- based on VDB, VGSC open and let Na+ in. VGSG then go into refractory
- if Na fullness then ApCtx. Here the threshold is based only on the integration of Na+
- increase SpikeTrainTraces (fast at spike)
- increase Ca2+ traces
- decrease Na: fast pump which decreases Na+, we do not model K+
-- there is a tug of war between Na entering and exiting. Na can reach fullness only if VDB increases fast (derivative)
- there are 2 context: ApCtx and RefractorySoma imlemented with timers and tunable
- decrease SpikeTraintraces slow, only if away from spiketrain this is empty
- Tune:
-- The threshold is tuned during the spiketrain. Low threshold at rest, to increase sensitivity, threshold increase during spike to increase discrimination
— secs:
- SpikeTrainTraces
— mins:
- Tune:
-- refractory lenght
---
**Tubs:**
- **VDB**: dendrites deliver current
- **Na**: are a proxy for the Coulombs of charge building up on the somatic membrane. They are used to check threshold, but also to mimic Na+ and K+ pumping
- **Ca2+**: Medium term traces to guide tuning and Night development. It is a local trace, ATP is a global (Astrocyte)
- **SpikeTrainTraces**: sono le tracce che consentono al neurone di far partire il Tuning neuronale, quando e' lontano da uno spike-train, ovvero e' in riposo.
As dendrites deliver current (VDB), the soma acts like a capacitor. It "stores" this charge in the form of membrane potential. This contextualizes VGSC-SOMA to open ion channels that let Na+ ions in.
This only applies if not ApCtx, or in other words, SOMA is not in refractory period.
```Gen
check_tpc: VDB-Concentration
contained_by: SOMA
tpc: any
rf: ( active: 60x )
condition: (VDB fullness ) AND NOT ApCtx
out_tpc: VDBMaxCtx
condition: ( VDB mediumness ) AND NOT ApCtx
out_tpc: VDBMediumCtx
condition: ( VDB emptiness ) AND NOT ApCtx
out_tpc: VDBLowCtx
```
#### SomaSpill: interacting
```Gen
interacting: SomaSpill
contained_by: SOMA
context: any
rf: ( active: 8x )
hypothesis: NOT NA emptiness
action: [ decrease NA ]
trace:
```
#### SomaSpike: check_tpc
Qui siamo nella fase effettiva di spike, non refractory che viene dopo. Fa da contesto di durata fra un RF ed un altro.
```Gen
check_tpc: SomaSpike
contained_by: SOMA
context: fixed
rf: ( active: 60x )
condition: ( Na fullness ) AND ( RefractorySoma emptiness )
out_context: ApCtx
out_context: bApCtx
```
#### ApBeh: interacting
Durante la fase effettiva di spike, eliminiamo Na accumulati, riempiamo RefractorySoma per fase di refractory e riempiamo Ca2+ per le tracce medio termine di potenziamento/depotenziamento.
```Gen
interacting: ApBeh
contained_by: SOMA
context: ApCtx
rf: ( active: 8x )
hypothesis: NOT Na empty
action: [ decrease Na ]
trace:
hypothesis: NOT RefractorySoma full
action: [ increase RefractorySoma ]
trace:
hypothesis: NOT Ca2+ full
action: [ increase Ca2+ ]
trace:
```
#### RefractoryBeh: interacting
```Gen
interacting: RefractoryBeh
contained_by: SOMA
context: any
rf: ( active: 8x )
hypothesis: NOT RefractorySoma empty
action: [ decrease RefractorySoma ]
trace:
```
### sec: SOMA
### min: SOMA
#### VGSC-SOMA-TUN: Tuner
```Gen
tuner: VGSC-SOMA-TUN
contained_by: SOMA
tunes: SOMA/expansion/VGSC-SOMA
context_intricated:
- TunPossible ( contained_by: DAY-N )
tub_local:
tub_intricated:
```
##### Check: check_tpc
```Gen
context: check_tpc
contained_by: VGSC-SOMA-TUN
context: TunPossible
rf: ( active: 60x )
condition:
out_context: TunSomaVcgg
```
##### ?: interacting
```Gen
interacting: ?
contained_by: TUN-PRE-VGCC
context: TunSomaVcgg
rf: ( active: x )
hypothesis:
action:
trace:
```
## VGSC-SOMA-H: container
Voltage Gated Sodium Channel: difficult to open (High)
```Gen
container: VGSC-SOMA-H
tub_local:
Ready ( )
tub_intricated:
Na ( contained_in: SOMA)
```
### sec: VGSC-SOMA-H
#### NaEnterH: interacting
Se metto il controllo sulla (NOT Ready fullness) il VGSC puo' far entrare un numero di Na non superiore ad un massimo.
```Gen
interacting: NaEnterH
contained_by: VGSC-H-SOMA
context: VDBMaxCtx AND ( NOT RefractoryH )
rf: ( active: 1x )
hypothesis: ( NOT Na fullness ) AND ( NOT ReadyH fullness )
action: [ Na increase, ReadyH increase ]
trace: None
```
##### CheckRefractoryH: check_tpc
Il check su refractory deve essere fatto ad un RF maggiore della eliminazione di Refractory. Questo perche' e' un era nella qualle avviene l'episodio.
```Gen
check_tpc: CheckRefractoryH
contained_by: VGSC-H-SOMA
context: NOT RefractoryH
rf: ( active: 60x )
condition: ( ReadyH fullness )
out_context: RefractoryH
```
##### RefractoryH: interacting
Questo episodio deve girare varie volte nell'ambito del contesto di refractory che viene controllato ad un RF maggiore.
```Gen
interacting: RefractoryH
contained_by: VGSC-H-SOMA
context: RefractoryH
rf: ( active: 1x )
hypothesis: NOT ( ReadyH emptyness )
action: [ ReadyH decrease ]
trace: None
```
## VGSC-SOMA-M: container
Voltage Gated Sodium Channel: less difficult to open (Medium)
```Gen
container: VGSC-SOMA-M
tub_local:
Ready ( )
tub_intricated:
Na ( contained_in: SOMA)
```
### sec: VGSC-SOMA-M
#### NaEnterM: interacting
Se metto il controllo sulla (NOT Ready fullness) il VGSC puo' far entrare un numero di Na non superiore ad un massimo.
```Gen
interacting: NaEnterM
contained_by: VGSC-M-SOMA
context: (VDBMediumCtx OR VDBMaxCtx) AND ( NOT RefractoryM )
rf: ( active: 1x )
hypothesis: ( NOT Na fullness ) AND ( NOT ReadyM fullness )
action: [ Na increase, ReadyM increase ]
trace: None
```
##### CheckRefractoryM: check_tpc
Il check su refractory deve essere fatto ad un RF maggiore della eliminazione di Refractory. Questo perche' e' un era nella qualle avviene l'episodio.
```Gen
check_tpc: CheckRefractoryM
contained_by: VGSC-M-SOMA
context: NOT RefractoryM
rf: ( active: 60x )
condition: ( ReadyM fullness )
out_context: RefractoryM
```
##### RefractoryM: interacting
Questo episodio deve girare varie volte nell'ambito del contesto di refractory che viene controllato ad un RF maggiore.
```Gen
interacting: RefractoryM
contained_by: VGSC-M-SOMA
context: RefractoryM
rf: ( active: 1x )
hypothesis: NOT ( ReadyM emptyness )
action: [ ReadyM decrease ]
trace: None
```
## VGSC-SOMA-L: container
Voltage Gated Sodium Channel: easy to open (Low)
```Gen
container: VGSC-SOMA-L
tub_local:
Ready ( )
tub_intricated:
Na ( contained_in: SOMA)
```
### sec: VGSC-SOMA-L
#### NaEnterL: interacting
Se metto il controllo sulla (NOT Ready fullness) il VGSC puo' far entrare un numero di Na non superiore ad un massimo.
```Gen
interacting: NaEnterL
contained_by: VGSC-L-SOMA
context: ( VDBLowCtx OR VDBMediumCtx OR VDBMaxCtx) AND ( NOT RefractoryL )
rf: ( active: 1x )
hypothesis: ( NOT Na fullness ) AND ( NOT ReadyL fullness )
