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2026-05-25 14:36:27 +02:00
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elements/neuron/presynapse.md
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@@ -9,22 +9,22 @@ Qui comprendiamo:
- PRESYNAPSE: Presynapse - PRESYNAPSE: Presynapse
- VGCC-PRE: Voltage-Controlled Gated Channels - VGCC-PRE: Voltage-Controlled Gated Channels
## PRESYNAPSE ## {PRESYNAPSE}
```Gen ```Gen
PRESYNAPSE {PRESYNAPSE}
type: comprehension type: comprehension
expand_comprehension: expand_comprehension:
_VgccPre: VGCC-PRE [ full: 10x, active: 5x, empty: 2x ] _VgccPre: {VGCC-PRE} [ full: 10x, active: 5x, empty: 2x ]
instantiate_container: instantiate_container:
@: $BehaviorPre [] BEHAVIOR_PRE: CONTAINER []
@: $TunVgccPre [pass: _VgccPre] TUNE_VGCC_PRE: CONTAINER [pass: _VgccPre]
``` ```
### $BehaviorPre ### BEHAVIOR_PRE
**Tubs:** **Tubs:**
@@ -36,10 +36,10 @@ PRESYNAPSE
- **_eCB**: retrograde signal updates from postsynapsis (postsynaptic input) - **_eCB**: retrograde signal updates from postsynapsis (postsynaptic input)
```Gen ```Gen
$BehaviorPre BEHAVIOR_PRE
type: container
activity_scope: !DAY activity_scope: !DAY
type: container
tub_local: tub_local:
_Ca2+: TUB [ full: 60x, active: 30x, empty: 0x ] _Ca2+: TUB [ full: 60x, active: 30x, empty: 0x ]
@@ -58,16 +58,26 @@ $BehaviorPre
snippets: snippets:
# &AP # &AP
NTreleaseLow: [RF: active 12x, type: accumulator] NTreleaseLow: ACCUMULATOR [RF: active 12x]
NTreleaseMedium [RF active 9x, type: accumulator] NTreleaseMedium: ACCUMULATOR [RF active 9x]
NTreleaseHigh: [RF active 9x, type: accumulator] NTreleaseHigh: ACCUMULATOR [RF active 9x]
Ca2+TracesAccLow: [RF active 3x, type: accumulator] Ca2+TracesAccLow: ACCUMULATOR [RF active 3x]
Ca2+TracesAccMedium: [RF active 6x, type: accumulator] Ca2+TracesAccMedium: ACCUMULATOR [RF active 6x]
Ca2+TracesAccHigh: [RF active 10x, type: accumulator] Ca2+TracesAccHigh: ACCUMULATOR [RF active 10x]
# NOT &AP # NOT &AP
eCBClearence: RF [active: 24x] eCBClearenceMedium: ACCUMULATOR [RF: active: 24x]
eCBClearenceLow: ACCUMULATOR [RF: active: 248x]
RPShuttleLow: ACCUMULATOR [RF: active: 24x]
RPShuttleMedium: ACCUMULATOR [RF: active: 48x]
RefillGlutamine: ACCUMULATOR [RF: active: 24x]
Ca2+TracesClearance: ACCUMULATOR [RF: active: 30x]
``` ```
#### &AP #### &AP
@@ -94,6 +104,7 @@ In tutti i casi di NT
NTreleaseLow NTreleaseLow
in_context: &AP in_context: &AP
hypothesis: ( _Ca2+ mediumness ) AND ( _Rrp mediumness ) AND NOT( _ATP empty ) hypothesis: ( _Ca2+ mediumness ) AND ( _Rrp mediumness ) AND NOT( _ATP empty )
action: [_Rrp decrease, _Nt increase, _ATP decrease] action: [_Rrp decrease, _Nt increase, _ATP decrease]
trace: None trace: None
@@ -104,7 +115,8 @@ NTreleaseLow
```Gen ```Gen
NTreleaseMedium NTreleaseMedium
in_context: AP_ctx in_context: &AP
hypothesis: (( Ca2+ fullness ) AND ( Rrp mediumness ) OR hypothesis: (( Ca2+ fullness ) AND ( Rrp mediumness ) OR
( Ca2+ mediumness ) AND ( Rrp fullness )) AND ( Ca2+ mediumness ) AND ( Rrp fullness )) AND
NOT( ATP empty ) NOT( ATP empty )
@@ -117,7 +129,8 @@ NTreleaseMedium
```Gen ```Gen
NTreleaseHigh NTreleaseHigh
in_context: AP_ctx in_context: &AP
hypothesis: ( Ca2+ fullness ) AND ( Rrp fullness ) AND hypothesis: ( Ca2+ fullness ) AND ( Rrp fullness ) AND
NOT( ATP empty ) NOT( ATP empty )
action: [Rrp decrease, NT increase, ATP decrease] action: [Rrp decrease, NT increase, ATP decrease]
@@ -130,16 +143,17 @@ Serve a:
- fare il tuning dei VGCC - fare il tuning dei VGCC
- dare la velocita' al trasporto di vesicles da RP a RRP, anche se non avendo ancora compreso ATP, la velocita' non cambia molto la sostanza. - dare la velocita' al trasporto di vesicles da RP a RRP, anche se non avendo ancora compreso ATP, la velocita' non cambia molto la sostanza.
