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---
include_toc: true
---
# Tripartite Synapse — Pseudocode v17 # Tripartite Synapse — Pseudocode v17
> Companion: `tripartite_synapse_v17_biology.md` · principle: `logic_principles_v5`. > Companion: `tripartite_synapse_v17_biology.md` · principle: `logic_principles_v5`.
@@ -134,7 +130,7 @@ its structure rebuilt) OR energy is spent (overloaded — unspent tags carry to
## Conventions ## Conventions
``` ```
SCOPE = {DAY, NIGHT} CONTEXT = {AP, NOT_AP, NOT_SPIKE_TRAIN, bAP, NOT_bAP, CONTINUOUS} SCOPE = {DAY, NIGHT} DAY CONTEXT = {AP, REFRACTORY⊂NOT_AP, NOT_AP, NOT_SPIKE_TRAIN, CONTINUOUS} NIGHT CONTEXT = {NON_REM_1, NON_REM_2, REM}
THE THREE CATEGORIES (see logic_principles "The Ring"): (ACTION ⇄ RECOVERY) × many, then PREPARATION THE THREE CATEGORIES (see logic_principles "The Ring"): (ACTION ⇄ RECOVERY) × many, then PREPARATION
ACTION the component's defining deed; deposits the fast trace. ALWAYS LOCAL to the acting ACTION the component's defining deed; deposits the fast trace. ALWAYS LOCAL to the acting
@@ -157,7 +153,23 @@ CONTEXT LICENSES PHASE (context = the imposed condition; phase = the work it per
NOT_SPIKE_TRAIN no spike AND no train ⊂ NOT_AP → adds PREPARATION (runs on top of NOT_AP) NOT_SPIKE_TRAIN no spike AND no train ⊂ NOT_AP → adds PREPARATION (runs on top of NOT_AP)
A process runs in the SHORTEST quiet its timescale fits: fast-trace decay and partial pool refill A process runs in the SHORTEST quiet its timescale fits: fast-trace decay and partial pool refill
in NOT_AP (they ride the train and set short-term depression); tag formation, full refill, and in NOT_AP (they ride the train and set short-term depression); tag formation, full refill, and
occupancy read-out in NOT_SPIKE_TRAIN. (Components without trains use bAP / NOT_bAP, or continuous.) occupancy read-out in NOT_SPIKE_TRAIN. (Components without trains use continuous flow.)
WHO EMITS THE CONTEXT (a context is a signal from ABOVE, not self-generated):
AP, REFRACTORY emitted by SOMA — its own firing state (AP = it fired; REFRACTORY = the recovery
window after, when it cannot fire again yet). What was "NOT_AP" is REFRACTORY.
NOT_SPIKE_TRAIN emitted by the NEURON — sustained absence of soma spikes can only be tracked from
ABOVE the soma (a component cannot easily know "I have not fired for a while");
the neuron keeps count of the gap and broadcasts it down.
NON_REM_1/2, REM emitted top-down within the NIGHT context (see DAY/NIGHT switch) — the night's
sub-phases: NON_REM_1 → ACTION (build⇄release), NON_REM_2 → RECOVERY
(import+free), REM → PREPARATION (replay+measure+prime).
POST INVERTS THE DAY MAP. For the postsynapse the deed is RECEIVING, which happens whenever no
descending spike is arriving, so: NOT_AP → ACTION (open AMPA/NMDA, respond), AP → RECOVERY (the
brief descending spike, driven from above, restore + boost traces), NOT_SPIKE_TRAIN → PREPARATION.
POST's ACTION continues through the soma's REFRACTORY (refractory is the soma's state, not POST's;
from POST it is NOT_AP), which is how the spine charges up to ready the next spike.
VARIABLE TIERS (timescale = meaning; see logic_principles "The Timescale Ladder") VARIABLE TIERS (timescale = meaning; see logic_principles "The Timescale Ladder")
FAST (ms–s) immediate response fast_trace FAST (ms–s) immediate response fast_trace
@@ -459,63 +471,67 @@ The postsynaptic spine is the synapse's primary memory locus: it detects coincid
runs the calcium dynamics that decide potentiation versus depression, and requires the most runs the calcium dynamics that decide potentiation versus depression, and requires the most
validation (three coincidences) before committing. validation (three coincidences) before committing.
