PRESYNAPSE_Status: check_tpc
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+18
-31
@@ -27,7 +27,7 @@ container: AXON
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**— ms:**
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- AP fires → VGCCs open, Ca²⁺ enters
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- AP fires → VGCCs open, Ca²⁺ enters, based on eCB e mGluR
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- Ca²⁺ cleared slowly (single decay term, no pump detail)
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- Ca²⁺ trace (Tr_Ca) integrates every ms
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- NT released into cleft — rate determined by Ca²⁺ level and NT already in cleft
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@@ -100,7 +100,7 @@ container: PRESYNAPSE
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### ms: behaviors
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#### AP-RRPConcentration: check_tpc
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#### PRESYNAPSE_Status: check_tpc
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Il rilascio di NT lo facciamo nel contesto di AP. Biologicamente dovrebbe avvenire solo in base alle concentrazioni, quindi anche al difuori degli AP.
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@@ -108,36 +108,26 @@ RF deve essere MOLTO piu' basso della durata di un AP. In maniera da essere atti
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Questo poi per permettere la diversa contestualizzazione degli episodi di NTrelease, a piu' o meno alta velocita'.
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```Gen
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check_tpc: AP-RRPConcentration
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check_tpc: PRESYNAPSE_Status
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contained_by: PRESYNAPSE
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in_context: AP
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rf: ( active: 60x )
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condition: (Rrp mediumness)
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out_context: RRPmediumness
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condition: ( Ca2+ full ) AND ( Rrp fullness )
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out_context: NTreleaseMax_ctx
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condition: (Rrp fullness)
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out_context: RRPFull
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```
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condition: ( Ca2+ fullness ) AND ( Rrp fullness )
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out_context: NTreleaseHigh_ctx
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#### AP-Ca2+Concentration: check_tpc
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condition: (( Ca2+ fullness ) AND ( Rrp mediumness )) OR (( Ca2+ mediumness ) AND ( Rrp fullness ))
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out_context: NTreleaseMed_ctx
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Qui controlliamo la concentrazione nel contesto di un AP.
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```Gen
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check_tpc: AP-Ca2+Concentration
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contained_by: PRESYNAPSE
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in_context: AP
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rf: ( active: 60x )
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condition: (Ca2+ mediumness)
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out_context: Ca2+mediumness
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condition: (Ca2+ fullness)
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out_context: Ca2+Full
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condition: ( Ca2+ mediumness ) AND ( Rrp mediumness )
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out_context: NTreleaseLow_ctx
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```
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#### NTrelease
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@@ -146,8 +136,6 @@ Non consideriamo le vesicles come liberate, ma direttamente gli NT. Questo perme
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Ci sono 4 casi che dipendono da RRP, Ca2+ e NT. L'idea e' che la quantita' di RRP sia il driver principale. Gli NT liberati sono di piu' al crescere di RRP e Ca2+ e di meno al crescere di NT. Gli NT nella sinapsi fanno da moderazione alla ulteriore liberazione di NT, ma non bloccano mai totalmente. NT suppression only matters when everything else is already at maximum — which is exactly the biological purpose: it prevents runaway release during peak activity, not during moderate activity.
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##### NTreleaseMaximum: interacting
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NT empty
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@@ -156,7 +144,7 @@ NT empty
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interacting: NTreleaseMaximum
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contained_by: PRESYNAPSE
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in_context: (Ca2+Full AND RRPFull)
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in_context: NTreleaseMax_ctx
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rf: ( active: 3x ) # Maximum
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hypothesis: NOT (NT empty)
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@@ -172,7 +160,7 @@ Solo in questo caso NT modera! NT NOT empty
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interacting: NTreleaseHigh
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contained_by: PRESYNAPSE
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in_context: (Ca2+Full AND RRPFull)
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in_context: NTreleaseHigh_ctx
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rf: ( active: 6x ) # High
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hypothesis: NOT (NT empty)
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@@ -188,7 +176,7 @@ In tutti i casi di NT
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interacting: NTreleaseMediumness
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contained_by: PRESYNAPSE
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in_context: (Ca2+Full AND RRPMediumness) OR (Ca2+Mediumness AND RRPFull)
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in_context: NTreleaseMed_ctx
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rf: ( active: 9x ) # Mediumness
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hypothesis: (NT empty) OR NOT (NT empty)
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@@ -204,8 +192,7 @@ In tutti i casi di NT
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interacting: NTreleaseLow
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contained_by: PRESYNAPSE
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in_context: (Ca2+Mediumness AND RRPMediumness)
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rf: ( active: 12x ) # Low
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in_context: NTreleaseLow_ctx
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hypothesis: (NT empty) OR NOT (NT empty)
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action: [Rrp decrease, Nt increase, ATP decrease]
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@@ -551,7 +538,7 @@ Qui sostituiamo:
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- CDI con concentrazione Ca2+
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-- CDI is calcium-dependent inactivation of VGCCs. The inactivation happens because Ca²⁺ enters through the channel and binds to a calmodulin tethered to the channel's intracellular face, physically blocking it from reopening. This is a local, channel-specific event — it requires Ca²⁺ to be flowing through that channel right now, not residual Ca²⁺ drifting in the cytosol between spikes.
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-- The recovery, by contrast, should run every millisecond unconditionally — CDI de-inactivation is a continuous process that proceeds whenever Ca²⁺ dissociates from calmodulin, which depends on the ambient Ca_micro level at all times.
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- mGluR con concentrazione NT (forse su tempi di sec e quindi avremmo bisono di un altro Tub)
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- mGluR con concentrazione NT (forse su tempi di sec e quindi avremmo bisogno di un altro Tub)
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- **Open** — zero active brakes. mGluR alone never escapes this group because its ceiling is alpha_mGluR = 0.4, meaning even at full it only removes 40% of conductance, leaving 60% — still above the 85% threshold. So mGluR is irrelevant to the open/not-open boundary. Only CDI and eCB decide.
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- **Reduced/partial** — exactly one meaningful brake active. Either CDI has started building (mediumness), or eCB has risen from sustained postsynaptic activity, but not both simultaneously. The system is aware something is happening but has not compounded yet. This is the normal operating range during moderate sustained firing.
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