diff --git a/neuron/soma.md b/neuron/soma.md index 4724d9a..3a5c36e 100644 --- a/neuron/soma.md +++ b/neuron/soma.md @@ -2,9 +2,14 @@ Qui comprendiamo: -- BEH-SOMA: il soma +- SOMA: il soma +- VGSC-SOMA-H: Na ion channels. Open only when VDB high +- VGSC-SOMA-M: Na ion channels. Open only when VDB medium +- VGSC-SOMA-L: Na ion channels. Open only when VDB low -## BEH-SOMA: Container +## SOMA: Container + +--- **Simplified behaviors**: @@ -54,11 +59,18 @@ Qui comprendiamo: --- ```Gen -container: BEH-SOMA +container: SOMA expansion: - - VGSC-SOMA ( fullness: 50x, active: 20x, emptiness: 10x ) - # modulated_by: TUN-SOMA-VCGG # possible/actual + - VGSC-SOMA-H ( fullness: 50x, active: 20x, emptiness: 10x ) + # modulated_by: VGSC-SOMA-H-TUN # possible/actual + + - VGSC-SOMA-M ( fullness: 50x, active: 20x, emptiness: 10x ) + # modulated_by: VGSC-SOMA-M-TUN # possible/actual + + - VGSC-SOMA-L ( fullness: 50x, active: 20x, emptiness: 10x ) + # modulated_by: VGSC-SOMA-L-TUN # possible/actual + tub_local: @@ -66,27 +78,21 @@ container: BEH-SOMA - Na - - AP - - - bAP - - Ca2+ tub_intricated: - SpikeTrainTraces ( contained_in: DAY-N ) ``` -### ms: behaviors SOMA +### ms: behaviors #### CheckVDB: Context -As dendrites deliver current (VDB​), the soma acts like a capacitor. It "stores" this charge in the form of membrane potential. VSOMA is proxy for the Coulombs of charge building up on the somatic membrane. - -Contestualizziamo in maniera Fixed? +As dendrites deliver current (VDB​), the soma acts like a capacitor. It "stores" this charge in the form of membrane potential. This contextualizes VGSC-SOMA to open ion channels that let Na+ ions in. ```Gen context: CheckVDB - contained_by: BEH-SOMA + contained_by: SOMA in_context: Fixed rf: ( active: 60x ) @@ -101,55 +107,29 @@ context: CheckVDB out_context: VDBLow ``` -##### AddVSOMAMax: Episode +#### CheckSomaSpike: Context + +The initiation and duration of a spike ```Gen -episode: AddVSOMAMax - contained_by: BEH-SOMA +context: CheckSomaSpike + contained_by: SOMA - in_context: VDBMax - rf: ( active: 2x ) + in_context: Fixed + rf: ( active: 60x ) - hypothesis: NOT (VSOMA full) - action: [VSOMA increase] - trace: -``` - -##### AddVSOMAMed: Episode - -```Gen -episode: AddVSOMAMed - contained_by: BEH-SOMA - - in_context: VDBMedium - rf: ( active: 4x ) - - hypothesis: NOT (VSOMA full) - action: [VSOMA increase] - trace: -``` - -##### AddVSOMALow: Episode - -```Gen -episode: AddVSOMALow - contained_by: BEH-SOMA - - in_context: VDBLow - rf: ( active: 8x ) - - hypothesis: NOT (VSOMA full) - action: [VSOMA increase] - trace: + condition: ( Na fullness OR APOngoing ) + out_context: AP + out_context: bAP ``` #### SomaSpike: Episode ```Gen episode: SomaSpike - contained_by: BEH-SOMA + contained_by: SOMA - in_context: + in_context: AP rf: ( active: 8x ) hypothesis: @@ -157,13 +137,13 @@ episode: SomaSpike trace: ``` -#### ClearVSOMA: Episode +#### ClearNa: Episode ```Gen -episode: ClearVSOMA - contained_by: BEH-SOMA +episode: ClearNa + contained_by: SOMA - in_context: + in_context: AP rf: ( active: 8x ) hypothesis: @@ -171,11 +151,11 @@ episode: ClearVSOMA trace: ``` -### sec: behaviors SOMA +### sec: behaviors -### min: behaviors SOMA +### min: behaviors -#### TUN-SOMA-VCGG: Tuner +#### VGSC-SOMA-TUN: Tuner ```Gen tuner: VGSC-SOMA-TUN @@ -196,7 +176,7 @@ tuner: VGSC-SOMA-TUN ```Gen context: Check - contained_by: TUN-SOMA-VCGG + contained_by: VGSC-SOMA-TUN in_context: TunPossible rf: ( active: 60x ) @@ -219,22 +199,20 @@ episode: ? trace: ``` -## VGSC-SOMA: Container +## VGSC-SOMA-H: Container Voltage Gated Sodium Channel ```Gen -container: VGSC-SOMA +container: VGSC-SOMA-H ``` -### ms: behaviors SOMA-VGSC - -#### Episode1 +### Episode1 ```Gen episode: ?? - contained_by: VGSC-SOMA + contained_by: VGSC-H-SOMA in_context: xxx rf: ( active: 1x ) @@ -244,4 +222,48 @@ episode: ?? trace: None ``` -## +## VGSC-SOMA-M: Container + +Voltage Gated Sodium Channel + +```Gen +container: VGSC-SOMA-M + +``` + +### Episode2 + +```Gen +episode: ?? + contained_by: VGSC-M-SOMA + + in_context: xxx + rf: ( active: 1x ) + + hypothesis: + action: + trace: None +``` + +## VGSC-SOMA-L: Container + +Voltage Gated Sodium Channel + +```Gen +container: VGSC-SOMA-M + +``` + +### Episode3 + +```Gen +episode: ?? + contained_by: VGSC-L-SOMA + + in_context: xxx + rf: ( active: 1x ) + + hypothesis: + action: + trace: None +```