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Update 2026-06-04-modulation-of-future-behavior.md

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ocrampal
2026-06-05 13:52:19 +02:00
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elements/astrocyte/appunti/2026-06-04-modulation-of-future-behavior.md
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@@ -64,7 +64,9 @@ The astrocyte's perisynaptic wall distance is the variable that makes both outco
```Gen ```Gen
global state variables
## global state variables
// ── Fast (ms–s): wave propagation ───────────────────────────── // ── Fast (ms–s): wave propagation ─────────────────────────────
// Presynapse // Presynapse
pre_Ca_residual // leftover Ca²⁺ between spikes — short-term trace pre_Ca_residual // leftover Ca²⁺ between spikes — short-term trace
@@ -105,7 +107,9 @@ perisynaptic_distance // how close astrocyte walls are to synapse
ECM_integrity // extracellular matrix density ECM_integrity // extracellular matrix density
D_serine_tonic_level // baseline co-agonist supply (sustained) D_serine_tonic_level // baseline co-agonist supply (sustained)
glutamate_clearance_rate // EAAT transporter density glutamate_clearance_rate // EAAT transporter density
fast time scale — wave propagation (ms → s)
## fast time scale — wave propagation (ms → s)
function fire_action_potential(input_freq): function fire_action_potential(input_freq):
// Presynapse: launch wavefront // Presynapse: launch wavefront
@@ -145,7 +149,9 @@ glutamate_cleft -= glutamate_clearance_rate × Δt
lactate_output += glycolysis_rate(glutamate_clearance_rate) lactate_output += glycolysis_rate(glutamate_clearance_rate)
membrane_potential restored by NaK_ATPase(lactate_output) membrane_potential restored by NaK_ATPase(lactate_output)
RRP_pool refilled by VATPase(lactate_output) RRP_pool refilled by VATPase(lactate_output)
intermediate time scale — temporary tuning (s → min)
## intermediate time scale — temporary tuning (s → min)
function short_term_plasticity(input_freq, duration): function short_term_plasticity(input_freq, duration):
// Presynapse: facilitate or depress based on Ca²⁺ history // Presynapse: facilitate or depress based on Ca²⁺ history
@@ -176,7 +182,9 @@ translocate(PKA → nucleus) → phosphorylate(CREB)
CREB_active = True // enables structural gene expression CREB_active = True // enables structural gene expression
// Acetylcholine: lower LTP threshold globally // Acetylcholine: lower LTP threshold globally
LTP_threshold *= (1 / (1 + ACh_level × mAChR_gain)) LTP_threshold *= (1 / (1 + ACh_level × mAChR_gain))
slow time scale — structural commit (h → weeks)
## slow time scale — structural commit (h → weeks)
function commit_to_structural_change(): function commit_to_structural_change():
// Hierarchical filter: three conditions must align // Hierarchical filter: three conditions must align
@@ -237,14 +245,18 @@ return "depressed"
else: else:
// All structural variables unchanged — system holds current state // All structural variables unchanged — system holds current state
return "baseline — no change" return "baseline — no change"
special case — shockwave lockdown (>100Hz uncoordinated)
## special case — shockwave lockdown (>100Hz uncoordinated)
function shockwave_lockdown(): function shockwave_lockdown():
astro_Ca_global = GLOBAL_WAVE // soma-level flood astro_Ca_global = GLOBAL_WAVE // soma-level flood
release(GABA, ATP) // gel floods postsynapse release(GABA, ATP) // gel floods postsynapse
AMPA_count -= mass_internalization() AMPA_count -= mass_internalization()
membrane_potential = HYPERPOLARIZED membrane_potential = HYPERPOLARIZED
cluster(VGCC → beneath_active_zone) // ensures signal survives chaos cluster(VGCC → beneath_active_zone) // ensures signal survives chaos
energy supply chain — metabolic gating (continuous)
## energy supply chain — metabolic gating (continuous)
function metabolic_loop(Δt): function metabolic_loop(Δt):
// Astrocyte: glucose → lactate pipeline // Astrocyte: glucose → lactate pipeline
glucose_uptake = blood_capillary_supply() glucose_uptake = blood_capillary_supply()
@@ -254,7 +266,8 @@ lactate_output *= load_factor(glutamate_clearance_rate)
// Pre + post absorb lactate → power their pumps // Pre + post absorb lactate → power their pumps
RRP_pool refill rate ∝ VATPase(lactate_output) RRP_pool refill rate ∝ VATPase(lactate_output)
membrane_potential reset ∝ NaK_ATPase(lactate_output) membrane_potential reset ∝ NaK_ATPase(lactate_output)
key asymmetry — perisynaptic distance is bidirectional
## key asymmetry — perisynaptic distance is bidirectional
// LTP: astrocyte moves IN → tighter diffusion barrier // LTP: astrocyte moves IN → tighter diffusion barrier
// → glutamate_clearance_rate ↓ (signal contained, not diluted) // → glutamate_clearance_rate ↓ (signal contained, not diluted)
// → D_serine_tonic_level ↑ (NMDA gate chronically primed) // → D_serine_tonic_level ↑ (NMDA gate chronically primed)