diff --git a/elements/neuron/presynapse.md b/elements/neuron/presynapse.md index b918660..105de0b 100644 --- a/elements/neuron/presynapse.md +++ b/elements/neuron/presynapse.md @@ -117,10 +117,10 @@ NTreleaseMedium in_context: &AP - hypothesis: (( Ca2+ fullness ) AND ( Rrp mediumness ) OR - ( Ca2+ mediumness ) AND ( Rrp fullness )) AND - NOT( ATP empty ) - action: [Rrp decrease, Nt increase, ATP decrease] + hypothesis: (( _Ca2+ fullness ) AND ( _Rrp mediumness ) OR + ( _Ca2+ mediumness ) AND ( _Rrp fullness )) AND + NOT( _ATP empty ) + action: [_Rrp decrease, Nt increase, _ATP decrease] trace: None ``` @@ -131,9 +131,9 @@ NTreleaseHigh in_context: &AP - hypothesis: ( Ca2+ fullness ) AND ( Rrp fullness ) AND - NOT( ATP empty ) - action: [Rrp decrease, NT increase, ATP decrease] + hypothesis: ( _Ca2+ fullness ) AND ( _Rrp fullness ) AND + NOT( _ATP empty ) + action: [_Rrp decrease, NT increase, _ATP decrease] trace: None ``` @@ -142,7 +142,7 @@ NTreleaseHigh Serve a: - fare il tuning dei VGCC -- dare la velocita' al trasporto di vesicles da RP a RRP, anche se non avendo ancora compreso ATP, la velocita' non cambia molto la sostanza. +- dare la velocita' al trasporto di vesicles da RP a RRP, anche se non avendo ancora compreso _ATP, la velocita' non cambia molto la sostanza. - le tracce vengono eliminate quando il neurone e' in pausa, lontano da uno spike train, &TunePossible - Abbiamo 3 tracce, high, medium and low. Andiamo a verificare una combinazione di queste per fare la modulazione - RF e' a 10, questo dovrebbe essere un RF di campionamento durante &AP context che dovremmo assicurarci sia tipo 100. Il che implicherebbe 10 campionamenti. @@ -154,7 +154,7 @@ Ca2+TracesAccuLow in_context: &AP - hypothesis: (Ca2+ emptiness) + hypothesis: (_Ca2+ emptiness) action: [CaTraceLow increase] trace: None ``` @@ -166,7 +166,7 @@ Ca2+TracesAccMedium in_context: &AP - hypothesis: (Ca2+ mediumness) + hypothesis: (_Ca2+ mediumness) action: [CaTraceMed increase] trace: None ``` @@ -178,7 +178,7 @@ Ca2+TracesAccumulationHigh in_context: &AP - hypothesis: (Ca2+ fullness) + hypothesis: (_Ca2+ fullness) action: [CaTraceHigh increase] trace: None ``` @@ -216,8 +216,8 @@ RPShuttleLow hypothesis: (CaTraceLow fullness) OR (RP emptiness) OR - (RRP fullness) - action: [RP decrease, RRP increase] + (_Rrp fullness) + action: [RP decrease, _Rrp increase] trace: None ``` @@ -232,17 +232,17 @@ RPShuttleMedium in_context: &AP - hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (RRP mediumness) OR - (CaTraceHigh fullness) AND (RP mediumness) AND (RRP mediumness) OR # signal boost - (CaTraceMedium fullness) AND (RP fullness) AND (RRP mediumness) OR # supply boost - (CaTraceMedium fullness) AND (RP mediumness) AND (RRP emptiness) # vacancy boost - action: [RP decrease, RRP increase] + hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (_Rrp mediumness) OR + (CaTraceHigh fullness) AND (RP mediumness) AND (_Rrp mediumness) OR # signal boost + (CaTraceMedium fullness) AND (RP fullness) AND (_Rrp mediumness) OR # supply boost + (CaTraceMedium fullness) AND (RP mediumness) AND (_Rrp emptiness) # vacancy boost + action: [RP decrease, _Rrp increase] trace: None ``` ##### RPShuttleHigh -The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull. +The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the _Rrp isn't empty enough to create that "maximal vacuum" pull. Rate: 1.25 – 1.94 @@ -251,10 +251,10 @@ RPShuttleHigh in_context: &AP - hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (RRP mediumness) OR # signal + supply - (CaTraceHigh fullness) AND (RP mediumness) AND (RRP emptiness) OR # signal + vacancy - (CaTraceMedium fullness) AND (RP fullness) AND (RRP emptiness) # supply + vacancy - action: [RP decrease, RRP increase] + hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (_Rrp mediumness) OR # signal + supply + (CaTraceHigh fullness) AND (RP mediumness) AND (_Rrp emptiness) OR # signal + vacancy + (CaTraceMedium fullness) AND (RP fullness) AND (_Rrp emptiness) # supply + vacancy + action: [RP decrease, _Rrp increase] trace: None ``` @@ -403,7 +403,7 @@ BEHAVIOR_VGCC_PRE type: container tub_intricated: - - Ca2+ ( contained_by: PRESYNAPSE-BHE ) + - _Ca2+ ( contained_by: PRESYNAPSE-BHE ) - NT ( contained_by: SYN ) context_intricated: @@ -449,8 +449,8 @@ Ca2+enterLow in_context: &AP - hypothesis: (Ca2+ empty) AND (eCB empty) - action: [Ca2+ increase, ATP decrease] + hypothesis: (_Ca2+ empty) AND (eCB empty) + action: [_Ca2+ increase, _ATP decrease] trace: None ``` @@ -461,10 +461,10 @@ Ca2+enterMedium in_context: &AP - hypothesis: (Ca2+ mediumness) OR - ((eCB mediumness) AND (Ca2+ empty)) OR - ((eCB full) AND (Ca2+ empty) AND (NT empty)) - action: [Ca2+ increase, ATP decrease] + hypothesis: (_Ca2+ mediumness) OR + ((eCB mediumness) AND (_Ca2+ empty)) OR + ((eCB full) AND (_Ca2+ empty) AND (NT empty)) + action: [_Ca2+ increase, _ATP decrease] trace: None ``` @@ -475,15 +475,15 @@ Ca2+enterHigh in_context: &AP - hypothesis: (Ca2+ mediumness) AND (eCB full) OR + hypothesis: (_Ca2+ mediumness) AND (eCB full) OR (eCB mediumness) - action: [Ca2+ increase, ATP decrease] + action: [_Ca2+ increase, _ATP decrease] trace: None ``` #### NOT &AP -Qui eliminiamo Ca2+. Il tempo che ci mette ad eliminare il Ca2+ dovrebbe essere minoe dell'inervallo fra un &AP e un'altra. Siccome non comprendiamo per ora ATP, non c'e' accumulo di Ca2+ per mancanza di ATP (stanchezza). +Qui eliminiamo Ca2+. Il tempo che ci mette ad eliminare il Ca2+ dovrebbe essere minoe dell'inervallo fra un &AP e un'altra. Siccome non comprendiamo per ora _ATP, non c'e' accumulo di Ca2+ per mancanza di _ATP (stanchezza). Non non comprendiamo anche il ristabilimento del Voltage, con altri Ioni entranti e uscenti, per ora tutto dipende da AP del SOMA. Non comprendiamo per ora: @@ -504,8 +504,8 @@ Ca2+ClearanceLow in_context: NOT &AP - hypothesis: (NOT Ca2+ fullness) AND (NOT Ca2+ empty) - action: [Ca2+ decrease] + hypothesis: (NOT _Ca2+ fullness) AND (NOT _Ca2+ empty) + action: [_Ca2+ decrease] trace: None ```