diff --git a/elements/neuron/appunti/2026-06-29-tripartite-synapse_v15.md b/elements/neuron/appunti/2026-06-29-biological-reference_v16.md similarity index 83% rename from elements/neuron/appunti/2026-06-29-tripartite-synapse_v15.md rename to elements/neuron/appunti/2026-06-29-biological-reference_v16.md index 9f7c709..0d4583a 100644 --- a/elements/neuron/appunti/2026-06-29-tripartite-synapse_v15.md +++ b/elements/neuron/appunti/2026-06-29-biological-reference_v16.md @@ -1,20 +1,20 @@ +# Tripartite Synapse — Pseudocode v16 -# Tripartite Synapse — Pseudocode v15 - -> Companion: `tripartite_synapse_v15_biology.md` · principle: `logic_principles_v3`. -> Changes from v14: -> (1) NIGHT is distributed into each component (a `NIGHT |` block per component), -> no longer a monolithic stand-alone section -> (2) NIGHT is ITERATED: a loop of cycles; each cycle every component runs the seven-group -> grammar on the slow tier with the flow REVERSED (RECEIVE material from producer, -> BEHAVE commit ceilings from own tags/needs, EMIT material to consumers) -> (3) DAY is bottom-up (evidence ascends, leaves-first); NIGHT is top-down (capacity -> descends, roots-first) — the directionality emerges from iterating local cycles -> (4) NIGHT terminates emergently: demand exhausted (no tag stands) OR supply spent -> (night energy used up); unspent tags CARRY to the next night -> (5) NIGHT produces AND spends energy+material each cycle (material recyclable, energy not); -> tags are consumed by commitment (tag-as-fuel) -> (6) genuinely cross-component NIGHT ops (coherence, homeostatic scaling) are a small shared coda +> Companion: `tripartite_synapse_v16_biology.md` · principle: `logic_principles_v3`. +> Changes from v15 — NIGHT gains HIGHER-SCALE ACTORS and a PHASED structure: +> (1) NIGHT is enacted by a hierarchy of homeostatic actors, NOT the DAY components alone: +> COMPONENT (commits own ceilings) → ASTROCYTE territory (reallocates across its synapses) +> → NEURON (renormalizes total weight) → [assembly/network replay: external arrived signal] +> (2) the NEURON and ASTROCYTE-territory actors ACCUMULATE aggregate traces by DAY +> (total weight/activity; territory demand) and ACT by NIGHT (renormalize; reallocate) +> (3) OCCUPANCY is reset each NIGHT: multiplicative-global downscaling drives VGCC_active, +> AMPA_surface, possible_tag back toward baseline — only CEILINGS persist across a night +> (4) NIGHT is PHASED: early cycles DOWNSCALE (subtractive, reset occupancy, make room), +> late cycles COMMIT (additive, build ceilings for the survivors) +> (5) governing rule: what persists across a night must have EARNED persistence — +> occupancy that earned no tag returns to baseline; the system acts locally, consolidates +> hierarchically +> Carried: cyclic NIGHT, tag-as-fuel, emergent termination, DAY-up/NIGHT-down, seven-group grammar. --- @@ -82,6 +82,36 @@ Unspent tags are NOT cleared; they carry to the next DAY and compete again next top-down order needs no schedule: iterating the local cycle delivers capacity to distal sites over successive cycles, as transport physically does. +NIGHT'S ACTORS ARE NOT DAY'S ACTORS — THE SYSTEM ACTS LOCALLY, CONSOLIDATES HIERARCHICALLY. +DAY is enacted by the six local components. NIGHT is enacted by a HIERARCHY of homeostatic +actors, each conserving a quantity at its own scale and constraining the scale below: + +``` + [ ASSEMBLY / NETWORK ] replay re-presents the day across neurons (EXTERNAL signal) + ↓ constrains → arrives as replay_reweight[·] (like dopamine/glucose: external) + NEURON (the whole cell) conserves TOTAL synaptic weight; renormalizes so no synapse + ↓ constrains grows beyond the cell's global budget; drives occupancy downscaling + ASTROCYTE territory conserves total metabolic output; reallocates energy/material + ↓ constrains across ALL synapses it wraps, by accumulated territory demand + COMPONENT commits its own ceilings within the allocation handed down +``` + +These higher actors are DORMANT-BUT-ACCUMULATING by DAY and ACTIVE-AND-CONSTRAINING by NIGHT. +By DAY they only integrate an aggregate trace of the components' emitted activity (they sum +what was emitted, never read a component's interior — locality holds): the NEURON accumulates +`neuron_total_weight` and `neuron_activity`; the ASTROCYTE territory accumulates +`astro_territory_demand[·]`. By NIGHT they act on those aggregates: the astrocyte reallocates, +the neuron renormalizes. The assembly/network tier is not modelled here; its effect enters as +an external arrived signal `replay_reweight`, exactly as dopamine and glucose do. + +NIGHT IS PHASED. Early cycles DOWNSCALE (subtractive): occupancy filled during the day — +VGCC_active, AMPA_surface, possible_tag — is driven back toward baseline by multiplicative-global +scaling, and total weight is renormalized. Late cycles COMMIT (additive): the survivors' tags +build ceilings. The rule the phasing enforces: WHAT PERSISTS ACROSS A NIGHT MUST HAVE EARNED +PERSISTENCE. Occupancy that earned no tag returns to baseline; only ceilings carry forward. The +relative potentiation of a tagged synapse survives because it was written into its ceiling, not +because its transient occupancy was spared. + --- ## Conventions @@ -138,6 +168,7 @@ transit(channel, τ_transport) -> arrival: // delivers in-trans ``` dopamine NE ACh // organism broadcasts (external) +replay_reweight[·] // assembly/network replay re-weighting (external, NIGHT) glucose geometry // physical (external) elig dop_thr tag_thr tag_expiry // strength gates (universal) traj_thr endur_thr // endurance gates (universal) @@ -157,6 +188,9 @@ maint_frac cap_frac // maintenance allocation decay_rate capacity_decay_rate recycle // passive ceiling decay + material recovery homeostatic_ceiling coherence_factor assembly_cost biogenesis_cost maint_cost f_dend f_axon f_spine f_bouton // per-cycle material/energy ship fractions (down the chain) +downscale_factor // per-early-cycle multiplicative occupancy reset (<1) +neuron_weight_ceiling // the cell's total-weight budget (renormalization target) +early_phase_frac // fraction of night cycles that are DOWNSCALE phase ``` --- @@ -572,6 +606,9 @@ DAY | AP: if dopamine > dop_thr and soma_possible_tag > tag_thr: soma_tag += dopamine × soma_possible_tag soma_budget -= creb_cost + // TRACE (NEURON-level aggregator — the cell sums what its components emit, by DAY) + neuron_activity += 1 // total firing this day + neuron_total_weight += Σ all component structure across the cell // running weight tally DAY | NOT_AP: // RECEIVE (integrate latest branch input — signal) @@ -755,6 +792,7 @@ DAY | CONTINUOUS: // per astrosynapse i astro_central_budget += glycolysis(glucose)·Δt // ADJUST (demand weights across territory) for each i: demand[i] = clearance_load[i] × astro_structure[i].delivery_eff + for each i: astro_territory_demand[i] += demand[i]·Δt // TRACE: territory-level aggregator (by DAY) factor = min(1, astro_central_budget / (Σ demand·lactate_cost + ε)) // EMIT (demand-weighted lactate to all components) for each i: @@ -832,46 +870,80 @@ DAY or NIGHT | OVERLOAD: --- --- -# NIGHT — the driver -NIGHT is not a component; it is the loop that runs every component's `NIGHT | cycle` block, -plus a small coda for the genuinely cross-component operations. The roots produce each cycle, -material+energy descend the supply chains over successive cycles, and tagged components commit -and spend their tags. The loop ends when demand is exhausted or the night's energy is spent. +# NIGHT — the driver (a hierarchy of actors, phased) +NIGHT runs a loop of cycles. Each cycle has FOUR actor tiers acting in order from the top of the +hierarchy down: the external replay signal arrives, the NEURON renormalizes, the ASTROCYTE +territory reallocates, then the COMPONENTS commit within what they were handed. The night is +PHASED: early cycles DOWNSCALE (reset occupancy, renormalize weight — subtractive, make room), +later cycles COMMIT (build ceilings for the survivors — additive). It ends emergently. ``` NIGHT driver: night_energy_spent = 0 + N_cycles_early = early_phase_frac × estimated_cycles repeat cycle = 1, 2, 3, …: - // 1. coherence signals (cross-component) computed from this cycle's standing tags + phase = (cycle ≤ N_cycles_early) ? DOWNSCALE : COMMIT + + // ── TIER 0: ASSEMBLY/NETWORK (external) ─────────────────────────────── + // replay_reweight[s] arrives this cycle: re-presents the day's patterns and + // re-weights which synapses the assembly found significant (external signal). + + // ── TIER 1: NEURON (renormalize total weight; drive occupancy downscaling) ── + if phase == DOWNSCALE: + // multiplicative-global occupancy reset — only CEILINGS will persist + for each synapse s: + VGCC_active[s] *= downscale_factor + AMPA_surface[s] *= downscale_factor + possible_tag[s] *= downscale_factor // medium evidence renormalized too + // renormalize total committed weight toward the cell's budget (Tononi-style) + if neuron_total_weight > neuron_weight_ceiling: + g = neuron_weight_ceiling / neuron_total_weight + for each component c in cell: c_structure *= g + soma_material += Σ reduction·recycle // freed material returns to pool + + // ── TIER 2: ASTROCYTE territory (reallocate metabolic support) ───────── + // reallocate this cycle's energy/material across the territory by accumulated demand, + // re-weighted by replay — the astrocyte is the metabolic arbiter of its synapses + for each astrosynapse i: + astro_alloc[i] = (astro_territory_demand[i] × replay_reweight[i]) + / Σ(astro_territory_demand × replay_reweight) + // (astro_alloc biases each synapse's share of the astrocyte's produced batch this cycle) + + // ── TIER 3: COMPONENTS (commit within the allocation handed down) ────── + // coherence signal (cross-component) from this cycle's standing tags for each synapse s: coherence_signal[s] = (pre_tag[s], post_tag[s], astro_tag[s] all > tag_expiry) ? coherence_factor : 1 - // 2. run every component's NIGHT | cycle block (order-independent; flow emerges over cycles) - run PRE, POST, DEND, SOMA, AXON, ASTRO NIGHT | cycle - // 3. termination — emergent, local, OR of two conditions - demand_left = Σ all tags > tag_expiry (system-wide) - if demand_left ≈ 0: break // DEMAND exhausted — learned all it could - if night_energy_spent ≥ night_energy_ceiling: break // SUPPLY spent — ran out of night + if phase == COMMIT: + run PRE, POST, DEND, SOMA, AXON, ASTRO NIGHT | cycle // build ceilings + else: + run SOMA, ASTRO NIGHT | cycle (PRODUCE + EMIT only) // pre-stage material downstream - // CODA (cross-component, once at end of night) - // homeostatic scaling: if the soma fired too much overall, scale all synapses down - if soma_tag > homeostatic_ceiling: - s = homeostatic_ceiling / soma_tag - for each synapse: post_structure.slot_ceiling *= s ; pre_structure.slot_ceiling *= s - soma_material += Σ reduction·recycle - // clear DAY traces; tags PERSIST (carry to next night), only fast/medium DAY traces reset + // ── termination — emergent, OR of two conditions ────────────────────── + night_energy_spent updated by the roots' production this cycle + demand_left = Σ all tags > tag_expiry (system-wide) + if demand_left ≈ 0: break // DEMAND exhausted (rested) + if night_energy_spent ≥ night_energy_ceiling: break // SUPPLY spent (overloaded) + + // ── CODA (once at end of night) ──────────────────────────────────────────── + // clear DAY traces and the DAY aggregators; occupancy already reset by downscaling all fast_trace, possible_tag, endurance_need = 0 soma_Na_inactivation = soma_adaptation = soma_refractory_alignment = 0 - // tags are NOT cleared here — unspent tags carry forward, decaying on their slow τ + neuron_activity = 0; neuron_total_weight = recomputed from surviving structure + astro_territory_demand[·] = 0 + // tags are NOT cleared — unspent tags carry forward, decaying on their slow τ // structure and budget_ceiling PERSIST as the next DAY's ceilings + // VGCC_active / AMPA_surface have been returned to baseline by downscaling ``` -Notes. (1) The cycle order of components does not matter: a consumer that has not yet received -this cycle simply commits less and tries again next cycle, so capacity reaches distal sites over -iterations rather than by schedule. (2) `coherence_signal` is treated as an arrived signal (like -a tag propagating), preserving locality — no component reads another's tag directly; the driver -computes the coincidence and broadcasts it. (3) A heavy-learning DAY deposits more tags, so the -night runs more cycles (or exhausts its energy first) — night length is emergent from the day. +Notes. (1) The phasing makes cycles genuinely different: an early cycle reshapes the landscape +(reset occupancy, renormalize weight, pre-stage material), a late cycle builds on the reshaped +landscape — so what gets committed depends on the order, and could not be computed in one shot. +(2) Higher actors never read a component's interior: the neuron renormalizes a sum it accumulated +from emitted activity; the astrocyte reallocates by demand it accumulated; coherence and replay +arrive as signals. Locality holds — the system acts locally and consolidates hierarchically. +(3) Occupancy is reset every night, so each DAY starts from baseline occupancy against whatever +ceilings persisted: the only thing that carries a day forward is what earned a ceiling. --- @@ -887,12 +959,16 @@ DAY grammar on OCCUPANCY within two ceilings (structure=strength, budget_ceil fast_trace + dopamine → tag (strength) FUEL shortfall + interrupted LOCAL success → endurance_need (endurance) OCCUPANCY/structure/timing shortfalls → short-term depression (NOT endurance) -NIGHT same grammar on the CEILINGS, ITERATED as a loop of cycles: - top-down: roots produce, capacity descends roots→leaves over successive cycles - each cycle: RECEIVE batch · BEHAVE commit (tag→structure, need→budget_ceiling, spend tag) · - EMIT batch downstream · RECOVER material · DECAY ceilings +NIGHT enacted by a HIERARCHY of actors (not the DAY components alone), PHASED: + assembly/network replay (external) → NEURON renormalize total weight + downscale occupancy + → ASTROCYTE territory reallocate → COMPONENTS commit ceilings within what's handed down + early cycles DOWNSCALE (reset occupancy multiplicatively-global, make room), + late cycles COMMIT (build ceilings for survivors) + higher actors ACCUMULATE aggregate traces by DAY, ACT by NIGHT (locality holds) ends when DEMAND exhausted (no tag stands) OR SUPPLY spent (night energy used) - unspent tags CARRY to next night; material recycles, ENERGY does not (the arrow of time) + what persists must EARN it: occupancy resets to baseline, only CEILINGS carry; + unspent tags carry to next night; material recycles, ENERGY does not (arrow of time) +RULE the system ACTS LOCALLY (DAY, local components) and CONSOLIDATES HIERARCHICALLY (NIGHT) FLOWS every flow has a timescale; shipment is transit-delayed (distal fills over cycles) LOCAL every group uses only own state + arrived signals; RECEIVE/EMIT are the only crossings ``` diff --git a/elements/neuron/appunti/2026-06-29-biological-reference_v15.md b/elements/neuron/appunti/2026-06-29-tripartite-synapse_v16.md similarity index 85% rename from elements/neuron/appunti/2026-06-29-biological-reference_v15.md rename to elements/neuron/appunti/2026-06-29-tripartite-synapse_v16.md index aeba0d4..c63d856 100644 --- a/elements/neuron/appunti/2026-06-29-biological-reference_v15.md +++ b/elements/neuron/appunti/2026-06-29-tripartite-synapse_v16.md @@ -1,16 +1,13 @@ -# Tripartite Synapse — Biological Reference (companion to v15 pseudocode) +# Tripartite Synapse — Biological Reference (companion to v16 pseudocode) -> Companion to `tripartite_synapse_v15_pseudocode.md` · principle: `logic_principles_v3`. -> v15 distributes NIGHT into each component as an iterated cycle. Biologically this reflects -> that consolidation is not a single event but proceeds across the repeated slow-wave cycles of -> NREM sleep: each cycle the producers (soma protein synthesis, astrocyte glycolysis/ECM -> synthesis) make a bounded batch of material and energy, it is transported one hop down the -> dendrite/axon/astrocytic processes, and tagged synapses incorporate what arrives. Distal sites -> consolidate later because their material arrives over more cycles. The night ends when there is -> nothing left worth consolidating (tags spent) or the night's metabolic supply is exhausted — -> a heavier learning day therefore demands a longer or fuller night, and unfinished consolidation -> carries to the following night. Energy spent on construction is irreversible (the system's one -> one-way flow); material released by pruned structure is recycled. +> Companion to `tripartite_synapse_v16_pseudocode.md` · principle: `logic_principles_v3`. +> v16 gives NIGHT a hierarchy of homeostatic actors at scales above the single synapse, and a +> phased structure. The actors of consolidation are not the actors of transmission: by day the +> six local components transmit; by night a hierarchy — astrocyte territory, the whole neuron, +> and (as an external signal) the assembly/network — renormalizes and reallocates. Early-night +> cycles downscale the day's transient changes (synaptic homeostasis); later cycles consolidate +> the survivors. Occupancy filled by day (receptor surface, channel coupling) is returned to +> baseline each night, so only what was written into a structural ceiling persists. --- @@ -405,3 +402,53 @@ consolidate over several nights or, if it decays first, never. returns to the pool and is reused; the energy burned to build or to prune is gone. Across a lifetime this energy throughput bounds how much the system can ever consolidate — the metabolic arrow of time underlying the whole model. + + +--- + +## NIGHT's hierarchy of actors — the biology + +**Why the actors differ from DAY's.** Transmission is local — a bouton releases, a spine +integrates, an astrosynapse clears. Consolidation is not: it involves quantities no single +synapse can see. Whether one synapse's strengthening "fits" depends on the neuron's total +synaptic weight; reallocating metabolic support depends on an astrocyte's whole territory; +deciding which memories to replay depends on assemblies of neurons. So NIGHT is enacted by +actors at higher scales, each conserving a quantity at its scale. + +**The astrocyte territory (Tier 2).** The astrocyte cell body supports hundreds to thousands of +synapses. By day it allocates lactate by demand; by night it reallocates its produced energy and +ECM material across its whole territory, biased by the demand it accumulated and by replay. This +is a genuine territory-level actor — the astrocyte is the metabolic arbiter of its domain, and +its nightly reallocation decides which of its synapses can afford to consolidate. + +**The neuron as a whole (Tier 1).** Synaptic homeostasis (the synaptic homeostasis hypothesis of +Tononi and Cirelli) operates on the neuron's *total* synaptic weight: across sleep, the cell's +synapses are renormalized downward multiplicatively, preserving relative differences while +restoring overall excitability and freeing capacity. This is a neuron-scale operation — no synapse +can perform it, because no synapse knows the cell's total weight. In the model the neuron +accumulates that total by day and renormalizes it by night, scaling all the cell's structures by +a common factor when the total exceeds the cell's budget. + +**The assembly / network (Tier 0, external).** Systems consolidation — hippocampal–cortical replay +— reactivates the day's patterns across ensembles of neurons during NREM, and this dialogue +selects which assemblies are written into cortex. This is a network-scale process beyond a single +neuron, so the model treats it as an external arrived signal (`replay_reweight`), exactly as it +treats dopamine and glucose. Fully modeling it requires a network of these neurons. + +**Occupancy downscaling — why only ceilings persist.** During the day, synapses fill occupancy: +receptors trafficked to the surface (AMPA_surface), calcium-channel coupling tightened +(VGCC_active), eligibility accumulated (possible_tag). These are transient and reversible. If they +carried across the night undiminished, a synapse could become lastingly strong without ever +earning a tag or paying the consolidation cost — bypassing the entire validation machinery. +Multiplicative-global downscaling during early-night cycles returns occupancy to baseline. A +synapse that was tagged and had its *ceiling* raised starts the next day strong; one that merely +filled occupancy during the day starts back at baseline. The relative potentiation survives only +where it was written into structure — which is precisely synaptic homeostasis enforcing that the +slow tier carries the learning and the fast/medium tier is renewed each day. + +**Why phased.** A single sweep cannot both reset and build, because building should act on the +*post-reset* landscape. Early cycles are subtractive (downscale occupancy, renormalize weight, +make metabolic room); later cycles are additive (commit the survivors). This is the NREM arc — +slow-wave-dominated downscaling early, selective consolidation later — and it makes each cycle's +*kind* depend on where in the night it falls, so the cycles are genuinely different operations, +not installments of one.