eliminato CDI e sostituito con Ca2+

neuron/BEH-AXO.md

@@ -233,33 +233,6 @@ Limita rilascio NT: Dipende da quanti NT sono stati gia' rilasciati nella Syn
 
 Limita rilascio NT: Dipende da POST che tende a bloccare rialascio di NT se non servono
 
-#### CDIs concentration
-
-probabilmente sta dentro VGCC? Possiamo metterlo come un controllo su fullness di Ca2+ e cmq spiegare che e' un floor a questo comportamento di CDI
-
-CDI is calcium-dependent inactivation of VGCCs. The inactivation happens because Ca²⁺ enters through the channel and binds to a calmodulin tethered to the channel's intracellular face, physically blocking it from reopening. This is a local, channel-specific event — it requires Ca²⁺ to be flowing through that channel right now, not residual Ca²⁺ drifting in the cytosol between spikes.
-So the rise increment should only fire when V_pre == 1 (the spike window when channels are actually open and Ca²⁺ is entering). The recovery, by contrast, should run every millisecond unconditionally — CDI de-inactivation is a continuous process that proceeds whenever Ca²⁺ dissociates from calmodulin, which depends on the ambient Ca_micro level at all times.
-
-Limita rilascio NT: Dipende dalla concentrazione alta di Ca2+ nella PRE. Driver Ca2+ > 0 between spikes CDI -> 1, effective_conductance -> 0.
-
-```Gen
-context: CDIConcentration
-  contained_by: BEH-PRE
-
-  in_context: NOT AP # prima volta NOT in un contesto
-  rf: ( active: 60x )
-
-  condition: (Ca2+ full) 
-    out_context: IncreaseCDIFast
-
-  condition: (Ca2+ medium) 
-    out_context: IncreaseCDIMedium
-
-condition: (Ca2+ empty) 
-    out_context: DecreaseCDI
-
-```
-
 #### CaTrace concentration
 
 Serve a dare la velocita' al trasporto di vesicles da RP a RRP. Ha un decadimento proprio il che dice alla Presinapsi di accellerare se da poco c'e' stata una spike, altrimenti di andare piu' piano. So after one second of silence Tr_Ca has fallen to ~37% of its peak value, after two seconds to ~14%, after three seconds to ~5%. It asymptotes toward zero but never exactly reaches it. Between spikes, Ca2+ falls toward zero as the pumps clear it.
@@ -300,6 +273,11 @@ Here we comprehend the breaking activity on VGCC by: CDI,eCB and mGluR:
 - **Suppressed** — two brakes multiplying. The compounding is what defines this zone — no single variable alone produces it (except CDI approaching full). 0.5 × 0.5 = 0.25 remaining is where the synapse starts losing significant transmission efficacy. Biologically this is the pre-silence warning zone: CDI is building from residual Ca²⁺ while eCB is already engaged from postsynaptic activity.
 - **Closed — CDI** = full is the only reliable hard rule. Because CDI can reach 1.0 and appears as (1 - CDI_factor) in the formula, it alone drives conductance to zero regardless of eCB and mGluR state. The three-brake overlap corner case (eCB=full + CDI=medium + mGluR=full) also reaches here, but in practice CDI reaching full is the primary biological mechanism.
 
+Qui sostituiamo il CDI con Ca2+:
+
+- CDI is calcium-dependent inactivation of VGCCs. The inactivation happens because Ca²⁺ enters through the channel and binds to a calmodulin tethered to the channel's intracellular face, physically blocking it from reopening. This is a local, channel-specific event — it requires Ca²⁺ to be flowing through that channel right now, not residual Ca²⁺ drifting in the cytosol between spikes.
+- The recovery, by contrast, should run every millisecond unconditionally — CDI de-inactivation is a continuous process that proceeds whenever Ca²⁺ dissociates from calmodulin, which depends on the ambient Ca_micro level at all times.
+
 Devo controllare che le condizioni sotto siano esaustive.
 
 #### Open: Episode
@@ -311,7 +289,7 @@ episode: Open
   in_context: AP
   rf: ( active: 6x )
 
-  hypothesis: (CDI empty) and (eCB empty)
+  hypothesis: (Ca2+ empty) and (eCB empty)
     action: [Ca2+ increase, ATP decrease]
     trace: None
 ```
@@ -325,7 +303,7 @@ episode: Reduced-partial
   in_context: AP
   rf: ( active: 6x )
 
-  hypothesis: (CDI medium) OR ((eCB medium) AND (CDI empty)) OR ((eCB full) AND (CDI empty) AND (mGluR empty))
+  hypothesis: (Ca2+ medium) OR ((eCB medium) AND (Ca2+ empty)) OR ((eCB full) AND (Ca2+ empty) AND (mGluR empty))
     action: [Ca2+ increase, ATP decrease]
     trace: None
 ```
@@ -339,7 +317,7 @@ episode: Supressed
   in_context: AP
   rf: ( active: 6x )
 
-  hypothesis: ((CDI medium) AND (eCB full) OR (eCB medium))
+  hypothesis: ((Ca2+ medium) AND (eCB full) OR (eCB medium))
     action: [Ca2+ increase, ATP decrease]
     trace: None
 ```