Edit presynapse.md
This commit is contained in:
Sergio Marchetti
+118
-134
@@ -160,7 +160,8 @@ Questo serve per il medio/lungo periodo
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```Gen
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container: PRESYNAPSE
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expansion: VGCC-PRE ( full: 10x, active: 5x, empty: 2x )
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expansion:
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- VGCC-PRE ( full: 10x, active: 5x, empty: 2x )
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tub_local:
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- Ca2+ ( full: 60x, active: 30x, empty: 0x )
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@@ -177,7 +178,7 @@ container: PRESYNAPSE
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- eCB ( contained_by: POST )
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context_intricated:
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- AP ( contained_by: SOMA )
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- AP_ctx ( contained_by: SOMA )
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```
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### AP_ctx: PRESYNAPSE
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@@ -202,7 +203,6 @@ In tutti i casi di NT
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```Gen
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NTreleaseLow: ( active: 12x ) # Low
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type: accumulator
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contained_by: PRESYNAPSE
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@@ -217,32 +217,30 @@ NTreleaseLow: ( active: 12x ) # Low
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In tutti i casi di NT
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```Gen
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interacting: NTreleaseMedium
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NTreleaseMedium: ( active: 9x ) # Medium
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type: accumulator
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contained_by: PRESYNAPSE
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in_context: AP_ctx
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rf: ( active: 9x ) # Medium
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hypothesis: (( Ca2+ fullness ) AND ( Rrp mediumness ) OR
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( Ca2+ mediumness ) AND ( Rrp fullness )) AND
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NOT( ATP empty )
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action: [Rrp decrease, Nt increase, ATP decrease]
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trace: None
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hypothesis: (( Ca2+ fullness ) AND ( Rrp mediumness ) OR
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( Ca2+ mediumness ) AND ( Rrp fullness )) AND
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NOT( ATP empty )
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action: [Rrp decrease, Nt increase, ATP decrease]
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trace: None
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```
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#### NTreleaseHigh: int: ms
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```Gen
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interacting: NTreleaseHigh
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NTreleaseHigh: ( active: 3x ) # High
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type: accumulator
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contained_by: PRESYNAPSE
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in_context: AP_ctx
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rf: ( active: 3x ) # High
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hypothesis: ( Ca2+ fullness ) AND ( Rrp fullness ) AND
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NOT( ATP empty )
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action: [Rrp decrease, NT increase, ATP decrease]
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trace: None
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hypothesis: ( Ca2+ fullness ) AND ( Rrp fullness ) AND
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NOT( ATP empty )
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action: [Rrp decrease, NT increase, ATP decrease]
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trace: None
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```
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#### Ca2+TracesAccumulationLow: int: ms
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@@ -259,44 +257,41 @@ Serve a:
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---
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```Gen
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interacting: Ca2+TracesAccumulationLow
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Ca2+TracesAccumulationLow: ( active: 10x )
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type: accumulator
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contained_by: PRESYNAPSE
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in_context: AP_ctx
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rf: ( active: 10x )
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hypothesis: (Ca2+ emptiness)
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action: [CaTraceLow increase]
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trace: None
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hypothesis: (Ca2+ emptiness)
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action: [CaTraceLow increase]
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trace: None
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```
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#### Ca2+TracesAccumulationMedium: int: ms
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```Gen
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interacting: Ca2+TracesAccumulationMedium
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Ca2+TracesAccumulationMedium: ( active: 6x ) # medium
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type: accumulator
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contained_by: PRESYNAPSE
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in_context: AP_ctx
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rf: ( active: 10x )
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hypothesis: (Ca2+ mediumness)
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action: [CaTraceMed increase]
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trace: None
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hypothesis: (Ca2+ mediumness)
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action: [CaTraceMed increase]
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trace: None
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```
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#### Ca2+TracesAccumulationHigh: int: ms
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```Gen
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interacting: Ca2+TracesAccumulationHigh
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Ca2+TracesAccumulationHigh: ( active: 10x ) # high
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type: accumulator
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contained_by: PRESYNAPSE
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in_context: AP_ctx
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rf: ( active: 10x ) # high
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hypothesis: (Ca2+ fullness)
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action: [CaTraceHigh increase]
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trace: None
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hypothesis: (Ca2+ fullness)
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action: [CaTraceHigh increase]
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trace: None
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```
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### NOT AP_ctx: PRESYNAPSE
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@@ -308,15 +303,14 @@ eCB dipende da POST. Tende a modulare l'entrata di Ca2+ degli VGCC.
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Qui non facciamo un flush di eCB, riduciamo ogni mezzo secondo (context) di un RF di questo episodio.
