aggiunto behavior ms, sec, min
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@@ -36,6 +36,14 @@ La fullness di un Tub puo' essere cambiata in DEV. Dal punto di vista della comp
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L'assegnazione dei livelli di fullness, active e emptiness viene fatta una volta completata l'espansione come per RF. Infatti l'assegnazione deve essere collegata a RF.
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#### full, medium and empty
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Il controllo della condition in un context o episode viene fatto con 3 "stati".
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- full: se gli actual sono maggiori o uguali a fullness
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- medium: se gli actual sono minori di fullness e maggiori di emptiness
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- empty: se gli actual sono uguali o meno di emptiness
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### RF
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Teorema di Shannon inverso. E' come se facessimo un campionamento su un ipotesi di continuita'.
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+66
-17
@@ -108,16 +108,23 @@ container: BEH-PRE
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- CaTraces ( fullness: 50x, active: 0x, emptiness: 0x )
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- mGluR ( fullness: 50x, active: 0x, emptiness: 0x )
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- CDI ( fullness: 50x, active: 0x, emptiness: 0x )
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tub_intricated:
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- NT
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- ATP
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- NT # SYN
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- ATP # AXO?
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- eCB # from POST
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context_intricated:
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- AP ( contained_by: BEH-SOMA )
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```
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### RRPConcentration: Context
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### ms: behavior
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#### RRPConcentration: Context
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Il rilascio di NT lo facciamo nel contesto di AP. Biologicamente dovrebbe avvenire solo in base alle concentrazioni, quindi anche al difuori degli AP.
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@@ -128,14 +135,14 @@ context: RRPConcentration
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in_context: AP
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rf: ( active: 60x )
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condition: NOT (Rrp empty) AND NOT (Rrp full)
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condition: (Rrp medium)
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out_context: RRPMedium
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condition: (Rrp full)
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out_context: RRPFull
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```
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### Ca2MicroConcentration: Context
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#### Ca2MicroConcentration: Context
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```Gen
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context: Ca2MicroConcentration
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@@ -144,20 +151,20 @@ context: Ca2MicroConcentration
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in_context: AP
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rf: ( active: 60x )
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condition: NOT (Ca2Micro empty) AND NOT (Ca2Micro full)
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condition: (Ca2Micro medium)
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out_context: Ca2MicroMedium
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condition: (Ca2Micro full)
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out_context: Ca2MicroFull
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```
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### NTrelease: Episodes
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#### NTrelease: Episodes
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Ci sono 4 casi che dipendono da RRP, CaMicro e NT. L'idea e' che la quantita' di RRP sia il driver principale. Gli NT liberati sono di piu' al crescere di RRP e CaMicro e di meno al crescere di NT. Gli NT nella sinapsi fanno da moderazione alla ulteriore liberazione di NT, ma non bloccano mai totalmente. NT suppression only matters when everything else is already at maximum — which is exactly the biological purpose: it prevents runaway release during peak activity, not during moderate activity.
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ATP cost of Na/K-ATPase recharge on each AP. The cost is per action potential. Here we charge it at every release of NT. This is the dominant ATP drain at high firing rates.
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#### NTreleaseMaximum: Episode
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##### NTreleaseMaximum: Episode
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```Gen
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episode: NTreleaseMaximum
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@@ -171,7 +178,7 @@ episode: NTreleaseMaximum
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trace: None
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```
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#### NTreleaseHigh: Episode
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##### NTreleaseHigh: Episode
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```Gen
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episode: NTreleaseHigh
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@@ -185,7 +192,7 @@ episode: NTreleaseHigh
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trace: None
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```
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#### NTreleaseMedium: Episode
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##### NTreleaseMedium: Episode
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```Gen
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episode: NTreleaseMedium
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@@ -199,7 +206,7 @@ episode: NTreleaseMedium
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trace: None
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```
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#### NTreleaseLow: Episode
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##### NTreleaseLow: Episode
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```Gen
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episode: NTreleaseLow
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@@ -213,6 +220,22 @@ episode: NTreleaseLow
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trace: None
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```
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### sec: behavior
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...
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#### mGlur
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#### eCB
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#### CDI
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#### RP->RRP
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### min: behavior
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#### Refill RP from Glutamine
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## BEH-PRE-VGCC: Container
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**Voltage-Controlled Gated Channels**:
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@@ -289,20 +312,46 @@ Here we comprehend the breaking activity on VGCC by: CDI,eCB and mGluR:
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- **Suppressed** — two brakes multiplying. The compounding is what defines this zone — no single variable alone produces it (except CDI approaching full). 0.5 × 0.5 = 0.25 remaining is where the synapse starts losing significant transmission efficacy. Biologically this is the pre-silence warning zone: CDI is building from residual Ca²⁺ while eCB is already engaged from postsynaptic activity.
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- **Closed — CDI** = full is the only reliable hard rule. Because CDI can reach 1.0 and appears as (1 - CDI_factor) in the formula, it alone drives conductance to zero regardless of eCB and mGluR state. The three-brake overlap corner case (eCB=full + CDI=medium + mGluR=full) also reaches here, but in practice CDI reaching full is the primary biological mechanism.
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#### Ca2+enterFast: Episode
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Devo controllare che le condizioni sotto siano esaustive.
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#### Ca2+enterMedium: Episode
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#### Ca2+enterSlow: Episode
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#### Open: Episode
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```Gen
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episode: Ca2+enter
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episode: Open
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contained_by: BEH-PRE-VGCC
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in_context: AP
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rf: ( active: 6x )
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hypothesis: NOT (Ca2+ full)
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hypothesis: (CDI empty) and (eCB empty)
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action: [Ca2+ increase, ATP decrease]
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trace: None
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```
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#### Reduced-partial: Episode
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```Gen
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episode: Reduced-partial
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contained_by: BEH-PRE-VGCC
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in_context: AP
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rf: ( active: 6x )
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hypothesis: (CDI medium) OR ((eCB medium) AND (CDI empty)) OR ((eCB full) AND (CDI empty) AND (mGluR empty))
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action: [Ca2+ increase, ATP decrease]
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trace: None
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```
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#### Suppressed: Episode
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```Gen
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episode: Supressed
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contained_by: BEH-PRE-VGCC
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in_context: AP
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rf: ( active: 6x )
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hypothesis: ((CDI medium) AND (eCB full) OR (eCB medium))
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action: [Ca2+ increase, ATP decrease]
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trace: None
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```
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