From c8c953f68de92c096da16b780c6223330f1dbb17 Mon Sep 17 00:00:00 2001 From: ocrampal Date: Thu, 25 Jun 2026 11:56:15 +0200 Subject: [PATCH] Update presynapse.md --- elements/neuron/presynapse.md | 21 ++++++++++++++++++++- 1 file changed, 20 insertions(+), 1 deletion(-) diff --git a/elements/neuron/presynapse.md b/elements/neuron/presynapse.md index 4ad8272..578330c 100644 --- a/elements/neuron/presynapse.md +++ b/elements/neuron/presynapse.md @@ -4,7 +4,6 @@ include_toc: true // presynapse.md -# PRESYNAPSE Expansions and modulations: - is expanded and developed by: [AXON](axon.md) @@ -12,6 +11,26 @@ Expansions and modulations: - expands and tunes: [PRE_VGG](pre_vgcc.md) - develops _Ca2, _Rrp + Introduction: + The presynaptic bouton releases neurotransmitter and gathers evidence about whether that release was worth strengthening and worth sustaining. Its behavior unfolds across two DAY contexts and the NIGHT scope. + + During DAY, during AP — the bouton releases neurotransmitter. The amount released depends on: + + - residual calcium from recent spikes (the fast trace), which sets the release drive; + - the two retrograde messages from the postsynapse — retro_eCB brakes the drive (the postsynapse is over-driven), retro_NO will later confirm that release reached a responsive target; + - the availability of both fuel and vesicles — release proceeds only if budget covers the cost and the readily-releasable pool is non-empty. These two shortfalls are read differently: a fuel shortfall on a succeeding release is evidence the bouton needs more endurance; an empty pool with fuel to spare is ordinary short-term depression. + + During DAY, during NOT_AP — the bouton consolidates and recovers. With no spike to release, it: + + - receives what arrived — latches the retrograde messages, refills its budget from astrocytic lactate and arrived axonal shipment (contested supply); + - maintains its traces — accumulates eligibility toward a tag, and stabilizes that tag if dopamine has arrived (the bridge toward strength); + - recovers its readily-releasable pool from the private reserve, between spikes (which is why high-frequency firing depletes faster than it recovers); + - lets its traces decay, closing the eligibility, endurance, and tagging windows. + + During NIGHT — the bouton's ceilings are rewritten. Acting on the evidence gathered across the day, NIGHT raises the bouton's structure (active-zone capacity) where a validated tag accumulated, and its budget capacity (mitochondrial endurance) where fuel repeatedly interrupted a succeeding release. Both draw on the same finite material and energy shipped down the axon, so the bouton's two kinds of growth compete — and whatever is not maintained drifts back down. + +# PRESYNAPSE + ```Gen include: