post
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@@ -15,7 +15,7 @@ Qui BEH-DB espande solo i BEH-POST, e' un cavo di collegamento come l'assone
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Container: BEH-BD
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expansion:
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- BEH-POST ( fullness: 50x, active: 20x, emptiness: 10x )
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- BEH-POST ( full: 50x, active: 20x, empty: 10x )
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modulated_by: DEV-BD-BEH-POST-TUB from DEV-N.md
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```
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@@ -27,7 +27,7 @@ Like its presynaptic partner, the postsynapse is governed by three interlocking
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---
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### 1. The $V_{post}$ Loop: The Fast Gatekeeper (Milliseconds)
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1.The $V_{post}$ Loop: The Fast Gatekeeper (Milliseconds)
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This is the primary electrophysiological response, where chemical signals are converted back into electricity.
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@@ -39,7 +39,7 @@ This is the primary electrophysiological response, where chemical signals are co
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---
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### 2. The $Ca^{2+}$ Loop: The Plasticity Controller (Seconds)
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2.The $Ca^{2+}$ Loop: The Plasticity Controller (Seconds)
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This loop translates electrical timing into biological "memory."
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@@ -51,7 +51,7 @@ This loop translates electrical timing into biological "memory."
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---
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### 3. The ATP Loop: The Metabolic Backbone (Minutes)
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3.The ATP Loop: The Metabolic Backbone (Minutes)
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This is the "Hidden Master" that determines if the other two loops are allowed to function.
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@@ -71,36 +71,46 @@ The system is beautifully asymmetric. While the presynapse is built to **supply*
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container: BEH-POST
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expansion:
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- BEH-POST-AMPA ( fullness: 10x, active: 5x, emptiness: 2x )
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- BEH-POST-AMPA ( full: 10x, active: 5x, empty: 2x )
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# modulated_by: TUN-POST-IC # possible/actual
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tub_local:
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- Ca2+ ( fullness: 60x, active: 30x, emptiness: 0x )
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- Ca2+ ( full: 60x, active: 30x, empty: 0x )
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# modulated_by: DEV-POST-???-FULL # Full
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- Nox ( fullness: 100x, active: 20x, emptiness: 0x ) # Nitric Oxide (NO): A gas that diffuses freely.
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- Nox ( full: 100x, active: 20x, empty: 0x ) # Nitric Oxide (NO): A gas that diffuses freely.
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- Ecb ( fullness: 100x, active: 20x, emptiness: 0x ) # Endocannabinoids (e.g., 2-AG)
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- Ecb ( full: 100x, active: 20x, empty: 0x ) # Endocannabinoids (e.g., 2-AG)
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tub_intricated:
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- Nt ( contained_by: BEH-SYN )
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- bAp ( contained_by: BEH-SOMA )
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```
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### Context
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### ms: behaviors POST
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#### CheckConditions:Context
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Contestualizziamo in maniera Fixed ogni mezzo secondo?
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```Gen
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context: captureNt
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contained_by: BEH-POST
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context: CheckConditions
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contained_by: BEH-POST
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in_context: Fixed
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rf: ( active: 10x )
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in_context: Fixed
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rf: ( active: 600x )
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condition: (Nt full) AND NOT (bAp)
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out_context: NtCaptured
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condition: NOT (RP empty) AND NOT (RRP full)
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out_context: RPShuttle
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condition: NOT (CaTrace empty)
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out_context: CaTracesNotEmpty
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condition: NOT (eCB empy)
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out_context: eCBNotEmpty
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```
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### Episode
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#### :Episode
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## BEH-POST-AMPA: Container
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@@ -114,7 +124,13 @@ container: BEH-POST-AMPA
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- bAp ( contained_by: BEH-SOMA )
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```
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### AmpaOpen: Episode
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### sec: behaviors POST
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### min: behaviors POST
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### ms: behaviors AMPA
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#### AmpaOpen: Episode
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- Timing: < 1 ms
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- InContext: Glutamate > FULLNESS
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@@ -134,7 +150,7 @@ episode: AmpaOpen
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trace: None # Se Ca+FULLNESS, lascio tracce di overflow per modulazione DOWN, da capire UP
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```
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### Depolarization by bAP
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#### Depolarization by bAP
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Da ricordare i Dendritic VCGG che si aprono facendo entrare Ca2+ all'arrivo di bAP. In teoria abbiamo 3 Ion Channel.
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@@ -142,23 +158,23 @@ Da ricordare i Dendritic VCGG che si aprono facendo entrare Ca2+ all'arrivo di b
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- InContext: bAP backpropagating action potential
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- Consequence: addition to local depolarization (EPSP) from bAP
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### Mg²⁺ NMDA unblock
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#### Mg²⁺ NMDA unblock
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- Timing: > 1 ms
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- InContext: local depolarization (EPSP) > FULLNESS (requires depolarization > -40mV)
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- OutContext: NMDA Mg²⁺ unblock
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### Full Ca+ influx by NDMA
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#### Full Ca+ influx by NDMA
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- Timing: < 1 ms
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- InContext: NMDA Mg²⁺ unblock
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- Consequence: Na⁺ influx
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- Consequence: addition to local depolarization (EPSP) from Full NMDA activation
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### Upregulation: Observable
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#### Upregulation: Observable
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- Upregulation: Depolarization relieves NMDA Mg²⁺ block → Ca²⁺ influx amplification
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### Downregulation: Observable
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#### Downregulation: Observable
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- Downregulation: AMPA desensitization acts as low-pass filter
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