Update 2026-06-04-modulation-of-future-behavior.md

elements/astrocyte/appunti/2026-06-04-modulation-of-future-behavior.md

@@ -64,7 +64,9 @@ The astrocyte's perisynaptic wall distance is the variable that makes both outco
 
 
 ```Gen
-global state variables
+
+## global state variables
+
   // ── Fast (ms–s): wave propagation ─────────────────────────────
   // Presynapse
   pre_Ca_residual // leftover Ca²⁺ between spikes — short-term trace
@@ -105,7 +107,9 @@ perisynaptic_distance // how close astrocyte walls are to synapse
   ECM_integrity // extracellular matrix density
   D_serine_tonic_level // baseline co-agonist supply (sustained)
   glutamate_clearance_rate // EAAT transporter density
-fast time scale — wave propagation (ms → s)
+
+## fast time scale — wave propagation (ms → s)
+
   function fire_action_potential(input_freq):
   
     // Presynapse: launch wavefront
@@ -145,7 +149,9 @@ glutamate_cleft -= glutamate_clearance_rate × Δt
     lactate_output += glycolysis_rate(glutamate_clearance_rate)
     membrane_potential restored by NaK_ATPase(lactate_output)
     RRP_pool refilled by VATPase(lactate_output)
-intermediate time scale — temporary tuning (s → min)
+  
+## intermediate time scale — temporary tuning (s → min)
+
   function short_term_plasticity(input_freq, duration):
   
     // Presynapse: facilitate or depress based on Ca²⁺ history
@@ -176,7 +182,9 @@ translocate(PKA → nucleus) → phosphorylate(CREB)
     CREB_active = True // enables structural gene expression
     // Acetylcholine: lower LTP threshold globally
     LTP_threshold *= (1 / (1 + ACh_level × mAChR_gain))
-slow time scale — structural commit (h → weeks)
+  
+## slow time scale — structural commit (h → weeks)
+
   function commit_to_structural_change():
   
     // Hierarchical filter: three conditions must align
@@ -237,14 +245,18 @@ return "depressed"
     else:
       // All structural variables unchanged — system holds current state
       return "baseline — no change"
-special case — shockwave lockdown (>100Hz uncoordinated)
+  
+## special case — shockwave lockdown (>100Hz uncoordinated)
+
   function shockwave_lockdown():
+
     astro_Ca_global = GLOBAL_WAVE // soma-level flood
     release(GABA, ATP) // gel floods postsynapse
     AMPA_count -= mass_internalization()
     membrane_potential = HYPERPOLARIZED
     cluster(VGCC → beneath_active_zone) // ensures signal survives chaos
-energy supply chain — metabolic gating (continuous)
+
+## energy supply chain — metabolic gating (continuous)
     function metabolic_loop(Δt):
       // Astrocyte: glucose → lactate pipeline
       glucose_uptake = blood_capillary_supply()
@@ -254,7 +266,8 @@ lactate_output *= load_factor(glutamate_clearance_rate)
       // Pre + post absorb lactate → power their pumps
       RRP_pool refill rate ∝ VATPase(lactate_output)
       membrane_potential reset ∝ NaK_ATPase(lactate_output)
-key asymmetry — perisynaptic distance is bidirectional
+
+## key asymmetry — perisynaptic distance is bidirectional
   // LTP: astrocyte moves IN → tighter diffusion barrier
   // → glutamate_clearance_rate ↓ (signal contained, not diluted)
   // → D_serine_tonic_level ↑ (NMDA gate chronically primed)