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**Tubs:** **Tubs:**
- **Ca2+**: Calcium Ion entering the Presynapse when VCGG open. They are key to check the concentration, release vescicles and modulation - **Ca2+**: Calcium Ion entering the Presynapse when VCGG open. They are key to check the concentration, release vescicles and modulation
- **Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. - **ReadyReleasablePool**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse.
-- Location: Directly touching the presynaptic membrane. -- Location: Directly touching the presynaptic membrane.
-- Function: These are the first to be released when an action potential arrives. -- Function: These are the first to be released when an action potential arrives.
-- Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. -- Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal.
- **RecP**: Recycling Pool - **RecyclingPool**: Recycling Pool
--The Recycling Pool is the next line of reinforcement. --The Recycling Pool is the next line of reinforcement.
-- Location: Slightly further back from the membrane than the RRP. -- Location: Slightly further back from the membrane than the RRP.
-- Function: These vesicles maintain release during moderate, physiological levels of stimulation. -- Function: These vesicles maintain release during moderate, physiological levels of stimulation.
-- Characteristics: They are continuously refilled as the neuron "recycles" the membranes of used vesicles through endocytosis. This pool is larger than the RRP (roughly 5% to 20% of the total). -- Characteristics: They are continuously refilled as the neuron "recycles" the membranes of used vesicles through endocytosis. This pool is larger than the RRP (roughly 5% to 20% of the total).
- **Rp**: The "Reserve Pool" (The true RP) - **ReservePool**: The "Reserve Pool" (The true RP)
-- In many textbooks, RP specifically stands for the Reserve Pool. -- In many textbooks, RP specifically stands for the Reserve Pool.
-- Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. -- Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin.
-- Function: These are only mobilized during intense, prolonged stimulation once the RRP and Recycling pools are depleted. -- Function: These are only mobilized during intense, prolonged stimulation once the RRP and Recycling pools are depleted.
-- Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%). -- Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%).
@@ -49,16 +49,16 @@ container: BEH-AXO
**Behaviors**: **Behaviors**:
L'idea e' che: L'idea e' che:
- Fast - **Fast Timing**
-- i VCGG si aprano all'arrivo di un AP dal SOMA. Il numero dei VCGG presenti e' stato modulato (TUN) in una fase di non attivita' della presynapse -- i VCGG si aprono all'arrivo di un AP dal SOMA. Il numero dei VCGG presenti e' stato modulato (TUN) in una fase di non attivita' della presynapse
-- I VCGG fanno entrare Ca2+ che ne aumenta la concentrazione -- I VCGG fanno entrare Ca2+ che ne aumenta la concentrazione
-- ad un certo livello di concentrazione, viene liberata una vescica, se ci sono Rrp disponibili. La vescica libera xxx Nt nella sinsapsi -- ad un certo livello di concentrazione, viene liberata una vescica, se ci sono ReadyReleasablePool disponibili. La vescica libera xxx Nt nella sinsapsi
- Medium timing - **Medium timing**
-- clearance dei Ca2+ che depolarizza la Presinapsi -- clearance dei Ca2+ che depolarizza la Presinapsi
-- riciclo delle vesciche, prendendole dalla Sinapsi e mettenedole dentro a RecP -- riciclo delle vesciche, prendendole dalla Sinapsi e mettenedole dentro a RecyclingPool
- Slow Timing - **Slow Timing**
-- riempimento vesciche di Nt e mettendole dentro Rp -- riempimento vesciche di Nt e mettendole dentro Rp
-- spostamento da Rp a RecP -- spostamento da ReservePool a ReadyReleasablePool
```Gen ```Gen
container: BEH-PRE container: BEH-PRE
@@ -230,7 +230,7 @@ episode: VesciclesRecycling
hypothesis: hypothesis:
``` ```
### VescicleFromRPtoRRP-Slow: Episode ### Slow-ReservePooltoReadilyReleasable: Episode
Superpriming requires ATP for phosphorylation reactions and for molecular motors that move vesicles. If the reserve pool is depleted or ATP is low, the superpriming "conveyor belt" has nothing to feed into the RRP. (Astrocyte) Superpriming requires ATP for phosphorylation reactions and for molecular motors that move vesicles. If the reserve pool is depleted or ATP is low, the superpriming "conveyor belt" has nothing to feed into the RRP. (Astrocyte)
@@ -252,7 +252,7 @@ episode: VescicleFromRPtoRRP-Slow
trace: None trace: None
``` ```
### VescicleFromRPtoRRP-Medium: Episode ### Medium-ReservePooltoReadilyReleasable: Episode
***Seconds-Minutes Time Scale*** ***Seconds-Minutes Time Scale***
@@ -268,7 +268,7 @@ episode: VescicleFromRPtoRRP-Medium
trace: None trace: None
``` ```
### VescicleFromRPtoRRP-Fast: Episode ### Fast-ReservePooltoReadilyReleasable: Episode
***Seconds-Minutes Time Scale*** ***Seconds-Minutes Time Scale***
@@ -284,23 +284,6 @@ episode: VescicleFromRPtoRRP-Fast
trace: None trace: None
``` ```
### VesiclesFillingRP: Episode
Qui riempiamo le vesciche. Fino ad un numero massimo, che viene modulato in DEV
***Seconds-Minutes Time Scale***
```Gen
episode: VesiclesFillingRP
contained_by: BEH-PRE
in_context: AwayFromSpike
rf: ( fullness: 100x, active: 60x, emptiness: 30x )
modulated_by: DEV-PRE-VesiclesFillingRP-RF from TUN-N
hypothesis:
```
## BEH-PRE-VGCC: Container ## BEH-PRE-VGCC: Container
**Voltage Gated Ion Channels**: When an AP arrives from the SOMA, VCGG are opened and they let in CA2+ initiating the possible release of NT from the vescicles. In theory each RRP has its own VCGG nearby. We do not comprehend this, but consider VCGG shared between all the RPP of the presynapse (we impose a floor) **Voltage Gated Ion Channels**: When an AP arrives from the SOMA, VCGG are opened and they let in CA2+ initiating the possible release of NT from the vescicles. In theory each RRP has its own VCGG nearby. We do not comprehend this, but consider VCGG shared between all the RPP of the presynapse (we impose a floor)