- le tracce vengono eliminate quando il neurone e' in pausa, lontano da uno spike train, TunPossible_ctx - le tracce vengono eliminate quando il neurone e' in pausa, lontano da uno spike train, &TunePossible
- Abbiamo 3 tracce, high, medium and low. Andiamo a verificare una combinazione di queste per fare la modulazione - Abbiamo 3 tracce, high, medium and low. Andiamo a verificare una combinazione di queste per fare la modulazione
- RF e' a 10, questo dovrebbe essere un RF di campionamento durante AP_ctx context che dovremmo assicurarci sia tipo 100. Il che implicherebbe 10 campionamenti. - RF e' a 10, questo dovrebbe essere un RF di campionamento durante &AP context che dovremmo assicurarci sia tipo 100. Il che implicherebbe 10 campionamenti.
- The biological meaning is that a synapse that has just been through a burst is primed for fast recovery — the molecular machinery for vesicle docking is already engaged, calcium-dependent priming factors are still elevated, and the system is in a ready state. A synapse that has been silent for several seconds has cooled down and replenishes slowly. - The biological meaning is that a synapse that has just been through a burst is primed for fast recovery — the molecular machinery for vesicle docking is already engaged, calcium-dependent priming factors are still elevated, and the system is in a ready state. A synapse that has been silent for several seconds has cooled down and replenishes slowly.
- So after one second of silence CaTrace has fallen to ~37% of its peak value, after two seconds to ~14%, after three seconds to ~5%. It asymptotes toward zero but never exactly reaches it. Between spikes, Ca2+ falls toward zero as the pumps clear it. The result is that CaTrace encodes not the instantaneous calcium level but the recent history of calcium activity — a smoothed, time-averaged measure of how active the synapse has been over the past one to two seconds. - So after one second of silence CaTrace has fallen to ~37% of its peak value, after two seconds to ~14%, after three seconds to ~5%. It asymptotes toward zero but never exactly reaches it. Between spikes, Ca2+ falls toward zero as the pumps clear it. The result is that CaTrace encodes not the instantaneous calcium level but the recent history of calcium activity — a smoothed, time-averaged measure of how active the synapse has been over the past one to two seconds.
