caTrace

neuron/presynapse.md

@@ -203,12 +203,12 @@ interacting: NTreleaseHigh
 
 ##### Ca2+TracesAccumulationLow: interacting
 
-Serve a dare la velocita' al trasporto di vesicles da RP a RRP. The biological meaning is that a synapse that has just been through a burst is primed for fast recovery — the molecular machinery for vesicle docking is already engaged, calcium-dependent priming factors are still elevated, and the system is in a ready state. A synapse that has been silent for several seconds has cooled down and replenishes slowly.
+Serve a dare la velocita' al trasporto di vesicles da RP a RRP.
-
+ - The biological meaning is that a synapse that has just been through a burst is primed for fast recovery — the molecular machinery for vesicle docking is already engaged, calcium-dependent priming factors are still elevated, and the system is in a ready state. A synapse that has been silent for several seconds has cooled down and replenishes slowly.
-So after one second of silence CaTrace has fallen to ~37% of its peak value, after two seconds to ~14%, after three seconds to ~5%. It asymptotes toward zero but never exactly reaches it. Between spikes, Ca2+ falls toward zero as the pumps clear it.
-
-The result is that Tr_Ca encodes not the instantaneous calcium level but the recent history of calcium activity — a smoothed, time-averaged measure of how active the synapse has been over the past one to two seconds.
 
+ - So after one second of silence CaTrace has fallen to ~37% of its peak value, after two seconds to ~14%, after three seconds to ~5%. It asymptotes toward zero but never exactly reaches it. Between spikes, Ca2+ falls toward zero as the pumps clear it. The result is that CaTrace encodes not the instantaneous calcium level but the recent history of calcium activity — a smoothed, time-averaged measure of how active the synapse has been over the past one to two seconds.
+ - Abbiamo 3 tracce, high, medium and low. Andiamo a verificare se una di queste e' high per fare la modulazione
+ - RF e' a 10, questo dovrebbe essere un RF di campionamento durante AP_ctx context che dovremmo assicurarci sia tipo 100. Il che implicherebbe 10 campionamenti.
 ---
 
 ```Gen
@@ -216,26 +216,39 @@ interacting: Ca2+TracesAccumulationLow
   contained_by: PRESYNAPSE
 
   in_context: AP_ctx
-  rf: ( active: 24x ) # Low
+  rf: ( active: 10x )
+
+  hypothesis: (Ca2+ emptiness)
+    action: [CaTraceLow increase]
+    trace: None
+```
+
+##### Ca2+TracesAccumulationMedium: interacting
+
+```Gen
+interacting: Ca2+TracesAccumulationMedium
+  contained_by: PRESYNAPSE
+
+  in_context: AP_ctx
+  rf: ( active: 10x )
 
   hypothesis: (Ca2+ mediumness)
-    action: [CaTrace increase]
+    action: [CaTraceMed increase]
     trace: None
 ```
 
 ##### Ca2+TracesAccumulationHigh: interacting
 
-Qui le tracce CaTrace si accumulano di piu' perche' RF e' minore, se c'e' la condizione, perche' va a fare il controllo piu' spesso.
 
 ```Gen
 interacting: Ca2+TracesAccumulationHigh
   contained_by: PRESYNAPSE
 
   in_context: AP_ctx
-  rf: ( active: 12x ) # high
+  rf: ( active: 10x ) # high
 
   hypothesis: (Ca2+ fullness)
-    action: [CaTrace increase]
+    action: [CaTraceHigh increase]
     trace: None
 ```
 
@@ -265,17 +278,27 @@ interacting: eCBClearance
 
 ##### Ca2+TracesClearance: interacting
 
-Qui non facciamo un flush di Catrace, riduciamo ogni mezzo secondo (context) di un RF di questo episodio.
+Qui non facciamo un flush di CaTraceX, riduciamo ogni mezzo secondo (context) di un RF di questo episodio.
 
 ```Gen
 interacting: Ca2+TracesClearance
   contained_by: PRESYNAPSE
 
   in_context: NOT AP_ctx
-  rf: ( active: 24x ) # Slow
+  rf: ( active: 30x ) # Slow
 
-  hypothesis: NOT (CaTrace empty)
+  hypothesis: NOT (CaTraceHigh empty)
-    action: [CaTRace decrease]
+    action: [CaTRaceHigh decrease]
+    trace: None
+
+  hypothesis: NOT (CaTraceMedium empty)
+    action: [CaTRaceMedium decrease]
+    trace: None
+
+  hypothesis: NOT (CaTraceLow empty)
+    action: [CaTRaceLow decrease]  hypothesis: NOT (CaTraceHigh empty)
+    action: [CaTRaceHigh decrease]
+    trace: None
     trace: None
 ```
 
@@ -294,7 +317,7 @@ interacting: RPShuttleLow
   in_context: NOT AP_ctx
   rf: ( active: 48x ) # Low
 
-  hypothesis: (CaTrace emptiness) OR 
+  hypothesis: (CaTraceLow fullness) OR 
               (RP emptiness) OR 
               (RRP fullness)  
     action: [RP decrease, RRP increase]
@@ -314,10 +337,10 @@ interacting: RPShuttleMedium
   in_context: AP_ctx
   rf: ( active: 24x ) # Medium
 
-  hypothesis: (CaTrace mediumness) AND (RP mediumness) AND (RRP mediumness) OR 
+  hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (RRP mediumness) OR 
-              (CaTrace fullness) AND (RP mediumness) AND (RRP mediumness) OR # signal boost
+              (CaTraceHigh fullness) AND (RP mediumness) AND (RRP mediumness) OR # signal boost
-              (CaTrace mediumness) AND (RP fullness) AND (RRP mediumness) OR # supply boost
+              (CaTraceMedium fullness) AND (RP fullness) AND (RRP mediumness) OR # supply boost
-              (CaTrace mediumness) AND (RP mediumness) AND (RRP emptiness) # vacancy boost
+              (CaTraceMedium fullness) AND (RP mediumness) AND (RRP emptiness) # vacancy boost
     action: [RP decrease, RRP increase]
     trace: None
 ```
@@ -335,9 +358,9 @@ interacting: RPShuttleHigh
   in_context: AP_ctx
   rf: ( active: 12x ) # Fast
 
-  hypothesis: (CaTrace fullness) AND (RP fullness) AND (RRP mediumness) OR # signal + supply
+  hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (RRP mediumness) OR # signal + supply
-              (CaTrace fullness) AND (RP mediumness) AND (RRP emptiness) OR # signal + vacancy
+              (CaTraceHigh fullness) AND (RP mediumness) AND (RRP emptiness) OR # signal + vacancy
-              (CaTrace mediumness) AND (RP fullness) AND (RRP emptiness) # supply + vacancy
+              (CaTraceMedium fullness) AND (RP fullness) AND (RRP emptiness) # supply + vacancy
     action: [RP decrease, RRP increase]
     trace: None
 ```