diff --git a/neuron/presynapse.md b/neuron/presynapse.md index e1deacb..935b975 100644 --- a/neuron/presynapse.md +++ b/neuron/presynapse.md @@ -53,11 +53,13 @@ Qui riportiamo la struttura della espressione G e una descrizione di come legger - il rilascio di NT avviene in base: - alla concetrazione di Ca2+ - alla concentrazione di Rrp (readily release pool) + - l'accumulo di CaTraces avviene durante AP_ctx. Qui cerchiamo di catturare il livello medio che raggiunge Ca2+ durante varie spike. Non lo possiamo catturare in NOT AP_ctx perche' li facciamo clearance. - -- NOT AP_ctx: quando la presynapsi e' in fase di "riposo": - - slkd - +- NOT AP_ctx: quando la presynapsi e' in fase di "riposo" fra AP facciamo pulizia. Questo riposo e' inter AP non quello alla fine di uno spike train: + - eCB clearance + - Ca2+Traces clearance + - RPShuttle + - RefillRPGlutamine (sec) --- @@ -199,11 +201,7 @@ interacting: NTreleaseHigh trace: None ``` -### NOT AP_ctx: PRESYNAPSE - -#### ms: NOT AP_ctx: PRESYNAPSE - -##### CaTracesAccumulationLow: interacting +##### Ca2+TracesAccumulationLow: interacting Serve a dare la velocita' al trasporto di vesicles da RP a RRP. The biological meaning is that a synapse that has just been through a burst is primed for fast recovery — the molecular machinery for vesicle docking is already engaged, calcium-dependent priming factors are still elevated, and the system is in a ready state. A synapse that has been silent for several seconds has cooled down and replenishes slowly. @@ -214,10 +212,10 @@ The result is that Tr_Ca encodes not the instantaneous calcium level but the rec --- ```Gen -interacting: CaTracesAccumulationLow +interacting: Ca2+TracesAccumulationLow contained_by: PRESYNAPSE - in_context: NOT AP_ctx + in_context: AP_ctx rf: ( active: 24x ) # Low hypothesis: (Ca2+ mediumness) @@ -225,15 +223,15 @@ interacting: CaTracesAccumulationLow trace: None ``` -##### CaTracesAccumulationHigh: interacting +##### Ca2+TracesAccumulationHigh: interacting Qui le tracce CaTrace si accumulano di piu' perche' RF e' minore, se c'e' la condizione, perche' va a fare il controllo piu' spesso. ```Gen -interacting: CaTracesAccumulationHigh +interacting: Ca2+TracesAccumulationHigh contained_by: PRESYNAPSE - in_context: NOT AP_ctx + in_context: AP_ctx rf: ( active: 12x ) # high hypothesis: (Ca2+ fullness) @@ -241,6 +239,10 @@ interacting: CaTracesAccumulationHigh trace: None ``` +### NOT AP_ctx: PRESYNAPSE + +#### ms: NOT AP_ctx: PRESYNAPSE + #### sec: NOT AP_ctx: PRESYNAPSE ##### eCB clearance: interacting @@ -261,12 +263,12 @@ interacting: eCBClearance trace: None ``` -##### CaTracesClearance: interacting +##### Ca2+TracesClearance: interacting Qui non facciamo un flush di Catrace, riduciamo ogni mezzo secondo (context) di un RF di questo episodio. ```Gen -interacting: CaTracesClearance +interacting: Ca2+TracesClearance contained_by: PRESYNAPSE in_context: NOT AP_ctx @@ -342,7 +344,7 @@ interacting: RPShuttleHigh #### min: NOT AP_ctx: PRESYNAPSE -##### Refill RP from Glutamine +##### RefillRPGlutamine This happens in the minutes loop, once per minute, via the glutamine shuttle from the astrocyte. It is a two-step process across two cells. @@ -512,7 +514,7 @@ interacting: Ca2+enterHigh #### ms: NOT AP_ctx: VGCC-PRE -##### CaClearanceLow: interacting +##### Ca2+ClearanceLow: interacting Qui eliminiamo Ca2+. Non non comprendiamo anche il ristabilimento del Voltage, con altri Ioni entranti e uscenti, per ora tutto dipende da AP del SOMA. Non comprendiamo per ora: - PMCA: primary, ATP-dependent @@ -525,7 +527,7 @@ Qui disinguiamo: - da capire se serve veramente questa distinzione anche in bae alle tracce di Ca2+ che prendiamo in presynapse. ```Gen -interacting: NotAP-CaClearance +interacting: Ca2+ClearanceLow contained_by: PRESYNAPSE in_context: NOT AP_ctx @@ -536,10 +538,10 @@ interacting: NotAP-CaClearance trace: None ``` -##### CaClearanceHigh: interacting +##### Ca2+ClearanceHigh: interacting ```Gen -interacting: NotAP-CaClearance +interacting: Ca2+ClearanceHigh contained_by: PRESYNAPSE in_context: NOT AP_ctx