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Sergio Marchetti
2026-05-04 10:29:21 +00:00
parent 72c3253830
commit 512cc96471
1 changed files with 118 additions and 134 deletions
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@@ -160,7 +160,8 @@ Questo serve per il medio/lungo periodo
```Gen ```Gen
container: PRESYNAPSE container: PRESYNAPSE
expansion: VGCC-PRE ( full: 10x, active: 5x, empty: 2x ) expansion:
- VGCC-PRE ( full: 10x, active: 5x, empty: 2x )
tub_local: tub_local:
- Ca2+ ( full: 60x, active: 30x, empty: 0x ) - Ca2+ ( full: 60x, active: 30x, empty: 0x )
@@ -177,7 +178,7 @@ container: PRESYNAPSE
- eCB ( contained_by: POST ) - eCB ( contained_by: POST )
context_intricated: context_intricated:
- AP ( contained_by: SOMA ) - AP_ctx ( contained_by: SOMA )
``` ```
### AP_ctx: PRESYNAPSE ### AP_ctx: PRESYNAPSE
@@ -202,7 +203,6 @@ In tutti i casi di NT
```Gen ```Gen
NTreleaseLow: ( active: 12x ) # Low NTreleaseLow: ( active: 12x ) # Low
type: accumulator type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
@@ -217,32 +217,30 @@ NTreleaseLow: ( active: 12x ) # Low
In tutti i casi di NT In tutti i casi di NT
```Gen ```Gen
interacting: NTreleaseMedium NTreleaseMedium: ( active: 9x ) # Medium
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 9x ) # Medium hypothesis: (( Ca2+ fullness ) AND ( Rrp mediumness ) OR
( Ca2+ mediumness ) AND ( Rrp fullness )) AND
hypothesis: (( Ca2+ fullness ) AND ( Rrp mediumness ) OR NOT( ATP empty )
( Ca2+ mediumness ) AND ( Rrp fullness )) AND action: [Rrp decrease, Nt increase, ATP decrease]
NOT( ATP empty ) trace: None
action: [Rrp decrease, Nt increase, ATP decrease]
trace: None
``` ```
#### NTreleaseHigh: int: ms #### NTreleaseHigh: int: ms
```Gen ```Gen
interacting: NTreleaseHigh NTreleaseHigh: ( active: 3x ) # High
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 3x ) # High hypothesis: ( Ca2+ fullness ) AND ( Rrp fullness ) AND
NOT( ATP empty )
hypothesis: ( Ca2+ fullness ) AND ( Rrp fullness ) AND action: [Rrp decrease, NT increase, ATP decrease]
NOT( ATP empty ) trace: None
action: [Rrp decrease, NT increase, ATP decrease]
trace: None
``` ```
#### Ca2+TracesAccumulationLow: int: ms #### Ca2+TracesAccumulationLow: int: ms
@@ -259,44 +257,41 @@ Serve a:
--- ---
```Gen ```Gen
interacting: Ca2+TracesAccumulationLow Ca2+TracesAccumulationLow: ( active: 10x )
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 10x ) hypothesis: (Ca2+ emptiness)
action: [CaTraceLow increase]
hypothesis: (Ca2+ emptiness) trace: None
action: [CaTraceLow increase]
trace: None
``` ```
#### Ca2+TracesAccumulationMedium: int: ms #### Ca2+TracesAccumulationMedium: int: ms
```Gen ```Gen
interacting: Ca2+TracesAccumulationMedium Ca2+TracesAccumulationMedium: ( active: 6x ) # medium
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 10x ) hypothesis: (Ca2+ mediumness)
action: [CaTraceMed increase]
hypothesis: (Ca2+ mediumness) trace: None
action: [CaTraceMed increase]
trace: None
``` ```
#### Ca2+TracesAccumulationHigh: int: ms #### Ca2+TracesAccumulationHigh: int: ms
```Gen ```Gen
interacting: Ca2+TracesAccumulationHigh Ca2+TracesAccumulationHigh: ( active: 10x ) # high
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 10x ) # high hypothesis: (Ca2+ fullness)
action: [CaTraceHigh increase]
hypothesis: (Ca2+ fullness) trace: None
action: [CaTraceHigh increase]
trace: None
``` ```
### NOT AP_ctx: PRESYNAPSE ### NOT AP_ctx: PRESYNAPSE
@@ -308,15 +303,14 @@ eCB dipende da POST. Tende a modulare l'entrata di Ca2+ degli VGCC.