```Gen ```Gen
Ca2+TracesAccuLow Ca2+TracesAccuLow
in_context: AP_ctx in_context: &AP
hypothesis: (Ca2+ emptiness) hypothesis: (Ca2+ emptiness)
action: [CaTraceLow increase] action: [CaTraceLow increase]
trace: None trace: None
@@ -150,7 +164,8 @@ Ca2+TracesAccuLow
```Gen ```Gen
Ca2+TracesAccMedium Ca2+TracesAccMedium
in_context: AP_ctx in_context: &AP
hypothesis: (Ca2+ mediumness) hypothesis: (Ca2+ mediumness)
action: [CaTraceMed increase] action: [CaTraceMed increase]
trace: None trace: None
@@ -161,7 +176,8 @@ Ca2+TracesAccMedium
```Gen ```Gen
Ca2+TracesAccumulationHigh Ca2+TracesAccumulationHigh
in_context: AP_ctx in_context: &AP
hypothesis: (Ca2+ fullness) hypothesis: (Ca2+ fullness)
action: [CaTraceHigh increase] action: [CaTraceHigh increase]
trace: None trace: None
@@ -169,26 +185,23 @@ Ca2+TracesAccumulationHigh
#### NOT &AP #### NOT &AP
##### eCB clearance: accumulator ##### eCBClearance
eCB dipende da POST. Tende a modulare l'entrata di Ca2+ degli VGCC. eCB dipende da POST. Tende a modulare l'entrata di Ca2+ degli VGCC.
Qui non facciamo un flush di eCB, riduciamo ogni mezzo secondo (context) di un RF di questo episodio. Qui non facciamo un flush di eCB, riduciamo ogni mezzo secondo (context) di un RF di questo episodio.
##### eCBClearance: ( active: 24x ) accumulator
```Gen ```Gen
eCBClearance: ( active: 24x ) # Slow eCBClearance: ( active: 24x ) # Slow
type: accumulator
contained_by: PRESYNAPSE-BEH
in_context: NOT AP_ctx in_context: NOT &AP
hypothesis: NOT (eCB empty) hypothesis: NOT (eCB empty)
action: [eCB decrease] action: [eCB decrease]
trace: None trace: None
``` ```
##### RPShuttleLow: ( active: 48x ) accumulator ##### RPShuttleLow
This happens in the seconds loop, once per second. This happens in the seconds loop, once per second.
@@ -197,11 +210,10 @@ The "Hard Bottleneck" State. Recruitment is throttled by a lack of signal, a lac
Rate: 0.00 – 0.25 Rate: 0.00 – 0.25
```Gen ```Gen
RPShuttleLow: ( active: 48x ) # Low RPShuttleLow
type: accumulator
contained_by: PRESYNAPSE-BEH in_context: NOT &AP
in_context: NOT AP_ctx
hypothesis: (CaTraceLow fullness) OR hypothesis: (CaTraceLow fullness) OR
(RP emptiness) OR (RP emptiness) OR
(RRP fullness) (RRP fullness)
@@ -209,18 +221,17 @@ RPShuttleLow: ( active: 48x ) # Low
trace: None trace: None
``` ```
##### RPShuttleMedium: ( active: 24x ) accumulator ##### RPShuttleMedium
The "Sub-Optimal" State. The machinery is working, but it's held back by partial limitations. This covers cases where the signal is steady but the "piston" isn't firing at full speed, or where a high vacancy in the RRP (emptiness) forces a low signal to work a bit harder. The "Sub-Optimal" State. The machinery is working, but it's held back by partial limitations. This covers cases where the signal is steady but the "piston" isn't firing at full speed, or where a high vacancy in the RRP (emptiness) forces a low signal to work a bit harder.
Rate: 0.50 – 0.97 Rate: 0.50 – 0.97
```Gen ```Gen
RPShuttleMedium: ( active: 24x ) # Medium RPShuttleMedium
type: accumulator
contained_by: PRESYNAPSE-BEH in_context: &AP
in_context: AP_ctx
hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (RRP mediumness) OR hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (RRP mediumness) OR
(CaTraceHigh fullness) AND (RP mediumness) AND (RRP mediumness) OR # signal boost (CaTraceHigh fullness) AND (RP mediumness) AND (RRP mediumness) OR # signal boost
(CaTraceMedium fullness) AND (RP fullness) AND (RRP mediumness) OR # supply boost (CaTraceMedium fullness) AND (RP fullness) AND (RRP mediumness) OR # supply boost
@@ -229,18 +240,17 @@ RPShuttleMedium: ( active: 24x ) # Medium
trace: None trace: None
``` ```
##### RPShuttleHigh: ( active: 12x ) accumulator ##### RPShuttleHigh
The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull. The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull.