**POST's ACTION is the synaptic event (context NOT_bAP).** Integration is graded and ongoing **POST's ACTION is the synaptic response (context NOT_AP).** Integration is graded and ongoing
rather than spike-punctate, so POST's action-context is "glutamate present, no bAP": three calcium rather than spike-punctate, so POST's action-context is "no descending AP arriving": it opens its
sources feed the fast trace — AMPA current (small Ca, begins ejecting the NMDA Mg block) and NMDA channels and responds to whatever glutamate has arrived. Three calcium sources feed the fast trace —
(large Ca, only on the local coincidence of depolarization + astrocyte D-serine + glutamate). The AMPA current (small Ca, begins ejecting the NMDA Mg block) and NMDA (large Ca, scaled by the local
action deposits the calcium trace and emits the two retrograde messages. Because POST's receptors coincidence of depolarization + astrocyte D-serine + glutamate). The action deposits the calcium
are physical coincidence detectors, two of its three tag-coincidences (astro D-serine, and the bAP trace and emits the two retrograde messages. Crucially POST's ACTION **continues through the soma's
below) are detected *in the action*; only the organism's dopamine coincidence is left to evaluation. refractory period**: the refractory belongs to the soma, not to POST — from POST it is simply NOT_AP,
so the spine keeps responding and integrating, charging up so the neuron is ready to fire again once
its refractory ends.
**bAP is a second, vertical action-context.** The soma's back-propagating spike arrives, adds **POST's RECOVERY is the descending AP (context AP) — a brief event.** When the soma's spike arrives
depolarization and calcium, and supralinearly amplifies an existing candidate — the soma's it adds depolarization and calcium, supralinearly boosts an existing candidate (the soma's
confirmation that it fired, detected in the action-moment (instantaneous coincidence). confirmation that it fired), and resets the spine: calcium extrudes, the NMDA Mg-block re-establishes
as Vm falls, and the trace relaxes — restoring the ability to respond again. This is the *alter-ego*
of the response, and it is short (the spike event), not the whole refractory window.
**EVALUATION FOLDS INTO PREPARATION.** POST runs the same three categories as every component. **EVALUATION FOLDS INTO PREPARATION (context NOT_SPIKE_TRAIN).** PREPARATION shapes what comes next:
ACTION is the synaptic response (integrate glutamate, detect the instantaneous coincidences, emit it fills AMPA surface toward the slot ceiling from accumulated calcium (short-term potentiation, no
the retrogrades). RECOVERY restores the ability to respond again — calcium extrusion and NMDA
Mg-block re-establishment, the fast alter-ego of the response. PREPARATION shapes what comes next:
fills AMPA surface toward the slot ceiling from accumulated calcium (short-term potentiation, no
dopamine — for the next response), climbs the tag on the dopamine coincidence (for the night), dopamine — for the next response), climbs the tag on the dopamine coincidence (for the night),
refills budget, and settles. A fuel shortfall while calcium was climbing toward a tag is endurance refills budget, and settles. A fuel shortfall while calcium was climbing toward a tag is endurance
evidence (a preparation deposit made during action); a surface already at its ceiling is a evidence (a preparation deposit made during action); a surface already at its ceiling is a
structural limit, not endurance. structural limit, not endurance.
**During NIGHT — the same three categories, turned inward.** RECOVERY imports material/energy and **During NIGHT — the same three categories, turned inward, in sleep-stage contexts.** NON_REM_2
primes AMPA responsiveness from the standing tag. PREPARATION replays: POST responds to the (RECOVERY) imports material/energy and primes AMPA responsiveness from the standing tag. REM
re-evoked glutamate exactly as it responds by day (same AMPA/NMDA machinery, same endurance (PREPARATION) replays: POST responds to the re-evoked glutamate exactly as it responds by day (same
deposit into the same trace), reading the response as participation rather than transmitting — no AMPA/NMDA machinery, same endurance deposit into the same trace), reading the response as
dopamine. ACTION is the structural change: general homeostatic lowering, then rebuild where the tag participation rather than transmitting — no dopamine. NON_REM_1 (ACTION) is the structural change:
stands and participation was confirmed, consuming the tag. Both ceilings draw the same finite pool rebuild where the tag stands and participation was confirmed (consuming the tag) ⇄ release where
and compete; unmaintained ceilings drift down. participation was low. Both ceilings draw the same finite pool and compete; unmaintained ceilings
drift down.
