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Sergio Marchetti
2026-05-04 10:29:21 +00:00
parent 72c3253830
commit 512cc96471
1 changed files with 118 additions and 134 deletions
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neuron/presynapse.md
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@@ -160,7 +160,8 @@ Questo serve per il medio/lungo periodo
```Gen ```Gen
container: PRESYNAPSE container: PRESYNAPSE
expansion: VGCC-PRE ( full: 10x, active: 5x, empty: 2x ) expansion:
- VGCC-PRE ( full: 10x, active: 5x, empty: 2x )
tub_local: tub_local:
- Ca2+ ( full: 60x, active: 30x, empty: 0x ) - Ca2+ ( full: 60x, active: 30x, empty: 0x )
@@ -177,7 +178,7 @@ container: PRESYNAPSE
- eCB ( contained_by: POST ) - eCB ( contained_by: POST )
context_intricated: context_intricated:
- AP ( contained_by: SOMA ) - AP_ctx ( contained_by: SOMA )
``` ```
### AP_ctx: PRESYNAPSE ### AP_ctx: PRESYNAPSE
@@ -202,7 +203,6 @@ In tutti i casi di NT
```Gen ```Gen
NTreleaseLow: ( active: 12x ) # Low NTreleaseLow: ( active: 12x ) # Low
type: accumulator type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
@@ -217,12 +217,11 @@ NTreleaseLow: ( active: 12x ) # Low
In tutti i casi di NT In tutti i casi di NT
```Gen ```Gen
interacting: NTreleaseMedium NTreleaseMedium: ( active: 9x ) # Medium
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 9x ) # Medium
hypothesis: (( Ca2+ fullness ) AND ( Rrp mediumness ) OR hypothesis: (( Ca2+ fullness ) AND ( Rrp mediumness ) OR
( Ca2+ mediumness ) AND ( Rrp fullness )) AND ( Ca2+ mediumness ) AND ( Rrp fullness )) AND
NOT( ATP empty ) NOT( ATP empty )
@@ -233,12 +232,11 @@ interacting: NTreleaseMedium
#### NTreleaseHigh: int: ms #### NTreleaseHigh: int: ms
```Gen ```Gen
interacting: NTreleaseHigh NTreleaseHigh: ( active: 3x ) # High
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 3x ) # High
hypothesis: ( Ca2+ fullness ) AND ( Rrp fullness ) AND hypothesis: ( Ca2+ fullness ) AND ( Rrp fullness ) AND
NOT( ATP empty ) NOT( ATP empty )
action: [Rrp decrease, NT increase, ATP decrease] action: [Rrp decrease, NT increase, ATP decrease]
@@ -259,12 +257,11 @@ Serve a:
--- ---
```Gen ```Gen
interacting: Ca2+TracesAccumulationLow Ca2+TracesAccumulationLow: ( active: 10x )
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 10x )
hypothesis: (Ca2+ emptiness) hypothesis: (Ca2+ emptiness)
action: [CaTraceLow increase] action: [CaTraceLow increase]
trace: None trace: None
@@ -273,12 +270,11 @@ interacting: Ca2+TracesAccumulationLow
#### Ca2+TracesAccumulationMedium: int: ms #### Ca2+TracesAccumulationMedium: int: ms
```Gen ```Gen
interacting: Ca2+TracesAccumulationMedium Ca2+TracesAccumulationMedium: ( active: 6x ) # medium
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 10x )
hypothesis: (Ca2+ mediumness) hypothesis: (Ca2+ mediumness)
action: [CaTraceMed increase] action: [CaTraceMed increase]
trace: None trace: None
@@ -288,12 +284,11 @@ interacting: Ca2+TracesAccumulationMedium
```Gen ```Gen
interacting: Ca2+TracesAccumulationHigh Ca2+TracesAccumulationHigh: ( active: 10x ) # high
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 10x ) # high
hypothesis: (Ca2+ fullness) hypothesis: (Ca2+ fullness)
action: [CaTraceHigh increase] action: [CaTraceHigh increase]
trace: None trace: None
@@ -308,12 +303,11 @@ eCB dipende da POST. Tende a modulare l'entrata di Ca2+ degli VGCC.
Qui non facciamo un flush di eCB, riduciamo ogni mezzo secondo (context) di un RF di questo episodio. Qui non facciamo un flush di eCB, riduciamo ogni mezzo secondo (context) di un RF di questo episodio.