Qui non facciamo un flush di eCB, riduciamo ogni mezzo secondo (context) di un RF di questo episodio. Qui non facciamo un flush di eCB, riduciamo ogni mezzo secondo (context) di un RF di questo episodio.
```Gen ```Gen
interacting: eCBClearance eCBClearance: ( active: 24x ) # Slow
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: NOT AP_ctx in_context: NOT AP_ctx
rf: ( active: 24x ) # Slow hypothesis: NOT (eCB empty)
action: [eCB decrease]
hypothesis: NOT (eCB empty) trace: None
action: [eCB decrease]
trace: None
``` ```
#### RPShuttleLow: int: sec #### RPShuttleLow: int: sec
@@ -328,17 +322,16 @@ The "Hard Bottleneck" State. Recruitment is throttled by a lack of signal, a lac
Rate: 0.00 – 0.25 Rate: 0.00 – 0.25
```Gen ```Gen
interacting: RPShuttleLow RPShuttleLow: ( active: 48x ) # Low
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: NOT AP_ctx in_context: NOT AP_ctx
rf: ( active: 48x ) # Low hypothesis: (CaTraceLow fullness) OR
(RP emptiness) OR
hypothesis: (CaTraceLow fullness) OR (RRP fullness)
(RP emptiness) OR action: [RP decrease, RRP increase]
(RRP fullness) trace: None
action: [RP decrease, RRP increase]
trace: None
``` ```
#### RPShuttleMedium: int: sec #### RPShuttleMedium: int: sec
@@ -348,18 +341,17 @@ The "Sub-Optimal" State. The machinery is working, but it's held back by partial
Rate: 0.50 – 0.97 Rate: 0.50 – 0.97
```Gen ```Gen
interacting: RPShuttleMedium RPShuttleMedium: ( active: 24x ) # Medium
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 24x ) # Medium hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (RRP mediumness) OR
(CaTraceHigh fullness) AND (RP mediumness) AND (RRP mediumness) OR # signal boost
hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (RRP mediumness) OR (CaTraceMedium fullness) AND (RP fullness) AND (RRP mediumness) OR # supply boost
(CaTraceHigh fullness) AND (RP mediumness) AND (RRP mediumness) OR # signal boost (CaTraceMedium fullness) AND (RP mediumness) AND (RRP emptiness) # vacancy boost
(CaTraceMedium fullness) AND (RP fullness) AND (RRP mediumness) OR # supply boost action: [RP decrease, RRP increase]
(CaTraceMedium fullness) AND (RP mediumness) AND (RRP emptiness) # vacancy boost trace: None
action: [RP decrease, RRP increase]
trace: None
``` ```
#### RPShuttleHigh: int: sec #### RPShuttleHigh: int: sec
@@ -369,17 +361,16 @@ The "High Performance" State. Multiple systems are optimized, but one is still a
Rate: 1.25 – 1.94 Rate: 1.25 – 1.94
```Gen ```Gen
interacting: RPShuttleHigh RPShuttleHigh: ( active: 12x ) # Fast
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 12x ) # Fast hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (RRP mediumness) OR # signal + supply
(CaTraceHigh fullness) AND (RP mediumness) AND (RRP emptiness) OR # signal + vacancy
hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (RRP mediumness) OR # signal + supply (CaTraceMedium fullness) AND (RP fullness) AND (RRP emptiness) # supply + vacancy
(CaTraceHigh fullness) AND (RP mediumness) AND (RRP emptiness) OR # signal + vacancy action: [RP decrease, RRP increase]
(CaTraceMedium fullness) AND (RP fullness) AND (RRP emptiness) # supply + vacancy trace: None
action: [RP decrease, RRP increase]
trace: None
``` ```
#### RefillRPGlutamine: int: min #### RefillRPGlutamine: int: min
@@ -419,32 +410,30 @@ Each tier buys time for the one below it to respond. When all three are depleted
Qui facciamo un flush di CaTraceX. Deve essere fatto a valle del tuning. Qui facciamo un flush di CaTraceX. Deve essere fatto a valle del tuning.