Rate: 1.25 – 1.94 Rate: 1.25 – 1.94
```Gen ```Gen
RPShuttleHigh: ( active: 12x ) # Fast RPShuttleHigh
type: accumulator
contained_by: PRESYNAPSE-BEH in_context: &AP
in_context: AP_ctx
hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (RRP mediumness) OR # signal + supply hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (RRP mediumness) OR # signal + supply
(CaTraceHigh fullness) AND (RP mediumness) AND (RRP emptiness) OR # signal + vacancy (CaTraceHigh fullness) AND (RP mediumness) AND (RRP emptiness) OR # signal + vacancy
(CaTraceMedium fullness) AND (RP fullness) AND (RRP emptiness) # supply + vacancy (CaTraceMedium fullness) AND (RP fullness) AND (RRP emptiness) # supply + vacancy
@@ -248,7 +258,7 @@ RPShuttleHigh: ( active: 12x ) # Fast
trace: None trace: None
``` ```
##### RefillRPGlutamine: accumulator ##### RefillRPGlutamine
This happens in the minutes loop, once per minute, via the glutamine shuttle from the astrocyte. It is a two-step process across two cells. This happens in the minutes loop, once per minute, via the glutamine shuttle from the astrocyte. It is a two-step process across two cells.
@@ -278,16 +288,15 @@ Gln — depletes over bursts, refilled by glucose (slowest, astrocyte-depend
Each tier buys time for the one below it to respond. When all three are depleted simultaneously — which only happens under prolonged high-frequency firing with insufficient glucose — the synapse has no remaining buffer and goes silent until the minutes loop restores the Glutamine_pool. Each tier buys time for the one below it to respond. When all three are depleted simultaneously — which only happens under prolonged high-frequency firing with insufficient glucose — the synapse has no remaining buffer and goes silent until the minutes loop restores the Glutamine_pool.
##### Ca2+TracesClearance: ( active: 30x ) accumulator ##### Ca2+TracesClearance
Qui facciamo un flush di CaTraceX. Deve essere fatto a valle del tuning. Qui facciamo un flush di CaTraceX. Deve essere fatto a valle del tuning.
```Gen ```Gen
Ca2+TracesClearance: ( active: 30x ) # Slow Ca2+TracesClearance
type: accumulator
contained_by: PRESYNAPSE-BHE in_context: NOT &TunePossible
in_context: NOT TunPossible_ctx
hypothesis: NOT (CaTraceHigh empty) hypothesis: NOT (CaTraceHigh empty)
action: [CaTRaceHigh decrease] action: [CaTRaceHigh decrease]
trace: None trace: None
@@ -301,41 +310,45 @@ Ca2+TracesClearance: ( active: 30x ) # Slow
trace: None trace: None
``` ```
### VGCC-PRE-TUN: Container ### TUNE_VGCC_PRE
```Gen ```Gen
VGCC-PRE-TUN TUNE_VGCC_PRE
# qui stiamo aggiungendo o eliminando VGCC-PRE. Fra un massimo full e minimo empty (empty puo' non essere 0) # qui stiamo aggiungendo o eliminando VGCC-PRE. Fra un massimo full e minimo empty (empty puo' non essere 0)
