v11
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# Tripartite Synapse — Pseudocode v11
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> Companion: `tripartite_synapse_v11_biology.md` explains the biology of every variable.
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> Changes from v10: each component now carries its own PARAMETERS and EXTERNAL INTERFACE
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> blocks; behaviors are organized into functional groups within each context; pool-filling
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> primitives return their increment (applied by the caller); the astrocyte no longer writes
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> PRE's drive (the spillover brake is PRE reading its own cleft).
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---
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## Functional groups (the uniform template, applied within each context)
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```
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RECEIVE take in resources + signals that arrived from outside
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BEHAVE the component's defining action
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EMIT send out — signals (messages) and resources (shipments) across the boundary
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SENSE deposit the fast trace that records the behavior
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RECOVER refill own private pools consumed by behaving
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EVALUATE judge the behavior — strength (needs dopamine) + endurance (interrupted success)
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DECAY let traces recede, closing their windows
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```
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Groups sit inside the DAY contexts (Option A): execution contexts (AP/bAP/CONTINUOUS) carry
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BEHAVE/EMIT/SENSE/endurance-EVALUATE; replenishment contexts (NOT_AP/NOT_bAP) carry
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RECEIVE/RECOVER/strength-EVALUATE/DECAY. Not every component uses every group.
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---
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## Conventions
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```
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SCOPE = {DAY, NIGHT} CONTEXT = {AP, NOT_AP, bAP, NOT_bAP, CONTINUOUS}
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DAY budget · fast_trace · possible_tag · endurance_need
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BRIDGE tag (POST: CANDIDATE→STABLE)
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NIGHT energy (not recoverable) · material (recoverable) · structure · budget_ceiling
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LOCALITY only local state + arrived signals; no component reads another's internal state.
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CLEFT MESSAGE CHANNELS (each component writes, others read)
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glutamate PRE → POST, ASTRO forward transmitter; ASTRO clears it
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astro_Dserine ASTRO → POST NMDA co-agonist gate
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retro_NO POST → PRE (+) "release reached a responsive target"
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retro_eCB POST → PRE (−) DSE: "over-driven, release less"
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SHIPMENT CHANNELS (source writes, target reads in its RECEIVE)
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soma_ship_dend SOMA→DEND soma_ship_axon SOMA→AXON
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dend_ship_post DEND→POST axon_ship_pre AXON→PRE
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```
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---
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## Primitives (return the increment; caller applies it)
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```
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sat(x, K) = x / (K + x)
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fill(pool, ceiling, rate, cost, budget) -> amount: // PRIVATE reserve
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amount = min(rate, ceiling - pool)·Δt
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budget -= amount·cost // intrinsic refill cost
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return amount
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refill(c from supply S) -> amount: // CONTESTED supply
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demand = c.budget_ceiling - c.budget
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factor = min(1, S / (Σ demand over components on S + ε))
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S -= demand·factor // consumes shared supply
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return demand·factor
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ship(from_budget, demand_sig, frac, cost) -> amount: // DIRECTED transfer
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amount = min(from_budget·frac, demand_sig) // demand_sig = propagated tag
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from_budget -= amount·(1 + cost)
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return amount // caller writes shipment channel
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```
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---
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## SHARED parameters (organism / physical / universal plasticity machinery)
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```
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// organism broadcasts (external; arrive as local levels)
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dopamine NE ACh
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// physical (external)
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glucose // vascular energy ceiling — root
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geometry // dendritic topology — bAP attenuation
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// universal plasticity gates (same mechanism in every component)
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elig dop_thr tag_thr tag_expiry // strength: eligibility → tag
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traj_thr endur_thr // endurance: interrupted-success → need
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// universal NIGHT
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decay_rate capacity_decay_rate recycle
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homeostatic_ceiling coherence_factor assembly_cost biogenesis_cost maint_cost
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// decay-time convention: each *= decay(τ) means relax toward 0 with time-constant τ
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```
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---
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---
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# DAY
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---
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## PRE
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```
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// PARAMETERS (pre)
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// K_release half-max Ca²⁺ for release release_cost gate to release
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// fusion_cost per unit NT_flux vatpase_cost per unit RRP refilled
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// spillover cleft level for autobrake brake autoreceptor factor
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//
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// EXTERNAL INTERFACE
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// EMIT glutamate → POST, ASTRO
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// RECEIVE astro_lactate[syn] ← ASTRO (primary fuel) ; axon_ship_pre ← AXON (fuel)
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// retro_NO, retro_eCB ← POST (backward messages)
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// pre_material ← AXON(NIGHT) ; pre_energy ← SOMA(NIGHT)
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// READ glutamate (own cleft, autobrake) ; dopamine (VTA, gates tag)
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// OWN pre_structure{slot_ceiling, VGCC_coupling, refill_ceiling} ; pre_budget_ceiling
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// EMERGENCY shockwave_lockdown ← ASTRO
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DAY | AP:
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// SENSE
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pre_fast_trace += spike_Ca(input_freq)
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// BEHAVE — release or fail
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if pre_budget < release_cost:
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suppress(NT_flux)
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// EVALUATE (endurance) — interrupted local success, confirmed by retro_NO
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if pre_fast_trace > traj_thr:
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pre_endurance_need += pre_fast_trace × (1 + retro_NO_local)
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exit
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drive = sat(pre_fast_trace, K_release) × (1 - retro_eCB_local)
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if RRP > 0:
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NT_flux = RRP × drive
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// EMIT
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glutamate += NT_flux·Δt
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RRP -= NT_flux·Δt; pre_budget -= NT_flux·fusion_cost
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if glutamate > spillover: drive *= brake // own-cleft autobrake
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DAY | NOT_AP:
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// RECEIVE
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retro_NO_local = retro_NO; retro_eCB_local = retro_eCB
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pre_budget += refill(pre from astro_lactate[syn] + axon_ship_pre)
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// RECOVER
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RRP += fill(RRP, pre_structure.slot_ceiling, pre_structure.refill_ceiling, vatpase_cost, pre_budget)
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// EVALUATE (strength)
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if pre_fast_trace > elig: pre_possible_tag += pre_fast_trace
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if dopamine > dop_thr and pre_possible_tag > tag_thr:
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pre_tag += dopamine × pre_possible_tag
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// DECAY
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pre_fast_trace *= decay(100ms); pre_possible_tag *= decay(s)
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pre_endurance_need *= decay(min); pre_tag *= decay(hr)
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dopamine *= decay(ms); retro_NO *= decay(s); retro_eCB *= decay(s)
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```
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---
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## POST
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```
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// PARAMETERS (post)
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// K_AMPA half-max glu for AMPA AMPA_Ca Ca fraction via AMPA
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// AMPA_cost NMDA_cost bAP_cost pka_cost traffic_cost req_cost
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// Mg_eject Vm to eject Mg block Dserine_thr NMDA co-agonist gate
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// Ca_STP fill-slots threshold Ca_TAG tagging threshold
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// eCB_thr Vm for endocannabinoid (DSE) drift baseline (STD relaxation)
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// NO_synth_cost eCB_synth_cost
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//
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// EXTERNAL INTERFACE
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// EMIT retro_NO (+), retro_eCB (−) → PRE
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// RECEIVE astro_lactate[syn] ← ASTRO ; dend_ship_post ← DEND
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// post_material ← DEND(NIGHT) ; post_energy ← SOMA(NIGHT)
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// READ glutamate ← PRE ; astro_Dserine ← ASTRO ; bAP (via dend_structure.bAP_fidelity)
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// dopamine (VTA, stabilizes tag)
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// OWN post_structure{slot_ceiling, spine_volume, reserve_ceiling} ; post_budget_ceiling
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// EMERGENCY shockwave_lockdown ← ASTRO
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DAY | NOT_bAP:
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// RECEIVE
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post_budget += refill(post from astro_lactate[syn] + dend_ship_post)
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// BEHAVE + SENSE — three Ca sources feed post_fast_trace
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a = sat(glutamate, K_AMPA) // SOURCE 1: AMPA
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AMPA_current = a × AMPA_surface; Vm += AMPA_current
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post_fast_trace += AMPA_Ca·AMPA_current; post_budget -= AMPA_cost
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if Vm > Mg_eject and astro_Dserine > Dserine_thr and glutamate > 0: // SOURCE 2: NMDA
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post_fast_trace += NMDA_Ca(glutamate)·rise_speed(); post_budget -= NMDA_cost
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// EMIT (+)
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retro_NO += NO_emit(post_fast_trace); post_budget -= NO_synth_cost
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// EMIT (−)
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if Vm > eCB_thr: retro_eCB += eCB_emit(Vm); post_budget -= eCB_synth_cost
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post_fast_trace *= decay(ms)
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// BEHAVE — STP fill slots (Ca-driven, private reserve); else STD drift (consequence)
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if post_fast_trace > Ca_STP:
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AMPA_surface = min(AMPA_surface + Ca_insert(post_fast_trace), post_structure.slot_ceiling)
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post_budget -= traffic_cost
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else:
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AMPA_surface = max(AMPA_surface - drift·Δt, baseline)
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// EVALUATE (endurance) — interrupted local success (own Ca climbing toward tag)
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if post_budget < req_cost and post_fast_trace > traj_thr and post_fast_trace_rising:
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post_endurance_need += post_fast_trace
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// EVALUATE (strength) — CANDIDATE then STABLE (dopamine)
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if post_fast_trace > Ca_TAG: post_possible_tag += post_fast_trace
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post_budget -= pka_cost
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if dopamine > dop_thr and post_possible_tag > tag_thr:
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post_tag += dopamine × post_possible_tag
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// DECAY
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post_possible_tag *= decay(min); post_endurance_need *= decay(min)
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post_tag *= decay(hr); dopamine *= decay(ms)
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DAY | bAP:
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// BEHAVE + SENSE — SOURCE 3: bAP amplifies an existing signal
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Vm += bAP_depol × dend_structure.bAP_fidelity; post_budget -= bAP_cost
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if post_possible_tag > Ca_TAG: post_fast_trace += bAP_Ca_boost()
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```
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---
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## DEND
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```
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// PARAMETERS (dend)
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// prop_cost branch_Ca_cost integrate_cost translate_cost
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//
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// EXTERNAL INTERFACE
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// EMIT bAP_local → POST ; branch_Vm → SOMA ; dend_ship_post → POST
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// RECEIVE astro_lactate[branch] ← ASTRO ; soma_ship_dend ← SOMA
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// dend_material, dend_energy ← SOMA(NIGHT)
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// READ SOMA.fired (bAP trigger) ; POST.Vm + spine spillover (to integrate)
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// dopamine ; ACh (commit-threshold context)
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// OWN dend_structure{bAP_fidelity(pos), translation_ceiling, transport_speed} ; dend_budget_ceiling
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DAY | bAP:
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// BEHAVE — propagate bAP (may fall short if depleted), integrate spines
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bAP_local, reached = propagate(SOMA.fired, dend_structure.bAP_fidelity, dend_budget, geometry)
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dend_budget -= prop_cost × reached
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// EVALUATE (endurance) — propagation cut short while branch strongly active (LOCAL)
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if reached < full and dend_fast_trace > traj_thr:
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dend_endurance_need += dend_fast_trace
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// SENSE
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dend_fast_trace += bAP_Ca(bAP_local) + spine_spillover(); dend_budget -= branch_Ca_cost
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// EMIT — propagated bAP to spines; integrated voltage to soma
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branch_Vm = integrate(POST.Vm, spines); dend_budget -= integrate_cost
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DAY | NOT_bAP:
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// RECEIVE
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dend_budget += refill(dend from astro_lactate[branch] + soma_ship_dend)
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// EMIT — ship budget downstream to spines (demand = post tag)
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dend_ship_post = ship(dend_budget, post_demand, post_ship_frac, ship_cost)
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// EVALUATE (strength)
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if dend_fast_trace > elig: dend_possible_tag += dend_fast_trace
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if dopamine > dop_thr and dend_possible_tag > tag_thr:
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dend_tag += dopamine × dend_possible_tag
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// BEHAVE — local translation if tagged (fills dend capacity faster)
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if dend_tag > tag_expiry and dend_budget > translate_cost: dend_budget -= translate_cost
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commit_threshold *= 1/(1 + ACh·gain)
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// DECAY
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dend_fast_trace *= decay(300ms); dend_possible_tag *= decay(s)
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dend_endurance_need *= decay(min); dend_tag *= decay(hr)
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```
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---
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## SOMA
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```
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// PARAMETERS (soma)
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// ap_cost nuclear_cost creb_cost mito_output (self-fuel rate)
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// inactivation ap_amp ap_contrib base_recovery
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// τ_Na τ_adapt τ_nuclear τ_align
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//
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// EXTERNAL INTERFACE
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// EMIT fired → AXON (propagate) + DEND (bAP) ; soma_ship_dend → DEND ; soma_ship_axon → AXON
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// RECEIVE self (mitochondria, ROOT) ; branch_Vm ← DEND
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// READ dopamine ; NE ; ACh
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// OWN soma_structure{baseline_threshold, AP_reliability, synthesis_ceiling} ; soma_budget_ceiling
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DAY | AP:
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threshold = soma_structure.baseline_threshold × (1 + soma_adaptation) × neuromod(NE, ACh)
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can_fire = soma_Na_inactivation < inactivation
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// BEHAVE — fire if able
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if branch_Vm > threshold and can_fire:
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if soma_budget < ap_cost:
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// EVALUATE (endurance) — fuel cut a firing train approaching CREB (LOCAL)
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if soma_fast_trace > traj_thr and soma_fast_trace_rising:
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soma_endurance_need += soma_fast_trace
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exit
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fired = True; soma_budget -= ap_cost // EMIT: fired → AXON, DEND
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// SENSE — three traces from one AP
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soma_Na_inactivation += ap_amp // → refractory (emergent)
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soma_adaptation += ap_contrib // → threshold rise
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soma_fast_trace += nuclear_Ca(); soma_budget -= nuclear_cost
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// EVALUATE (strength)
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if soma_fast_trace > elig: soma_possible_tag += soma_fast_trace
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if dopamine > dop_thr and soma_possible_tag > tag_thr:
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soma_tag += dopamine × soma_possible_tag
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soma_budget -= creb_cost
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DAY | NOT_AP:
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// BEHAVE — bottom-up refractory alignment (suprathreshold input during refractory)
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if branch_Vm > threshold and soma_Na_inactivation > inactivation:
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soma_refractory_alignment += (branch_Vm - threshold) × soma_Na_inactivation
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// RECOVER — recovery rate sped by alignment trace
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recovery = base_recovery × (1 + soma_refractory_alignment)
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soma_Na_inactivation *= decay(τ_Na / recovery)
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// RECEIVE — self-replenish (private root) + integrate input
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soma_budget += fill(soma_budget, soma_budget_ceiling, mito_output, 0, soma_budget)
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branch_Vm = integrate(DEND.branch_Vm, branches)
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// EMIT — ship downstream (demand = propagated tags)
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soma_ship_dend = ship(soma_budget, dend_demand, dend_ship_frac, ship_cost)
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soma_ship_axon = ship(soma_budget, axon_demand, axon_ship_frac, ship_cost)
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// DECAY
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soma_adaptation *= decay(τ_adapt); soma_fast_trace *= decay(τ_nuclear)
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soma_refractory_alignment *= decay(τ_align) // self-limiting
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soma_possible_tag *= decay(s); soma_endurance_need *= decay(min)
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soma_tag *= decay(hr); dopamine *= decay(ms)
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```
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---
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## AXON
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```
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// PARAMETERS (axon)
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// prop_cost budget_factor (depleted-propagation penalty)
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//
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// EXTERNAL INTERFACE
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// EMIT APs_delivered → PRE (propagation) ; axon_ship_pre → PRE
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// RECEIVE soma_ship_axon ← SOMA ; astro_lactate[shaft] ← ASTRO
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// axon_material, axon_energy ← SOMA(NIGHT)
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// READ SOMA.fired ; dopamine
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// OWN axon_structure{propagation, transport_ceiling, mito_density} ; axon_budget_ceiling
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DAY | AP:
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reliability = axon_structure.propagation × (1 - fail(axon_fast_trace))
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// BEHAVE — propagate (degraded if depleted)
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if axon_budget < prop_cost:
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reliability *= budget_factor
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// EVALUATE (endurance) — propagating a strong train when fuel failed (LOCAL)
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if axon_fast_trace > traj_thr: axon_endurance_need += axon_fast_trace
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delivered = fired × reliability; axon_budget -= prop_cost × delivered
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// EMIT — delivered APs reach boutons
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// SENSE
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axon_fast_trace += delivered; axon_fast_trace *= decay(s)
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DAY | NOT_AP:
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// RECEIVE
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axon_budget += refill(axon from soma_ship_axon + astro_lactate[shaft])
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// EMIT — ship budget to boutons (demand = pre tag)
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axon_ship_pre = ship(axon_budget, pre_demand, pre_ship_frac, ship_cost)
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// EVALUATE (strength)
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if axon_fast_trace > elig: axon_possible_tag += axon_fast_trace
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if dopamine > dop_thr and axon_possible_tag > tag_thr:
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axon_tag += dopamine × axon_possible_tag
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// DECAY
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axon_fast_trace *= decay(s); axon_possible_tag *= decay(s)
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axon_endurance_need *= decay(min); axon_tag *= decay(hr)
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```
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---
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## ASTRO
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```
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// PARAMETERS (astro)
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// K_Dserine half-max Ca for D-serine Ds_max Ds_frac Ds_cost
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// EAAT_cost per unit glutamate cleared lactate_cost per unit exported
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// spillover overflow threshold overload lockdown threshold
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//
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// EXTERNAL INTERFACE
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// EMIT astro_lactate[i] → pre/post/dend budgets ; astro_Dserine[i] → POST (gate)
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// RECEIVE glucose (ROOT) ; astro_material, astro_energy ← cell body (NIGHT)
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// READ glutamate ← PRE (clearance + spillover) ; dopamine
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// OWN astro_structure{perisynaptic_distance⁻¹, EAAT, Dserine_tonic, ECM} ; astro_budget_ceiling
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// EMERGENCY emits shockwave_lockdown on overload
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DAY | CONTINUOUS: // per astrosynapse i
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// RECEIVE — root production, capped by glucose
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astro_central_budget += glycolysis(glucose)·Δt
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// EMIT — demand-weighted lactate allocation across territory
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for each i: demand[i] = clearance_load[i] × astro_structure[i].delivery_eff
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factor = min(1, astro_central_budget / (Σ demand·lactate_cost + ε))
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for each i:
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astro_lactate[i] = demand[i] × factor; astro_central_budget -= astro_lactate[i]·lactate_cost
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// BEHAVE — clear glutamate; supply tonic D-serine
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glutamate[i] -= astro_structure[i].EAAT × glutamate[i]·Δt; astro_central_budget -= clearance·EAAT_cost
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astro_Dserine[i] += astro_structure[i].Dserine_tonic·Δt
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if glutamate[i] > spillover:
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// SENSE
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astro_fast_trace[i] += mGluR_Ca(); astro_fast_trace[i] *= decay(s)
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// BEHAVE + EMIT — D-serine pulse (demand-driven, budget-limited)
|
||||
want = sat(astro_fast_trace[i], K_Dserine) × Ds_max
|
||||
got = min(want, astro_central_budget × Ds_frac)
|
||||
astro_Dserine[i] += got; astro_central_budget -= got·Ds_cost
|
||||
// EVALUATE (endurance) — ran out of synthesis under high own demand (LOCAL)
|
||||
if got < want and astro_fast_trace[i] > traj_thr:
|
||||
astro_endurance_need[i] += (want - got)
|
||||
// EVALUATE (strength)
|
||||
if astro_fast_trace[i] > elig: astro_possible_tag[i] += astro_fast_trace[i]
|
||||
if dopamine > dop_thr and astro_possible_tag[i] > tag_thr:
|
||||
astro_tag[i] += dopamine × astro_possible_tag[i]
|
||||
// DECAY
|
||||
astro_possible_tag[i] *= decay(s); astro_endurance_need[i] *= decay(min)
|
||||
astro_tag[i] *= decay(hr)
|
||||
// EMERGENCY
|
||||
if astro_fast_trace[i] > overload: emit(shockwave_lockdown)
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## Special — Shockwave Lockdown
|
||||
|
||||
```
|
||||
DAY or NIGHT | OVERLOAD:
|
||||
Vm = HYPERPOLARIZED; AMPA_surface = mass_internalize() → post reserve
|
||||
axon_fast_trace += overdrive(); astro_central_budget -= emergency_cost
|
||||
```
|
||||
|
||||
---
|
||||
---
|
||||
# NIGHT
|
||||
System-wide consolidation (not a per-component DAY cycle). Build ceilings from DAY evidence.
|
||||
|
||||
```
|
||||
NIGHT | 1 REPLENISH & DISTRIBUTE
|
||||
// energy economy: astrocyte central → astrosynapses (astro_tag-weighted)
|
||||
astro_central_{budget,energy,material} += overnight_*(glucose, …)·Δt
|
||||
for each i with astro_tag[i] > tag_expiry: w = astro_tag[i]/Σastro_tag
|
||||
astro_energy[i] += astro_central_energy·w; astro_material[i] += astro_central_material·w
|
||||
// material economy: soma → branch/axon → spine/bouton
|
||||
soma_budget += overnight_mito()·Δt; soma_energy += overnight_soma_energy()·Δt
|
||||
soma_material += CREB_synth(soma_tag)·Δt // bottleneck
|
||||
dend_material += soma_material·f_dend; axon_material += soma_material·f_axon; soma_material -= …
|
||||
post_material += dend_material·f_spine; pre_material += axon_material·f_bouton
|
||||
{pre,post,dend,axon}_energy += soma_energy·f[·]
|
||||
{pre,post,dend,axon}_budget += astro_lactate_reserve·f[·]·Δt
|
||||
|
||||
NIGHT | 2 STRENGTH COMMITS (raise structure)
|
||||
coherence = (pre_tag, post_tag, astro_tag all > tag_expiry) ? coherence_factor : 1
|
||||
for each c with c_tag > tag_expiry:
|
||||
Δ = min(slot_cost, c_material, c_energy·f)
|
||||
c_structure += Δ × (coherence if c in {pre,post,astro} else 1)
|
||||
c_material -= Δ; c_energy -= Δ·assembly_cost
|
||||
if Δ < slot_cost: queue(c_strength_deficit → next NIGHT)
|
||||
|
||||
NIGHT | 2b ENDURANCE COMMITS (raise budget_ceiling) — no dopamine; competes with step 2
|
||||
for each c with c_endurance_need > endur_thr:
|
||||
Δ = min(cap_cost, c_material·f_cap, c_energy·f_cap)
|
||||
c_budget_ceiling += Δ; c_material -= Δ; c_energy -= Δ·biogenesis_cost
|
||||
if Δ < cap_cost: queue(c_endurance_deficit → next NIGHT)
|
||||
|
||||
NIGHT | 3 PASSIVE DECAY (both ceilings, by neglect)
|
||||
maint = (total_material - consumed) × maint_frac / synapse_count
|
||||
for each synapse:
|
||||
{pre,post,dend,astro}_structure -= decay_rate·Δt
|
||||
{pre,post,dend,astro}_budget_ceiling -= capacity_decay_rate·Δt
|
||||
if maint ≥ maint_cost: structure += full_maint; budget_ceiling += full_cap_maint
|
||||
else: structure += maint·frac; budget_ceiling += maint·cap_frac
|
||||
for each synapse with net_change < 0: // material recovered, energy not
|
||||
{pre,post,astro}_material += |net_change|·recycle·frac
|
||||
|
||||
NIGHT | 4 HOMEOSTATIC SCALING
|
||||
if soma_tag > homeostatic_ceiling:
|
||||
s = homeostatic_ceiling / soma_tag
|
||||
for each synapse: post_structure.slot_ceiling *= s; pre_structure.slot_ceiling *= s
|
||||
soma_material += Σ reduction·recycle
|
||||
|
||||
NIGHT | 5 CLEAR TRACES
|
||||
all fast_trace, possible_tag, endurance_need = 0
|
||||
soma_Na_inactivation = soma_adaptation = soma_refractory_alignment = 0
|
||||
for each tag: if tag < tag_expiry: tag = 0 // else carry forward
|
||||
// structure and budget_ceiling PERSIST
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## One-view summary
|
||||
|
||||
```
|
||||
DAY per context, per component: RECEIVE → BEHAVE/EMIT/SENSE → RECOVER → EVALUATE → DECAY
|
||||
behavior runs within structure (strength) and budget_ceiling (endurance),
|
||||
both filled by competition (refill = contested, fill = private, ship = directed)
|
||||
fast_trace + dopamine coincidence → tag (strength evidence)
|
||||
depletion + interrupted LOCAL success → endurance_need (endurance evidence)
|
||||
NIGHT tag → structure ; endurance_need → budget_ceiling ; both draw one pool (compete)
|
||||
unmaintained ceilings decay → freed material funds the rest
|
||||
LOCAL every evaluation uses only own state + arrived signals; coupling is via channels.
|
||||
```
|
||||
@@ -0,0 +1,480 @@
|
||||
# Tripartite Synapse — Pseudocode v11
|
||||
|
||||
> Companion: `tripartite_synapse_v11_biology.md` explains the biology of every variable.
|
||||
> Changes from v10: each component now carries its own PARAMETERS and EXTERNAL INTERFACE
|
||||
> blocks; behaviors are organized into functional groups within each context; pool-filling
|
||||
> primitives return their increment (applied by the caller); the astrocyte no longer writes
|
||||
> PRE's drive (the spillover brake is PRE reading its own cleft).
|
||||
|
||||
---
|
||||
|
||||
## Functional groups (the uniform template, applied within each context)
|
||||
|
||||
```
|
||||
RECEIVE take in resources + signals that arrived from outside
|
||||
BEHAVE the component's defining action
|
||||
EMIT send out — signals (messages) and resources (shipments) across the boundary
|
||||
SENSE deposit the fast trace that records the behavior
|
||||
RECOVER refill own private pools consumed by behaving
|
||||
EVALUATE judge the behavior — strength (needs dopamine) + endurance (interrupted success)
|
||||
DECAY let traces recede, closing their windows
|
||||
```
|
||||
Groups sit inside the DAY contexts (Option A): execution contexts (AP/bAP/CONTINUOUS) carry
|
||||
BEHAVE/EMIT/SENSE/endurance-EVALUATE; replenishment contexts (NOT_AP/NOT_bAP) carry
|
||||
RECEIVE/RECOVER/strength-EVALUATE/DECAY. Not every component uses every group.
|
||||
|
||||
---
|
||||
|
||||
## Conventions
|
||||
|
||||
```
|
||||
SCOPE = {DAY, NIGHT} CONTEXT = {AP, NOT_AP, bAP, NOT_bAP, CONTINUOUS}
|
||||
|
||||
DAY budget · fast_trace · possible_tag · endurance_need
|
||||
BRIDGE tag (POST: CANDIDATE→STABLE)
|
||||
NIGHT energy (not recoverable) · material (recoverable) · structure · budget_ceiling
|
||||
|
||||
LOCALITY only local state + arrived signals; no component reads another's internal state.
|
||||
|
||||
CLEFT MESSAGE CHANNELS (each component writes, others read)
|
||||
glutamate PRE → POST, ASTRO forward transmitter; ASTRO clears it
|
||||
astro_Dserine ASTRO → POST NMDA co-agonist gate
|
||||
retro_NO POST → PRE (+) "release reached a responsive target"
|
||||
retro_eCB POST → PRE (−) DSE: "over-driven, release less"
|
||||
|
||||
SHIPMENT CHANNELS (source writes, target reads in its RECEIVE)
|
||||
soma_ship_dend SOMA→DEND soma_ship_axon SOMA→AXON
|
||||
dend_ship_post DEND→POST axon_ship_pre AXON→PRE
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## Primitives (return the increment; caller applies it)
|
||||
|
||||
```
|
||||
sat(x, K) = x / (K + x)
|
||||
|
||||
fill(pool, ceiling, rate, cost, budget) -> amount: // PRIVATE reserve
|
||||
amount = min(rate, ceiling - pool)·Δt
|
||||
budget -= amount·cost // intrinsic refill cost
|
||||
return amount
|
||||
|
||||
refill(c from supply S) -> amount: // CONTESTED supply
|
||||
demand = c.budget_ceiling - c.budget
|
||||
factor = min(1, S / (Σ demand over components on S + ε))
|
||||
S -= demand·factor // consumes shared supply
|
||||
return demand·factor
|
||||
|
||||
ship(from_budget, demand_sig, frac, cost) -> amount: // DIRECTED transfer
|
||||
amount = min(from_budget·frac, demand_sig) // demand_sig = propagated tag
|
||||
from_budget -= amount·(1 + cost)
|
||||
return amount // caller writes shipment channel
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## SHARED parameters (organism / physical / universal plasticity machinery)
|
||||
|
||||
```
|
||||
// organism broadcasts (external; arrive as local levels)
|
||||
dopamine NE ACh
|
||||
// physical (external)
|
||||
glucose // vascular energy ceiling — root
|
||||
geometry // dendritic topology — bAP attenuation
|
||||
// universal plasticity gates (same mechanism in every component)
|
||||
elig dop_thr tag_thr tag_expiry // strength: eligibility → tag
|
||||
traj_thr endur_thr // endurance: interrupted-success → need
|
||||
// universal NIGHT
|
||||
decay_rate capacity_decay_rate recycle
|
||||
homeostatic_ceiling coherence_factor assembly_cost biogenesis_cost maint_cost
|
||||
// decay-time convention: each *= decay(τ) means relax toward 0 with time-constant τ
|
||||
```
|
||||
|
||||
---
|
||||
---
|
||||
# DAY
|
||||
---
|
||||
|
||||
## PRE
|
||||
|
||||
```
|
||||
// PARAMETERS (pre)
|
||||
// K_release half-max Ca²⁺ for release release_cost gate to release
|
||||
// fusion_cost per unit NT_flux vatpase_cost per unit RRP refilled
|
||||
// spillover cleft level for autobrake brake autoreceptor factor
|
||||
//
|
||||
// EXTERNAL INTERFACE
|
||||
// EMIT glutamate → POST, ASTRO
|
||||
// RECEIVE astro_lactate[syn] ← ASTRO (primary fuel) ; axon_ship_pre ← AXON (fuel)
|
||||
// retro_NO, retro_eCB ← POST (backward messages)
|
||||
// pre_material ← AXON(NIGHT) ; pre_energy ← SOMA(NIGHT)
|
||||
// READ glutamate (own cleft, autobrake) ; dopamine (VTA, gates tag)
|
||||
// OWN pre_structure{slot_ceiling, VGCC_coupling, refill_ceiling} ; pre_budget_ceiling
|
||||
// EMERGENCY shockwave_lockdown ← ASTRO
|
||||
|
||||
DAY | AP:
|
||||
// SENSE
|
||||
pre_fast_trace += spike_Ca(input_freq)
|
||||
// BEHAVE — release or fail
|
||||
if pre_budget < release_cost:
|
||||
suppress(NT_flux)
|
||||
// EVALUATE (endurance) — interrupted local success, confirmed by retro_NO
|
||||
if pre_fast_trace > traj_thr:
|
||||
pre_endurance_need += pre_fast_trace × (1 + retro_NO_local)
|
||||
exit
|
||||
drive = sat(pre_fast_trace, K_release) × (1 - retro_eCB_local)
|
||||
if RRP > 0:
|
||||
NT_flux = RRP × drive
|
||||
// EMIT
|
||||
glutamate += NT_flux·Δt
|
||||
RRP -= NT_flux·Δt; pre_budget -= NT_flux·fusion_cost
|
||||
if glutamate > spillover: drive *= brake // own-cleft autobrake
|
||||
|
||||
DAY | NOT_AP:
|
||||
// RECEIVE
|
||||
retro_NO_local = retro_NO; retro_eCB_local = retro_eCB
|
||||
pre_budget += refill(pre from astro_lactate[syn] + axon_ship_pre)
|
||||
// RECOVER
|
||||
RRP += fill(RRP, pre_structure.slot_ceiling, pre_structure.refill_ceiling, vatpase_cost, pre_budget)
|
||||
// EVALUATE (strength)
|
||||
if pre_fast_trace > elig: pre_possible_tag += pre_fast_trace
|
||||
if dopamine > dop_thr and pre_possible_tag > tag_thr:
|
||||
pre_tag += dopamine × pre_possible_tag
|
||||
// DECAY
|
||||
pre_fast_trace *= decay(100ms); pre_possible_tag *= decay(s)
|
||||
pre_endurance_need *= decay(min); pre_tag *= decay(hr)
|
||||
dopamine *= decay(ms); retro_NO *= decay(s); retro_eCB *= decay(s)
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## POST
|
||||
|
||||
```
|
||||
// PARAMETERS (post)
|
||||
// K_AMPA half-max glu for AMPA AMPA_Ca Ca fraction via AMPA
|
||||
// AMPA_cost NMDA_cost bAP_cost pka_cost traffic_cost req_cost
|
||||
// Mg_eject Vm to eject Mg block Dserine_thr NMDA co-agonist gate
|
||||
// Ca_STP fill-slots threshold Ca_TAG tagging threshold
|
||||
// eCB_thr Vm for endocannabinoid (DSE) drift baseline (STD relaxation)
|
||||
// NO_synth_cost eCB_synth_cost
|
||||
//
|
||||
// EXTERNAL INTERFACE
|
||||
// EMIT retro_NO (+), retro_eCB (−) → PRE
|
||||
// RECEIVE astro_lactate[syn] ← ASTRO ; dend_ship_post ← DEND
|
||||
// post_material ← DEND(NIGHT) ; post_energy ← SOMA(NIGHT)
|
||||
// READ glutamate ← PRE ; astro_Dserine ← ASTRO ; bAP (via dend_structure.bAP_fidelity)
|
||||
// dopamine (VTA, stabilizes tag)
|
||||
// OWN post_structure{slot_ceiling, spine_volume, reserve_ceiling} ; post_budget_ceiling
|
||||
// EMERGENCY shockwave_lockdown ← ASTRO
|
||||
|
||||
DAY | NOT_bAP:
|
||||
// RECEIVE
|
||||
post_budget += refill(post from astro_lactate[syn] + dend_ship_post)
|
||||
// BEHAVE + SENSE — three Ca sources feed post_fast_trace
|
||||
a = sat(glutamate, K_AMPA) // SOURCE 1: AMPA
|
||||
AMPA_current = a × AMPA_surface; Vm += AMPA_current
|
||||
post_fast_trace += AMPA_Ca·AMPA_current; post_budget -= AMPA_cost
|
||||
if Vm > Mg_eject and astro_Dserine > Dserine_thr and glutamate > 0: // SOURCE 2: NMDA
|
||||
post_fast_trace += NMDA_Ca(glutamate)·rise_speed(); post_budget -= NMDA_cost
|
||||
// EMIT (+)
|
||||
retro_NO += NO_emit(post_fast_trace); post_budget -= NO_synth_cost
|
||||
// EMIT (−)
|
||||
if Vm > eCB_thr: retro_eCB += eCB_emit(Vm); post_budget -= eCB_synth_cost
|
||||
post_fast_trace *= decay(ms)
|
||||
// BEHAVE — STP fill slots (Ca-driven, private reserve); else STD drift (consequence)
|
||||
if post_fast_trace > Ca_STP:
|
||||
AMPA_surface = min(AMPA_surface + Ca_insert(post_fast_trace), post_structure.slot_ceiling)
|
||||
post_budget -= traffic_cost
|
||||
else:
|
||||
AMPA_surface = max(AMPA_surface - drift·Δt, baseline)
|
||||
// EVALUATE (endurance) — interrupted local success (own Ca climbing toward tag)
|
||||
if post_budget < req_cost and post_fast_trace > traj_thr and post_fast_trace_rising:
|
||||
post_endurance_need += post_fast_trace
|
||||
// EVALUATE (strength) — CANDIDATE then STABLE (dopamine)
|
||||
if post_fast_trace > Ca_TAG: post_possible_tag += post_fast_trace
|
||||
post_budget -= pka_cost
|
||||
if dopamine > dop_thr and post_possible_tag > tag_thr:
|
||||
post_tag += dopamine × post_possible_tag
|
||||
// DECAY
|
||||
post_possible_tag *= decay(min); post_endurance_need *= decay(min)
|
||||
post_tag *= decay(hr); dopamine *= decay(ms)
|
||||
|
||||
DAY | bAP:
|
||||
// BEHAVE + SENSE — SOURCE 3: bAP amplifies an existing signal
|
||||
Vm += bAP_depol × dend_structure.bAP_fidelity; post_budget -= bAP_cost
|
||||
if post_possible_tag > Ca_TAG: post_fast_trace += bAP_Ca_boost()
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## DEND
|
||||
|
||||
```
|
||||
// PARAMETERS (dend)
|
||||
// prop_cost branch_Ca_cost integrate_cost translate_cost
|
||||
//
|
||||
// EXTERNAL INTERFACE
|
||||
// EMIT bAP_local → POST ; branch_Vm → SOMA ; dend_ship_post → POST
|
||||
// RECEIVE astro_lactate[branch] ← ASTRO ; soma_ship_dend ← SOMA
|
||||
// dend_material, dend_energy ← SOMA(NIGHT)
|
||||
// READ SOMA.fired (bAP trigger) ; POST.Vm + spine spillover (to integrate)
|
||||
// dopamine ; ACh (commit-threshold context)
|
||||
// OWN dend_structure{bAP_fidelity(pos), translation_ceiling, transport_speed} ; dend_budget_ceiling
|
||||
|
||||
DAY | bAP:
|
||||
// BEHAVE — propagate bAP (may fall short if depleted), integrate spines
|
||||
bAP_local, reached = propagate(SOMA.fired, dend_structure.bAP_fidelity, dend_budget, geometry)
|
||||
dend_budget -= prop_cost × reached
|
||||
// EVALUATE (endurance) — propagation cut short while branch strongly active (LOCAL)
|
||||
if reached < full and dend_fast_trace > traj_thr:
|
||||
dend_endurance_need += dend_fast_trace
|
||||
// SENSE
|
||||
dend_fast_trace += bAP_Ca(bAP_local) + spine_spillover(); dend_budget -= branch_Ca_cost
|
||||
// EMIT — propagated bAP to spines; integrated voltage to soma
|
||||
branch_Vm = integrate(POST.Vm, spines); dend_budget -= integrate_cost
|
||||
|
||||
DAY | NOT_bAP:
|
||||
// RECEIVE
|
||||
dend_budget += refill(dend from astro_lactate[branch] + soma_ship_dend)
|
||||
// EMIT — ship budget downstream to spines (demand = post tag)
|
||||
dend_ship_post = ship(dend_budget, post_demand, post_ship_frac, ship_cost)
|
||||
// EVALUATE (strength)
|
||||
if dend_fast_trace > elig: dend_possible_tag += dend_fast_trace
|
||||
if dopamine > dop_thr and dend_possible_tag > tag_thr:
|
||||
dend_tag += dopamine × dend_possible_tag
|
||||
// BEHAVE — local translation if tagged (fills dend capacity faster)
|
||||
if dend_tag > tag_expiry and dend_budget > translate_cost: dend_budget -= translate_cost
|
||||
commit_threshold *= 1/(1 + ACh·gain)
|
||||
// DECAY
|
||||
dend_fast_trace *= decay(300ms); dend_possible_tag *= decay(s)
|
||||
dend_endurance_need *= decay(min); dend_tag *= decay(hr)
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## SOMA
|
||||
|
||||
```
|
||||
// PARAMETERS (soma)
|
||||
// ap_cost nuclear_cost creb_cost mito_output (self-fuel rate)
|
||||
// inactivation ap_amp ap_contrib base_recovery
|
||||
// τ_Na τ_adapt τ_nuclear τ_align
|
||||
//
|
||||
// EXTERNAL INTERFACE
|
||||
// EMIT fired → AXON (propagate) + DEND (bAP) ; soma_ship_dend → DEND ; soma_ship_axon → AXON
|
||||
// RECEIVE self (mitochondria, ROOT) ; branch_Vm ← DEND
|
||||
// READ dopamine ; NE ; ACh
|
||||
// OWN soma_structure{baseline_threshold, AP_reliability, synthesis_ceiling} ; soma_budget_ceiling
|
||||
|
||||
DAY | AP:
|
||||
threshold = soma_structure.baseline_threshold × (1 + soma_adaptation) × neuromod(NE, ACh)
|
||||
can_fire = soma_Na_inactivation < inactivation
|
||||
// BEHAVE — fire if able
|
||||
if branch_Vm > threshold and can_fire:
|
||||
if soma_budget < ap_cost:
|
||||
// EVALUATE (endurance) — fuel cut a firing train approaching CREB (LOCAL)
|
||||
if soma_fast_trace > traj_thr and soma_fast_trace_rising:
|
||||
soma_endurance_need += soma_fast_trace
|
||||
exit
|
||||
fired = True; soma_budget -= ap_cost // EMIT: fired → AXON, DEND
|
||||
// SENSE — three traces from one AP
|
||||
soma_Na_inactivation += ap_amp // → refractory (emergent)
|
||||
soma_adaptation += ap_contrib // → threshold rise
|
||||
soma_fast_trace += nuclear_Ca(); soma_budget -= nuclear_cost
|
||||
// EVALUATE (strength)
|
||||
if soma_fast_trace > elig: soma_possible_tag += soma_fast_trace
|
||||
if dopamine > dop_thr and soma_possible_tag > tag_thr:
|
||||
soma_tag += dopamine × soma_possible_tag
|
||||
soma_budget -= creb_cost
|
||||
|
||||
DAY | NOT_AP:
|
||||
// BEHAVE — bottom-up refractory alignment (suprathreshold input during refractory)
|
||||
if branch_Vm > threshold and soma_Na_inactivation > inactivation:
|
||||
soma_refractory_alignment += (branch_Vm - threshold) × soma_Na_inactivation
|
||||
// RECOVER — recovery rate sped by alignment trace
|
||||
recovery = base_recovery × (1 + soma_refractory_alignment)
|
||||
soma_Na_inactivation *= decay(τ_Na / recovery)
|
||||
// RECEIVE — self-replenish (private root) + integrate input
|
||||
soma_budget += fill(soma_budget, soma_budget_ceiling, mito_output, 0, soma_budget)
|
||||
branch_Vm = integrate(DEND.branch_Vm, branches)
|
||||
// EMIT — ship downstream (demand = propagated tags)
|
||||
soma_ship_dend = ship(soma_budget, dend_demand, dend_ship_frac, ship_cost)
|
||||
soma_ship_axon = ship(soma_budget, axon_demand, axon_ship_frac, ship_cost)
|
||||
// DECAY
|
||||
soma_adaptation *= decay(τ_adapt); soma_fast_trace *= decay(τ_nuclear)
|
||||
soma_refractory_alignment *= decay(τ_align) // self-limiting
|
||||
soma_possible_tag *= decay(s); soma_endurance_need *= decay(min)
|
||||
soma_tag *= decay(hr); dopamine *= decay(ms)
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## AXON
|
||||
|
||||
```
|
||||
// PARAMETERS (axon)
|
||||
// prop_cost budget_factor (depleted-propagation penalty)
|
||||
//
|
||||
// EXTERNAL INTERFACE
|
||||
// EMIT APs_delivered → PRE (propagation) ; axon_ship_pre → PRE
|
||||
// RECEIVE soma_ship_axon ← SOMA ; astro_lactate[shaft] ← ASTRO
|
||||
// axon_material, axon_energy ← SOMA(NIGHT)
|
||||
// READ SOMA.fired ; dopamine
|
||||
// OWN axon_structure{propagation, transport_ceiling, mito_density} ; axon_budget_ceiling
|
||||
|
||||
DAY | AP:
|
||||
reliability = axon_structure.propagation × (1 - fail(axon_fast_trace))
|
||||
// BEHAVE — propagate (degraded if depleted)
|
||||
if axon_budget < prop_cost:
|
||||
reliability *= budget_factor
|
||||
// EVALUATE (endurance) — propagating a strong train when fuel failed (LOCAL)
|
||||
if axon_fast_trace > traj_thr: axon_endurance_need += axon_fast_trace
|
||||
delivered = fired × reliability; axon_budget -= prop_cost × delivered
|
||||
// EMIT — delivered APs reach boutons
|
||||
// SENSE
|
||||
axon_fast_trace += delivered; axon_fast_trace *= decay(s)
|
||||
|
||||
DAY | NOT_AP:
|
||||
// RECEIVE
|
||||
axon_budget += refill(axon from soma_ship_axon + astro_lactate[shaft])
|
||||
// EMIT — ship budget to boutons (demand = pre tag)
|
||||
axon_ship_pre = ship(axon_budget, pre_demand, pre_ship_frac, ship_cost)
|
||||
// EVALUATE (strength)
|
||||
if axon_fast_trace > elig: axon_possible_tag += axon_fast_trace
|
||||
if dopamine > dop_thr and axon_possible_tag > tag_thr:
|
||||
axon_tag += dopamine × axon_possible_tag
|
||||
// DECAY
|
||||
axon_fast_trace *= decay(s); axon_possible_tag *= decay(s)
|
||||
axon_endurance_need *= decay(min); axon_tag *= decay(hr)
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## ASTRO
|
||||
|
||||
```
|
||||
// PARAMETERS (astro)
|
||||
// K_Dserine half-max Ca for D-serine Ds_max Ds_frac Ds_cost
|
||||
// EAAT_cost per unit glutamate cleared lactate_cost per unit exported
|
||||
// spillover overflow threshold overload lockdown threshold
|
||||
//
|
||||
// EXTERNAL INTERFACE
|
||||
// EMIT astro_lactate[i] → pre/post/dend budgets ; astro_Dserine[i] → POST (gate)
|
||||
// RECEIVE glucose (ROOT) ; astro_material, astro_energy ← cell body (NIGHT)
|
||||
// READ glutamate ← PRE (clearance + spillover) ; dopamine
|
||||
// OWN astro_structure{perisynaptic_distance⁻¹, EAAT, Dserine_tonic, ECM} ; astro_budget_ceiling
|
||||
// EMERGENCY emits shockwave_lockdown on overload
|
||||
|
||||
DAY | CONTINUOUS: // per astrosynapse i
|
||||
// RECEIVE — root production, capped by glucose
|
||||
astro_central_budget += glycolysis(glucose)·Δt
|
||||
// EMIT — demand-weighted lactate allocation across territory
|
||||
for each i: demand[i] = clearance_load[i] × astro_structure[i].delivery_eff
|
||||
factor = min(1, astro_central_budget / (Σ demand·lactate_cost + ε))
|
||||
for each i:
|
||||
astro_lactate[i] = demand[i] × factor; astro_central_budget -= astro_lactate[i]·lactate_cost
|
||||
// BEHAVE — clear glutamate; supply tonic D-serine
|
||||
glutamate[i] -= astro_structure[i].EAAT × glutamate[i]·Δt; astro_central_budget -= clearance·EAAT_cost
|
||||
astro_Dserine[i] += astro_structure[i].Dserine_tonic·Δt
|
||||
if glutamate[i] > spillover:
|
||||
// SENSE
|
||||
astro_fast_trace[i] += mGluR_Ca(); astro_fast_trace[i] *= decay(s)
|
||||
// BEHAVE + EMIT — D-serine pulse (demand-driven, budget-limited)
|
||||
want = sat(astro_fast_trace[i], K_Dserine) × Ds_max
|
||||
got = min(want, astro_central_budget × Ds_frac)
|
||||
astro_Dserine[i] += got; astro_central_budget -= got·Ds_cost
|
||||
// EVALUATE (endurance) — ran out of synthesis under high own demand (LOCAL)
|
||||
if got < want and astro_fast_trace[i] > traj_thr:
|
||||
astro_endurance_need[i] += (want - got)
|
||||
// EVALUATE (strength)
|
||||
if astro_fast_trace[i] > elig: astro_possible_tag[i] += astro_fast_trace[i]
|
||||
if dopamine > dop_thr and astro_possible_tag[i] > tag_thr:
|
||||
astro_tag[i] += dopamine × astro_possible_tag[i]
|
||||
// DECAY
|
||||
astro_possible_tag[i] *= decay(s); astro_endurance_need[i] *= decay(min)
|
||||
astro_tag[i] *= decay(hr)
|
||||
// EMERGENCY
|
||||
if astro_fast_trace[i] > overload: emit(shockwave_lockdown)
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## Special — Shockwave Lockdown
|
||||
|
||||
```
|
||||
DAY or NIGHT | OVERLOAD:
|
||||
Vm = HYPERPOLARIZED; AMPA_surface = mass_internalize() → post reserve
|
||||
axon_fast_trace += overdrive(); astro_central_budget -= emergency_cost
|
||||
```
|
||||
|
||||
---
|
||||
---
|
||||
# NIGHT
|
||||
System-wide consolidation (not a per-component DAY cycle). Build ceilings from DAY evidence.
|
||||
|
||||
```
|
||||
NIGHT | 1 REPLENISH & DISTRIBUTE
|
||||
// energy economy: astrocyte central → astrosynapses (astro_tag-weighted)
|
||||
astro_central_{budget,energy,material} += overnight_*(glucose, …)·Δt
|
||||
for each i with astro_tag[i] > tag_expiry: w = astro_tag[i]/Σastro_tag
|
||||
astro_energy[i] += astro_central_energy·w; astro_material[i] += astro_central_material·w
|
||||
// material economy: soma → branch/axon → spine/bouton
|
||||
soma_budget += overnight_mito()·Δt; soma_energy += overnight_soma_energy()·Δt
|
||||
soma_material += CREB_synth(soma_tag)·Δt // bottleneck
|
||||
dend_material += soma_material·f_dend; axon_material += soma_material·f_axon; soma_material -= …
|
||||
post_material += dend_material·f_spine; pre_material += axon_material·f_bouton
|
||||
{pre,post,dend,axon}_energy += soma_energy·f[·]
|
||||
{pre,post,dend,axon}_budget += astro_lactate_reserve·f[·]·Δt
|
||||
|
||||
NIGHT | 2 STRENGTH COMMITS (raise structure)
|
||||
coherence = (pre_tag, post_tag, astro_tag all > tag_expiry) ? coherence_factor : 1
|
||||
for each c with c_tag > tag_expiry:
|
||||
Δ = min(slot_cost, c_material, c_energy·f)
|
||||
c_structure += Δ × (coherence if c in {pre,post,astro} else 1)
|
||||
c_material -= Δ; c_energy -= Δ·assembly_cost
|
||||
if Δ < slot_cost: queue(c_strength_deficit → next NIGHT)
|
||||
|
||||
NIGHT | 2b ENDURANCE COMMITS (raise budget_ceiling) — no dopamine; competes with step 2
|
||||
for each c with c_endurance_need > endur_thr:
|
||||
Δ = min(cap_cost, c_material·f_cap, c_energy·f_cap)
|
||||
c_budget_ceiling += Δ; c_material -= Δ; c_energy -= Δ·biogenesis_cost
|
||||
if Δ < cap_cost: queue(c_endurance_deficit → next NIGHT)
|
||||
|
||||
NIGHT | 3 PASSIVE DECAY (both ceilings, by neglect)
|
||||
maint = (total_material - consumed) × maint_frac / synapse_count
|
||||
for each synapse:
|
||||
{pre,post,dend,astro}_structure -= decay_rate·Δt
|
||||
{pre,post,dend,astro}_budget_ceiling -= capacity_decay_rate·Δt
|
||||
if maint ≥ maint_cost: structure += full_maint; budget_ceiling += full_cap_maint
|
||||
else: structure += maint·frac; budget_ceiling += maint·cap_frac
|
||||
for each synapse with net_change < 0: // material recovered, energy not
|
||||
{pre,post,astro}_material += |net_change|·recycle·frac
|
||||
|
||||
NIGHT | 4 HOMEOSTATIC SCALING
|
||||
if soma_tag > homeostatic_ceiling:
|
||||
s = homeostatic_ceiling / soma_tag
|
||||
for each synapse: post_structure.slot_ceiling *= s; pre_structure.slot_ceiling *= s
|
||||
soma_material += Σ reduction·recycle
|
||||
|
||||
NIGHT | 5 CLEAR TRACES
|
||||
all fast_trace, possible_tag, endurance_need = 0
|
||||
soma_Na_inactivation = soma_adaptation = soma_refractory_alignment = 0
|
||||
for each tag: if tag < tag_expiry: tag = 0 // else carry forward
|
||||
// structure and budget_ceiling PERSIST
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## One-view summary
|
||||
|
||||
```
|
||||
DAY per context, per component: RECEIVE → BEHAVE/EMIT/SENSE → RECOVER → EVALUATE → DECAY
|
||||
behavior runs within structure (strength) and budget_ceiling (endurance),
|
||||
both filled by competition (refill = contested, fill = private, ship = directed)
|
||||
fast_trace + dopamine coincidence → tag (strength evidence)
|
||||
depletion + interrupted LOCAL success → endurance_need (endurance evidence)
|
||||
NIGHT tag → structure ; endurance_need → budget_ceiling ; both draw one pool (compete)
|
||||
unmaintained ceilings decay → freed material funds the rest
|
||||
LOCAL every evaluation uses only own state + arrived signals; coupling is via channels.
|
||||
```
|
||||
@@ -0,0 +1,333 @@
|
||||
# Tripartite Synapse — Biological Reference (companion to v10 pseudocode)
|
||||
|
||||
> This document explains what each variable and behavior in `tripartite_synapse_v10_pseudocode.md`
|
||||
> conflates biologically. The pseudocode aggregates many molecular details into single
|
||||
> variables for clarity; here each aggregation is unpacked. Read the pseudocode for the
|
||||
> logic; read this when you need to know what a variable physically represents.
|
||||
|
||||
---
|
||||
|
||||
## The three synaptic components and their support structures
|
||||
|
||||
A SYNAPSE is composed of three first-class components:
|
||||
- **PRE** — presynaptic bouton (the axon's terminal at this synapse)
|
||||
- **POST** — postsynaptic spine (the dendrite's terminal at this synapse)
|
||||
- **ASTRO** — astrosynapse, the perisynaptic astrocytic process (the astrocyte's terminal)
|
||||
|
||||
Each has an upstream support structure that supplies it:
|
||||
- **AXON** supplies PRE (transmission + transport from soma)
|
||||
- **DEND** supplies POST (integration + transport from soma)
|
||||
- the **astrocyte cell body** supplies ASTRO (energy + ECM material)
|
||||
- **SOMA** is the integrating center and the root of neuronal material
|
||||
|
||||
The compartment analogy: AXON:PRE = DEND:POST = astrocyte-body:ASTRO = supply line : terminal.
|
||||
|
||||
---
|
||||
|
||||
## Resource variables
|
||||
|
||||
### DAY budget (one per component)
|
||||
Aggregates fast energy AND fast consumables — everything needed to run moment-to-moment.
|
||||
|
||||
- **pre_budget** — ATP for VGCC gating, vesicle fusion (SNARE), VATPase vesicle refill,
|
||||
plus fast consumables: vesicle membrane lipids, synaptotagmin recycling.
|
||||
- **post_budget** — ATP for the NaK pump (membrane reset after current), NMDA current
|
||||
handling, plus fast actin monomers for transient spine changes and receptor-recycling lipids.
|
||||
- **dend_budget** — ATP for bAP propagation (NaK reset along branch), local translation
|
||||
(ribosome running cost), SERCA Ca²⁺ resequestration, plus fast mRNA consumed by translation.
|
||||
- **soma_budget** — ATP for AP generation (Na⁺/K⁺ currents + NaK reset), CREB
|
||||
phosphorylation, nuclear Ca²⁺ handling, plus shipping running costs.
|
||||
- **axon_budget** — ATP for AP propagation at nodes of Ranvier, kinesin/dynein motor
|
||||
running cost, fast myelin maintenance.
|
||||
- **astro_central_budget** — ATP from glycolysis at the astrocyte cell body; funds EAAT
|
||||
clearance, serine→D-serine synthesis, lactate export, fast process motility.
|
||||
|
||||
### astro_lactate[i]
|
||||
Lactate exported from the astrocyte cell body to synapse i. Biologically: glucose →
|
||||
(glycolysis) → lactate, released into extracellular space, absorbed by neuronal MCT2
|
||||
transporters, converted to pyruvate → TCA → ATP in the neuron's mitochondria. The astrocyte
|
||||
is the primary fast-energy supplier to pre, post, and dend.
|
||||
|
||||
### NIGHT energy (one per component) — NOT recoverable
|
||||
ATP for structural assembly. Distinct from DAY budget because it is spent on building, and
|
||||
the work of assembly is thermodynamically gone once done (cannot be recovered by disassembly).
|
||||
- pre_energy: RIM/Munc13 incorporation, VGCC clustering.
|
||||
- post_energy: CaMKII anchoring, actin polymerization, PSD scaffold remodeling.
|
||||
- dend_energy: mitochondria incorporation, cytoskeletal reinforcement.
|
||||
- soma_energy: ribosome biogenesis, ion-channel incorporation.
|
||||
- axon_energy: myelination, microtubule stabilization.
|
||||
- astro_energy: process retraction, ECM secretion, racemase upregulation.
|
||||
|
||||
### NIGHT material (one per component) — RECOVERABLE
|
||||
Slow structural proteins. Recoverable because disassembly (LTD) returns the proteins to a
|
||||
reusable pool (ubiquitin-proteasome → amino acids; internalized receptors → endosomal reserve).
|
||||
- **soma_material** (root) — all neuronal structural proteins from CREB-driven synthesis:
|
||||
AMPA subunits, PSD scaffold, AZ scaffold, mRNA transcripts (Arc, BDNF), organelles.
|
||||
- **dend_material** — from soma: Arc/plasticity mRNA, mitochondria, cytoskeletal proteins,
|
||||
AMPA subunits in transit to spines.
|
||||
- **post_material** — from dend: AMPA receptor subunits (GluA1/2), PSD scaffold (PSD-95,
|
||||
SHANK, Homer), structural actin, CaMKII.
|
||||
- **axon_material** — from soma: kinesin/dynein motors, microtubule components, myelin proteins.
|
||||
- **pre_material** — from axon: RIM, Munc13, VGCC subunits, structural vesicle proteins.
|
||||
- **astro_material** (root: astrocyte cell body) — EAAT proteins, serine racemase, ECM
|
||||
proteins (Glypicans, Thrombospondins), process cytoskeleton.
|
||||
|
||||
**Why energy and material are separate in NIGHT but combined in DAY:** during DAY both are
|
||||
fast consumables replenished on the same timescale, so one `budget` variable suffices. During
|
||||
NIGHT they diverge — material is recoverable after LTD, energy is not — so they must be two
|
||||
variables. This asymmetry (material returns to the pool, energy is gone) is what makes one
|
||||
synapse's depression genuinely fund another's potentiation.
|
||||
|
||||
---
|
||||
|
||||
## Structural variables (strength ceilings — written in NIGHT)
|
||||
|
||||
Each aggregates several correlated structural properties into one capacity.
|
||||
|
||||
- **pre_structure** — active zone capacity:
|
||||
slot_ceiling (number of vesicle docking slots) + VGCC_coupling (Ca²⁺-channel proximity to
|
||||
slots, sets release efficiency) + refill_ceiling (max RRP replenishment rate).
|
||||
- **post_structure** — spine sensitivity capacity:
|
||||
slot_ceiling (number of PSD anchoring slots for AMPA) + spine_volume (local reserve and
|
||||
actin machinery) + reserve_ceiling (endosomal AMPA pool size).
|
||||
- **dend_structure** — branch capacity:
|
||||
bAP_fidelity(position) (mitochondrial density sets propagation strength, attenuates with
|
||||
distance) + translation_ceiling (local mRNA capacity) + transport_speed (cytoskeletal integrity).
|
||||
- **soma_structure** — somatic output capacity:
|
||||
baseline_threshold (inverse: ion-channel density at axon initial segment) + AP_reliability
|
||||
(Na⁺ channel density) + synthesis_ceiling (ribosome density + CREB machinery).
|
||||
- **axon_structure** — axonal capacity:
|
||||
propagation reliability (myelination density) + transport_ceiling (motor density + microtubule
|
||||
integrity) + mitochondrial density.
|
||||
- **astro_structure** — astrosynaptic environmental capacity:
|
||||
perisynaptic_distance⁻¹ (wall proximity — closer = more glutamate contained) + EAAT_density
|
||||
(clearance ceiling) + Dserine_tonic (baseline co-agonist) + ECM_integrity.
|
||||
**Self-reinforcing both directions:** tighter wrap + more tonic D-serine make future
|
||||
potentiation easier; looser wrap + zero tonic D-serine make future depression easier.
|
||||
|
||||
---
|
||||
|
||||
## Budget ceilings (endurance ceilings — written in NIGHT)
|
||||
|
||||
- **{component}_budget_ceiling** — the maximum fuel the component can hold / the maximum
|
||||
duration of sustained behavior. Biologically: mitochondrial density and local fuel-storage
|
||||
capacity. Built by activity-driven mitochondrial biogenesis; lost by mitophagy when idle.
|
||||
Parallel to structure: structure is strength capacity, budget_ceiling is endurance capacity.
|
||||
|
||||
---
|
||||
|
||||
## Trace variables
|
||||
|
||||
### fast_trace (one per component) — DAY only, decays automatically
|
||||
The local record of recent activity that biases the next behavior.
|
||||
- **pre_fast_trace** — residual presynaptic Ca²⁺ after spikes (τ≈100ms). Biases NT release
|
||||
(facilitation) and provides tagging eligibility.
|
||||
- **post_fast_trace** — spine Ca²⁺ amplitude × rise-speed (τ≈tens ms). Encodes the LTP-vs-LTD
|
||||
instruction (fast rise → CaMKII → potentiation; slow rise → phosphatase → depression).
|
||||
- **dend_fast_trace** — branch Ca²⁺ from bAP + spine spillover (τ≈300ms). Integrates branch co-activity.
|
||||
- **soma_fast_trace** — nuclear Ca²⁺ from each AP (τ≈seconds). Drives toward CREB activation.
|
||||
- **axon_fast_trace** — propagation load (τ≈seconds). High load → Na⁺ inactivation at branch
|
||||
points → propagation failure (this is axonal short-term depression).
|
||||
- **astro_fast_trace** — perisynaptic Ca²⁺ from mGluR5 activation by glutamate spillover
|
||||
(τ≈seconds). Drives D-serine release.
|
||||
|
||||
### soma timing traces (emergent refractory + adaptation + alignment)
|
||||
- **soma_Na_inactivation** (τ≈ms) — sodium-channel inactivation after an AP. Its recovery IS
|
||||
the refractory period (emergent, not a hardcoded timer). High → absolute refractory; decaying
|
||||
→ relative refractory; recovered → normal.
|
||||
- **soma_adaptation** (τ≈100s of ms) — slow K⁺ channel (SK/M-type) activation accumulating
|
||||
over a spike train, raising threshold. This is spike-frequency adaptation.
|
||||
- **soma_refractory_alignment** — deposited when a suprathreshold input arrives during
|
||||
refractoriness (a missed coincidence). Speeds future recovery so the soma aligns to its input
|
||||
rhythm. Bottom-up: no rhythm is represented; alignment emerges from accumulated local
|
||||
mismatches and decays when mismatches stop (self-limiting).
|
||||
|
||||
### possible_tag (one per component) — intermediate, τ≈s–min
|
||||
Graded accumulation of tagging eligibility. For POST, this is the CANDIDATE tag lifetime.
|
||||
|
||||
### endurance_need (one per component) — intermediate, τ≈s–min
|
||||
Deposited when budget depletion interrupts a behavior that was on a LOCALLY successful
|
||||
trajectory. Records that fuel — not structure, not significance — was the binding constraint
|
||||
on a forming success. Requires NO dopamine (homeostatic, not associative).
|
||||
**Local success proxy per component** (each uses only its own state + arrived signals):
|
||||
- PRE: own fast_trace high (was releasing strongly), optionally amplified by retrograde
|
||||
messenger (endocannabinoid / NO / BDNF) that has arrived.
|
||||
- POST: own Ca²⁺ climbing toward tagging threshold (naturally local).
|
||||
- DEND: own branch strongly active (high branch voltage/Ca²⁺) when propagation fell short.
|
||||
- SOMA: own nuclear Ca²⁺ climbing toward CREB.
|
||||
- AXON: own propagation load high (was carrying a strong train).
|
||||
- ASTRO: own local glutamate/Ca²⁺ high (was under heavy clearance/D-serine demand).
|
||||
|
||||
### tag (one per component) — DAY→NIGHT bridge, τ≈hours
|
||||
The validated record of significance that survives to NIGHT and gates strength commits.
|
||||
Formed by coincidence of local eligibility + non-local validation (dopamine).
|
||||
**POST is special — two-phase, three coincidences:**
|
||||
- CANDIDATE: local Ca²⁺ above threshold + astrosynapse D-serine present (coincidence 1).
|
||||
- amplified when bAP confirms soma fired (coincidence 2).
|
||||
- STABLE: CANDIDATE + dopamine within stabilization window (coincidence 3).
|
||||
Biologically: early CaMKII creates a labile tag (early-LTP); PKA driven by dopamine via D1R
|
||||
stabilizes it (late-LTP). Without dopamine, the candidate degrades — early-LTP reverses.
|
||||
|
||||
---
|
||||
|
||||
## Behaviors — biological meaning
|
||||
|
||||
### PRE | AP — neurotransmitter release
|
||||
`NT_flux = RRP × sat(pre_fast_trace, K_release)` models continuous NT release proportional to
|
||||
the readily-releasable pool and a saturating Ca²⁺ drive (synaptotagmin's cooperative Ca²⁺
|
||||
sensitivity, simplified to a saturating curve). RRP depletes as released (short-term depression
|
||||
as a consequence) and refills via VATPase (energy-throttled, so low budget deepens depression).
|
||||
The mGluR2/3 brake is presynaptic autoinhibition by spillover (Gi → reduced VGCC opening).
|
||||
|
||||
### POST | NOT_bAP — three calcium sources, two plasticity cases
|
||||
- **Source 1 (AMPA):** glutamate opens AMPA → depolarizing current + small Ca²⁺; the
|
||||
depolarization begins ejecting the NMDA Mg²⁺ block.
|
||||
- **Source 2 (NMDA):** if depolarized enough (Mg²⁺ ejected) AND D-serine present (astrocyte
|
||||
co-agonist) AND glutamate bound → large Ca²⁺ influx. This is the coincidence detector.
|
||||
- **Source 3 (bAP, separate context):** back-propagating AP adds depolarization + Ca²⁺,
|
||||
amplifying an existing signal supralinearly.
|
||||
- **Case 1 (STP):** high Ca²⁺ drives AMPA receptors from the local reserve to the surface,
|
||||
bounded by the anchoring-slot ceiling. Fast, reversible, NO dopamine. When Ca²⁺ falls,
|
||||
receptors drift back — short-term depression as a passive consequence, never signaled.
|
||||
- **Case 2 (LTP tag):** high Ca²⁺ + (later) dopamine sets the tag that NIGHT uses to raise the
|
||||
slot ceiling. NIGHT builds slots; DAY fills them.
|
||||
|
||||
### DEND | bAP — bidirectional signaling
|
||||
Propagates the bAP from soma toward spines (fidelity attenuates with distance — distal spines
|
||||
get weaker confirmation, are harder to potentiate) and integrates spine signals toward the soma.
|
||||
|
||||
### SOMA | AP — integration, firing, emergent timing
|
||||
Fires when integrated branch input exceeds a threshold that is the baseline (from structure)
|
||||
raised by adaptation and modulated by neuromodulators, gated by the emergent refractory state.
|
||||
Each AP deposits three traces (inactivation → refractory, adaptation → threshold rise, nuclear
|
||||
Ca²⁺ → plasticity). The soma is the coincidence detector at the cellular scale (nuclear Ca²⁺ +
|
||||
dopamine → CREB), and the production bottleneck: its tag gates how much material all downstream
|
||||
components get in NIGHT.
|
||||
|
||||
### AXON | AP — reliable propagation with frequency-dependent failure
|
||||
Propagation reliability is set by myelination and degraded by high-frequency load (Na⁺
|
||||
inactivation at branch points = axonal STD). The axon also transports material to boutons and
|
||||
sets the timescale of presynaptic structural commits.
|
||||
|
||||
### ASTRO | CONTINUOUS — gatekeeper and energy hub
|
||||
Clears glutamate (EAAT), supplies D-serine (the NMDA co-agonist that gates postsynaptic LTP),
|
||||
and distributes lactate to the territory by demand-weighting (active synapses generating more
|
||||
clearance load pull more fuel; slow synapses get less). The same spillover that excites the
|
||||
astrocyte (mGluR5 → Ca²⁺ → D-serine) also brakes the presynapse (mGluR2/3 → Gi) — one signal,
|
||||
opposite effects via different receptors. The astrocyte is the energy root and the gain control
|
||||
of the whole synapse.
|
||||
|
||||
---
|
||||
|
||||
## NIGHT operations — biological meaning
|
||||
|
||||
- **Step 1 (replenish/distribute):** overnight protein synthesis peaks (CREB-driven, gated by
|
||||
soma_tag — corresponds to slow-wave-sleep replay). Soma material flows to branches/axon then
|
||||
spines/boutons; astrocyte material flows to astrosynapses, tag-weighted.
|
||||
- **Step 2 (strength commits):** tagged components build structure — more slots, tighter
|
||||
coupling, tighter astrosynaptic wrap. Coherence bonus when pre+post+astro all tagged (the
|
||||
whole synapse agrees). astro_structure self-reinforces.
|
||||
- **Step 2b (endurance commits):** components with high endurance_need build budget_ceiling —
|
||||
mitochondrial biogenesis. Competes with step 2 for the same material/energy.
|
||||
- **Step 3 (passive decay):** both ceilings decay; maintenance from the remaining pool resists
|
||||
decay only where sufficient. Depotentiation and endurance-loss are both by neglect — no
|
||||
signal weakens anything; unmaintained capacity simply drifts down. Recovered material (not
|
||||
energy) returns to pools.
|
||||
- **Step 4 (homeostatic scaling):** if the soma fired too much overall, all synapses scale down
|
||||
proportionally (sleep-associated global downscaling), preserving relative differences.
|
||||
- **Step 5 (clear traces):** fast traces, possible tags, endurance needs, and soma timing traces
|
||||
reset; tags below expiry clear, above-expiry tags carry forward (multi-night consolidation);
|
||||
structure and budget_ceiling persist.
|
||||
|
||||
### Shockwave lockdown
|
||||
Emergency global astrocytic Ca²⁺ wave → GABA + ATP release → mass AMPA internalization and
|
||||
hyperpolarization. Bypasses budget gates. A circuit breaker against runaway excitation.
|
||||
|
||||
---
|
||||
|
||||
## Pool-filling: private reserve vs contested supply
|
||||
|
||||
The pseudocode uses two filling primitives, distinguished by where the resource comes from.
|
||||
|
||||
**`fill` (private reserve).** The pool is replenished from a source the component owns
|
||||
outright, uncontested by siblings, bounded by the component's own ceiling and a rate cap.
|
||||
- RRP refill — vesicles mobilized from the bouton's own reserve pool toward the docking-slot
|
||||
ceiling, rate-limited by VATPase. The reserve is private to the bouton.
|
||||
- SOMA self-replenish — the soma fuels itself from its own mitochondria toward its budget
|
||||
ceiling. No other component draws on it.
|
||||
|
||||
**`refill` (contested supply).** The pool is replenished from a supply that multiple
|
||||
components compete for, rationed by demand (gap to ceiling).
|
||||
- pre/post/dend/axon budgets — drawn from astrocytic lactate (shared across all synapses the
|
||||
astrocyte wraps) plus shipment from soma/axon/dendrite (shared across downstream targets).
|
||||
|
||||
**Neither primitive (their own forms).** Some inflows are not fills toward a ceiling:
|
||||
- AMPA surface insertion — Ca²⁺-driven rate from the spine's private endosomal reserve, with
|
||||
an explicit passive drift-back (short-term depression) when Ca²⁺ is low. Not a steady fill.
|
||||
- D-serine release — demand-driven (saturating in astro Ca²⁺) and budget-limited, like NT
|
||||
release; a release process, not a pool top-up.
|
||||
- Root productions — `glycolysis(glucose)` at the astrocyte and `CREB_synth(soma_tag)` at the
|
||||
soma are the system's energy and material roots: raw inflows capped only by the external
|
||||
vascular supply, not fills toward an internal ceiling.
|
||||
|
||||
The distinction matters biologically: a private reserve guarantees a component some autonomy
|
||||
(the bouton can refill its RRP from its own vesicles even when lactate is scarce), while a
|
||||
contested supply couples a component's fate to its neighbours' demands (operational budget
|
||||
fails first where many active synapses compete for the same lactate).
|
||||
|
||||
---
|
||||
|
||||
## PRE ↔ POST interaction: local computation, message-only coupling
|
||||
|
||||
The presynapse and postsynapse never read each other's internal state. They interact only
|
||||
by writing to and reading from shared cleft channels. Each side computes entirely locally on
|
||||
what it has: its own variables plus whatever signals have arrived in the cleft. This is the
|
||||
message-passing realization of the locality principle.
|
||||
|
||||
**Forward channel — glutamate (PRE → POST and ASTRO).** The presynapse writes glutamate via
|
||||
NT_flux. The postsynapse reads it (AMPA, NMDA) and the astrosynapse reads it (clearance,
|
||||
mGluR5). The astrosynapse clears it. PRE never knows whether POST responded — it only emits.
|
||||
|
||||
**Gate channel — astro_Dserine (ASTRO → POST).** The astrosynapse writes D-serine; the
|
||||
postsynapse reads it as the obligatory NMDA co-agonist. POST cannot open NMDA without this
|
||||
arrived signal, but it does not read the astrocyte's state — only the delivered D-serine.
|
||||
|
||||
**Backward channel + — retro_NO (POST → PRE).** When the postsynapse's NMDA opens (Mg²⁺
|
||||
ejected, D-serine present, glutamate bound), nNOS — physically tethered to the NMDA receptor
|
||||
through PSD-95 — synthesises nitric oxide (and, on a slower timescale, BDNF is released).
|
||||
These diffuse retrogradely to the presynapse. Biologically this is the classic retrograde
|
||||
messenger of LTP: it tells the bouton that its release landed on a postsynapse that genuinely
|
||||
responded. In the model, POST emits `retro_NO` proportional to its own NMDA-driven calcium —
|
||||
computed purely from POST's local state — and PRE reads it as `retro_NO_local`.
|
||||
|
||||
`retro_NO_local` is exactly the grounding of the presynaptic endurance signal. The
|
||||
presynapse's local success proxy is "I was releasing strongly" (`pre_fast_trace` high). On
|
||||
its own that only says the bouton was working hard, not that the work mattered. `retro_NO`
|
||||
adds the missing confirmation — that the postsynapse responded — without PRE ever reading
|
||||
POST's calcium. So PRE deposits endurance need as `pre_fast_trace × (1 + retro_NO_local)`:
|
||||
strong release that was confirmed effective makes the strongest claim that fuel, not
|
||||
futility, was what interrupted a forming success. retro_NO is short-lived (NO degrades and
|
||||
diffuses within seconds), so the channel decays fast — confirmation must be recent to count.
|
||||
|
||||
**Backward channel − — retro_eCB (POST → PRE).** When the postsynapse is strongly
|
||||
depolarised, it synthesises endocannabinoids (2-AG, anandamide) that diffuse retrogradely and
|
||||
bind presynaptic CB1 receptors, suppressing release. This is depolarisation-induced
|
||||
suppression of excitation (DSE) — a homeostatic negative feedback: an over-driven postsynapse
|
||||
tells the presynapse to release less. In the model, POST emits `retro_eCB` from its own
|
||||
membrane potential, and PRE reads it as `retro_eCB_local`, which reduces the release drive
|
||||
`sat(...) × (1 - retro_eCB_local)`. Again POST computes from its own state; PRE adjusts from
|
||||
the arrived signal; neither reads the other's interior.
|
||||
|
||||
The two backward channels are opposite-signed messages the postsynapse sends about its own
|
||||
condition: retro_NO says "your input was effective — worth sustaining," retro_eCB says "I am
|
||||
saturated — ease off." Together with the forward glutamate and the D-serine gate, they make
|
||||
the synapse a fully message-coupled system of locally-computing components.
|
||||
|
||||
**Why RRP refill is in NOT_AP only.** During an AP the bouton releases — RRP depletes. Refill
|
||||
(VATPase reloading vesicles from the reserve pool) is a recovery process that proceeds between
|
||||
spikes. Placing `fill(RRP, ...)` only in the NOT_AP context makes the AP context pure
|
||||
depletion and the NOT_AP context pure recovery. A consequence falls out for free: during
|
||||
sustained high-frequency firing there are many AP steps and few NOT_AP steps, so RRP depletes
|
||||
faster than it recovers — short-term depression deepens with frequency, with no explicit
|
||||
depression rule. The release itself is throttled further when budget is low (VATPase refill
|
||||
is energy-limited), coupling metabolic state to the depth of depression.
|
||||
@@ -0,0 +1,510 @@
|
||||
# Tripartite Synapse — Pseudocode v10
|
||||
|
||||
> Companion document: `tripartite_synapse_v10_biology.md` explains the biological
|
||||
> meaning of every variable and behavior. This document is the logic only.
|
||||
|
||||
---
|
||||
|
||||
## Conventions
|
||||
|
||||
```
|
||||
SCOPE = { DAY, NIGHT }
|
||||
CONTEXT = { AP, NOT_AP, bAP, NOT_bAP, CONTINUOUS }
|
||||
COMPONENTS = { PRE, POST, DEND, SOMA, AXON, ASTRO }
|
||||
|
||||
DAY variables
|
||||
budget fast resource (energy + consumables), consumed by behavior
|
||||
fast_trace local record, decays in ms–s, biases next behavior
|
||||
possible_tag accumulates from fast_trace, decays in s–min
|
||||
endurance_need accumulates on interrupted local success, decays in s–min
|
||||
|
||||
DAY→NIGHT bridge
|
||||
tag decays in hours; POST: CANDIDATE → STABLE
|
||||
|
||||
NIGHT variables
|
||||
energy assembly ATP, NOT recoverable
|
||||
material structural proteins, RECOVERABLE after decay
|
||||
structure strength ceiling — READ in DAY, WRITTEN in NIGHT
|
||||
budget_ceiling endurance ceiling — READ in DAY, WRITTEN in NIGHT
|
||||
|
||||
LOCALITY RULE
|
||||
every evaluation uses only local state + signals that have arrived.
|
||||
no component reads another compartment's internal state.
|
||||
|
||||
CLEFT MESSAGE CHANNELS (the only PRE/POST/ASTRO interaction — each writes, others read)
|
||||
glutamate PRE → POST, ASTRO (forward transmitter; cleared by ASTRO)
|
||||
astro_Dserine ASTRO → POST (NMDA co-agonist gate)
|
||||
retro_NO POST → PRE (+) (NO/BDNF: "release reached a responsive target")
|
||||
retro_eCB POST → PRE (−) (endocannabinoid: "over-driven, suppress release" = DSE)
|
||||
Each channel decays/clears; a component reads a channel into a local copy and computes locally.