```Gen ```Gen
interacting: Ca2+TracesClearance Ca2+TracesClearance: ( active: 30x ) # Slow
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: NOT TunPossible_ctx in_context: NOT TunPossible_ctx
rf: ( active: 30x ) # Slow hypothesis: NOT (CaTraceHigh empty)
action: [CaTRaceHigh decrease]
trace: None
hypothesis: NOT (CaTraceHigh empty) hypothesis: NOT (CaTraceMedium empty)
action: [CaTRaceHigh decrease] action: [CaTRaceMedium decrease]
trace: None trace: None
hypothesis: NOT (CaTraceMedium empty) hypothesis: NOT (CaTraceLow empty)
action: [CaTRaceMedium decrease] action: [CaTRaceLow decrease]
trace: None trace: None
hypothesis: NOT (CaTraceLow empty)
action: [CaTRaceLow decrease]
trace: None
``` ```
## VGCC-PRE-TUN: Tuner ## VGCC-PRE-TUN: Tuner
```Gen ```Gen
tuner: VGCC-PRE-TUN VGCC-PRE-TUN
type: tuner
# qui stiamo aggiungendo o eliminando VGCC-PRE. Fra un massimo full e minimo empty (empty puo' non essere 0) # qui stiamo aggiungendo o eliminando VGCC-PRE. Fra un massimo full e minimo empty (empty puo' non essere 0)
# contained_by: PRESYNAPSE non e' contenuto, si attacca. # contained_by: PRESYNAPSE non e' contenuto, si attacca.
tunes: PRESYNAPSE/expansion/VCGG-PRE tunes: PRESYNAPSE/expansion/VCGG-PRE
@@ -467,45 +456,42 @@ tuner: VGCC-PRE-TUN
Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantita' di VGCC Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantita' di VGCC
```Gen ```Gen
contexting: CheckVgccPreTun CheckVgccPreTun: ( active: 60x )
type: contexting
contained_by: VGCC-PRE-TUN contained_by: VGCC-PRE-TUN
in_context: TunPossible_ctx in_context: TunPossible_ctx
rf: ( active: 60x ) condition: ( CaTraceHigh fullness )
out_context: TryTunUpPreVcgg_ctx
condition: ( CaTraceHigh fullness ) condition: ( CaTraceLow fullness )
out_context: TryTunUpPreVcgg_ctx out_context: TryTunDownPreVcgg_ctx
condition: ( CaTraceLow fullness )
out_context: TryTunDownPreVcgg_ctx
``` ```
#### PossibleUpPreVgccTun: int: sec #### PossibleUpPreVgccTun: int: sec
```Gen ```Gen
interacting: PossibleUpPreVgccTun PossibleUpPreVgccTun: ( active: 10x )
type: accumulator
contained_by: VGCC-PRE-TUN contained_by: VGCC-PRE-TUN
in_context: TryTunUpPreVcgg_ctx in_context: TryTunUpPreVcgg_ctx
rf: ( active: 10x ) hypothesis:
action:
hypothesis: trace:
action:
trace:
``` ```
#### PossibleDownPreVgccTun: int: sec #### PossibleDownPreVgccTun: int: sec
```Gen ```Gen
interacting: PossibleDownPreVgccTun PossibleDownPreVgccTun: ( active: 10x )
type: accumulator
contained_by: VGCC-PRE-TUN contained_by: VGCC-PRE-TUN
in_context: TryTunDownPreVcgg_ctx in_context: TryTunDownPreVcgg_ctx
rf: ( active: 10x ) hypothesis:
action:
hypothesis: trace:
action:
trace:
``` ```
## VGCC-PRE: Container ## VGCC-PRE: Container
@@ -513,7 +499,8 @@ interacting: PossibleDownPreVgccTun
Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare. Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare.