# contained_by: PRESYNAPSE non e' contenuto, si attacca. # contained_by: PRESYNAPSE non e' contenuto, si attacca.
type: container
activity_scope: !DAY activity_scope: !DAY
type: container
context_intricated: context_intricated:
- TunPossible_ctx ( contained_by: DAY-N ) - &TunePossible ( contained_by: DAY-N )
tub_passed: tub_passed:
VGCC-PRE_ALL: pass.VGCC-PRE_ALL _VgccPre: pass._VgccPre
tub_local: tub_local:
tub_intricated: tub_intricated:
snippets:
CheckVgccPreTun: CONTEXTOR [RF: active 60x]
PossibleUpPreVgccTun: ACCUMULATOR [RF:active 10x]
PossibleDownPreVgccTun: ACCUMULATOR [RF:active 10x]
``` ```
#### TunPossible_ctx #### &TunePossible
##### CheckVgccPreTun: ( active: 60x ) contexting ##### CheckVgccPreTun
Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantita' di VGCC Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantita' di VGCC
```Gen ```Gen
CheckVgccPreTun: ( active: 60x ) CheckVgccPreTun
type: contexting
contained_by: VGCC-PRE-TUN in_context: &TunePossible
in_context: TunPossible_ctx
condition: ( CaTraceHigh fullness ) condition: ( CaTraceHigh fullness )
out_context: TryTunUpPreVcgg_ctx out_context: TryTunUpPreVcgg_ctx
@@ -343,14 +356,13 @@ CheckVgccPreTun: ( active: 60x )
out_context: TryTunDownPreVcgg_ctx out_context: TryTunDownPreVcgg_ctx
``` ```
##### PossibleUpPreVgccTun: ( active: 10x ) accumulator ##### PossibleUpPreVgccTun
```Gen ```Gen
PossibleUpPreVgccTun: ( active: 10x ) PossibleUpPreVgccTun
type: accumulator
contained_by: VGCC-PRE-TUN
in_context: TryTunUpPreVcgg_ctx in_context: TryTunUpPreVcgg_ctx
hypothesis: hypothesis:
action: action:
trace: trace:
@@ -359,37 +371,36 @@ PossibleUpPreVgccTun: ( active: 10x )
##### PossibleDownPreVgccTun: ( active: 10x ) accumulator ##### PossibleDownPreVgccTun: ( active: 10x ) accumulator
```Gen ```Gen
PossibleDownPreVgccTun: ( active: 10x ) PossibleDownPreVgccTun
type: accumulator
contained_by: VGCC-PRE-TUN
in_context: TryTunDownPreVcgg_ctx in_context: TryTunDownPreVcgg_ctx
hypothesis: hypothesis:
action: action:
trace: trace:
``` ```
## VGCC-PRE: Comprehension ## {VGCC-PRE}
Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare. Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare.
```Gen ```Gen
VGCC-PRE {VGCC-PRE}
type: comprehension type: comprehension
instantiate_container: instantiate_container:
VGCC-PRE-BEH [] BEHAVIOR_VGCC_PRE: CONTAINER []
``` ```
### VGCC-PRE-BEH: Container ### BEHAVIOR_VGCC_PRE
Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare. Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare.
```Gen ```Gen
VGCC-PRE-PRE BEHAVIOR_VGCC_PRE
type: container
activity_scope: !DAY activity_scope: !DAY
type: container
tub_intricated: tub_intricated:
- Ca2+ ( contained_by: PRESYNAPSE-BHE ) - Ca2+ ( contained_by: PRESYNAPSE-BHE )
@@ -397,9 +408,19 @@ VGCC-PRE-PRE
context_intricated: context_intricated:
- AP ( contained_by: SOMA ) - AP ( contained_by: SOMA )
snippets:
Ca2+enterLow: ACCUMULATOR [RF: active 12x]
Ca2+enterMedium: ACCUMULATOR [RF: active 6x]
Ca2+enterHigh: ACCUMULATOR [RF: active 3x]
Ca2+ClearanceLow: ACCUMULATOR [RF: active 24x]
Ca2+ClearanceHigh: ACCUMULATOR [RF: active 4x]
``` ```
#### AP_ctx #### &AP
Da rivedere le condizioni per aggiungere mGluR che ha come proxy NT concentration!!!!! Da rivedere le condizioni per aggiungere mGluR che ha come proxy NT concentration!!!!!
@@ -421,27 +442,25 @@ Qui semplifichiamo:
Devo controllare che le condizioni sotto siano esaustive. Qui ho confuso high con low, e inoltre ho messo NT per mGluR che devo controllare che abbia senso. Devo controllare che le condizioni sotto siano esaustive. Qui ho confuso high con low, e inoltre ho messo NT per mGluR che devo controllare che abbia senso.
