v6

2026-06-11 15:37:33 +02:00
parent c3a8231e84
commit 755f558a17
2 changed files with 969 additions and 0 deletions
@@ -1085,3 +1085,41 @@ RECOVERY FLOWS (LTD → returns material to pools):
    pre LTD  → AZ proteins    → pre_material  (axonal pool)
    astro LTD → ECM fragments → astro_material (partial, recycling_fraction)
 ```
+
+# Flows
+
+## Energy flow
+
+```
+VASCULAR SUPPLY
+    → ASTROCYTE CELL BODY
+        glucose → lactate (glycolysis)
+        → astro_budget (local ATP for clearance, D-serine, ECM, process motility)
+        → lactate exported to:
+            → pre_budget  (ATP for VGCC, vesicle fusion, VATPase)
+            → post_budget (ATP for NaK pump, AMPA trafficking, actin)
+            → dend_budget (ATP for bAP propagation, local translation)
+        
+    → SOMA
+        soma has own mitochondria — partly self-fueled
+        soma_budget (ATP for AP generation, CREB, protein synthesis, shipping)
+        → dend_budget top-up (organelle delivery)
+        → axon_budget top-up (transport machinery)
+```
+
+## Material flow
+
+```
+SOMA
+    protein synthesis (CREB-driven, peaks in NIGHT)
+    → soma_material (receptors, scaffold proteins, organelles, mRNA)
+        → dend_material (branch receives proteins + mRNA from soma)
+            → post_material (spine receives receptors + actin from branch)
+        → axon_material (boutons receive AZ proteins + VGCCs from soma via axon)
+            → pre_material (bouton active zone proteins)
+
+ASTROSYNAPSE
+    ECM proteins synthesized in astrocyte cell body
+    → astro_material (Glypicans, Thrombospondins, serine for D-serine)
+        → cleft environment (ECM sealing, D-serine availability)
+```