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```Gen
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interacting: eCBClearance
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eCBClearance: ( active: 24x ) # Slow
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type: accumulator
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contained_by: PRESYNAPSE
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in_context: NOT AP_ctx
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rf: ( active: 24x ) # Slow
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hypothesis: NOT (eCB empty)
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action: [eCB decrease]
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trace: None
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hypothesis: NOT (eCB empty)
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action: [eCB decrease]
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trace: None
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```
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#### RPShuttleLow: int: sec
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@@ -328,17 +322,16 @@ The "Hard Bottleneck" State. Recruitment is throttled by a lack of signal, a lac
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Rate: 0.00 – 0.25
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```Gen
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interacting: RPShuttleLow
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RPShuttleLow: ( active: 48x ) # Low
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type: accumulator
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contained_by: PRESYNAPSE
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in_context: NOT AP_ctx
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rf: ( active: 48x ) # Low
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hypothesis: (CaTraceLow fullness) OR
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(RP emptiness) OR
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(RRP fullness)
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action: [RP decrease, RRP increase]
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trace: None
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hypothesis: (CaTraceLow fullness) OR
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(RP emptiness) OR
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(RRP fullness)
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action: [RP decrease, RRP increase]
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trace: None
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```
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#### RPShuttleMedium: int: sec
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@@ -348,18 +341,17 @@ The "Sub-Optimal" State. The machinery is working, but it's held back by partial
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Rate: 0.50 – 0.97
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```Gen
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interacting: RPShuttleMedium
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RPShuttleMedium: ( active: 24x ) # Medium
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type: accumulator
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contained_by: PRESYNAPSE
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in_context: AP_ctx
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rf: ( active: 24x ) # Medium
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hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (RRP mediumness) OR
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(CaTraceHigh fullness) AND (RP mediumness) AND (RRP mediumness) OR # signal boost
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(CaTraceMedium fullness) AND (RP fullness) AND (RRP mediumness) OR # supply boost
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(CaTraceMedium fullness) AND (RP mediumness) AND (RRP emptiness) # vacancy boost
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action: [RP decrease, RRP increase]
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trace: None
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hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (RRP mediumness) OR
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(CaTraceHigh fullness) AND (RP mediumness) AND (RRP mediumness) OR # signal boost
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(CaTraceMedium fullness) AND (RP fullness) AND (RRP mediumness) OR # supply boost
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(CaTraceMedium fullness) AND (RP mediumness) AND (RRP emptiness) # vacancy boost
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action: [RP decrease, RRP increase]
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trace: None
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```
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#### RPShuttleHigh: int: sec
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@@ -369,17 +361,16 @@ The "High Performance" State. Multiple systems are optimized, but one is still a
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Rate: 1.25 – 1.94
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```Gen
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interacting: RPShuttleHigh
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RPShuttleHigh: ( active: 12x ) # Fast
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type: accumulator
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contained_by: PRESYNAPSE
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in_context: AP_ctx
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rf: ( active: 12x ) # Fast
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hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (RRP mediumness) OR # signal + supply
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(CaTraceHigh fullness) AND (RP mediumness) AND (RRP emptiness) OR # signal + vacancy
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(CaTraceMedium fullness) AND (RP fullness) AND (RRP emptiness) # supply + vacancy
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action: [RP decrease, RRP increase]
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trace: None
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hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (RRP mediumness) OR # signal + supply
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(CaTraceHigh fullness) AND (RP mediumness) AND (RRP emptiness) OR # signal + vacancy
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(CaTraceMedium fullness) AND (RP fullness) AND (RRP emptiness) # supply + vacancy
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action: [RP decrease, RRP increase]
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trace: None
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```
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#### RefillRPGlutamine: int: min
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@@ -419,32 +410,30 @@ Each tier buys time for the one below it to respond. When all three are depleted
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Qui facciamo un flush di CaTraceX. Deve essere fatto a valle del tuning.
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```Gen
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interacting: Ca2+TracesClearance
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Ca2+TracesClearance: ( active: 30x ) # Slow
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type: accumulator
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contained_by: PRESYNAPSE
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in_context: NOT TunPossible_ctx
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rf: ( active: 30x ) # Slow
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hypothesis: NOT (CaTraceHigh empty)
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action: [CaTRaceHigh decrease]
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trace: None
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hypothesis: NOT (CaTraceHigh empty)
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action: [CaTRaceHigh decrease]
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trace: None
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hypothesis: NOT (CaTraceMedium empty)
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action: [CaTRaceMedium decrease]
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trace: None
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hypothesis: NOT (CaTraceMedium empty)
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action: [CaTRaceMedium decrease]
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trace: None
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hypothesis: NOT (CaTraceLow empty)
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action: [CaTRaceLow decrease]
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trace: None
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hypothesis: NOT (CaTraceLow empty)
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action: [CaTRaceLow decrease]
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trace: None
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```
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## VGCC-PRE-TUN: Tuner
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```Gen
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tuner: VGCC-PRE-TUN
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VGCC-PRE-TUN
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type: tuner
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# qui stiamo aggiungendo o eliminando VGCC-PRE. Fra un massimo full e minimo empty (empty puo' non essere 0)
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# contained_by: PRESYNAPSE non e' contenuto, si attacca.