##### Ca2+enterLow: ( active: 12x ) accumulator ##### Ca2+enterLow
```Gen ```Gen
Ca2+enterLow: ( active: 12x ) # Low Ca2+enterLow
type: accumulator
contained_by: VGCC-PRE-BEH in_context: &AP
in_context: AP_ctx
hypothesis: (Ca2+ empty) AND (eCB empty) hypothesis: (Ca2+ empty) AND (eCB empty)
action: [Ca2+ increase, ATP decrease] action: [Ca2+ increase, ATP decrease]
trace: None trace: None
``` ```
##### Ca2+enterMedium: ( active: 6x ) accumulator ##### Ca2+enterMedium
```Gen ```Gen
Ca2+enterMedium: ( active: 6x ) # Medium Ca2+enterMedium
type: accumulator
contained_by: VGCC-PRE-BEH in_context: &AP
in_context: AP_ctx
hypothesis: (Ca2+ mediumness) OR hypothesis: (Ca2+ mediumness) OR
((eCB mediumness) AND (Ca2+ empty)) OR ((eCB mediumness) AND (Ca2+ empty)) OR
((eCB full) AND (Ca2+ empty) AND (NT empty)) ((eCB full) AND (Ca2+ empty) AND (NT empty))
@@ -449,23 +468,22 @@ Ca2+enterMedium: ( active: 6x ) # Medium
trace: None trace: None
``` ```
##### Ca2+enterHigh: ( active: 3x ) accumulator ##### Ca2+enterHigh
```Gen ```Gen
Ca2+enterHigh: ( active: 3x ) # High Ca2+enterHigh
type: accumulator
contained_by: VGCC-PRE-BEH in_context: &AP
in_context: AP_ctx
hypothesis: (Ca2+ mediumness) AND (eCB full) OR hypothesis: (Ca2+ mediumness) AND (eCB full) OR
(eCB mediumness) (eCB mediumness)
action: [Ca2+ increase, ATP decrease] action: [Ca2+ increase, ATP decrease]
trace: None trace: None
``` ```
#### NOT AP_ctx #### NOT &AP
Qui eliminiamo Ca2+. Il tempo che ci mette ad eliminare il Ca2+ dovrebbe essere minoe dell'inervallo fra un AP_ctx e un'altra. Siccome non comprendiamo per ora ATP, non c'e' accumulo di Ca2+ per mancanza di ATP (stanchezza). Qui eliminiamo Ca2+. Il tempo che ci mette ad eliminare il Ca2+ dovrebbe essere minoe dell'inervallo fra un &AP e un'altra. Siccome non comprendiamo per ora ATP, non c'e' accumulo di Ca2+ per mancanza di ATP (stanchezza).
Non non comprendiamo anche il ristabilimento del Voltage, con altri Ioni entranti e uscenti, per ora tutto dipende da AP del SOMA. Non comprendiamo per ora: Non non comprendiamo anche il ristabilimento del Voltage, con altri Ioni entranti e uscenti, per ora tutto dipende da AP del SOMA. Non comprendiamo per ora:
@@ -479,27 +497,25 @@ Qui disinguiamo:
- NOT ca2+ fullness che svuota piu' lentamente - NOT ca2+ fullness che svuota piu' lentamente
- da capire se serve veramente questa distinzione per il tempo di svuotamento. - da capire se serve veramente questa distinzione per il tempo di svuotamento.
##### Ca2+ClearanceLow: ( active: 24x ) accumulator ##### Ca2+ClearanceLow
```Gen ```Gen
Ca2+ClearanceLow: ( active: 24x ) # Low Ca2+ClearanceLow
type: accumulator
contained_by: VGCC-PRE-BEH in_context: NOT &AP
in_context: NOT AP_ctx
hypothesis: (NOT Ca2+ fullness) AND (NOT Ca2+ empty) hypothesis: (NOT Ca2+ fullness) AND (NOT Ca2+ empty)
action: [Ca2+ decrease] action: [Ca2+ decrease]
trace: None trace: None
``` ```
##### Ca2+ClearanceHigh: ( active: 4x ) accumulator ##### Ca2+ClearanceHigh
```Gen ```Gen
Ca2+ClearanceHigh: ( active: 4x ) # High Ca2+ClearanceHigh
type: accumulator
contained_by: VGCC-PRE-BEH in_context: NOT &AP
in_context: NOT AP_ctx
hypothesis: NOT (Ca2+ empty) hypothesis: NOT (Ca2+ empty)
action: [Ca2+ decrease] action: [Ca2+ decrease]
trace: None trace: None