concentration VGCC

neuron/BEH-AXO.md

@@ -228,7 +228,72 @@ container: BEH-PRE-VGCC
     - AP ( contained_by: BEH-SOMA )
 ```
 
-### Ca2+enter: Episode
+### VGCC-Breaking: Contexts
+
+#### CDIConcentration: Context
+
+```Gen
+context: CDIConcentration
+  contained_by: BEH-PRE-VGCC
+
+  in_context: AP
+  rf: ( active: 60x )
+
+  condition: NOT (Ca2Micro empty) AND NOT (Ca2Micro full) 
+    out_context: Ca2MicroMedium
+
+  condition: (Ca2Micro full) 
+    out_context: Ca2MicroFull
+```
+
+#### eCBConcentration: Context
+
+```Gen
+context: eCBConcentration
+  contained_by: BEH-PRE-VGCC
+
+  in_context: AP
+  rf: ( active: 60x )
+
+  condition: NOT (Ca2Micro empty) AND NOT (Ca2Micro full) 
+    out_context: Ca2MicroMedium
+
+  condition: (Ca2Micro full) 
+    out_context: Ca2MicroFull
+```
+
+#### mGluRConcentration: Context
+
+```Gen
+context: mGluRConcentration
+  contained_by: BEH-PRE-VGCC
+
+  in_context: AP
+  rf: ( active: 60x )
+
+  condition: NOT (Ca2Micro empty) AND NOT (Ca2Micro full) 
+    out_context: Ca2MicroMedium
+
+  condition: (Ca2Micro full) 
+    out_context: Ca2MicroFull
+```
+
+### Ca2+enter: Episodes
+
+Here we comprehend the breaking activity on VGCC by: CDI,eCB and mGluR:
+
+![breaking-cases.png](.attachments/breaking-cases.png)
+
+- **Open** — zero active brakes. mGluR alone never escapes this group because its ceiling is alpha_mGluR = 0.4, meaning even at full it only removes 40% of conductance, leaving 60% — still above the 85% threshold. So mGluR is irrelevant to the open/not-open boundary. Only CDI and eCB decide.
+- **Reduced/partial** — exactly one meaningful brake active. Either CDI has started building (medium), or eCB has risen from sustained postsynaptic activity, but not both simultaneously. The system is aware something is happening but has not compounded yet. This is the normal operating range during moderate sustained firing.
+- **Suppressed** — two brakes multiplying. The compounding is what defines this zone — no single variable alone produces it (except CDI approaching full). 0.5 × 0.5 = 0.25 remaining is where the synapse starts losing significant transmission efficacy. Biologically this is the pre-silence warning zone: CDI is building from residual Ca²⁺ while eCB is already engaged from postsynaptic activity.
+- **Closed — CDI** = full is the only reliable hard rule. Because CDI can reach 1.0 and appears as (1 - CDI_factor) in the formula, it alone drives conductance to zero regardless of eCB and mGluR state. The three-brake overlap corner case (eCB=full + CDI=medium + mGluR=full) also reaches here, but in practice CDI reaching full is the primary biological mechanism.
+
+#### Ca2+enterFast: Episode
+
+#### Ca2+enterMedium: Episode
+
+#### Ca2+enterSlow: Episode
 
 ```Gen
 episode: Ca2+enter

neuron/appunti/2026-03-16-nuovo-modello-tripartita-semplificato.md

@@ -1,4 +1,4 @@
-## The Biological "Cascade of Failure"
+# The Biological "Cascade of Failure"
 
 This model now demonstrates **Metabolic Silencing**, which is a highly consistent biological behavior: