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ocrampal
2026-04-30 23:08:40 +02:00
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neuron/README.md
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@@ -73,7 +73,8 @@ This is where your ATP loop and Ca2+ loop intersect. If the firing frequency is
2. Timescale: This operates on the scale of hundreds of milliseconds to seconds, effectively mapping the decay curve of your calcium clearance pumps. 2. Timescale: This operates on the scale of hundreds of milliseconds to seconds, effectively mapping the decay curve of your calcium clearance pumps.
4. Modulation by the "State" of the Channel 4. Modulation by the "State" of the Channel
In the minutes and beyond category, the accumulation of $Ca^{2+}$ changes the structural landscape of the VGCCs through two medium-term signals: In the minutes and beyond category, the accumulation of $Ca^{2+}$ changes the structural landscape of the VGCCs through two medium-term signals:
1. A. The "Clogged" Channel Signal (Minutes)If $Ca^{2+}$ accumulation is high enough to keep CDI active for a prolonged period (as in your "self-imposed silence" scenario), the channel spends too much time in the inactivated state. 1. A. The "Clogged" Channel Signal (Minutes)
If $Ca^{2+}$ accumulation is high enough to keep CDI active for a prolonged period (as in your "self-imposed silence" scenario), the channel spends too much time in the inactivated state.
1. Ubiquitination: Inactivated channels are more susceptible to being tagged by E3 ubiquitin ligases (like Nedd4-1). 1. Ubiquitination: Inactivated channels are more susceptible to being tagged by E3 ubiquitin ligases (like Nedd4-1).
2. Elimination: Once tagged, they are endocytosed (removed from the membrane). This is a medium-term "down-scaling" to prevent excitotoxicity. 2. Elimination: Once tagged, they are endocytosed (removed from the membrane). This is a medium-term "down-scaling" to prevent excitotoxicity.
2. B. The Calcineurin Pathway (Minutes to Hours) 2. B. The Calcineurin Pathway (Minutes to Hours)
neuron/presynapse.md
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@@ -485,7 +485,7 @@ Qui semplifichiamo:
- **Suppressed** — two brakes multiplying. The compounding is what defines this zone — no single variable alone produces it (except CDI approaching full). 0.5 × 0.5 = 0.25 remaining is where the synapse starts losing significant transmission efficacy. Biologically this is the pre-silence warning zone: CDI is building from residual Ca²⁺ while eCB is already engaged from postsynaptic activity. - **Suppressed** — two brakes multiplying. The compounding is what defines this zone — no single variable alone produces it (except CDI approaching full). 0.5 × 0.5 = 0.25 remaining is where the synapse starts losing significant transmission efficacy. Biologically this is the pre-silence warning zone: CDI is building from residual Ca²⁺ while eCB is already engaged from postsynaptic activity.
- **Closed — CDI** = full is the only reliable hard rule. Because CDI can reach 1.0 and appears as (1 - CDI_factor) in the formula, it alone drives conductance to zero regardless of eCB and mGluR state. The three-brake overlap corner case (eCB=full + CDI=mediumness + mGluR=full) also reaches here, but in practice CDI reaching full is the primary biological mechanism. - **Closed — CDI** = full is the only reliable hard rule. Because CDI can reach 1.0 and appears as (1 - CDI_factor) in the formula, it alone drives conductance to zero regardless of eCB and mGluR state. The three-brake overlap corner case (eCB=full + CDI=mediumness + mGluR=full) also reaches here, but in practice CDI reaching full is the primary biological mechanism.
Devo controllare che le condizioni sotto siano esaustive. Devo controllare che le condizioni sotto siano esaustive. Qui ho confuso high con low, e inoltre ho messo NT per mGluR che devo controllare che abbia senso.
```Gen ```Gen
interacting: Ca2+enterLow interacting: Ca2+enterLow
@@ -536,7 +536,9 @@ interacting: Ca2+enterHigh
##### Ca2+ClearanceLow: interacting ##### Ca2+ClearanceLow: interacting
Qui eliminiamo Ca2+. Non non comprendiamo anche il ristabilimento del Voltage, con altri Ioni entranti e uscenti, per ora tutto dipende da AP del SOMA. Non comprendiamo per ora: Qui eliminiamo Ca2+. Il tempo che ci mette ad eliminare il Ca2+ dovrebbe essere minoe dell'inervallo fra un AP_ctx e un'altra. Siccome non comprendiamo per ora ATP, non c'e' accumulo di Ca2+ per mancanza di ATP (stanchezza).
Non non comprendiamo anche il ristabilimento del Voltage, con altri Ioni entranti e uscenti, per ora tutto dipende da AP del SOMA. Non comprendiamo per ora:
- PMCA: primary, ATP-dependent - PMCA: primary, ATP-dependent
- NCX: fast, NOT ATP-dependent - NCX: fast, NOT ATP-dependent
- SERCA: slowest, ATP-dependent - SERCA: slowest, ATP-dependent
@@ -544,7 +546,7 @@ Qui eliminiamo Ca2+. Non non comprendiamo anche il ristabilimento del Voltage, c
Qui disinguiamo: Qui disinguiamo:
- Ca+2 fullness che si puo' verificare alla fine di un AP - Ca+2 fullness che si puo' verificare alla fine di un AP
- NOT ca2+ fullness che svuota piu' lentamente - NOT ca2+ fullness che svuota piu' lentamente
- da capire se serve veramente questa distinzione anche in bae alle tracce di Ca2+ che prendiamo in presynapse. - da capire se serve veramente questa distinzione per il tempo di svuotamento.
```Gen ```Gen
interacting: Ca2+ClearanceLow interacting: Ca2+ClearanceLow