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2026-04-01 12:03:56 +02:00
parent 537ac9428c
commit 865f3952da
4 changed files with 321 additions and 95 deletions
+38 -22
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@@ -15,7 +15,7 @@ Qui BEH-DB espande solo i BEH-POST, e' un cavo di collegamento come l'assone
Container: BEH-BD
expansion:
- BEH-POST ( fullness: 50x, active: 20x, emptiness: 10x )
- BEH-POST ( full: 50x, active: 20x, empty: 10x )
modulated_by: DEV-BD-BEH-POST-TUB from DEV-N.md
```
@@ -27,7 +27,7 @@ Like its presynaptic partner, the postsynapse is governed by three interlocking
---
### 1. The $V_{post}$ Loop: The Fast Gatekeeper (Milliseconds)
1.The $V_{post}$ Loop: The Fast Gatekeeper (Milliseconds)
This is the primary electrophysiological response, where chemical signals are converted back into electricity.
@@ -39,7 +39,7 @@ This is the primary electrophysiological response, where chemical signals are co
---
### 2. The $Ca^{2+}$ Loop: The Plasticity Controller (Seconds)
2.The $Ca^{2+}$ Loop: The Plasticity Controller (Seconds)
This loop translates electrical timing into biological "memory."
@@ -51,7 +51,7 @@ This loop translates electrical timing into biological "memory."
---
### 3. The ATP Loop: The Metabolic Backbone (Minutes)
3.The ATP Loop: The Metabolic Backbone (Minutes)
This is the "Hidden Master" that determines if the other two loops are allowed to function.
@@ -71,36 +71,46 @@ The system is beautifully asymmetric. While the presynapse is built to **supply*
container: BEH-POST
expansion:
- BEH-POST-AMPA ( fullness: 10x, active: 5x, emptiness: 2x )
- BEH-POST-AMPA ( full: 10x, active: 5x, empty: 2x )
# modulated_by: TUN-POST-IC # possible/actual
tub_local:
- Ca2+ ( fullness: 60x, active: 30x, emptiness: 0x )
- Ca2+ ( full: 60x, active: 30x, empty: 0x )
# modulated_by: DEV-POST-???-FULL # Full
- Nox ( fullness: 100x, active: 20x, emptiness: 0x ) # Nitric Oxide (NO): A gas that diffuses freely.
- Nox ( full: 100x, active: 20x, empty: 0x ) # Nitric Oxide (NO): A gas that diffuses freely.
- Ecb ( fullness: 100x, active: 20x, emptiness: 0x ) # Endocannabinoids (e.g., 2-AG)
- Ecb ( full: 100x, active: 20x, empty: 0x ) # Endocannabinoids (e.g., 2-AG)
tub_intricated:
- Nt ( contained_by: BEH-SYN )
- bAp ( contained_by: BEH-SOMA )
```
### Context
### ms: behaviors POST
#### CheckConditions:Context
Contestualizziamo in maniera Fixed ogni mezzo secondo?
```Gen
context: captureNt
contained_by: BEH-POST
context: CheckConditions
contained_by: BEH-POST
in_context: Fixed
rf: ( active: 10x )
in_context: Fixed
rf: ( active: 600x )
condition: (Nt full) AND NOT (bAp)
out_context: NtCaptured
condition: NOT (RP empty) AND NOT (RRP full)
out_context: RPShuttle
condition: NOT (CaTrace empty)
out_context: CaTracesNotEmpty
condition: NOT (eCB empy)
out_context: eCBNotEmpty
```
### Episode
#### :Episode
## BEH-POST-AMPA: Container
@@ -114,7 +124,13 @@ container: BEH-POST-AMPA
- bAp ( contained_by: BEH-SOMA )
```
### AmpaOpen: Episode
### sec: behaviors POST
### min: behaviors POST
### ms: behaviors AMPA
#### AmpaOpen: Episode
- Timing: < 1 ms
- InContext: Glutamate > FULLNESS
@@ -134,7 +150,7 @@ episode: AmpaOpen
trace: None # Se Ca+FULLNESS, lascio tracce di overflow per modulazione DOWN, da capire UP
```
### Depolarization by bAP
#### Depolarization by bAP
Da ricordare i Dendritic VCGG che si aprono facendo entrare Ca2+ all'arrivo di bAP. In teoria abbiamo 3 Ion Channel.
@@ -142,23 +158,23 @@ Da ricordare i Dendritic VCGG che si aprono facendo entrare Ca2+ all'arrivo di b
- InContext: bAP backpropagating action potential
- Consequence: addition to local depolarization (EPSP) from bAP
### Mg²⁺ NMDA unblock
#### Mg²⁺ NMDA unblock
- Timing: > 1 ms
- InContext: local depolarization (EPSP) > FULLNESS (requires depolarization > -40mV)
- OutContext: NMDA Mg²⁺ unblock
### Full Ca+ influx by NDMA
#### Full Ca+ influx by NDMA
- Timing: < 1 ms
- InContext: NMDA Mg²⁺ unblock
- Consequence: Na⁺ influx
- Consequence: addition to local depolarization (EPSP) from Full NMDA activation
### Upregulation: Observable
#### Upregulation: Observable
- Upregulation: Depolarization relieves NMDA Mg²⁺ block → Ca²⁺ influx amplification
### Downregulation: Observable
#### Downregulation: Observable
- Downregulation: AMPA desensitization acts as low-pass filter