From 51098e995acdd4821a5ad556d4eaba8ec8436cc1 Mon Sep 17 00:00:00 2001 From: Sergio Marchetti Date: Sat, 2 May 2026 18:27:35 +0000 Subject: [PATCH] Edit postsynapse.md --- neuron/postsynapse.md | 217 ++++++++++++++++-------------------------- 1 file changed, 83 insertions(+), 134 deletions(-) diff --git a/neuron/postsynapse.md b/neuron/postsynapse.md index 651b28d..fa33326 100644 --- a/neuron/postsynapse.md +++ b/neuron/postsynapse.md @@ -44,36 +44,36 @@ POSTSYNAPSE bAP_ctx ms -- Ca Influx - CaNDMAEnterMax: interacting - CaNDMAEnterMed: interacting + CaNDMAEnterMax: accumulator + CaNDMAEnterMed: accumulator NOT bAP_ctx: ms -- Ca Influx - CaNDMAEnterMedNotBap: interacting - CaNDMAEnterLow: interacting + CaNDMAEnterMedNotBap: accumulator + CaNDMAEnterLow: accumulator -- Ca Clearence - CaClearance: interacting + CaClearance: accumulator -- V Influx - VPostMax: interacting - VPostMed: interacting - VPostLow: interacting + VPostMax: accumulator + VPostMed: accumulator + VPostLow: accumulator -- V Clearence - VPostClearance: interacting + VPostClearance: accumulator POST-AMPA NOT bAP_ctx ms -- Na Influx - NaAMPAEnterMax: interacting - NaAMPAEnterMed: interacting + NaAMPAEnterMax: accumulator + NaAMPAEnterMed: accumulator POST-NA-CLEAR NOT bAP_ctx ms -- Na Clearence - NaClearanceHigh: interacting - NaClearanceLow: interacting + NaClearanceHigh: accumulator + NaClearanceLow: accumulator ``` @@ -89,7 +89,9 @@ POSTSYNAPSE --- ```Gen -container: POSTSYNAPSE +POSTSYNAPSE + + type: container expansion: - POST-AMPA ( full: 10x, active: 5x, empty: 2x ) @@ -108,190 +110,137 @@ container: POSTSYNAPSE - VPost ( contained_by: BD ) context_intricated: - - bAp ( contained_by: SOMA ) + - bAp_ctx ( contained_by: SOMA ) ``` ### ms: behaviors POST ![post-ltp-ltd.png](.attachments/post-ltp-ltd.png) -#### CheckNa: Contexting + +##### CaNDMAEnterMax: Accumulator ```Gen -context: CheckNa ## DA ELIMINARE ## - contained_by: BEH-POST +CaNDMAEnterMax: ( active: 2x ) - in_context: Fixed - rf: ( active: 60x ) - - condition: (Na fullness) - out_context: NaMax - - condition: (Na mediumness) - out_context: NaMedium - - condition: (Na emptiness) - out_context: NaLow -``` - -##### CaNDMAEnterMax: Interacting - -```Gen -interacting: CaNDMAEnterMax + type: accumulator contained_by: POSTSYNAPSE - in_context: bAp - rf: ( active: 2x ) - - hypothesis: NOT (Ca2+ full) AND - (Na fullness OR Na mediumness) - action: [Ca2+ increase] - trace: + in_context: bAp_ctx + hypothesis: NOT (Ca2+ full) AND + (Na fullness OR Na mediumness) + action: [Ca2+ increase] + trace: ``` -##### CaNDMAEnterMed: Interacting +##### CaNDMAEnterMed: Accumulator ```Gen -interacting: CaNDMAEnterMed +CaNDMAEnterMed: ( active: 4x ) + + type: accumulator contained_by: POSTSYNAPSE - in_context: bAp - rf: ( active: 4x ) - - hypothesis: NOT (Ca2+ full) AND (Na emptiness) - action: [Ca2+ increase] - trace: + in_context: bAp_ctx + hypothesis: NOT (Ca2+ full) AND (Na emptiness) + action: [Ca2+ increase] + trace: ``` -##### CaNDMAEnterMedNotBap: Interacting +##### CaNDMAEnterMedNotBap: Accumulator ```Gen -interacting: CaNDMAEnterMedNotBap +CaNDMAEnterMedNotBap: ( active: 4x ) + + type: accumulator contained_by: POSTSYNAPSE - in_context: NOT bAP - rf: ( active: 4x ) - - hypothesis: NOT (Ca2+ full) AND (Na fullness) - action: [Ca2+ increase] - trace: + in_context: NOT bAP_ctx + hypothesis: NOT (Ca2+ full) AND (Na fullness) + action: [Ca2+ increase] + trace: ``` -##### CaNDMAEnterLow: Interacting +##### CaNDMAEnterLow: Accumulator ```Gen -interacting: CaNDMAEnterLow +CaNDMAEnterLow: ( active: 12x ) + + type: accumulator contained_by: POSTSYNAPSE - in_context: NOT bAP - rf: ( active: 12x ) - - hypothesis: NOT (Ca2+ full) AND (Na mediumness) - action: [Ca2+ increase] - trace: + in_context: NOT bAP_ctx + hypothesis: NOT (Ca2+ full) AND (Na mediumness) + action: [Ca2+ increase] + trace: ``` -#### CaClearance: Interacting +#### CaClearance: Accumulator ```Gen -interacting: CaClearance +CaClearance: ( active: 24x ) # Low + + type: accumulator contained_by: POSTSYNAPSE - in_context: NOT bAP - rf: ( active: 24x ) # Low - - hypothesis: NOT (Ca2+ empty) - action: [Ca2+ decrease] - trace: None + in_context: NOT bAP_ctx + hypothesis: NOT (Ca2+ empty) + action: [Ca2+ decrease] + trace: None ``` -#### CheckCaVPost:Contexting +##### VPostMax: Accumulator -Qui controlliamo il livello di Ca2+, che e' stato fatto entrare da NMDA, e creaiamo VPost nel DB. Abbiamo fatto una semplificazione, perche' il Ca2+ dovrebbe entrare nel DB in base a V_Post che fa aprire canali in DB. Invece creaimo direttamente il VPost. +##### VPostMed: Accumulator -```Gen -context: CheckCaVPost ### DA ELIMINARE ### - contained_by: BEH-POST +##### VPostMin: Accumulator - in_context: Fixed - rf: ( active: 60x ) - - condition: (Ca2+ fullness) - out_context: CaMax - - condition: (Ca2+ mediumness) - out_context: CaMedium - - condition: (Ca2+ emptiness) - out_context: CaLow -``` - -##### VPostMax:Interacting - -##### VPostMed:Interacting - -##### VPostMin:Interacting - -##### VPostClearance:Interacting +##### VPostClearance: Accumulator Il clearance lo facciamo qui nel container dove creaiamo anche i VPost, perche' altrimenti, se lo facessimo in DB, perderemmo l'aspetto temporale della contribuzione dei singoli POST. ## POST-AMPA: Container ```Gen -container: POST-AMPA +POST-AMPA - tub_intricated: - - NT ( contained_by: SYNAPSE ) + type: container - context_intricated: - - Na ( contained_by: POSTSYNAPSE ) + tub_intricated: + - NT ( contained_by: SYNAPSE ) + + context_intricated: + - Na ( contained_by: POSTSYNAPSE ) ``` ### ms: behaviors AMPA -#### CheckNTPost: Contexting +##### NaAMPAEnterMax: Accumulator ```Gen -context: CheckNTPost ### DA ELIMINARE ### +NaAMPAEnterMax: ( active: 2x ) + + type: accumulator contained_by: POST-AMPA in_context: NOT bAP_ctx - rf: ( active: 8x ) - - condition: (NT mediumness) - out_context: NTMedium - - condition: (NT fullness) - out_context: NTFull + hypothesis: (NT fullness) + action: [Na increase] + trace: ``` -##### NaAMPAEnterMax: Interacting +##### NaAMPAEnterMed: Accumulator ```Gen -interacting: NaAMPAEnterMax +NaAMPAEnterMed: ( active: 4x ) + + type: accumulator contained_by: POST-AMPA in_context: NOT bAP_ctx - rf: ( active: 2x ) - - hypothesis: (NT fullness) - action: [Na increase] - trace: -``` - -##### NaAMPAEnterMed: Interacting - -```Gen -interacting: NaAMPAEnterMed - contained_by: POST-AMPA - - in_context: NOT bAP_ctx - rf: ( active: 4x ) - - hypothesis: (NT mediumness) - action: [Na increase] - trace: + hypothesis: (NT mediumness) + action: [Na increase] + trace: ``` #### TUN-POST-AMPA: Tuner