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tunes: PRESYNAPSE/expansion/VCGG-PRE
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@@ -467,45 +456,42 @@ tuner: VGCC-PRE-TUN
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Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantita' di VGCC
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```Gen
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contexting: CheckVgccPreTun
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CheckVgccPreTun: ( active: 60x )
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type: contexting
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contained_by: VGCC-PRE-TUN
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in_context: TunPossible_ctx
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rf: ( active: 60x )
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condition: ( CaTraceHigh fullness )
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out_context: TryTunUpPreVcgg_ctx
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condition: ( CaTraceHigh fullness )
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out_context: TryTunUpPreVcgg_ctx
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condition: ( CaTraceLow fullness )
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out_context: TryTunDownPreVcgg_ctx
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condition: ( CaTraceLow fullness )
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out_context: TryTunDownPreVcgg_ctx
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```
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#### PossibleUpPreVgccTun: int: sec
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```Gen
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interacting: PossibleUpPreVgccTun
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PossibleUpPreVgccTun: ( active: 10x )
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type: accumulator
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contained_by: VGCC-PRE-TUN
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in_context: TryTunUpPreVcgg_ctx
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rf: ( active: 10x )
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hypothesis:
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action:
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trace:
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hypothesis:
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action:
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trace:
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```
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#### PossibleDownPreVgccTun: int: sec
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```Gen
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interacting: PossibleDownPreVgccTun
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PossibleDownPreVgccTun: ( active: 10x )
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type: accumulator
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contained_by: VGCC-PRE-TUN
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in_context: TryTunDownPreVcgg_ctx
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rf: ( active: 10x )
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hypothesis:
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action:
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trace:
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hypothesis:
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action:
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trace:
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```
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## VGCC-PRE: Container
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@@ -513,7 +499,8 @@ interacting: PossibleDownPreVgccTun
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Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare.
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```Gen
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container: VGCC-PRE
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VGCC-PRE
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type: container
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tub_intricated:
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- Ca2+ ( contained_by: PRESYNAPSE )
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@@ -548,46 +535,43 @@ Qui semplifichiamo:
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Devo controllare che le condizioni sotto siano esaustive. Qui ho confuso high con low, e inoltre ho messo NT per mGluR che devo controllare che abbia senso.
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```Gen
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interacting: Ca2+enterLow
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Ca2+enterLow: ( active: 12x ) # Low
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type: accumulator
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contained_by: VGCC-PRE
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in_context: AP_ctx
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rf: ( active: 12x ) # Low
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hypothesis: (Ca2+ empty) AND (eCB empty)
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action: [Ca2+ increase, ATP decrease]
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trace: None
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hypothesis: (Ca2+ empty) AND (eCB empty)
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action: [Ca2+ increase, ATP decrease]
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trace: None
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```
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#### Ca2+enterMedium: int: ms
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```Gen
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interacting: Ca2+enterMedium
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Ca2+enterMedium: ( active: 6x ) # Medium
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type: accumulator
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contained_by: VGCC-PRE
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in_context: AP_ctx
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rf: ( active: 6x ) # Medium
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hypothesis: (Ca2+ mediumness) OR
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((eCB mediumness) AND (Ca2+ empty)) OR
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((eCB full) AND (Ca2+ empty) AND (NT empty))
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action: [Ca2+ increase, ATP decrease]
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trace: None
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hypothesis: (Ca2+ mediumness) OR
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((eCB mediumness) AND (Ca2+ empty)) OR
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((eCB full) AND (Ca2+ empty) AND (NT empty))
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action: [Ca2+ increase, ATP decrease]
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trace: None
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```
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#### Ca2+enterHigh: int: ms
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```Gen
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interacting: Ca2+enterHigh
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Ca2+enterHigh: ( active: 3x ) # High
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type: accumulator
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contained_by: VGCC-PRE
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in_context: AP_ctx
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rf: ( active: 3x ) # High
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hypothesis: (Ca2+ mediumness) AND (eCB full) OR
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(eCB mediumness)
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action: [Ca2+ increase, ATP decrease]
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trace: None
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hypothesis: (Ca2+ mediumness) AND (eCB full) OR
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(eCB mediumness)
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action: [Ca2+ increase, ATP decrease]
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trace: None
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```
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### NOT AP_ctx: VGCC-PRE
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@@ -607,27 +591,27 @@ Qui disinguiamo:
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- da capire se serve veramente questa distinzione per il tempo di svuotamento.
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```Gen
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interacting: Ca2+ClearanceLow
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Ca2+ClearanceLow: ( active: 24x ) # Low
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type: accumulator
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contained_by: PRESYNAPSE
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in_context: NOT AP_ctx
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rf: ( active: 24x ) # Low
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hypothesis: (NOT Ca2+ fullness) AND (NOT Ca2+ empty)
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action: [Ca2+ decrease]
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trace: None
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hypothesis: (NOT Ca2+ fullness) AND (NOT Ca2+ empty)
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action: [Ca2+ decrease]
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trace: None
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```
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#### Ca2+ClearanceHigh: int: ms
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```Gen
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interacting: Ca2+ClearanceHigh
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Ca2+ClearanceHigh: ( active: 4x ) # High
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type: accumulator
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contained_by: PRESYNAPSE
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in_context: NOT AP_ctx
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rf: ( active: 4x ) # High
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hypothesis: NOT (Ca2+ empty)
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action: [Ca2+ decrease]
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trace: None
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```
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hypothesis: NOT (Ca2+ empty)
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action: [Ca2+ decrease]
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trace: None
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