From 79bdd9dbedf5158ab55c593588408ca96ad8e25a Mon Sep 17 00:00:00 2001 From: ocrampal Date: Wed, 15 Apr 2026 12:13:52 +0200 Subject: [PATCH] varie --- neuron/soma.md | 42 +++++++++++++++++++++++++----------------- 1 file changed, 25 insertions(+), 17 deletions(-) diff --git a/neuron/soma.md b/neuron/soma.md index cf74a8c..ba6ab79 100644 --- a/neuron/soma.md +++ b/neuron/soma.md @@ -11,17 +11,26 @@ Qui comprendiamo: — ms: - Resting at -70 mV: Leak channels + pumps (keep at resting) +-- ? - VDB Depolarization : ~1-2 ms: Na⁺ enters (some VGSCs open) - Opened VGSC remain closed for a refractory period Spike if depolarized above threshold: to -50 mV + -- Here the threshold is based only on the integration of Na+ + -- The threshold is tuned during the spiketrain. Low threshold at rest, to increase sensitivity, threshold increase during spike to increase discrimination + -- increase SpikeTrainTraces (fast at spike) + -- increase Ca2+ traces - Repolarization to -70 mV: ~1-2 ms: K⁺ exits (VG K⁺ channels open) ← NOT pumps! +-- fast pump which decreases Na+, we do not model K+ - After-hyperpolarization: ~5-20 ms: K⁺ channels still open +-- must figure out how to deal with deoplarization +-- decrease SpikeTraintraces slow, only if away from spiketrain this is empty — seconds: - Return to exact -70 mV: ~100-1000 ms: Na⁺/K⁺ pumps restore gradients +-- slow pump - Ca2+ accumulation: SpikeTrainTraces - +-- ? — mins: - VGSC modulation @@ -32,12 +41,14 @@ Qui comprendiamo: - **VDB**: dendrites deliver current -- **VSOMA**: are a proxy for the Coulombs of charge building up on the somatic membrane. +- **Na**: are a proxy for the Coulombs of charge building up on the somatic membrane. They are used to check threshold, but also to mimic Na+ and K+ pumping - **AP**: - **bAP**: +- **Ca2+**: Medium term traces to guide tuning and Night development + - **SpikeTrainTraces**: sono le tracce che consentono al neurone di far partire il Tuning neuronale, quando e' lontano da uno spike-train, ovvero e' in riposo. --- @@ -46,21 +57,23 @@ Qui comprendiamo: container: BEH-SOMA expansion: - - BEH-SOMA-VGSC ( fullness: 50x, active: 20x, emptiness: 10x ) + - VGSC-SOMA ( fullness: 50x, active: 20x, emptiness: 10x ) # modulated_by: TUN-SOMA-VCGG # possible/actual tub_local: - VDB - - VSOMA + - Na - AP - bAP - tub_intricated: - - SpikeTrainTraces ( contained_by: TUN-N ) + - Ca2+ + + tub_intricated: + - SpikeTrainTraces ( contained_in: DAY-N ) ``` ### ms: behaviors SOMA @@ -165,16 +178,11 @@ episode: ClearVSOMA #### TUN-SOMA-VCGG: Tuner ```Gen -tuner: TUN-SOMA-VCGG +tuner: VGSC-SOMA-TUN - contained_by: BEH-SOMA + contained_by: SOMA - tunes: BEH-SOMA/expansion/BEH-SOMA-VCGG - - expansion: BEH-SOMA-VCGG - tub_modulation: # in TUN agiamo su POS/ACT - - posMod ( fullness: None, active: BEH-SOMA-VCGG/fullness, empty: 0x) # riferimento a possible di BEH-PRE - - actMod ( fullness: None, active: BEH-SOMA-VCGG/active, empty: BEH-SOMA-VCGG/emptiness) # riferimento a active di BEH-PRE + tunes: SOMA/expansion/VGSC-SOMA context_intricated: - TunPossible ( contained_by: DAY-N ) @@ -211,12 +219,12 @@ episode: ? trace: ``` -## BEH-SOMA-VGSC: Container +## VGSC-SOMA: Container Voltage Gated Sodium Channel ```Gen -container: BEH-SOMA-VGSC +container: VGSC-SOMA ``` @@ -226,7 +234,7 @@ container: BEH-SOMA-VGSC ```Gen episode: ?? - contained_by: BEH-SOMA-VGSC + contained_by: VGSC-SOMA in_context: xxx rf: ( active: 1x )