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## Saturating form (used wherever a graded signal drives output)
|
||||
|
||||
```
|
||||
sat(x, K) = x / (K + x)
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## Fixed parameters
|
||||
|
||||
```
|
||||
K_release K_AMPA K_Dserine
|
||||
Mg_eject Ca_STP Ca_TAG eCB_thr
|
||||
elig dop_thr tag_thr tag_expiry
|
||||
traj_thr endur_thr
|
||||
spillover inactivation overload
|
||||
homeostatic_ceiling decay_rate capacity_decay_rate recycle
|
||||
|
||||
dopamine NE ACh // organism broadcast (external)
|
||||
glucose // vascular ceiling (external)
|
||||
geometry // dendritic topology (external)
|
||||
```
|
||||
|
||||
---
|
||||
---
|
||||
# DAY
|
||||
|
||||
Execution contexts (AP, bAP, CONTINUOUS): run behavior, spend budget, deposit traces.
|
||||
Replenishment contexts (NOT_AP, NOT_bAP): competitive refill, ship downstream, decay traces, set tags.
|
||||
|
||||
---
|
||||
|
||||
## Pool-filling primitives
|
||||
|
||||
Two shapes share the core "rise toward a ceiling, bounded by the gap, paying budget":
|
||||
|
||||
```
|
||||
// PRIVATE: fill own pool from own reserve toward own ceiling, at a rate cap
|
||||
fill(pool, ceiling, rate_cap, cost, budget):
|
||||
amount = min(rate_cap, ceiling - pool)·Δt // bounded by rate AND gap
|
||||
pool += amount
|
||||
budget -= amount·cost
|
||||
|
||||
// CONTESTED: fill toward ceiling by a rationed share of a shared supply S
|
||||
refill(component c from supply S):
|
||||
demand = c.budget_ceiling - c.budget // claim = gap to ceiling
|
||||
total = Σ demand over components on S
|
||||
factor = min(1, S / (total + ε))
|
||||
c.budget += demand × factor // never exceeds ceiling
|
||||
S -= demand × factor
|
||||
```
|
||||
|
||||
Choose by source: a pool drawn from a **private reserve** uses `fill`; a pool drawn from a
|
||||
**contested shared supply** uses `refill`. The distinction is biologically real — RRP comes
|
||||
from the bouton's private reserve pool, while operational budget comes from astrocytic lactate
|
||||
that neighbours compete for.
|
||||
|
||||
---
|
||||
|
||||
## PRE
|
||||
|
||||
```
|
||||
// ─── PRESYNAPSE EXTERNAL INTERFACE ────────────────────────────────────────
|
||||
// PRE computes locally. Everything below crosses its boundary as a signal it
|
||||
// emits or a resource/signal it receives. It never reads another component's state.
|
||||
//
|
||||
// OUTPUT (PRE writes; others read)
|
||||
// glutamate → POST, ASTRO forward transmitter; ASTRO clears it
|
||||
//
|
||||
// RESOURCES IN (others write; PRE reads in NOT_AP)
|
||||
// astro_lactate[syn] ← ASTRO primary fast fuel → pre_budget
|
||||
// axon_ship_pre ← AXON secondary fuel → pre_budget
|
||||
// ship(axon_budget → pre_budget, gap_to(pre))
|
||||
// pre_material ← AXON (NIGHT) AZ proteins (RIM, Munc13, VGCC subunits)
|
||||
// pre_energy ← SOMA (NIGHT) assembly ATP for active-zone construction
|
||||
//
|
||||
// BACKWARD MESSAGES IN (POST writes from its own state; PRE reads)
|
||||
// retro_NO (+) ← POST "release reached a responsive target" → endurance
|
||||
// retro_eCB (−) ← POST DSE: "over-driven, release less" → brake
|
||||
//
|
||||
// CLEFT SELF-FEEDBACK (PRE reads the channel it writes)
|
||||
// glutamate ← cleft spillover autoreceptor brake (mGluR2/3 on PRE)
|
||||
//
|
||||
// ORGANISM BROADCAST IN (external; arrives as a local level)
|
||||
// dopamine ← VTA gates pre_tag (the non-local coincidence)
|
||||
// NE, ACh ← LC, basal excitability/threshold context
|
||||
//
|
||||
// OWN STRUCTURE (written NIGHT, read DAY)
|
||||
// pre_structure slot_ceiling, VGCC_coupling, refill_ceiling
|
||||
// pre_budget_ceiling endurance ceiling (bounds replenishment)
|
||||
//
|
||||
// EMERGENCY
|
||||
// shockwave_lockdown ← ASTRO global Ca²⁺ wave overrides PRE
|
||||
// ──────────────────────────────────────────────────────────────────────────
|
||||
|
||||
DAY | AP:
|
||||
// SENSE — deposit fast trace (residual Ca²⁺ from this spike; also drives release)
|
||||
pre_fast_trace += spike_Ca(input_freq)
|
||||
|
||||
// BEHAVE — release, or fail if depleted
|
||||
if pre_budget < release_cost:
|
||||
suppress(NT_flux)
|
||||
// EVALUATE (endurance) — interrupted LOCAL success, confirmed by retro_NO
|
||||
if pre_fast_trace > traj_thr:
|
||||
pre_endurance_need += pre_fast_trace × (1 + retro_NO_local)
|
||||
exit
|
||||
drive = sat(pre_fast_trace, K_release) × (1 - retro_eCB_local) // received DSE brake
|
||||
if RRP > 0:
|
||||
NT_flux = RRP × drive
|
||||
// EMIT — glutamate into cleft (read by POST, ASTRO)
|
||||
glutamate += NT_flux·Δt
|
||||
RRP -= NT_flux·Δt; pre_budget -= NT_flux·fusion_cost
|
||||
if glutamate > spillover: drive *= brake // own-cleft autoreceptor brake
|
||||
// no RECOVER here — RRP refills in NOT_AP; high-frequency firing depletes
|
||||
// faster than it recovers → short-term depression deepens
|
||||
|
||||
DAY | NOT_AP:
|
||||
// RECEIVE — latch arrived backward messages; replenish budget (contested supply)
|
||||
retro_NO_local = retro_NO
|
||||
retro_eCB_local = retro_eCB
|
||||
refill(pre from astro_lactate[syn] + axon_ship_pre)
|
||||
|
||||
// RECOVER — refill RRP from private reserve toward its ceiling
|
||||
fill(RRP, pre_structure.slot_ceiling, pre_structure.refill_ceiling, vatpase_cost, pre_budget)
|
||||
|
||||
// EVALUATE (strength) — eligibility → possible_tag → tag (needs dopamine)
|
||||
if pre_fast_trace > elig: pre_possible_tag += pre_fast_trace
|
||||
if dopamine > dop_thr and pre_possible_tag > tag_thr:
|
||||
pre_tag += dopamine × pre_possible_tag
|
||||
|
||||
// DECAY — all traces and channels recede, closing their windows
|
||||
pre_fast_trace *= decay(100ms)
|
||||
pre_possible_tag *= decay(s)
|
||||
pre_endurance_need *= decay(min)
|
||||
pre_tag *= decay(hr)
|
||||
dopamine *= decay(ms) // broadcast transient fades
|
||||
retro_NO *= decay(s); retro_eCB *= decay(s) // backward channels clear
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## POST
|
||||
|
||||
```
|
||||
DAY | NOT_bAP:
|
||||
refill(post from astro_lactate[syn] + dend_ship_post)
|
||||
|
||||
// SOURCE 1 — AMPA: current + small Ca + begins Mg ejection
|
||||
a = sat(glutamate, K_AMPA)
|
||||
AMPA_current = a × AMPA_surface; Vm += AMPA_current
|
||||
post_fast_trace += AMPA_Ca·AMPA_current; post_budget -= AMPA_cost
|
||||
|
||||
// SOURCE 2 — NMDA: large Ca if local coincidence
|
||||
if Vm > Mg_eject and astro_Dserine > thr and glutamate > 0:
|
||||
post_fast_trace += NMDA_Ca(glutamate)·rise_speed(); post_budget -= NMDA_cost
|
||||
retro_NO += NO_emit(post_fast_trace); post_budget -= NO_synth_cost
|
||||
// POST → PRE (+): nNOS coupled to NMDA emits NO/BDNF — "your release was effective"
|
||||
|
||||
// backward brake to PRE (−): strong depolarization → endocannabinoid (DSE)
|
||||
if Vm > eCB_thr:
|
||||
retro_eCB += eCB_emit(Vm); post_budget -= eCB_synth_cost
|
||||
// POST → PRE (−): "I am over-driven — reduce release"
|
||||
|
||||
post_fast_trace *= decay(ms)
|
||||
|
||||
// CASE 1 — short-term potentiation: fill slots from private reserve (no dopamine)
|
||||
// NOT generic fill(): rate is Ca-driven, and the else-branch is the STD consequence
|
||||
if post_fast_trace > Ca_STP:
|
||||
AMPA_surface = min(AMPA_surface + Ca_insert(post_fast_trace),
|
||||
post_structure.slot_ceiling) // private: spine endosomal reserve
|
||||
post_budget -= traffic_cost
|
||||
else:
|
||||
AMPA_surface = max(AMPA_surface - drift·Δt, baseline) // STD = consequence
|
||||
|
||||
// interrupted success (LOCAL: my Ca was climbing toward a tag)
|
||||
if post_budget < req_cost and post_fast_trace > traj_thr and post_fast_trace_rising:
|
||||
post_endurance_need += post_fast_trace
|
||||
|
||||
// CASE 2 — tagging CANDIDATE
|
||||
if post_fast_trace > Ca_TAG: post_possible_tag += post_fast_trace
|
||||
post_possible_tag *= decay(min); post_endurance_need *= decay(min)
|
||||
post_budget -= pka_cost
|
||||
dopamine *= decay(ms)
|
||||
if dopamine > dop_thr and post_possible_tag > tag_thr:
|
||||
post_tag += dopamine × post_possible_tag // STABLE
|
||||
post_tag *= decay(hr)
|
||||
|
||||
DAY | bAP:
|
||||
// SOURCE 3 — bAP: depolarization + Ca, amplifies existing signal
|
||||
Vm += bAP_depol × dend_structure.bAP_fidelity; post_budget -= bAP_cost
|
||||
if post_possible_tag > Ca_TAG: post_fast_trace += bAP_Ca_boost()
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## DEND
|
||||
|
||||
```
|
||||
DAY | bAP:
|
||||
bAP_local, reached = propagate(SOMA.fired, dend_structure.bAP_fidelity,
|
||||
dend_budget, geometry)
|
||||
dend_budget -= prop_cost × reached
|
||||
// interrupted success (LOCAL: my branch was strongly active)
|
||||
if reached < full and dend_fast_trace > traj_thr:
|
||||
dend_endurance_need += dend_fast_trace
|
||||
dend_fast_trace += bAP_Ca(bAP_local) + spine_spillover(); dend_fast_trace *= decay(300ms)
|
||||
dend_budget -= branch_Ca_cost
|
||||
branch_Vm = integrate(POST.Vm, spines); dend_budget -= integrate_cost
|
||||
|
||||
DAY | NOT_bAP:
|
||||
dend_fast_trace *= decay(300ms); dend_endurance_need *= decay(min)
|
||||
refill(dend from astro_lactate[branch] + soma_ship_dend)
|
||||
ship(dend_budget → post_budget, gap_to(post))
|
||||
if dend_fast_trace > elig: dend_possible_tag += dend_fast_trace
|
||||
dend_possible_tag *= decay(s); dopamine *= decay(ms)
|
||||
if dopamine > dop_thr and dend_possible_tag > tag_thr:
|
||||
dend_tag += dopamine × dend_possible_tag
|
||||
dend_tag *= decay(hr)
|
||||
if dend_tag > tag_expiry and dend_budget > translate_cost:
|
||||
dend_budget -= translate_cost
|
||||
commit_threshold *= 1/(1 + ACh·gain)
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## SOMA
|
||||
|
||||
```
|
||||
DAY | AP:
|
||||
threshold = soma_structure.baseline / (1) // baseline strength
|
||||
× (1 + soma_adaptation)
|
||||
