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neuron/BEH-AXO.md
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@@ -8,13 +8,16 @@ Qui comprendiamo:
## BEH-AXO: Container
**Axon**: Axon does not contain specific behavior, here we comprehend it as a “cable” transporting the AP from SOMA to Presynapse. It expands BEH-PRE which can be Modulated (TUN).
**Axon**: Axon does not contain specific behavior, here we comprehend it as a “cable” transporting the AP from SOMA to Presynapse. It expands BEH-PRE which:
- can be developed by DEV-PRE
- the associations between BEH-PRE, BEH-POST e BEH-SYN is performed by the module that instantiate the Neurons and the Atrocytes, for example BEH-EXH or BEH-INH from winnertakeall.
```Gen
container: BEH-AXO
expansion: BEH-PRE ( fullness: 50x, active: 0x, emptiness: 10x )
# managed_by: BEH-WTA-PRE-POST from BEH-WTA
# managed_by: BEH-EXH or BEH-INH from winnertakeall
# developed_by: DEV-AXO-BEH-PRE-TUB from DEV-N
```
@@ -24,38 +27,38 @@ container: BEH-AXO
**Tubs:**
- Ca2+: Calcium Ion entering the Presynapse when VCGG open. They are key to check the concentration, release vescicles and modulation
- Rrp: Readily Releasable Pool
The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse.
Location: Directly touching the presynaptic membrane.
Function: These are the first to be released when an action potential arrives.
Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal.
- RecP: Recycling Pool
The Recycling Pool is the next line of reinforcement.
Location: Slightly further back from the membrane than the RRP.
Function: These vesicles maintain release during moderate, physiological levels of stimulation.
Characteristics: They are continuously refilled as the neuron "recycles" the membranes of used vesicles through endocytosis. This pool is larger than the RRP (roughly 5% to 20% of the total).
- Rp: The "Reserve Pool" (The true RP)
In many textbooks, RP specifically stands for the Reserve Pool.
Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin.
Function: These are only mobilized during intense, prolonged stimulation once the RRP and Recycling pools are depleted.
Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%).
- Nt: Neuro Transmitter, released in the synapse by the vescicles
- TagRelease: forse non serve, ma indica il rilascio di NT da parte di una syn.
- **Ca2+**: Calcium Ion entering the Presynapse when VCGG open. They are key to check the concentration, release vescicles and modulation
- **Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse.
-- Location: Directly touching the presynaptic membrane.
-- Function: These are the first to be released when an action potential arrives.
-- Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal.
- **RecP**: Recycling Pool
--The Recycling Pool is the next line of reinforcement.
-- Location: Slightly further back from the membrane than the RRP.
-- Function: These vesicles maintain release during moderate, physiological levels of stimulation.
-- Characteristics: They are continuously refilled as the neuron "recycles" the membranes of used vesicles through endocytosis. This pool is larger than the RRP (roughly 5% to 20% of the total).
- **Rp**: The "Reserve Pool" (The true RP)
-- In many textbooks, RP specifically stands for the Reserve Pool.
-- Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin.
-- Function: These are only mobilized during intense, prolonged stimulation once the RRP and Recycling pools are depleted.
-- Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%).
- **Nt**: Neuro Transmitter, released in the synapse by the vescicles
- **CaTraces**: sono le tracce di permanenza della concentrazione di Ca2+. Servono alla modulazione (TUN)
- **TagRelease**: forse non serve, ma indica il rilascio di NT da parte di una Pre.
**Behaviors**:
L'idea e' che:
- Fast
-- i VCGG si aprano all'arrivo di un AP dal SOMA. Il numero dei VCGG presenti e' stato modulato (TUN) in una fase di non attivita' della presynapse
-- I VCGG fanno entrare Ca2+ che ne aumenta la concentrazione
-- ad un certo livello di concentrazione, viene liberata una vescica, se ci sono Rrp disponibili. La vescica libera xxx Nt nella sinsapsi
- Medium
-- clearance dei Ca2+ che depolarizza la Presinapsi
-- riciclo delle vesciche, prendendole dalla Sinapsi e mettenedole dentro a RecP
- Slow
-- riempimento vesciche di Nt e mettendole dentro Rp
-- spostamento da Rp a RecP
-- i VCGG si aprano all'arrivo di un AP dal SOMA. Il numero dei VCGG presenti e' stato modulato (TUN) in una fase di non attivita' della presynapse
-- I VCGG fanno entrare Ca2+ che ne aumenta la concentrazione
-- ad un certo livello di concentrazione, viene liberata una vescica, se ci sono Rrp disponibili. La vescica libera xxx Nt nella sinsapsi
- Medium timing
-- clearance dei Ca2+ che depolarizza la Presinapsi
-- riciclo delle vesciche, prendendole dalla Sinapsi e mettenedole dentro a RecP
- Slow Timing
-- riempimento vesciche di Nt e mettendole dentro Rp
-- spostamento da Rp a RecP
```Gen
container: BEH-PRE
@@ -80,14 +83,14 @@ container: BEH-PRE
tub_intricated:
```
### IntegrateCa2+: Context
### Ca2+Concentration: Context
Qui verifichiamo il livello di CA2+ nella presynapse. I comportamenti nella presinapsi dipendo tutti da questa concentrazione, sia quelli immediati di rilascio NT da vescicles che quelli di modulazione.
***Tens Milliseconds Time Scale***
```Gen
context: IntegrateCa2+
context: Ca2+Concentration
contained_by: BEH-PRE
in_context: Fixed