varie

neuron/axon.md

@@ -520,9 +520,10 @@ container: VGCC-PRE
 
   tub_intricated:
     - Ca2+ ( contained_by: PRESYNAPSE )
+    - NT ( contained_by: SYN )
 
   context_intricated:
-    - AP ( contained_by: BEH-SOMA )
+    - AP ( contained_by: SOMA )
 ```
 
 ### ms: behavior
@@ -535,10 +536,10 @@ Here we comprehend the breaking activity on VGCC by: CDI, eCB and mGluR:
 
 Qui sostituiamo:
 
-- CDI con concentrazione Ca2+
+- Approssimiamo CDI con concentrazione di Ca2+.
 -- CDI is calcium-dependent inactivation of VGCCs. The inactivation happens because Ca²⁺ enters through the channel and binds to a calmodulin tethered to the channel's intracellular face, physically blocking it from reopening. This is a local, channel-specific event — it requires Ca²⁺ to be flowing through that channel right now, not residual Ca²⁺ drifting in the cytosol between spikes.
 -- The recovery, by contrast, should run every millisecond unconditionally — CDI de-inactivation is a continuous process that proceeds whenever Ca²⁺ dissociates from calmodulin, which depends on the ambient Ca_micro level at all times.
-- mGluR con concentrazione NT (forse su tempi di sec e quindi avremmo bisogno di un altro Tub)
+- Approssimiamo mGluR con concentrazione NT
 
 - **Open** — zero active brakes. mGluR alone never escapes this group because its ceiling is alpha_mGluR = 0.4, meaning even at full it only removes 40% of conductance, leaving 60% — still above the 85% threshold. So mGluR is irrelevant to the open/not-open boundary. Only CDI and eCB decide.
 - **Reduced/partial** — exactly one meaningful brake active. Either CDI has started building (mediumness), or eCB has risen from sustained postsynaptic activity, but not both simultaneously. The system is aware something is happening but has not compounded yet. This is the normal operating range during moderate sustained firing.
@@ -570,7 +571,7 @@ interacting: Ca2+enterReduced-partial
   in_context: AP
   rf: ( active: 6x )
 
-  hypothesis: (Ca2+ mediumness) OR ((eCB mediumness) AND (Ca2+ empty)) OR ((eCB full) AND (Ca2+ empty) AND (mGluR empty))
+  hypothesis: (Ca2+ mediumness) OR ((eCB mediumness) AND (Ca2+ empty)) OR ((eCB full) AND (Ca2+ empty) AND (NT empty))
     action: [Ca2+ increase, ATP decrease]
     trace: None
 ```