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Sergio Marchetti
2026-05-04 10:29:21 +00:00
parent 72c3253830
commit 512cc96471
1 changed files with 118 additions and 134 deletions
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neuron/presynapse.md
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@@ -160,7 +160,8 @@ Questo serve per il medio/lungo periodo
```Gen
container: PRESYNAPSE
expansion: VGCC-PRE ( full: 10x, active: 5x, empty: 2x )
expansion:
- VGCC-PRE ( full: 10x, active: 5x, empty: 2x )
tub_local:
- Ca2+ ( full: 60x, active: 30x, empty: 0x )
@@ -177,7 +178,7 @@ container: PRESYNAPSE
- eCB ( contained_by: POST )
context_intricated:
- AP ( contained_by: SOMA )
- AP_ctx ( contained_by: SOMA )
```
### AP_ctx: PRESYNAPSE
@@ -202,7 +203,6 @@ In tutti i casi di NT
```Gen
NTreleaseLow: ( active: 12x ) # Low
type: accumulator
contained_by: PRESYNAPSE
@@ -217,12 +217,11 @@ NTreleaseLow: ( active: 12x ) # Low
In tutti i casi di NT
```Gen
interacting: NTreleaseMedium
NTreleaseMedium: ( active: 9x ) # Medium
type: accumulator
contained_by: PRESYNAPSE
in_context: AP_ctx
rf: ( active: 9x ) # Medium
hypothesis: (( Ca2+ fullness ) AND ( Rrp mediumness ) OR
( Ca2+ mediumness ) AND ( Rrp fullness )) AND
NOT( ATP empty )
@@ -233,12 +232,11 @@ interacting: NTreleaseMedium
#### NTreleaseHigh: int: ms
```Gen
interacting: NTreleaseHigh
NTreleaseHigh: ( active: 3x ) # High
type: accumulator
contained_by: PRESYNAPSE
in_context: AP_ctx
rf: ( active: 3x ) # High
hypothesis: ( Ca2+ fullness ) AND ( Rrp fullness ) AND
NOT( ATP empty )
action: [Rrp decrease, NT increase, ATP decrease]
@@ -259,12 +257,11 @@ Serve a:
---
```Gen
interacting: Ca2+TracesAccumulationLow
Ca2+TracesAccumulationLow: ( active: 10x )
type: accumulator
contained_by: PRESYNAPSE
in_context: AP_ctx
rf: ( active: 10x )
hypothesis: (Ca2+ emptiness)
action: [CaTraceLow increase]
trace: None
@@ -273,12 +270,11 @@ interacting: Ca2+TracesAccumulationLow
#### Ca2+TracesAccumulationMedium: int: ms
```Gen
interacting: Ca2+TracesAccumulationMedium
Ca2+TracesAccumulationMedium: ( active: 6x ) # medium
type: accumulator
contained_by: PRESYNAPSE
in_context: AP_ctx
rf: ( active: 10x )
hypothesis: (Ca2+ mediumness)
action: [CaTraceMed increase]
trace: None
@@ -288,12 +284,11 @@ interacting: Ca2+TracesAccumulationMedium
```Gen
interacting: Ca2+TracesAccumulationHigh
Ca2+TracesAccumulationHigh: ( active: 10x ) # high
type: accumulator
contained_by: PRESYNAPSE
in_context: AP_ctx
rf: ( active: 10x ) # high
hypothesis: (Ca2+ fullness)
action: [CaTraceHigh increase]
trace: None
@@ -308,12 +303,11 @@ eCB dipende da POST. Tende a modulare l'entrata di Ca2+ degli VGCC.
Qui non facciamo un flush di eCB, riduciamo ogni mezzo secondo (context) di un RF di questo episodio.
```Gen
interacting: eCBClearance
eCBClearance: ( active: 24x ) # Slow
type: accumulator
contained_by: PRESYNAPSE
in_context: NOT AP_ctx
rf: ( active: 24x ) # Slow
hypothesis: NOT (eCB empty)
action: [eCB decrease]
trace: None
@@ -328,12 +322,11 @@ The "Hard Bottleneck" State. Recruitment is throttled by a lack of signal, a lac
Rate: 0.00 – 0.25
```Gen
interacting: RPShuttleLow
RPShuttleLow: ( active: 48x ) # Low
type: accumulator
contained_by: PRESYNAPSE
in_context: NOT AP_ctx
rf: ( active: 48x ) # Low
hypothesis: (CaTraceLow fullness) OR
(RP emptiness) OR
(RRP fullness)
@@ -348,12 +341,11 @@ The "Sub-Optimal" State. The machinery is working, but it's held back by partial
Rate: 0.50 – 0.97
```Gen
interacting: RPShuttleMedium
RPShuttleMedium: ( active: 24x ) # Medium
type: accumulator
contained_by: PRESYNAPSE
in_context: AP_ctx
rf: ( active: 24x ) # Medium
hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (RRP mediumness) OR
(CaTraceHigh fullness) AND (RP mediumness) AND (RRP mediumness) OR # signal boost
(CaTraceMedium fullness) AND (RP fullness) AND (RRP mediumness) OR # supply boost
@@ -369,12 +361,11 @@ The "High Performance" State. Multiple systems are optimized, but one is still a
Rate: 1.25 – 1.94
```Gen
interacting: RPShuttleHigh
RPShuttleHigh: ( active: 12x ) # Fast
type: accumulator
contained_by: PRESYNAPSE
in_context: AP_ctx
rf: ( active: 12x ) # Fast
hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (RRP mediumness) OR # signal + supply
(CaTraceHigh fullness) AND (RP mediumness) AND (RRP emptiness) OR # signal + vacancy
(CaTraceMedium fullness) AND (RP fullness) AND (RRP emptiness) # supply + vacancy
@@ -419,12 +410,11 @@ Each tier buys time for the one below it to respond. When all three are depleted
Qui facciamo un flush di CaTraceX. Deve essere fatto a valle del tuning.