```Gen ```Gen
interacting: eCBClearance eCBClearance: ( active: 24x ) # Slow
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: NOT AP_ctx in_context: NOT AP_ctx
rf: ( active: 24x ) # Slow
hypothesis: NOT (eCB empty) hypothesis: NOT (eCB empty)
action: [eCB decrease] action: [eCB decrease]
trace: None trace: None
@@ -328,12 +322,11 @@ The "Hard Bottleneck" State. Recruitment is throttled by a lack of signal, a lac
Rate: 0.00 – 0.25 Rate: 0.00 – 0.25
```Gen ```Gen
interacting: RPShuttleLow RPShuttleLow: ( active: 48x ) # Low
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: NOT AP_ctx in_context: NOT AP_ctx
rf: ( active: 48x ) # Low
hypothesis: (CaTraceLow fullness) OR hypothesis: (CaTraceLow fullness) OR
(RP emptiness) OR (RP emptiness) OR
(RRP fullness) (RRP fullness)
@@ -348,12 +341,11 @@ The "Sub-Optimal" State. The machinery is working, but it's held back by partial
Rate: 0.50 – 0.97 Rate: 0.50 – 0.97
```Gen ```Gen
interacting: RPShuttleMedium RPShuttleMedium: ( active: 24x ) # Medium
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 24x ) # Medium
hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (RRP mediumness) OR hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (RRP mediumness) OR
(CaTraceHigh fullness) AND (RP mediumness) AND (RRP mediumness) OR # signal boost (CaTraceHigh fullness) AND (RP mediumness) AND (RRP mediumness) OR # signal boost
(CaTraceMedium fullness) AND (RP fullness) AND (RRP mediumness) OR # supply boost (CaTraceMedium fullness) AND (RP fullness) AND (RRP mediumness) OR # supply boost
@@ -369,12 +361,11 @@ The "High Performance" State. Multiple systems are optimized, but one is still a
Rate: 1.25 – 1.94 Rate: 1.25 – 1.94
```Gen ```Gen
interacting: RPShuttleHigh RPShuttleHigh: ( active: 12x ) # Fast
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 12x ) # Fast
hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (RRP mediumness) OR # signal + supply hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (RRP mediumness) OR # signal + supply
(CaTraceHigh fullness) AND (RP mediumness) AND (RRP emptiness) OR # signal + vacancy (CaTraceHigh fullness) AND (RP mediumness) AND (RRP emptiness) OR # signal + vacancy
(CaTraceMedium fullness) AND (RP fullness) AND (RRP emptiness) # supply + vacancy (CaTraceMedium fullness) AND (RP fullness) AND (RRP emptiness) # supply + vacancy
@@ -419,12 +410,11 @@ Each tier buys time for the one below it to respond. When all three are depleted
Qui facciamo un flush di CaTraceX. Deve essere fatto a valle del tuning. Qui facciamo un flush di CaTraceX. Deve essere fatto a valle del tuning.
```Gen ```Gen
interacting: Ca2+TracesClearance Ca2+TracesClearance: ( active: 30x ) # Slow
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: NOT TunPossible_ctx in_context: NOT TunPossible_ctx
rf: ( active: 30x ) # Slow
hypothesis: NOT (CaTraceHigh empty) hypothesis: NOT (CaTraceHigh empty)
action: [CaTRaceHigh decrease] action: [CaTRaceHigh decrease]
trace: None trace: None
@@ -441,10 +431,9 @@ interacting: Ca2+TracesClearance
## VGCC-PRE-TUN: Tuner ## VGCC-PRE-TUN: Tuner
```Gen ```Gen
tuner: VGCC-PRE-TUN VGCC-PRE-TUN
type: tuner
# qui stiamo aggiungendo o eliminando VGCC-PRE. Fra un massimo full e minimo empty (empty puo' non essere 0) # qui stiamo aggiungendo o eliminando VGCC-PRE. Fra un massimo full e minimo empty (empty puo' non essere 0)
# contained_by: PRESYNAPSE non e' contenuto, si attacca. # contained_by: PRESYNAPSE non e' contenuto, si attacca.
tunes: PRESYNAPSE/expansion/VCGG-PRE tunes: PRESYNAPSE/expansion/VCGG-PRE
@@ -467,12 +456,11 @@ tuner: VGCC-PRE-TUN
Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantita' di VGCC Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantita' di VGCC
```Gen ```Gen
contexting: CheckVgccPreTun CheckVgccPreTun: ( active: 60x )
type: contexting
contained_by: VGCC-PRE-TUN contained_by: VGCC-PRE-TUN
in_context: TunPossible_ctx in_context: TunPossible_ctx
rf: ( active: 60x )
condition: ( CaTraceHigh fullness ) condition: ( CaTraceHigh fullness )
out_context: TryTunUpPreVcgg_ctx out_context: TryTunUpPreVcgg_ctx
@@ -483,12 +471,11 @@ contexting: CheckVgccPreTun
#### PossibleUpPreVgccTun: int: sec #### PossibleUpPreVgccTun: int: sec
```Gen ```Gen
interacting: PossibleUpPreVgccTun PossibleUpPreVgccTun: ( active: 10x )
type: accumulator
contained_by: VGCC-PRE-TUN contained_by: VGCC-PRE-TUN
in_context: TryTunUpPreVcgg_ctx in_context: TryTunUpPreVcgg_ctx
rf: ( active: 10x )
hypothesis: hypothesis:
action: action:
trace: trace:
@@ -497,12 +484,11 @@ interacting: PossibleUpPreVgccTun
#### PossibleDownPreVgccTun: int: sec #### PossibleDownPreVgccTun: int: sec
```Gen ```Gen
interacting: PossibleDownPreVgccTun PossibleDownPreVgccTun: ( active: 10x )
type: accumulator
contained_by: VGCC-PRE-TUN contained_by: VGCC-PRE-TUN
in_context: TryTunDownPreVcgg_ctx in_context: TryTunDownPreVcgg_ctx
rf: ( active: 10x )
hypothesis: hypothesis:
action: action:
trace: trace:
@@ -513,7 +499,8 @@ interacting: PossibleDownPreVgccTun
Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare. Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare.