``` ```
// PARAMETERS K_AMPA · AMPA_Ca · AMPA_cost · NMDA_cost · bAP_cost · pka_cost · traffic_cost // PARAMETERS K_AMPA · AMPA_Ca · AMPA_cost · NMDA_cost · AP_cost · pka_cost · traffic_cost
// req_cost · Mg_eject · K_Ds · Ca_STP · Ca_TAG · eCB_thr · drift · baseline // req_cost · Mg_eject · K_Ds · Ca_STP · Ca_TAG · eCB_thr · drift · baseline
// NO_synth_cost · eCB_synth_cost // NO_synth_cost · eCB_synth_cost
// INTERFACE // INTERFACE
// EMIT retro_NO (+), retro_eCB (−) → PRE // EMIT retro_NO (+), retro_eCB (−) → PRE
// RECEIVE (signals) glutamate ← PRE ; astro_Dserine ← ASTRO ; bAP ← DEND/SOMA ; dopamine // RECEIVE (signals) glutamate ← PRE ; astro_Dserine ← ASTRO ; AP (descending) ← DEND/SOMA ; dopamine
// READ glutamate ; astro_Dserine (GAIN, not gate) ; bAP (dend_structure.bAP_fidelity) ; dopamine // READ glutamate ; astro_Dserine (GAIN, not gate) ; AP via dend_structure.bAP_fidelity ; dopamine
// OWN post_structure{slot_ceiling, spine_volume, reserve_ceiling} ; post_budget_ceiling // OWN post_structure{slot_ceiling, spine_volume, reserve_ceiling} ; post_budget_ceiling
// SUPPLY astro_lactate[syn] ← ASTRO ; dend_ship_post ← DEND ; post_material ← DEND(NIGHT) ; post_energy ← SOMA(NIGHT) // SUPPLY astro_lactate[syn] ← ASTRO ; dend_ship_post ← DEND ; post_material ← DEND(NIGHT) ; post_energy ← SOMA(NIGHT)
// EMERGENCY shockwave_lockdown ← ASTRO // EMERGENCY shockwave_lockdown ← ASTRO
// NOTE POST endurance is own-state only (own Ca climbing); no arrived feedback term. // NOTE POST endurance is own-state only (own Ca climbing); no arrived feedback term.
// coincidences sort by timescale: D-serine/bAP detected IN ACTION (instantaneous); dopamine in PREPARATION.
// THE THREE CATEGORIES (same at DAY and NIGHT; here DAY, subject = arrived glutamate / bAP): // THE THREE CATEGORIES (same at DAY and NIGHT; here DAY, subject = arrived glutamate / AP):
// ACTION respond: integrate glutamate, detect instantaneous coincidences, emit retro (NOT_bAP); // ACTION (NOT_AP) respond: open AMPA/NMDA channels, integrate glutamate, detect the
// bAP is a second, vertical action-context (soma's spike confirms) // instantaneous coincidence, emit retro. This is POST's defining deed and it happens
// RECOVERY restore the ability to respond: Ca extrusion + NMDA Mg-block re-establish // ALWAYS EXCEPT during an arriving AP — INCLUDING through the soma's refractory period:
// PREPARATION shape what comes next: AMPA fill (next response) + tag climb (NIGHT) + refill + settle // refractory is the SOMA's state, not POST's; from POST it is simply NOT_AP, so POST
// Coincidences sort by timescale: D-serine/bAP detected IN ACTION (instantaneous); dopamine in PREPARATION. // keeps responding and integrating, charging the spine so the neuron is ready to fire
// again once refractory ends.
// RECOVERY (AP) the BRIEF descending-spike arrival (ms): POST is driven from above, restores its
// ability to respond (Ca extrusion, Mg-block re-establishes as Vm falls), and deposits/
// boosts traces. Short event, not a long window.
// PREPARATION (NOT_SPIKE_TRAIN) shape what comes next: AMPA fill (next response) + tag climb (NIGHT)
// + refill + settle.
// Coincidences sort by timescale: D-serine detected IN ACTION (instantaneous); dopamine in PREPARATION.
// ===== ACTION ===== // ===== ACTION (NOT_AP: open channels, respond — continues through the soma's refractory) =====
DAY | bAP: // second action-context (vertical): soma confirms DAY | NOT_AP: // respond to arrived input (the defining deed)
Vm += bAP_depol × dend_structure.bAP_fidelity; post_budget -= bAP_cost
if post_possible_tag > Ca_TAG: post_fast_trace += bAP_Ca_boost() // amplify only if candidate present
DAY | NOT_bAP: // respond to arrived input (the defining deed)
a = sat(glutamate, K_AMPA) a = sat(glutamate, K_AMPA)
AMPA_current = a × AMPA_surface; Vm += AMPA_current; post_budget -= AMPA_cost // SOURCE 1 AMPA AMPA_current = a × AMPA_surface; Vm += AMPA_current; post_budget -= AMPA_cost // SOURCE 1 AMPA
post_fast_trace += AMPA_Ca·AMPA_current // @cut affords: channel-opening frequency, response magnitude (quantity of response) [ms] post_fast_trace += AMPA_Ca·AMPA_current // @cut affords: channel-opening frequency, response magnitude (quantity of response) [ms]
@@ -526,13 +542,15 @@ DAY | NOT_bAP: // respond to arrived
if Vm > eCB_thr: if Vm > eCB_thr:
retro_eCB += eCB_emit(Vm); post_budget -= eCB_synth_cost // EMIT − brake retro_eCB += eCB_emit(Vm); post_budget -= eCB_synth_cost // EMIT − brake
// ===== RECOVERY (restore the ability to respond; alter-ego of the response) ===== // ===== RECOVERY (AP: brief descending-spike arrival — restore + boost traces) =====
DAY | NOT_bAP · recovered: // Ca extrusion + Mg-block re-establish DAY | AP: // soma's spike arrives (ms event), driven from above
post_fast_trace *= decay(ms) // FAST — Ca extruded, trace relaxes Vm += AP_depol × dend_structure.bAP_fidelity; post_budget -= AP_cost
if post_possible_tag > Ca_TAG: post_fast_trace += AP_Ca_boost() // boost only if a candidate is present
post_fast_trace *= decay(ms) // Ca extruded, trace relaxes — ready to respond again
// (NMDA Mg-block re-establishes as Vm falls — implicit in the Vm>Mg_eject gate next response) // (NMDA Mg-block re-establishes as Vm falls — implicit in the Vm>Mg_eject gate next response)
// ===== PREPARATION (shape the next response AND the NIGHT) ===== // ===== PREPARATION (NOT_SPIKE_TRAIN: shape the next response AND the NIGHT) =====
DAY | quiet: // sustained quiet DAY | NOT_SPIKE_TRAIN: // sustained quiet (emitted by NEURON — above SOMA)
// for NIGHT: climb the tag; dopamine is the integrable coincidence (#3) // for NIGHT: climb the tag; dopamine is the integrable coincidence (#3)
if post_fast_trace > Ca_TAG: post_possible_tag += post_fast_trace; post_budget -= pka_cost // @cut affords: participation / consistency of co-activity (running average) [min] if post_fast_trace > Ca_TAG: post_possible_tag += post_fast_trace; post_budget -= pka_cost // @cut affords: participation / consistency of co-activity (running average) [min]
if dopamine > dop_thr and post_possible_tag > tag_thr: if dopamine > dop_thr and post_possible_tag > tag_thr:
@@ -557,7 +575,7 @@ DAY | quiet: // sustained quiet
// ACTION (same AMPA/NMDA machinery, same endurance trace), read for participation not significance. // ACTION (same AMPA/NMDA machinery, same endurance trace), read for participation not significance.
// ===== ACTION (build ⇄ release; participation gates direction; tag funds build, persists across cycles) ===== // ===== ACTION (build ⇄ release; participation gates direction; tag funds build, persists across cycles) =====
NIGHT | build or release: NIGHT | NON_REM_1:
if rest_permission and post_tag > tag_expiry and post_participation ≥ MEDIUM: // BUILD (slice) if rest_permission and post_tag > tag_expiry and post_participation ≥ MEDIUM: // BUILD (slice)
Δ = min(slot_batch, post_material, post_energy·f_cap, post_tag) × post_participation Δ = min(slot_batch, post_material, post_energy·f_cap, post_tag) × post_participation
post_structure += Δ; post_material -= Δ; post_energy -= Δ·assembly_cost post_structure += Δ; post_material -= Δ; post_energy -= Δ·assembly_cost
@@ -573,7 +591,7 @@ NIGHT | build or release:
// else: HOLD — tag waits for its pattern // else: HOLD — tag waits for its pattern
// ===== RECOVERY (acquire material/energy in CONTENTION with other components; receive freed material) ===== // ===== RECOVERY (acquire material/energy in CONTENTION with other components; receive freed material) =====
NIGHT | import + free: NIGHT | NON_REM_2:
post_material += transit(post_material_ship, τ_transport_spine) // import (contested pool) post_material += transit(post_material_ship, τ_transport_spine) // import (contested pool)
post_energy += transit(post_energy_ship, τ_transport_spine) post_energy += transit(post_energy_ship, τ_transport_spine)
post_material += post_freed_material; post_freed_material = 0 // reclaim what release freed post_material += post_freed_material; post_freed_material = 0 // reclaim what release freed
@@ -584,7 +602,7 @@ NIGHT | import + free:
post_structure += min(post_maint, maint_cost) // hold up what is used post_structure += min(post_maint, maint_cost) // hold up what is used
// ===== PREPARATION (REPLAY the response — SAME machinery as day ACTION; multi-timescale) ===== // ===== PREPARATION (REPLAY the response — SAME machinery as day ACTION; multi-timescale) =====
NIGHT | replay + measure + prime: NIGHT | REM:
// FAST: replay the response to the re-evoked input (probe) // FAST: replay the response to the re-evoked input (probe)
if arrived_glutamate_replay or arrived_replay_AP: if arrived_glutamate_replay or arrived_replay_AP:
a = sat(glutamate, K_AMPA) a = sat(glutamate, K_AMPA)