```Gen ```Gen
container: VGCC-PRE VGCC-PRE
type: container
tub_intricated: tub_intricated:
- Ca2+ ( contained_by: PRESYNAPSE ) - Ca2+ ( contained_by: PRESYNAPSE )
@@ -548,46 +535,43 @@ Qui semplifichiamo:
Devo controllare che le condizioni sotto siano esaustive. Qui ho confuso high con low, e inoltre ho messo NT per mGluR che devo controllare che abbia senso. Devo controllare che le condizioni sotto siano esaustive. Qui ho confuso high con low, e inoltre ho messo NT per mGluR che devo controllare che abbia senso.
```Gen ```Gen
interacting: Ca2+enterLow Ca2+enterLow: ( active: 12x ) # Low
type: accumulator
contained_by: VGCC-PRE contained_by: VGCC-PRE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 12x ) # Low hypothesis: (Ca2+ empty) AND (eCB empty)
action: [Ca2+ increase, ATP decrease]
hypothesis: (Ca2+ empty) AND (eCB empty) trace: None
action: [Ca2+ increase, ATP decrease]
trace: None
``` ```
#### Ca2+enterMedium: int: ms #### Ca2+enterMedium: int: ms
```Gen ```Gen
interacting: Ca2+enterMedium Ca2+enterMedium: ( active: 6x ) # Medium
type: accumulator
contained_by: VGCC-PRE contained_by: VGCC-PRE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 6x ) # Medium hypothesis: (Ca2+ mediumness) OR
((eCB mediumness) AND (Ca2+ empty)) OR
hypothesis: (Ca2+ mediumness) OR ((eCB full) AND (Ca2+ empty) AND (NT empty))
((eCB mediumness) AND (Ca2+ empty)) OR action: [Ca2+ increase, ATP decrease]
((eCB full) AND (Ca2+ empty) AND (NT empty)) trace: None
action: [Ca2+ increase, ATP decrease]
trace: None
``` ```
#### Ca2+enterHigh: int: ms #### Ca2+enterHigh: int: ms
```Gen ```Gen
interacting: Ca2+enterHigh Ca2+enterHigh: ( active: 3x ) # High
type: accumulator
contained_by: VGCC-PRE contained_by: VGCC-PRE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 3x ) # High hypothesis: (Ca2+ mediumness) AND (eCB full) OR
(eCB mediumness)
hypothesis: (Ca2+ mediumness) AND (eCB full) OR action: [Ca2+ increase, ATP decrease]
(eCB mediumness) trace: None
action: [Ca2+ increase, ATP decrease]
trace: None
``` ```
### NOT AP_ctx: VGCC-PRE ### NOT AP_ctx: VGCC-PRE
@@ -607,27 +591,27 @@ Qui disinguiamo:
- da capire se serve veramente questa distinzione per il tempo di svuotamento. - da capire se serve veramente questa distinzione per il tempo di svuotamento.
```Gen ```Gen
interacting: Ca2+ClearanceLow Ca2+ClearanceLow: ( active: 24x ) # Low
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: NOT AP_ctx in_context: NOT AP_ctx
rf: ( active: 24x ) # Low hypothesis: (NOT Ca2+ fullness) AND (NOT Ca2+ empty)
action: [Ca2+ decrease]
hypothesis: (NOT Ca2+ fullness) AND (NOT Ca2+ empty) trace: None
action: [Ca2+ decrease]
trace: None
``` ```
#### Ca2+ClearanceHigh: int: ms #### Ca2+ClearanceHigh: int: ms
```Gen ```Gen
interacting: Ca2+ClearanceHigh Ca2+ClearanceHigh: ( active: 4x ) # High
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: NOT AP_ctx in_context: NOT AP_ctx
rf: ( active: 4x ) # High hypothesis: NOT (Ca2+ empty)
action: [Ca2+ decrease]
trace: None
```
hypothesis: NOT (Ca2+ empty)
action: [Ca2+ decrease]
trace: None