receptors the central logic gate of the postsynapse.
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To do this, the postsynapse maintains two types of receptor on its membrane surface. AMPA receptors are the fast responders: when NT binds them, they immediately open and allow sodium ions to rush in, raising the local membrane potential (V_post). NMDA receptors are the coincidence detectors: they can only open fully when two conditions are simultaneously true — NT must be present in the cleft, and the membrane must already be strongly depolarised. Under resting conditions a magnesium ion physically plugs the NMDA channel from the inside, blocking calcium entry. Only a sufficiently large depolarisation can eject this plug. This dual requirement makes NMDA receptors the central logic gate of the postsynapse.
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@@ -41,7 +43,7 @@ The Critical Connection with the presynapse: The system is beautifully asymmetri
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---
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---
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1.The $V_{post}$ Loop: The Fast Gatekeeper (Milliseconds)
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**The $V_{post}$ Loop**: The Fast Gatekeeper (Milliseconds)
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This is the primary electrophysiological response, where chemical signals are converted back into electricity.
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This is the primary electrophysiological response, where chemical signals are converted back into electricity.
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@@ -53,7 +55,7 @@ This is the primary electrophysiological response, where chemical signals are co
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---
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---
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2.The $Ca^{2+}$ Loop: The Plasticity Controller (Seconds)
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**The $Ca^{2+}$ Loop**: The Plasticity Controller (Seconds)
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This loop translates electrical timing into biological "memory."
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This loop translates electrical timing into biological "memory."
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@@ -65,7 +67,7 @@ This loop translates electrical timing into biological "memory."
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---
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---
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3.The ATP Loop: The Metabolic Backbone (Minutes)
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**The ATP Loop**: The Metabolic Backbone (Minutes)
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This is the "Hidden Master" that determines if the other two loops are allowed to function.
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This is the "Hidden Master" that determines if the other two loops are allowed to function.
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@@ -79,7 +81,7 @@ The failure of the ATP loop in the postsynapse is arguably more dangerous; if th
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---
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---
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Behaviors:
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**Behaviors**:
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— ms:
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— ms:
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@@ -115,7 +117,7 @@ Behaviors:
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---
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---
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Simplified comprehension:
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**Simplified comprehension**:
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In this comprehension we decide to simplify:
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In this comprehension we decide to simplify:
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@@ -131,7 +133,7 @@ The simplification implies that:
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---
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---
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Simplified Behaviors:
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**Simplified Behaviors**:
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— ms:
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— ms:
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@@ -159,6 +161,12 @@ Simplified Behaviors:
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- If Plasticity_LTD tagged → AMPA density decreases
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- If Plasticity_LTD tagged → AMPA density decreases
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- AMPA density feeds back into receptor_conductance ceiling for next cycle
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- AMPA density feeds back into receptor_conductance ceiling for next cycle
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---
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**Tubs:**
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---
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```Gen
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```Gen
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container: BEH-POST
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container: BEH-POST
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