```Gen ```Gen
container: VGCC-PRE VGCC-PRE
type: container
tub_intricated: tub_intricated:
- Ca2+ ( contained_by: PRESYNAPSE ) - Ca2+ ( contained_by: PRESYNAPSE )
@@ -548,12 +535,11 @@ Qui semplifichiamo:
Devo controllare che le condizioni sotto siano esaustive. Qui ho confuso high con low, e inoltre ho messo NT per mGluR che devo controllare che abbia senso. Devo controllare che le condizioni sotto siano esaustive. Qui ho confuso high con low, e inoltre ho messo NT per mGluR che devo controllare che abbia senso.
```Gen ```Gen
interacting: Ca2+enterLow Ca2+enterLow: ( active: 12x ) # Low
type: accumulator
contained_by: VGCC-PRE contained_by: VGCC-PRE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 12x ) # Low
hypothesis: (Ca2+ empty) AND (eCB empty) hypothesis: (Ca2+ empty) AND (eCB empty)
action: [Ca2+ increase, ATP decrease] action: [Ca2+ increase, ATP decrease]
trace: None trace: None
@@ -562,12 +548,11 @@ interacting: Ca2+enterLow
#### Ca2+enterMedium: int: ms #### Ca2+enterMedium: int: ms
```Gen ```Gen
interacting: Ca2+enterMedium Ca2+enterMedium: ( active: 6x ) # Medium
type: accumulator
contained_by: VGCC-PRE contained_by: VGCC-PRE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 6x ) # Medium
hypothesis: (Ca2+ mediumness) OR hypothesis: (Ca2+ mediumness) OR
((eCB mediumness) AND (Ca2+ empty)) OR ((eCB mediumness) AND (Ca2+ empty)) OR
((eCB full) AND (Ca2+ empty) AND (NT empty)) ((eCB full) AND (Ca2+ empty) AND (NT empty))
@@ -578,12 +563,11 @@ interacting: Ca2+enterMedium
#### Ca2+enterHigh: int: ms #### Ca2+enterHigh: int: ms
```Gen ```Gen
interacting: Ca2+enterHigh Ca2+enterHigh: ( active: 3x ) # High
type: accumulator
contained_by: VGCC-PRE contained_by: VGCC-PRE
in_context: AP_ctx in_context: AP_ctx
rf: ( active: 3x ) # High
hypothesis: (Ca2+ mediumness) AND (eCB full) OR hypothesis: (Ca2+ mediumness) AND (eCB full) OR
(eCB mediumness) (eCB mediumness)
action: [Ca2+ increase, ATP decrease] action: [Ca2+ increase, ATP decrease]
@@ -607,12 +591,11 @@ Qui disinguiamo:
- da capire se serve veramente questa distinzione per il tempo di svuotamento. - da capire se serve veramente questa distinzione per il tempo di svuotamento.
```Gen ```Gen
interacting: Ca2+ClearanceLow Ca2+ClearanceLow: ( active: 24x ) # Low
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: NOT AP_ctx in_context: NOT AP_ctx
rf: ( active: 24x ) # Low
hypothesis: (NOT Ca2+ fullness) AND (NOT Ca2+ empty) hypothesis: (NOT Ca2+ fullness) AND (NOT Ca2+ empty)
action: [Ca2+ decrease] action: [Ca2+ decrease]
trace: None trace: None
@@ -621,13 +604,14 @@ interacting: Ca2+ClearanceLow
#### Ca2+ClearanceHigh: int: ms #### Ca2+ClearanceHigh: int: ms
```Gen ```Gen
interacting: Ca2+ClearanceHigh Ca2+ClearanceHigh: ( active: 4x ) # High
type: accumulator
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: NOT AP_ctx in_context: NOT AP_ctx
rf: ( active: 4x ) # High
hypothesis: NOT (Ca2+ empty) hypothesis: NOT (Ca2+ empty)
action: [Ca2+ decrease] action: [Ca2+ decrease]
trace: None trace: None
```