× neuromod(NE, ACh)
|
||||
can_fire = soma_Na_inactivation < inactivation
|
||||
if branch_Vm > threshold and can_fire:
|
||||
if soma_budget < ap_cost:
|
||||
// interrupted success (LOCAL: nuclear Ca climbing toward CREB)
|
||||
if soma_fast_trace > traj_thr and soma_fast_trace_rising:
|
||||
soma_endurance_need += soma_fast_trace
|
||||
exit
|
||||
fired = True; soma_budget -= ap_cost
|
||||
soma_Na_inactivation += ap_amp // → refractory (emergent)
|
||||
soma_adaptation += ap_contrib // → threshold rise
|
||||
soma_fast_trace += nuclear_Ca() // → plasticity
|
||||
soma_budget -= nuclear_cost
|
||||
if soma_fast_trace > elig: soma_possible_tag += soma_fast_trace
|
||||
soma_possible_tag *= decay(s); dopamine *= decay(ms)
|
||||
if dopamine > dop_thr and soma_possible_tag > tag_thr:
|
||||
soma_tag += dopamine × soma_possible_tag
|
||||
soma_tag *= decay(hr); soma_budget -= creb_cost
|
||||
|
||||
DAY | NOT_AP:
|
||||
// bottom-up alignment: suprathreshold input during refractory (LOCAL)
|
||||
if branch_Vm > threshold and soma_Na_inactivation > inactivation:
|
||||
soma_refractory_alignment += (branch_Vm - threshold) × soma_Na_inactivation
|
||||
recovery = base_recovery × (1 + soma_refractory_alignment)
|
||||
soma_Na_inactivation *= decay(τ_Na / recovery)
|
||||
soma_adaptation *= decay(τ_adapt)
|
||||
soma_fast_trace *= decay(τ_nuclear)
|
||||
soma_refractory_alignment *= decay(τ_align) // self-limiting
|
||||
soma_endurance_need *= decay(min)
|
||||
fill(soma_budget, soma_budget_ceiling, mito_output, 0, soma_budget) // private: own mitochondria, no external cost
|
||||
branch_Vm = integrate(DEND.branch_Vm, branches)
|
||||
ship(soma_budget → dend_budget, gap_to(dend))
|
||||
ship(soma_budget → axon_budget, gap_to(axon))
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## AXON
|
||||
|
||||
```
|
||||
DAY | AP:
|
||||
reliability = axon_structure.propagation × (1 - fail(axon_fast_trace))
|
||||
if axon_budget < prop_cost:
|
||||
reliability *= budget_factor
|
||||
// interrupted success (LOCAL: I was propagating a strong train)
|
||||
if axon_fast_trace > traj_thr:
|
||||
axon_endurance_need += axon_fast_trace
|
||||
delivered = fired × reliability; axon_budget -= prop_cost × delivered
|
||||
axon_fast_trace += delivered; axon_fast_trace *= decay(s)
|
||||
|
||||
DAY | NOT_AP:
|
||||
axon_fast_trace *= decay(s); axon_endurance_need *= decay(min)
|
||||
refill(axon from soma_ship_axon + astro_lactate[shaft])
|
||||
ship(axon_budget → pre_budget, gap_to(pre))
|
||||
if axon_fast_trace > elig: axon_possible_tag += axon_fast_trace
|
||||
axon_possible_tag *= decay(s); dopamine *= decay(ms)
|
||||
if dopamine > dop_thr and axon_possible_tag > tag_thr:
|
||||
axon_tag += dopamine × axon_possible_tag
|
||||
axon_tag *= decay(hr)
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## ASTRO
|
||||
|
||||
```
|
||||
DAY | CONTINUOUS:
|
||||
astro_central_budget += glycolysis(glucose)·Δt // root, capped by glucose
|
||||
|
||||
// demand-weighted lactate allocation across territory
|
||||
for each astrosynapse i:
|
||||
demand[i] = clearance_load[i] × astro_structure[i].delivery_eff
|
||||
factor = min(1, astro_central_budget / (Σ demand · lactate_cost + ε))
|
||||
for each i:
|
||||
astro_lactate[i] = demand[i] × factor
|
||||
astro_central_budget -= astro_lactate[i] × lactate_cost
|
||||
|
||||
// per-astrosynapse fast operation (synapse i)
|
||||
glutamate[i] -= astro_structure[i].EAAT × glutamate[i]·Δt
|
||||
astro_central_budget -= clearance × EAAT_cost
|
||||
astro_Dserine[i] += astro_structure[i].Dserine_tonic·Δt
|
||||
|
||||
if glutamate[i] > spillover:
|
||||
astro_fast_trace[i] += mGluR_Ca(); astro_fast_trace[i] *= decay(s)
|
||||
want = sat(astro_fast_trace[i], K_Dserine) × Ds_max
|
||||
got = min(want, astro_central_budget × Ds_frac)
|
||||
// interrupted success (LOCAL: I was under high demand)
|
||||
if got < want and astro_fast_trace[i] > traj_thr:
|
||||
astro_endurance_need[i] += (want - got)
|
||||
astro_Dserine[i] += got; astro_central_budget -= got × Ds_cost
|
||||
drive_pre[i] *= brake // same signal, PRE brake
|
||||
if astro_fast_trace[i] > elig: astro_possible_tag[i] += astro_fast_trace[i]
|
||||
astro_possible_tag[i] *= decay(s); dopamine *= decay(ms)
|
||||
if dopamine > dop_thr and astro_possible_tag[i] > tag_thr:
|
||||
astro_tag[i] += dopamine × astro_possible_tag[i]
|
||||
astro_tag[i] *= decay(hr)
|
||||
astro_endurance_need[i] *= decay(min)
|
||||
if astro_fast_trace[i] > overload: trigger(lockdown)
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## Special — Shockwave Lockdown
|
||||
|
||||
```
|
||||
DAY or NIGHT | OVERLOAD:
|
||||
Vm = HYPERPOLARIZED; AMPA_surface = mass_internalize() → post reserve
|
||||
axon_fast_trace += overdrive(); astro_central_budget -= emergency_cost
|
||||
```
|
||||
|
||||
---
|
||||
---
|
||||
# NIGHT
|
||||
|
||||
Build ceilings (structure = strength, budget_ceiling = endurance) from DAY evidence.
|
||||
Two economies (energy: astrocyte→astrosynapse ; material: soma→spine/bouton) compete.
|
||||
Unmaintained ceilings decay; recovered material funds the rest.
|
||||
|
||||
---
|
||||
|
||||
## Step 1 — Replenish and distribute
|
||||
|
||||
```
|
||||
NIGHT | 1:
|
||||
// energy economy (astrocyte central → astrosynapses, tag-weighted)
|
||||
astro_central_budget += overnight_glycolysis(glucose)·Δt
|
||||
astro_central_energy += overnight_astro_energy()·Δt
|
||||
astro_central_material += astro_cellbody_synth()·Δt
|
||||
W = Σ astro_tag[i] over astro_tag[i] > tag_expiry
|
||||
for each i with astro_tag[i] > tag_expiry:
|
||||
w = astro_tag[i]/W
|
||||
astro_energy[i] += astro_central_energy × w
|
||||
astro_material[i] += astro_central_material × w
|
||||
|
||||
// material economy (soma → branch/axon → spine/bouton)
|
||||
soma_budget += overnight_mito()·Δt
|
||||
soma_energy += overnight_soma_energy()·Δt
|
||||
soma_material += CREB_synth(soma_tag)·Δt // bottleneck
|
||||
|
||||
dend_material += soma_material × f_dend; axon_material += soma_material × f_axon
|
||||
soma_material -= (f_dend + f_axon)·soma_material
|
||||
post_material += dend_material × f_spine; dend_material -= f_spine·dend_material
|
||||
pre_material += axon_material × f_bouton; axon_material -= f_bouton·axon_material
|
||||
|
||||
{pre,post,dend,axon}_energy += soma_energy × f_energy[·]
|
||||
{pre,post,dend,axon}_budget += astro_lactate_reserve × f[·]·Δt
|
||||
```
|
||||
|
||||
## Step 2 — Strength commits (raise structure)
|
||||
|
||||
```
|
||||
NIGHT | 2:
|
||||
coherence = (pre_tag, post_tag, astro_tag all > tag_expiry) ? bonus : 1
|
||||
|
||||
for each component c with c_tag > tag_expiry:
|
||||
Δ = min(slot_cost, c_material, c_energy × f)
|
||||
c_structure += Δ × (coherence if c in {pre,post,astro} else 1)
|
||||
c_material -= Δ; c_energy -= Δ × assembly_cost
|
||||
if Δ < slot_cost: queue(c_strength_deficit → next NIGHT)
|
||||
// astro_structure self-reinforcing: higher → future LTP easier
|
||||
```
|
||||
|
||||
## Step 2b — Endurance commits (raise budget_ceiling)
|
||||
|
||||
```
|
||||
NIGHT | 2b:
|
||||
// driven by endurance_need (interrupted local success), NO dopamine
|
||||
// competes with step 2 for the SAME material + energy
|
||||
for each component c with c_endurance_need > endur_thr:
|
||||
Δ = min(cap_cost, c_material × f_cap, c_energy × f_cap)
|
||||
c_budget_ceiling += Δ
|
||||
c_material -= Δ; c_energy -= Δ × biogenesis_cost
|
||||
if Δ < cap_cost: queue(c_endurance_deficit → next NIGHT)
|
||||
```
|
||||
|
||||
## Step 3 — Passive decay (both ceilings, by neglect)
|
||||
|
||||
```
|
||||
NIGHT | 3:
|
||||
remaining = total_material - consumed_by_commits
|
||||
maint = remaining × maint_frac / synapse_count
|
||||
|
||||
for each synapse:
|
||||
{pre,post,dend,astro}_structure -= decay_rate·Δt
|
||||
{pre,post,dend,astro}_budget_ceiling -= capacity_decay_rate·Δt
|
||||
if maint ≥ maint_cost:
|
||||
structure += full_maint; budget_ceiling += full_cap_maint
|
||||
else:
|
||||
structure += maint × frac; budget_ceiling += maint × cap_frac
|
||||
// both drift down — depotentiation / endurance-loss by neglect
|
||||
|
||||
for each synapse with net_change < 0:
|
||||
rec = |net_change| × recycle
|
||||
{pre,post,astro}_material += rec × frac // material recovered, energy not
|
||||
```
|
||||
|
||||
## Step 4 — Homeostatic scaling
|
||||
|
||||
```
|
||||
NIGHT | 4:
|
||||
if soma_tag > homeostatic_ceiling:
|
||||
s = homeostatic_ceiling / soma_tag
|
||||
for each synapse:
|
||||
post_structure.slot_ceiling *= s; pre_structure.slot_ceiling *= s
|
||||
soma_material += Σ reduction × recycle
|
||||
```
|
||||
|
||||
## Step 5 — Clear traces
|
||||
|
||||
```
|
||||
NIGHT | 5:
|
||||
all fast_trace = 0; all possible_tag = 0; all endurance_need = 0
|
||||
soma_Na_inactivation = soma_adaptation = soma_refractory_alignment = 0
|
||||
for each tag: if tag < tag_expiry: tag = 0 // else carry forward
|
||||
// structure and budget_ceiling PERSIST
|
||||
```
|
||||
|
||||
---
|
||||
|
||||
## One-view summary
|
||||
|
||||
```
|
||||
DAY behavior runs within structure (strength) and budget_ceiling (endurance),
|
||||
both filled by competition; consumes budget; deposits fast_trace.
|
||||
fast_trace + non-local coincidence → tag (strength evidence)
|
||||
depletion + interrupted LOCAL success → endurance_need (endurance evidence)
|
||||
traces decay in NOT/CONTINUOUS contexts.
|
||||
|
||||
NIGHT tag → raise structure
|
||||
endurance_need → raise budget_ceiling
|
||||
both draw the SAME material + energy → strength and endurance compete
|
||||
unmaintained ceilings decay → freed material funds the rest.
|
||||
|
||||
LOCALITY every evaluation uses only local state + arrived signals.
|
||||
cross-compartment influence travels only as signals that become local.
|
||||
```
|
||||
Reference in New Issue
Block a user