```Gen
interacting: Ca2+TracesClearance
Ca2+TracesClearance: ( active: 30x ) # Slow
type: accumulator
contained_by: PRESYNAPSE
in_context: NOT TunPossible_ctx
rf: ( active: 30x ) # Slow
hypothesis: NOT (CaTraceHigh empty)
action: [CaTRaceHigh decrease]
trace: None
@@ -441,10 +431,9 @@ interacting: Ca2+TracesClearance
## VGCC-PRE-TUN: Tuner
```Gen
tuner: VGCC-PRE-TUN
VGCC-PRE-TUN
type: tuner
# qui stiamo aggiungendo o eliminando VGCC-PRE. Fra un massimo full e minimo empty (empty puo' non essere 0)
# contained_by: PRESYNAPSE non e' contenuto, si attacca.
tunes: PRESYNAPSE/expansion/VCGG-PRE
@@ -467,12 +456,11 @@ tuner: VGCC-PRE-TUN
Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantita' di VGCC
```Gen
contexting: CheckVgccPreTun
CheckVgccPreTun: ( active: 60x )
type: contexting
contained_by: VGCC-PRE-TUN
in_context: TunPossible_ctx
rf: ( active: 60x )
condition: ( CaTraceHigh fullness )
out_context: TryTunUpPreVcgg_ctx
@@ -483,12 +471,11 @@ contexting: CheckVgccPreTun
#### PossibleUpPreVgccTun: int: sec
```Gen
interacting: PossibleUpPreVgccTun
PossibleUpPreVgccTun: ( active: 10x )
type: accumulator
contained_by: VGCC-PRE-TUN
in_context: TryTunUpPreVcgg_ctx
rf: ( active: 10x )
hypothesis:
action:
trace:
@@ -497,12 +484,11 @@ interacting: PossibleUpPreVgccTun
#### PossibleDownPreVgccTun: int: sec
```Gen
interacting: PossibleDownPreVgccTun
PossibleDownPreVgccTun: ( active: 10x )
type: accumulator
contained_by: VGCC-PRE-TUN
in_context: TryTunDownPreVcgg_ctx
rf: ( active: 10x )
hypothesis:
action:
trace:
@@ -513,7 +499,8 @@ interacting: PossibleDownPreVgccTun
Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare.
```Gen
container: VGCC-PRE
VGCC-PRE
type: container
tub_intricated:
- Ca2+ ( contained_by: PRESYNAPSE )
@@ -548,12 +535,11 @@ Qui semplifichiamo:
Devo controllare che le condizioni sotto siano esaustive. Qui ho confuso high con low, e inoltre ho messo NT per mGluR che devo controllare che abbia senso.
```Gen
interacting: Ca2+enterLow
Ca2+enterLow: ( active: 12x ) # Low
type: accumulator
contained_by: VGCC-PRE
in_context: AP_ctx
rf: ( active: 12x ) # Low
hypothesis: (Ca2+ empty) AND (eCB empty)
action: [Ca2+ increase, ATP decrease]
trace: None
@@ -562,12 +548,11 @@ interacting: Ca2+enterLow
#### Ca2+enterMedium: int: ms
```Gen
interacting: Ca2+enterMedium
Ca2+enterMedium: ( active: 6x ) # Medium
type: accumulator
contained_by: VGCC-PRE
in_context: AP_ctx
rf: ( active: 6x ) # Medium
hypothesis: (Ca2+ mediumness) OR
((eCB mediumness) AND (Ca2+ empty)) OR
((eCB full) AND (Ca2+ empty) AND (NT empty))
@@ -578,12 +563,11 @@ interacting: Ca2+enterMedium
#### Ca2+enterHigh: int: ms
```Gen
interacting: Ca2+enterHigh
Ca2+enterHigh: ( active: 3x ) # High
type: accumulator
contained_by: VGCC-PRE
in_context: AP_ctx
rf: ( active: 3x ) # High
hypothesis: (Ca2+ mediumness) AND (eCB full) OR
(eCB mediumness)
action: [Ca2+ increase, ATP decrease]
@@ -607,12 +591,11 @@ Qui disinguiamo:
- da capire se serve veramente questa distinzione per il tempo di svuotamento.
```Gen
interacting: Ca2+ClearanceLow
Ca2+ClearanceLow: ( active: 24x ) # Low
type: accumulator
contained_by: PRESYNAPSE
in_context: NOT AP_ctx
rf: ( active: 24x ) # Low
hypothesis: (NOT Ca2+ fullness) AND (NOT Ca2+ empty)
action: [Ca2+ decrease]
trace: None
@@ -621,13 +604,14 @@ interacting: Ca2+ClearanceLow
#### Ca2+ClearanceHigh: int: ms
```Gen
interacting: Ca2+ClearanceHigh
Ca2+ClearanceHigh: ( active: 4x ) # High
type: accumulator
contained_by: PRESYNAPSE
in_context: NOT AP_ctx
rf: ( active: 4x ) # High
hypothesis: NOT (Ca2+ empty)
action: [Ca2+ decrease]
trace: None
```